CN102652714A - Preparation method of compound ketoconazole shampoo - Google Patents
Preparation method of compound ketoconazole shampoo Download PDFInfo
- Publication number
- CN102652714A CN102652714A CN2011100502945A CN201110050294A CN102652714A CN 102652714 A CN102652714 A CN 102652714A CN 2011100502945 A CN2011100502945 A CN 2011100502945A CN 201110050294 A CN201110050294 A CN 201110050294A CN 102652714 A CN102652714 A CN 102652714A
- Authority
- CN
- China
- Prior art keywords
- shampoo
- clobetasol propionate
- minutes
- ketoconazol
- compound ketoconazole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002453 shampoo Substances 0.000 title claims abstract description 35
- XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 title claims abstract description 34
- 229960004125 ketoconazole Drugs 0.000 title claims abstract description 34
- 150000001875 compounds Chemical class 0.000 title claims abstract description 19
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- CBGUOGMQLZIXBE-XGQKBEPLSA-N clobetasol propionate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CCl)(OC(=O)CC)[C@@]1(C)C[C@@H]2O CBGUOGMQLZIXBE-XGQKBEPLSA-N 0.000 claims abstract description 28
- 229960004703 clobetasol propionate Drugs 0.000 claims abstract description 28
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 27
- 239000002994 raw material Substances 0.000 claims abstract description 20
- 238000000034 method Methods 0.000 claims abstract description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 11
- MUQNGPZZQDCDFT-JNQJZLCISA-N Halcinonide Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CCl)[C@@]1(C)C[C@@H]2O MUQNGPZZQDCDFT-JNQJZLCISA-N 0.000 claims abstract description 9
- 229960002383 halcinonide Drugs 0.000 claims abstract description 9
- 239000004006 olive oil Substances 0.000 claims abstract description 9
- 235000008390 olive oil Nutrition 0.000 claims abstract description 9
- 239000008213 purified water Substances 0.000 claims abstract description 9
- 238000003756 stirring Methods 0.000 claims description 20
- FCIZRDXBLQAYLY-UHFFFAOYSA-N C(CCCCCCCCCCC)(=O)OCCOCCOC(CCCCCCCCCCC)=O.C(CCCCCCCCCCCCCCCCC)(=O)O Chemical compound C(CCCCCCCCCCC)(=O)OCCOCCOC(CCCCCCCCCCC)=O.C(CCCCCCCCCCCCCCCCC)(=O)O FCIZRDXBLQAYLY-UHFFFAOYSA-N 0.000 claims description 8
- 239000004166 Lanolin Substances 0.000 claims description 8
- 125000000217 alkyl group Chemical group 0.000 claims description 8
- 230000002421 anti-septic effect Effects 0.000 claims description 8
- 229940039717 lanolin Drugs 0.000 claims description 8
- 235000019388 lanolin Nutrition 0.000 claims description 8
- 239000007788 liquid Substances 0.000 claims description 8
- 238000010792 warming Methods 0.000 claims description 5
- 239000000686 essence Substances 0.000 claims description 3
- 210000004209 hair Anatomy 0.000 abstract description 7
- 239000000463 material Substances 0.000 abstract description 7
- 241000101040 Pityriasis Species 0.000 abstract description 4
- 208000003251 Pruritus Diseases 0.000 abstract description 4
- 206010039793 Seborrhoeic dermatitis Diseases 0.000 abstract description 4
- 206010040844 Skin exfoliation Diseases 0.000 abstract description 4
- 230000035618 desquamation Effects 0.000 abstract description 4
- 208000008742 seborrheic dermatitis Diseases 0.000 abstract description 4
- 238000010923 batch production Methods 0.000 abstract description 3
- 239000002537 cosmetic Substances 0.000 abstract description 3
- 230000008569 process Effects 0.000 abstract description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 abstract 2
- 235000021355 Stearic acid Nutrition 0.000 abstract 1
- -1 alkyl glycoside Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229930182470 glycoside Natural products 0.000 abstract 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- ONHFWHCMZAJCFB-UHFFFAOYSA-N myristamine oxide Chemical compound CCCCCCCCCCCCCC[N+](C)(C)[O-] ONHFWHCMZAJCFB-UHFFFAOYSA-N 0.000 abstract 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 abstract 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 abstract 1
- 239000003755 preservative agent Substances 0.000 abstract 1
- 239000008117 stearic acid Substances 0.000 abstract 1
- 239000000047 product Substances 0.000 description 14
- 208000001840 Dandruff Diseases 0.000 description 4
- 239000003814 drug Substances 0.000 description 3
- 241000233866 Fungi Species 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 241001480043 Arthrodermataceae Species 0.000 description 1
- 241001480035 Epidermophyton Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 241000223238 Trichophyton Species 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 230000037304 dermatophytes Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 150000002460 imidazoles Chemical class 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 210000004761 scalp Anatomy 0.000 description 1
- VIDTVPHHDGRGAF-UHFFFAOYSA-N selenium sulfide Chemical compound [Se]=S VIDTVPHHDGRGAF-UHFFFAOYSA-N 0.000 description 1
- 229960005265 selenium sulfide Drugs 0.000 description 1
- 229930193551 sterin Natural products 0.000 description 1
- 210000004895 subcellular structure Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- PICXIOQBANWBIZ-UHFFFAOYSA-N zinc;1-oxidopyridine-2-thione Chemical compound [Zn+2].[O-]N1C=CC=CC1=S.[O-]N1C=CC=CC1=S PICXIOQBANWBIZ-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a preparation method of a compound ketoconazole shampoo. The compound ketoconazole shampoo belongs to the field of manufacturing of cosmetics, and is prepared from general materials for preparing shampoos, ketoconazole and auxiliary materials, wherein the raw materials comprise purified water, alkyl glycoside, myristyl dimethyl amine oxide, olive oil, stearic acid glycol double ester, fluilanol, glycerol, essence, compound ketoconazole, clobetasol propionate, halcinonide solution and preservatives. The compound ketoconazole shampoo can be used for quickly relieving desquamation and pruritus caused by seborrheic dermatitis and capitis pityriasis; and when being used, the compound ketoconazole shampoo is applied on wet hairs and then kneaded to fully contact the hairs, and after 3 to 5 minutes, the compound ketoconazole shampoo is washed by clean water. The preparation method of the compound ketoconazole shampoo has the advantages that the process is simple and easy to control, the sources of the raw materials are rich, the raw materials are low in cost, the batch production is facilitated, the product quality is good, and the like.
Description
Technical field:
The invention belongs to cosmetics and make the field, it is characterized in that relating to a kind of compound method of Ketoconazol/Clobetasol Propionate shampoo.
Background technology:
Shampoo is to use hair and scalp basic nursing cosmetic product the most widely, and the ketoconazole shampoo is wherein a kind of.Because a variety of causes; Everyone can have the dandruff; Just have fewly more, and the shampoo of treatment dandruff has multiple: like zinc pyridinethione shampoo, tar shampoo, salicylic acid shampoo, selenium sulfide shampoo, the difference of the reason that can produce according to dandruff is selected different shampoos.The ketoconazole shampoo is a kind of antidandruff shampoo, and is general under all invalid situation of various antidandruff shampoos, can try out the ketoconazole shampoo and treat dandruff.Ketoconazole is an imidazoles broad-spectrum antifungal medicine, can suppress the biosynthesis of sterin such as the black alcohol of fungus Ergota, can damage fungal cell membrane; Change its permeability; Cause important substance leakage in the cell, can cause peroxide excessive buildup in cell, cause degeneration of fungus subcellular structure and necrosis; Dermatophytes such as Trichophyton, Epidermophyton, Microsporon there is strong antibacterial action; Especially chlosma is had very strong bactericidal activity, prove through zoopery, the external safety clinically of Ketoconazol/Clobetasol Propionate preparation is higher.Product of the present invention is to prepare with versatile material and ketoconazole and the adjuvant medicine of preparation shampoo, and the raw material of use has: purified water, alkyl polyglucoside, CH3-(CH2)13N(CH3)2-O, olive oil, stearic acid diethylene glycol dilaurate, liquid lanolin, glycerol, essence, Ketoconazol/Clobetasol Propionate, clobetasol propionate, halcinonide, antiseptic.Can alleviate desquamation and the pruritus that causes by seborrheic dermatitis and capitis pityriasis rapidly with product of the present invention, during use this shampoo is applied on the hair of moistening, the rubbing, let it fully contact with hair, treat 3～5 minutes after, totally get final product with flushing with clean water.The compound method of this product has: technology is simple to operation, raw material sources are abundant, the prices of raw and semifnished materials are low, be convenient to advantages such as batch process, good product quality.
Summary of the invention:
The problem that the present invention will solve provides a kind of compound method of Ketoconazol/Clobetasol Propionate shampoo.The effect of Ketoconazol/Clobetasol Propionate shampoo is an antidandruff, but mainly is under all invalid situation of various antidandruff shampoos, to use.This shampoo is a raw material with general shampoo material, is equipped with ketoconazole and ancillary drug, and this hair washing fluid power is alleviated desquamation and the pruritus that is caused by seborrheic dermatitis and capitis pityriasis rapidly.The compound method of this product has that technology is simple to operation, raw material sources are abundant, the prices of raw and semifnished materials are low, be convenient to advantages such as batchs process, good product quality, and the raw material of producing this product use is: purified water 74%, alkyl polyglucoside 4%-6%, CH3-(CH2)13N(CH3)2-O 4%-6%, olive oil 2%, stearic acid diethylene glycol dilaurate 2%, liquid lanolin 3%, glycerol 2%, essence 2%, Ketoconazol/Clobetasol Propionate 3.8%, clobetasol propionate 0.1%, halcinonide 0.1%, antiseptic 1%.
The present invention can realize through following technical scheme:
A kind of method of batch preparation Ketoconazol/Clobetasol Propionate shampoo, its characteristic is made up of following steps:
1. purified water is sent into the preparation container, the limit is warming up to 55 ℃ of limits and stirs, and the rotating speed of agitator is 40 rev/mins; Add Ketoconazol/Clobetasol Propionate, clobetasol propionate, halcinonide successively; The interval of every kind of raw material interpolation is 2 minutes, and interpolation was stirred 20 minutes after finishing.
2. continue to stir, rotating speed is constant, is cooled to 40 ℃; Add alkyl polyglucoside, CH3-(CH2)13N(CH3)2-O, olive oil, stearic acid diethylene glycol dilaurate, liquid lanolin, glycerol, essence successively; The interval of every kind of raw material interpolation is 4 minutes, and interpolation was stirred 20 minutes after finishing.
3. continue to stir, rotating speed is constant, adds antiseptic after being cooled to room temperature, add finish after, stirred 5 minutes, stop stirring, obtain finished product.
The invention has the beneficial effects as follows: the compound method that a kind of Ketoconazol/Clobetasol Propionate shampoo is provided; This hair washing fluid power is alleviated rapidly desquamation and the pruritus that is caused by seborrheic dermatitis and capitis pityriasis, and the compound method of this finished product has that technology is simple to operation, raw material sources enrich, the prices of raw and semifnished materials are low, be convenient to advantages such as batch process, good product quality.
The specific embodiment
Embodiment below in conjunction with concrete describes in further detail the present invention.
Embodiment 1
With accounting for total amount is that 74% purified water is sent into the preparation container; The limit is warming up to 55 ℃ of limits and stirs; The rotating speed of agitator is 40 rev/mins, adds successively that to account for total amount be 3.8% Ketoconazol/Clobetasol Propionate, 0.1% clobetasol propionate, 0.1% halcinonide, and the interval that every kind of raw material adds is 2 minutes; After adding end, stirred 20 minutes; Continue to stir; Rotating speed is constant; Be cooled to 40 ℃, add successively that to account for total amount be 4% alkyl polyglucoside, 6% CH3-(CH2)13N(CH3)2-O, 2% olive oil, 2% stearic acid diethylene glycol dilaurate, 3% liquid lanolin, 2% glycerol, 2% essence, the interval that every kind of raw material adds is 4 minutes; After adding end, stirred 20 minutes; Continue to stir, rotating speed is constant, is cooled to add that to account for total amount be 1% antiseptic behind the room temperature, add finish after, stirred 5 minutes, stop stirring, obtain finished product.
Embodiment 2
With accounting for total amount is that 74% purified water is sent into the preparation container; The limit is warming up to 55 ℃ of limits and stirs; The rotating speed of agitator is 40 rev/mins, adds successively that to account for total amount be 3.8% Ketoconazol/Clobetasol Propionate, 0.1% clobetasol propionate, 0.1% halcinonide, and the interval that every kind of raw material adds is 2 minutes; After adding end, stirred 20 minutes; Continue to stir; Rotating speed is constant; Be cooled to 40 ℃, add successively that to account for total amount be 5% alkyl polyglucoside, 5% CH3-(CH2)13N(CH3)2-O, 2% olive oil, 2% stearic acid diethylene glycol dilaurate, 3% liquid lanolin, 2% glycerol, 2% essence, the interval that every kind of raw material adds is 4 minutes; After adding end, stirred 20 minutes; Continue to stir, rotating speed is constant, is cooled to add that to account for total amount be 1% antiseptic behind the room temperature, add finish after, stirred 5 minutes, stop stirring, obtain finished product.
Embodiment 3
With accounting for total amount is that 74% purified water is sent into the preparation container; The limit is warming up to 55 ℃ of limits and stirs; The rotating speed of agitator is 40 rev/mins, adds successively that to account for total amount be 3.8% Ketoconazol/Clobetasol Propionate, 0.1% clobetasol propionate, 0.1% halcinonide, and the interval that every kind of raw material adds is 2 minutes; After adding end, stirred 20 minutes; Continue to stir; Rotating speed is constant; Be cooled to 40 ℃, add successively that to account for total amount be 6% alkyl polyglucoside, 4% CH3-(CH2)13N(CH3)2-O, 2% olive oil, 2% stearic acid diethylene glycol dilaurate, 3% liquid lanolin, 2% glycerol, 2% essence, the interval that every kind of raw material adds is 4 minutes; After adding end, stirred 20 minutes; Continue to stir, rotating speed is constant, is cooled to add that to account for total amount be 1% antiseptic behind the room temperature, add finish after, stirred 5 minutes, stop stirring, obtain finished product.
Most preferred embodiment of the present invention is embodiment 3.
Claims (4)
1. the compound method of a Ketoconazol/Clobetasol Propionate shampoo; It is characterized in that: with purified water 74%, alkyl polyglucoside 4%-6%, CH3-(CH2)13N(CH3)2-O 4%-6%, olive oil 2%, stearic acid diethylene glycol dilaurate 2%, liquid lanolin 3%, glycerol 2%, essence 2%, Ketoconazol/Clobetasol Propionate 3.8%, clobetasol propionate 0.1%, halcinonide 0.1%, antiseptic 1% is raw material, obtains finished product through following steps.
2. the compound method of a kind of Ketoconazol/Clobetasol Propionate shampoo according to claim 1; The characteristic of its first step is: purified water is sent into the preparation container, and the limit is warming up to 55 ℃ of limits and stirs, and the rotating speed of agitator is 40 rev/mins; Add Ketoconazol/Clobetasol Propionate, clobetasol propionate, halcinonide successively; The interval of every kind of raw material interpolation is 2 minutes, and interpolation was stirred 20 minutes after finishing.
3. the compound method of a kind of Ketoconazol/Clobetasol Propionate shampoo according to claim 1; The characteristic in its second step is: continue to stir, rotating speed is constant, is cooled to 40 ℃; Add alkyl polyglucoside, CH3-(CH2)13N(CH3)2-O, olive oil, stearic acid diethylene glycol dilaurate, liquid lanolin, glycerol, essence successively; The interval of every kind of raw material interpolation is 4 minutes, and interpolation was stirred 20 minutes after finishing.
4. the compound method of a kind of Ketoconazol/Clobetasol Propionate shampoo according to claim 1, the characteristic in its 3rd step is: continue to stir, rotating speed is constant, adds antiseptic after being cooled to room temperature, add finish after, stirred 5 minutes, stop stirring, obtain finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011100502945A CN102652714A (en) | 2011-03-01 | 2011-03-01 | Preparation method of compound ketoconazole shampoo |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011100502945A CN102652714A (en) | 2011-03-01 | 2011-03-01 | Preparation method of compound ketoconazole shampoo |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102652714A true CN102652714A (en) | 2012-09-05 |
Family
ID=46728548
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011100502945A Pending CN102652714A (en) | 2011-03-01 | 2011-03-01 | Preparation method of compound ketoconazole shampoo |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102652714A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104127422A (en) * | 2014-07-17 | 2014-11-05 | 李泽填 | Composition for treating pruritus and acne and preparation method thereof |
| CN105434445A (en) * | 2015-12-08 | 2016-03-30 | 浙江鼎泰药业有限公司 | Hair lotion treating scalp superficial fungal infection and preparation method thereof |
-
2011
- 2011-03-01 CN CN2011100502945A patent/CN102652714A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104127422A (en) * | 2014-07-17 | 2014-11-05 | 李泽填 | Composition for treating pruritus and acne and preparation method thereof |
| CN104127422B (en) * | 2014-07-17 | 2015-10-14 | 李泽填 | A kind of composition and method of making the same for the treatment of pruritus and comedo |
| CN105434445A (en) * | 2015-12-08 | 2016-03-30 | 浙江鼎泰药业有限公司 | Hair lotion treating scalp superficial fungal infection and preparation method thereof |
| CN105434445B (en) * | 2015-12-08 | 2018-04-13 | 浙江鼎泰药业股份有限公司 | A kind of hair lotion for treating scalp superficial part mycotic infection and preparation method thereof |
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| Date | Code | Title | Description |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20120905 |