CN102667463B - 利用球形末端的入射和输出光纤和/或共平面的入射和输出光导和分离通道的生物分析 - Google Patents

利用球形末端的入射和输出光纤和/或共平面的入射和输出光导和分离通道的生物分析 Download PDF

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Publication number
CN102667463B
CN102667463B CN201180001774.0A CN201180001774A CN102667463B CN 102667463 B CN102667463 B CN 102667463B CN 201180001774 A CN201180001774 A CN 201180001774A CN 102667463 B CN102667463 B CN 102667463B
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radiation
optical fiber
detection zone
light guide
longitudinal axis
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CN102667463A (zh
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V.D.阿米尔克哈尼安
蔡守冠
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
    • G01N27/44721—Arrangements for investigating the separated zones, e.g. localising zones by optical means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/74—Optical detectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Optical Measuring Cells (AREA)
CN201180001774.0A 2010-01-28 2011-01-28 利用球形末端的入射和输出光纤和/或共平面的入射和输出光导和分离通道的生物分析 Active CN102667463B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29930110P 2010-01-28 2010-01-28
US61/299,301 2010-01-28
PCT/US2011/023071 WO2011094648A2 (en) 2010-01-28 2011-01-28 Bio-analysis using ball-ended incident and output optical fiber

Publications (2)

Publication Number Publication Date
CN102667463A CN102667463A (zh) 2012-09-12
CN102667463B true CN102667463B (zh) 2016-09-07

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CN201180001774.0A Active CN102667463B (zh) 2010-01-28 2011-01-28 利用球形末端的入射和输出光纤和/或共平面的入射和输出光导和分离通道的生物分析

Country Status (6)

Country Link
US (1) US8784626B2 (cg-RX-API-DMAC7.html)
EP (1) EP2529211B8 (cg-RX-API-DMAC7.html)
JP (1) JP5852584B2 (cg-RX-API-DMAC7.html)
KR (1) KR101712691B1 (cg-RX-API-DMAC7.html)
CN (1) CN102667463B (cg-RX-API-DMAC7.html)
WO (1) WO2011094648A2 (cg-RX-API-DMAC7.html)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103328963A (zh) 2010-08-24 2013-09-25 光鼎生物科技股份有限公司 一次性生物分析试剂盒和使用其进行生物分析的仪器
WO2012165890A2 (ko) * 2011-05-31 2012-12-06 주식회사 엘지화학 전력저장용 단위 랙의 연결을 위한 전압 평준화 장치 및 이를 포함하는 전력저장 시스템
US20150338347A1 (en) * 2014-05-22 2015-11-26 Bioptic, Inc. Glycan profiling utilizing capillary electrophoresis
EP3454964B1 (en) * 2016-05-13 2021-06-23 Agilent Technologies, Inc. Automated alignment, calibration and standardization of electrophoresis data
USD859685S1 (en) 2017-02-21 2019-09-10 Bioptic, Inc. Disposable bio-analysis cartridge
EP4490501A1 (en) 2022-03-10 2025-01-15 Bioptic, Inc. Portable electrophoresis system with integrated thermocycler
DE112024000232T5 (de) * 2023-03-24 2025-09-04 Hitachi High-Tech Corporation Kapillarelektrophoresevorrichtung

Citations (3)

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US4675300A (en) * 1985-09-18 1987-06-23 The Board Of Trustees Of The Leland Stanford Junior University Laser-excitation fluorescence detection electrokinetic separation
US20020092770A1 (en) * 2000-12-01 2002-07-18 Hedberg Herbert J. High throughput capilliary electrophoresis system
US20030116436A1 (en) * 2001-10-19 2003-06-26 Varouj Amirkhanian Multi-color multiplexed analysis in a bio-separation system

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US4985129A (en) * 1988-12-02 1991-01-15 Bio-Rad Laboratories, Inc. Apparatus for capillary electrophoresis
CA2094343A1 (en) * 1992-07-17 1994-01-18 Gerald L. Klein Method and apparatus for displaying capillary electrophoresis data
JP3515646B2 (ja) * 1995-09-18 2004-04-05 大塚電子株式会社 マルチキャピラリ電気泳動装置
US6592733B1 (en) * 1999-11-12 2003-07-15 Motorola, Inc. Capillary electrophoresis devices incorporating optical waveguides
US6184990B1 (en) 1999-12-22 2001-02-06 Beckman Coulter, Inc. Miniature multiple wavelength excitation and emission optical system and method for laser-induced fluorescence detectors in capillary electrophoresis
JP3893849B2 (ja) * 2000-05-15 2007-03-14 株式会社日立製作所 キャピラリアレイ電気泳動装置及び電気泳動方法
JP3969699B2 (ja) * 2000-11-17 2007-09-05 日本板硝子株式会社 マイクロ化学システム用チップ部材、及び該チップ部材を用いたマイクロ化学システム
AU2002247040A1 (en) 2001-01-26 2002-08-06 Biocal Technology, Inc. Multi-channel bio-separation cartridge
WO2002059592A2 (en) 2001-01-26 2002-08-01 Biocal Technology, Inc. Optical detection in a multi-channel bio-separation system
GB2383127B (en) * 2001-12-12 2004-10-20 Proimmune Ltd Device and method for investigating analytes in liquid suspension or solution
US7250099B2 (en) * 2002-12-13 2007-07-31 Biocal Technology, Inc. Optical detection alignment coupling apparatus
US20040047535A1 (en) * 2002-09-09 2004-03-11 Ljerka Ukrainczyk Enhanced fiber-optic sensor
JP2004361239A (ja) * 2003-06-04 2004-12-24 Enplas Corp マイクロ分析システム用光学系
US7924425B2 (en) * 2005-06-27 2011-04-12 The United States Of America As Represented By The Department Of Health And Human Services Spatially selective fixed-optics multicolor fluorescence detection system for a multichannel microfluidic device, and method for detection
US20070131870A1 (en) * 2005-12-12 2007-06-14 Combisep Multiplexed CE fluorescence system
JP2008116395A (ja) * 2006-11-07 2008-05-22 Fujitsu Ltd 蛍光検出装置

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4675300A (en) * 1985-09-18 1987-06-23 The Board Of Trustees Of The Leland Stanford Junior University Laser-excitation fluorescence detection electrokinetic separation
US20020092770A1 (en) * 2000-12-01 2002-07-18 Hedberg Herbert J. High throughput capilliary electrophoresis system
US20030116436A1 (en) * 2001-10-19 2003-06-26 Varouj Amirkhanian Multi-color multiplexed analysis in a bio-separation system

Also Published As

Publication number Publication date
KR101712691B1 (ko) 2017-03-06
JP2013518290A (ja) 2013-05-20
US20110253540A1 (en) 2011-10-20
EP2529211A2 (en) 2012-12-05
KR20120112821A (ko) 2012-10-11
EP2529211B8 (en) 2017-10-04
JP5852584B2 (ja) 2016-02-03
US8784626B2 (en) 2014-07-22
WO2011094648A3 (en) 2011-11-03
EP2529211B1 (en) 2017-05-03
CN102667463A (zh) 2012-09-12
WO2011094648A2 (en) 2011-08-04

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