CN102652712A - Antibacterial oral care composition and preparation method thereof - Google Patents
Antibacterial oral care composition and preparation method thereof Download PDFInfo
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- CN102652712A CN102652712A CN2011100516543A CN201110051654A CN102652712A CN 102652712 A CN102652712 A CN 102652712A CN 2011100516543 A CN2011100516543 A CN 2011100516543A CN 201110051654 A CN201110051654 A CN 201110051654A CN 102652712 A CN102652712 A CN 102652712A
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Abstract
The invention discloses an antibacterial oral care composition which is a mixture of chitosan, organic acid, bioflavonoid, xylitol and pure water. The invention also discloses a preparation method of the oral care composition. The oral care composition can be used for effectively inhibiting the growth of bacteria such as staphylococcus aureus, streptococcus mutans and candidaalbicans in an oral cavity, and reducing the occurrence rate of dental caries; and the composition is capable of reducing the damage on oral mucosa and the harm on a human body without being additionally added with chemical preservatives and antibacterial agent.
Description
Technical field
The present invention relates to a kind of MC constituent, relate in particular to the antimicrobial MC constituent of a kind of tool.The invention still further relates to the method for making of this MC constituent.
Background technology
Dental plaque mainly is by the polysaccharide that bacterial metabolism produced (polysaccharide) in the oral cavity and is coated on the formed speckle shape of antibacterial thing wherein, and its adhesion is strong, and easy-clear not, usually is the main cause that causes periodontal disease and dental caries.And owing to the attention of people for oral hygiene, therefore with the also more and more polynary change of the Related product of oral cavity health, and all be in oral health products, to add antimicrobial composition at present; Can reach the effect that suppresses dental plaque; In addition, owing to antibiotic and deodorant are one integrity with both sides, if can suppress bacterial reproduction; Just can prevent that it from decomposing food debris, produces the smelly source of putrefactive fermentation.
Yet, with regard to the collutory in the oral health products, though it has the antibacterial effect of part; But be added with chemical preservative and antibacterial in its composition mostly, single is long service time, may make oral mucosa impaired; And if life-time service, maybe be harmful.
Summary of the invention
The technical problem that the present invention will solve provides the antimicrobial MC constituent of a kind of tool, and it can also reduce the impaired of oral mucosa and to the injury of human body except that having antimicrobial function.
For solving the problems of the technologies described above; The antimicrobial MC constituent of tool of the present invention comprises the spherical chitosan of weight 0.5～30%, the organic acid of weight 0.5～30%, the bioflavonoids of weight 0.1～25%, the xylitol of weight 0.1～25% and the pure water of weight 20～95%.
Preferable, said bioflavonoids is a weight 0.3～5%, xylitol is a weight 1～5%.
Preferable, said organic acid is formic acid, acetic acid (acetic acid), oxalic acid (ethanedioic acid), malonic acid, succinic acid (succinic acid), tartaric acid, gluconic acid, malic acid, citric acid, lactic acid or its composite acid.
Preferable, the acid degradation after said spherical chitosan and organic acid are fused is viscosity 200～5000cps (rotating speed 10rpm).
Another technical problem that the present invention will solve provides the method for making of above-mentioned MC constituent.
For solving the problems of the technologies described above, the method for making of the antimicrobial MC constituent of tool of the present invention comprises following steps:
Mixed dissolution step: the organic acid of the spherical chitosan of weight 0.5～30% and weight 0.5～30% placed add water in the airtight reactive tank and stir;
Oxidation completely cuts off step: in this reactive tank, feed noble gas, avoid oxidation reaction with secluding air;
The thermosol forming step: the temperature of controlling this reactive tank is between 50～80 ℃, and the response time is 60～120 minutes, continues to stir, and makes this spherical chitosan and organic acid be fused into acidifying spherical chitosan;
Mediation step: in this acidifying spherical chitosan, add the bioflavonoids that comprises weight 0.1～25%, the xylitol of weight 0.1～25% and the pure water of weight 20～95% and be in harmonious proportion, to be in harmonious proportion out this liquid state constituent.
Preferable, in the said mixed dissolution step,, put into this organic acid stirring again and dissolved in 30～120 minutes earlier with adding the water stirring in this spherical chitosan placing response groove after 15～30 minutes.
Preferable, the noble gas that the isolated step of said oxidation is added is to be selected from the following group that constitutes: nitrogen, helium, neon, argon, krypton gas, xenon, and their combination.
Preferable, the acid degradation after this spherical chitosan and this organic acid fuse in the said thermosol forming step is viscosity 200～5000cps (rotating speed 10rpm).
Preferable; Said mediation step also comprises the thickening agent of adding 0.2～10% to adjust its viscosity; Make this constituent be paste; Wherein this thickening agent can be gelatin (gelatine), Eucheuma gelatinosum (Agar, Kanten), hydroxyethyl-cellulose (Hydroxyethyl Cellulose, HEC), hydroxypropyl cellulose (Hydroxypropyl Cellulose, HPC), hydroxypropyl emthylcellulose (Hydroxypropylmethyl Cellulose; HPMC), methylcellulose (Methyl Cellulose; MC), carboxy methyl cellulose (Carboxymethyl Cellulose, CMC), hydrophobicity upgrading hydroxyethyl-cellulose (Hydrophobically ModifiedHydroxyethyl Cellulose, HMHEC).
Preferable; Said mediation step also comprises and adds wetting agent, sodium chloride, sodium fluoride, interfacial agent, sweeting agent, spice, colorant; And 20～60% grinding agent; Reaching oral cavity decontamination and the facing effect of light of rubbing, and make this constituent be paste, wherein this grinding agent can be calcium carbonate (Calcium Carbonate), calcium hydrogen phosphate (Dicalcium phosphate), calcium pyrophosphate (Calcium pyrophosphate), silicon dioxide (Silica).
The present invention uses several natural materials to process the MC constituent; The bacteriostasis, xylitol of utilizing chitosan and bioflavonoids realizes the health care to oral cavity and gingiva to reducing dental caries and suppressing effect that the tooth dirt produces, chitosan to removing the effect of acid odorant.Therefore simultaneously, owing to do not contain chemical preservative and antibacterial in this MC constituent, can also reduce the impaired of oral mucosa and to the injury of human body.
Description of drawings
Accompanying drawing is a flow chart of the present invention.
Description of reference numerals is following among the figure:
11: mixed dissolution step 12: oxidation completely cuts off step
13: thermosol forming step 14: the mediation step
The specific embodiment
Understand for technology contents of the present invention, characteristics and effect being had more specifically, combine illustrated embodiment at present, details are as follows:
The antimicrobial MC constituent of a kind of tool that the embodiment of the invention provided; This constituent comprises the organic acid of a spherical chitosan as antibiotic effective ingredient and weight 0.5～30%, weight 0.5～30%, the bioflavonoids of weight 0.1～25%, the xylitol (Xylitol) of weight 0.1～25% and the pure water of weight 20～95%; Wherein this bioflavonoids is that weight 0.3～5% is for best; This xylitol is that weight 1～5% is for best; Acid degradation viscosity after this spherical chitosan and this organic acid are fused is 200～5000cps (rotating speed 10rpm), and is liquid by this constituent that above-mentioned constituent is formed.
Wherein, this organic acid can be formic acid, acetic acid (acetic acid), oxalic acid (ethanedioic acid), malonic acid, succinic acid (succinic acid), tartaric acid, gluconic acid, malic acid, citric acid, lactic acid or its composite acid.
In view of the above, constituent of the present invention effectively suppresses staphylococcus aureus (Staphylococcus aureus) 99.9%, Streptococcus mutans (Streptococcus mutans) 99.9%, candida albicans (Candidaalbicans) 99.9%; Effectively suppress intraoral bacteria breed, reduce the dental caries incidence rate; The present invention simultaneously can prevent just that by suppressing bacterial reproduction it from decomposing food debris, produces the smelly source of putrefactive fermentation; To reduce the stink in oral cavity; Keep fresh breath, and do not have interpolation chemical preservative and antibacterial in the constituent of the present invention, use the injury of the impaired and human body that reduces oral mucosa.
The above is constituent main component of the present invention and effect explanation thereof.
Below be the antibacterial experiment of aqueous constituent, explain as follows for the present invention.
One, the aqueous constituent of the present invention is following to the antibacterial tests result of staphylococcus aureus (Staphylococcus aureus), Streptococcus mutans (Streptococcus mutans), candida albicans (Candida albicans):
Antibacterial tests is with reference to U.S.Pharmacopeia 26 NF 21 Microbiological Tests (51) Antimicrobial Effectiveness Testing.Its test result is shown in table one, and the sample described in this table one is constituent of the present invention, and CFU/ml is an aerobic plate count.
Table one
Wherein above-mentioned test condition is following:
1. bacterium liquid is planted in configuration, and getting 1ml needs the bacterium liquid suspensions of test organisms to join the aseptic phosphate buffer of 9ml, and mix homogeneously is got 1ml again to 100ml 0.5%Triton X-100, and mix homogeneously, bacterial concentration are 1 * 10
5～10
6Organi sms.
With 1: 1 mode with sample with plant bacterium liquid and respectively get 1ml in aseptic culture dish, mix homogeneously.
3. quiet stagnating 1 hour, sample thief 1ml is in culture dish, the suitable culture medium of reinjecting, mix homogeneously.
Two, the check of the aerobic plate count of the aqueous constituent of the present invention:
The check of aerobic plate count is the method for inspection with reference to CNS10890 (2009/01/17 revised edition) food microorganisms, and its test result is shown in table two, and this method of inspection is lower than the measured value of detecting limit and representes with " feminine gender " or " not detecting ".
Table two
Consult shown in Figure 1, the method for making of the antimicrobial MC constituent of a kind of tool provided by the present invention, it mainly is made by the isolated step 12 of mixed dissolution step 11, oxidation, thermosol forming step 13 and the consecutive steps such as step 14 that are in harmonious proportion, wherein:
This mixed dissolution step 11: the spherical chitosan of weight 0.5～30% is positioned over earlier in the airtight reactive tank stirred 15～30 minutes, again the organic acid of weight 0.5～30% is placed and added water in this reactive tank and stir and dissolved in 30～120 minutes.
This oxidation completely cuts off step 12: in this reactive tank, feed noble gas, avoid oxidation reaction with secluding air, wherein this noble gas is to be selected from the following group that constitutes: nitrogen, helium, neon, argon, krypton gas, xenon, and their combination.
This thermosol forming step 13: this reactive tank is heated; And the temperature of controlling this reactive tank is between 50～80 ℃; Response time is 30～120 minutes, continues to stir, and makes this spherical chitosan and organic acid be fused into acidifying spherical chitosan; And to make its acid degradation be viscosity 200～5000cps (rotating speed 10rpm), and wherein this acidifying spherical chitosan can be water-soluble.
This is in harmonious proportion step 14: adds the bioflavonoids of weight 0.1～25%, the xylitol of weight 0.1～25% and the pure water of weight 20～95% at this acidifying spherical chitosan and is in harmonious proportion, and being in harmonious proportion out this constituent, and this constituent is aqueous.Preferably, this mediation step also comprises and adds wetting agent, sodium chloride, sodium fluoride, interfacial agent, sweeting agent, spice, colorant, to be in harmonious proportion out this aqueous constituent.
The above is the method for making explanation of the aqueous constituent of the present invention.
What be worth explanation is; In above-mentioned recipe step; Also comprise and add 0.2～10% thickening agent to adjust its viscosity being in harmonious proportion step 14, make this constituent be paste, wherein this thickening agent can be gelatin (gelatine), Eucheuma gelatinosum (Agar, Kanten), hydroxyethyl-cellulose (Hydroxyethyl Cellulose; HEC), hydroxypropyl cellulose (Hydroxypropyl Cellulose; HPC), hydroxypropyl emthylcellulose (Hydroxypropylmethyl Cellulose, HPMC), methylcellulose (Methyl Cellulose, MC), carboxy methyl cellulose (Carboxymethyl Cellulose; CMC), hydrophobicity upgrading hydroxyethyl-cellulose (Hydrophobically Modified Hydroxyethyl Cellulose, HMHEC) etc.
Simultaneously; In above-mentioned recipe step; The grinding agent that in this mediation step 14, also comprises adding 20～60%; Reaching oral cavity decontamination and the facing effect of light of rubbing, and make this constituent be paste, wherein this grinding agent can be calcium carbonate (Calcium Carbonate), calcium hydrogen phosphate (Dicalcium phosphate), calcium pyrophosphate (Calcium pyrophosphate), silicon dioxide (Silica) etc.
Preferably, this mediation step also comprises and adds wetting agent, sodium chloride, sodium fluoride, interfacial agent, sweeting agent, spice, colorant, to be in harmonious proportion out this paste constituent.
Below for the present invention be paste constituent antibacterial experiment explanation as follows.
One, paste constituent of the present invention is following to the antibacterial tests result of staphylococcus aureus (Staphylococcus aureus), Streptococcus mutans (Streptococcus mutans), candida albicans (Candida albicans):
Antibacterial tests is that its test result is shown in table three with reference to AATCC Test Method 30-2004 Antifungal Activity, and CFU/ml is an aerobic plate count.
Table three
Wherein above-mentioned test condition is following:
1. the paste constituent is coated on the cloth cover, to be dried after, the specimen of cutting out circular 38mm diameter, plant bacterium after 37 ℃ cultivated 48 hours.
2. the inhibition zone account form is following:
W＝(T-D)/2
The width mm of W=inhibition zone
The overall width mm of T=specimen and inhibition zone
The width mm of D=specimen
3. the expression bacterial growth situation of result of the test
The Excellent contact area is completely without colony growth
There is the minority colony growth Fair contact area
The bacterium colony procreation appears in the Unsatisfactory contact area
～; Represent test sample surface because of tissue or color, cause experimental result to judge
Four, the check of the aerobic plate count of paste constituent of the present invention:
The check of aerobic plate count is the method for inspection with reference to CNS10890 (2009/01/17 revised edition) food microorganisms, and its test result is shown in table four, and this method of inspection is lower than the measured value of detecting limit and representes with " feminine gender " or " not detecting ".
Table four
In sum, the present invention to be applied to the health care of oral cavity and gingiva, is wherein extracted and changes through biochemical machine the chitosan of gained by the composition of several natural materials by shrimp, Carapax Eriocheir sinensis; And by the bioflavonoids (being commonly called as Citrin) that is extracted in natural citrus peel and the sarcocarp, these two kinds of materials all belong to natural antibacterial agent, for intraoral harmful strain certain bacteriostasis are arranged; By the natural plant sweetening agent-xylitol that extracts in the plants such as silver birch and Oak Tree, the generation for reducing dental caries and tooth dirt also has suitable effect in addition; And chitosan contains amido because of the intrachain glucose unit of its macromolecule; For because of the microbial decomposition food debris, the removal of the acid odorant of generation also has good effect; And the foregoing description and diagram are merely preferred embodiment of the present invention; When not limiting the scope that the present invention implements with this, promptly all equalizations of doing according to claim of the present invention change and modify, and all should belong in the scope that patent of the present invention contains.
Claims (10)
1. antimicrobial MC constituent of tool, it is characterized in that: this constituent comprises the spherical chitosan of weight 0.5～30%, the organic acid of weight 0.5～30%, the bioflavonoids of weight 0.1～25%, the xylitol of weight 0.1～25% and the pure water of weight 20～95%.
2. the antimicrobial MC constituent of tool as claimed in claim 1 is characterized in that: said bioflavonoids is a weight 0.3～5%, and xylitol is a weight 1～5%.
3. the antimicrobial MC constituent of tool as claimed in claim 1 is characterized in that: said organic acid is formic acid, acetic acid (acetic acid), oxalic acid (ethanedioic acid), malonic acid, succinic acid (succinic acid), tartaric acid, gluconic acid, malic acid, citric acid, lactic acid or its composite acid.
4. the antimicrobial MC constituent of tool as claimed in claim 1 is characterized in that: the acid degradation after said spherical chitosan and organic acid are fused is viscosity 200～5000cps (rotating speed 10rpm).
5. the method for making of the antimicrobial MC constituent of tool is characterized in that, comprises:
Mixed dissolution step: the organic acid of the spherical chitosan of weight 0.5～30% and weight 0.5～30% placed add water in the airtight reactive tank and stir;
Oxidation completely cuts off step: in this reactive tank, feed noble gas, avoid oxidation reaction with secluding air;
The thermosol forming step: the temperature of controlling this reactive tank is between 50～80 ℃, and the response time is 60～120 minutes, continues to stir, and makes this spherical chitosan and organic acid be fused into acidifying spherical chitosan;
Mediation step: in this acidifying spherical chitosan, add the bioflavonoids that comprises weight 0.1～25%, the xylitol of weight 0.1～25% and the pure water of weight 20～95% and be in harmonious proportion, to be in harmonious proportion out this liquid state constituent.
6. the antimicrobial MC constituent of tool as claimed in claim 5; It is characterized in that: in the said mixed dissolution step; Earlier with adding the water stirring in this spherical chitosan placing response groove after 15～30 minutes; Put into this organic acid stirring again and dissolved in 30～120 minutes, wherein this organic acid is formic acid, acetic acid (acetic acid), oxalic acid (ethanedioic acid), malonic acid, succinic acid (succinic acid), tartaric acid, gluconic acid, malic acid, citric acid, lactic acid or its composite acid.
7. the antimicrobial MC constituent of tool as claimed in claim 5; It is characterized in that; The noble gas that the isolated step of said oxidation is added is to be selected from the following group that constitutes: nitrogen, helium, neon, argon, krypton gas, xenon, and their combination.
8. the antimicrobial MC constituent of tool as claimed in claim 5 is characterized in that: the acid degradation after this spherical chitosan and this organic acid fuse in the said thermosol forming step is viscosity 200～5000cps (rotating speed 10rpm).
9. the antimicrobial MC constituent of tool as claimed in claim 5; It is characterized in that: said mediation step also comprises the thickening agent of adding 0.2～10% to adjust its viscosity; Make this constituent be paste; Wherein this thickening agent can be gelatin (gelatine), Eucheuma gelatinosum (Agar, Kanten), hydroxyethyl-cellulose (Hydroxyethyl Cellulose, HEC), hydroxypropyl cellulose (Hydroxypropyl Cellulose, HPC), hydroxypropyl emthylcellulose (Hydroxypropylmethyl Cellulose; HPMC), methylcellulose (Methyl Cellulose; MC), carboxy methyl cellulose (Carboxymethyl Cellulose, CMC), hydrophobicity upgrading hydroxyethyl-cellulose (Hydrophobically Modified Hydroxyethyl Cellulose, HMHEC).
10. the antimicrobial MC constituent of tool as claimed in claim 5; It is characterized in that: said mediation step also comprises and adds wetting agent, sodium chloride, sodium fluoride, interfacial agent, sweeting agent, spice, colorant; And 20～60% grinding agent; To reach the rub effect of light of oral cavity decontamination and facing; And make this constituent be paste, wherein this grinding agent can be calcium carbonate (Calcium Carbonate), calcium hydrogen phosphate (Dicalciumphosphate), calcium pyrophosphate (Calcium pyrophosphate), silicon dioxide (Silica).
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5913721A (en) * | 1982-07-15 | 1984-01-24 | Tsurui Yakuhin Kogyo Kk | Agent for suppressing formation of bacterial plaque on tooth |
| JP2004035416A (en) * | 2002-06-28 | 2004-02-05 | Sangi Co Ltd | Improved 3ds home care agent and system for microbial removal of dental caries |
| WO2005097053A1 (en) * | 2004-04-01 | 2005-10-20 | Smithkline Beecham Corporation | Dissolvable tooth whitening strip |
| WO2006107334A1 (en) * | 2005-03-31 | 2006-10-12 | Smithkline Beecham Corporation | Dissolvable tooth whitening strip |
| CN101111288A (en) * | 2004-12-02 | 2008-01-23 | 高露洁-棕榄公司 | Oral care composition comprising a phenolic compound and antioxidant vitamins and vitamin derivatives |
| CN101166522A (en) * | 2005-03-18 | 2008-04-23 | 高露洁-棕榄公司 | Antibacterial 5,5'-disubstituted 3,3'-dialkoxy-2,2'-dihydroxy-1,1'-biphenyl compounds and related methods |
| CN101495090A (en) * | 2006-07-20 | 2009-07-29 | 奥雷登特有限公司 | Oral compositions, their preparation and use |
-
2011
- 2011-03-04 CN CN2011100516543A patent/CN102652712A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5913721A (en) * | 1982-07-15 | 1984-01-24 | Tsurui Yakuhin Kogyo Kk | Agent for suppressing formation of bacterial plaque on tooth |
| JP2004035416A (en) * | 2002-06-28 | 2004-02-05 | Sangi Co Ltd | Improved 3ds home care agent and system for microbial removal of dental caries |
| WO2005097053A1 (en) * | 2004-04-01 | 2005-10-20 | Smithkline Beecham Corporation | Dissolvable tooth whitening strip |
| CN101111288A (en) * | 2004-12-02 | 2008-01-23 | 高露洁-棕榄公司 | Oral care composition comprising a phenolic compound and antioxidant vitamins and vitamin derivatives |
| CN101166522A (en) * | 2005-03-18 | 2008-04-23 | 高露洁-棕榄公司 | Antibacterial 5,5'-disubstituted 3,3'-dialkoxy-2,2'-dihydroxy-1,1'-biphenyl compounds and related methods |
| WO2006107334A1 (en) * | 2005-03-31 | 2006-10-12 | Smithkline Beecham Corporation | Dissolvable tooth whitening strip |
| CN101495090A (en) * | 2006-07-20 | 2009-07-29 | 奥雷登特有限公司 | Oral compositions, their preparation and use |
| CN101495089A (en) * | 2006-07-20 | 2009-07-29 | 奥雷登特有限公司 | Oral compositions, their preparation and use |
Non-Patent Citations (2)
| Title |
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| 谭天伟: "化妆品原料中的新宠——壳聚糖", 《牙膏工业》, vol. 1999, no. 2, 28 February 1999 (1999-02-28), pages 31 - 32 * |
| 陈春刚，等: "生物类黄酮的研究与应用综述", 《安徽农业科学》, vol. 34, no. 13, 31 December 2006 (2006-12-31), pages 2949 - 2951 * |
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Application publication date: 20120905 |