CN102652127A - 氮杂双环[3.1.0]己-2-基衍生物、制备方法和包含它们的药物组合物 - Google Patents

氮杂双环[3.1.0]己-2-基衍生物、制备方法和包含它们的药物组合物 Download PDF

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Publication number
CN102652127A
CN102652127A CN2010800559947A CN201080055994A CN102652127A CN 102652127 A CN102652127 A CN 102652127A CN 2010800559947 A CN2010800559947 A CN 2010800559947A CN 201080055994 A CN201080055994 A CN 201080055994A CN 102652127 A CN102652127 A CN 102652127A
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CN
China
Prior art keywords
formula
compound
group
azabicyclo
cis
Prior art date
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Pending
Application number
CN2010800559947A
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English (en)
Chinese (zh)
Inventor
P·加萨拉
A-M·科勒
A·戴诺
J-M·贺琳
P·莱斯塔格
F·帕纳伊
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Les Laboratoires Servier SAS
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Les Laboratoires Servier SAS
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42711699&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN102652127(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Les Laboratoires Servier SAS filed Critical Les Laboratoires Servier SAS
Publication of CN102652127A publication Critical patent/CN102652127A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN2010800559947A 2009-12-09 2010-12-08 氮杂双环[3.1.0]己-2-基衍生物、制备方法和包含它们的药物组合物 Pending CN102652127A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR09.05953 2009-12-09
FR0905953A FR2953521B1 (fr) 2009-12-09 2009-12-09 Nouveaux derives azabicyclo[3.1.0]hex-2-yl, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
PCT/FR2010/000823 WO2011070253A1 (fr) 2009-12-09 2010-12-08 Derives azabicyclo [3.1.0] hex- 2 -yl, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
CN102652127A true CN102652127A (zh) 2012-08-29

Family

ID=42711699

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2010800559947A Pending CN102652127A (zh) 2009-12-09 2010-12-08 氮杂双环[3.1.0]己-2-基衍生物、制备方法和包含它们的药物组合物

Country Status (32)

Country Link
US (1) US20120283245A1 (https=)
EP (1) EP2509947A1 (https=)
JP (1) JP2013513589A (https=)
KR (1) KR20120102763A (https=)
CN (1) CN102652127A (https=)
AP (1) AP2012006352A0 (https=)
AR (1) AR079265A1 (https=)
AU (1) AU2010329762B2 (https=)
BR (1) BR112012013666A2 (https=)
CA (1) CA2782469C (https=)
CL (1) CL2012001479A1 (https=)
CO (1) CO6541535A2 (https=)
CR (1) CR20120286A (https=)
CU (1) CU20120091A7 (https=)
EA (1) EA201200849A1 (https=)
EC (1) ECSP12011950A (https=)
FR (1) FR2953521B1 (https=)
GE (1) GEP20156227B (https=)
IN (1) IN2012DN04966A (https=)
MA (1) MA33882B1 (https=)
MX (1) MX2012006578A (https=)
NI (1) NI201200099A (https=)
PE (1) PE20121475A1 (https=)
PH (1) PH12012501053A1 (https=)
SA (1) SA110320011B1 (https=)
SG (1) SG181082A1 (https=)
TN (1) TN2012000267A1 (https=)
TW (1) TW201200499A (https=)
UA (1) UA102950C2 (https=)
UY (1) UY33072A (https=)
WO (1) WO2011070253A1 (https=)
ZA (1) ZA201203943B (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105764510A (zh) * 2013-09-09 2016-07-13 赛诺菲 H3受体拮抗剂与胆碱酶抑制剂组合用于阿尔茨海默氏病治疗中的用途

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006136223A1 (en) * 2005-04-15 2006-12-28 Glaxo Group Limited Azabicyclo (3.1.0) hexane derivatives useful as modulators of dopamine d3 receptors
CN101230033A (zh) * 2004-02-20 2008-07-30 瑟维尔实验室 新型氮杂双环衍生物、其制备方法及包含其的药物组合物
CN101316835A (zh) * 2005-11-30 2008-12-03 霍夫曼-拉罗奇有限公司 5-取代的吲哚-2-甲酰胺衍生物

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101230033A (zh) * 2004-02-20 2008-07-30 瑟维尔实验室 新型氮杂双环衍生物、其制备方法及包含其的药物组合物
WO2006136223A1 (en) * 2005-04-15 2006-12-28 Glaxo Group Limited Azabicyclo (3.1.0) hexane derivatives useful as modulators of dopamine d3 receptors
CN101316835A (zh) * 2005-11-30 2008-12-03 霍夫曼-拉罗奇有限公司 5-取代的吲哚-2-甲酰胺衍生物

Also Published As

Publication number Publication date
SA110320011B1 (ar) 2013-10-01
NI201200099A (es) 2012-11-09
CO6541535A2 (es) 2012-10-16
CL2012001479A1 (es) 2013-02-08
TN2012000267A1 (fr) 2013-12-12
AP2012006352A0 (en) 2012-08-31
AR079265A1 (es) 2012-01-04
US20120283245A1 (en) 2012-11-08
MA33882B1 (fr) 2013-01-02
PH12012501053A1 (en) 2013-02-04
GEP20156227B (en) 2015-01-26
ZA201203943B (en) 2013-08-28
IN2012DN04966A (https=) 2015-09-25
JP2013513589A (ja) 2013-04-22
CA2782469A1 (fr) 2011-06-16
PE20121475A1 (es) 2012-10-20
UA102950C2 (ru) 2013-08-27
AU2010329762A1 (en) 2012-06-21
WO2011070253A1 (fr) 2011-06-16
FR2953521A1 (fr) 2011-06-10
MX2012006578A (es) 2012-06-25
WO2011070253A8 (fr) 2012-08-02
BR112012013666A2 (pt) 2016-04-19
FR2953521B1 (fr) 2011-11-18
CA2782469C (fr) 2014-04-08
SG181082A1 (en) 2012-07-30
EP2509947A1 (fr) 2012-10-17
KR20120102763A (ko) 2012-09-18
EA201200849A1 (ru) 2013-01-30
CR20120286A (es) 2012-08-20
TW201200499A (en) 2012-01-01
ECSP12011950A (es) 2012-07-31
UY33072A (es) 2011-05-31
AU2010329762B2 (en) 2013-10-03
CU20120091A7 (es) 2012-07-31

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