CN102645515A - Ultrahigh-pressure biological test device with elevation-type screw rod - Google Patents
Ultrahigh-pressure biological test device with elevation-type screw rod Download PDFInfo
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- CN102645515A CN102645515A CN2012100807859A CN201210080785A CN102645515A CN 102645515 A CN102645515 A CN 102645515A CN 2012100807859 A CN2012100807859 A CN 2012100807859A CN 201210080785 A CN201210080785 A CN 201210080785A CN 102645515 A CN102645515 A CN 102645515A
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Abstract
The invention relates to an ultrahigh-pressure biological test device with an elevation-type screw rod. A 600Mpa ultrahigh-pressure self-tightening sealing structure with double functions comprises a cylinder, a self-tightening pressing sleeve, a positioning combinational sealing ring, a self-tightening pressing head, a pre-sealing ring, a plunger and an expansion ring. The cylinder is internally provided with the self-tightening pressing sleeve contacted with the outer side at the front end of the self-tightening pressing head; the tail end of the self-tightening pressing sleeve is connected with the positioning combinational sealing ring; the pre-sealing ring is arranged on the outer side of the self-tightening pressing head; the plunger is arranged on the inner side of the cylinder; the plunger extends into a groove on the outer side of the self-tightening pressing head; and the front end of the plunger is provided with the expansion ring in matched contact with the self-tightening pressing head. The invention solves the problem that the sealing structure of the ultrahigh-pressure generating device in the prior art is poor in a sealing effect and can not meet the high-pressure requirement. The ultrahigh-pressure self-tightening sealing structure with double functions provided by the invention has a simple structure and a favorable sealing effect, and can meet the pressure requirement of 300-600Mpa.
Description
Technical field
The present invention relates to a kind of screw mandrel lifting structure, particularly relate to a kind of linear guide pillar guide rail and the cooperation of steel ball guiding ring set and the UHV (ultra-high voltage) test unit that ultra-high pressure cylinder is connected with the split of high pressure big piston.
Background technology
Domestic generally acknowledged import UHV (ultra-high voltage) test unit costs an arm and a leg at present, is the bottleneck of the Chinese ultra high pressure liquid technical application of compacting technical development.In order to break the expensive application bottleneck of import price, the Ministry of Industry and Information Technology issues " the crucial common technology development of industry guide (2011) " a few days ago." development guide " industry common technology concerns the current techique of industry development; Possessing accurate public product character, can be one or more industry widespread uses through associated effect, excitation effect and demonstration effect, realizes the social sharing of industry common technology and achievement in research thereof; Become the ladder of industrial technology leap, structure updating; Thereby produce huge economic and social benefits, drive the whole industry technical merit and improve rapidly, cause upgrading of industries.We can say that the research and development of industry common technology are foundation stones of enterprise innovation, do not have the industry common technology just to be difficult to form the enterprise key technology, autonomous innovation is not just known where to begin, and says nothing of the sustainable development of industry.In the equipment manufacture field, " development guide " proposes to greatly develop high-pressure and hydraulic element foundry engieering, digital hydraulic intelligent technology etc.
This testing machine pressure can be provided with arbitrarily below 600Mpa, is exactly UHV (ultra-high voltage) when pressure surpasses 100Mpa, under ultra-high pressure condition; Non-total combinations such as the hydrogen bonded in the biosome high molecular weight steric structure, hydrophobic combination, ions bind change, and make protein denaturation, starch gelatinization; Enzyme deactivation, component leaks in the membranolysis, thalline; Vital movement stops, and microbial cells destroys and death.The amino acid whose low molecular compounds such as ammonia combination, vitamin, fragrance component that contract of protein are total the combinations, under UHV (ultra-high voltage), can not destroy, be able to intactly keep, can do inactivation of virus and generate antibody experiment etc.The most of dependence of at present domestic UHV (ultra-high voltage) test unit import; The domestic technology development time that receives at the early-stage limits; The too fat to move effect of type is relatively poor, generally can only reach 100-300 Mpa, can't satisfy the more needs of High Voltage use; Usable range is restricted, restricts the development of enterprise application greatly.
Summary of the invention
Relatively poor in order to solve in the prior art the too fat to move effect of UHV (ultra-high voltage) test unit type; Flexible Application is difficult; The problem that usage space is restricted, manufacturing cost is big; The invention provides a kind of simple in structurely, type is light and handy, can automatically control, effect 600Mpa screw mandrel lift UHV (ultra-high voltage) test unit preferably, and it is required to reach 300Mpa-600Mpa pressure.
Principle of the present invention is: open UHV (ultra-high voltage) port form with the screw mandrel quick open and close of going up and down; Can form a complete ultra high pressure liquid application system; Working pressure 300-600Mpa; With reference to TSG R0002-2005 technical manual burst pressure 3246.3 (Mpa) design pressure 1136.5 (Mpa) maximum working pressure (MOP) 612.75 (Mpa) safe-working pressure 568.25 (Moa) useful volume space one, 100mm * 250mm/2L; Two, 75mm * 250mm/1L WATER AS FLOW MEDIUM, material 17-4PH stainless steel, tensile strength 1310Mpa yield strength 1000Mpa and 35CrMo45 high-strength alloy structural steel.
In order to solve the problems of the prior art, the technical scheme that the present invention taked is:
A kind of 600Mpa screw mandrel lift UHV (ultra-high voltage) test unit comprises high pressure, UHV (ultra-high voltage) assembly cylinder-body, upper piston plunger pressure head, self-tightening sealing, location combination guide pillar guide rail, steel ball guiding ring set.It is characterized in that:
Also comprise: screw mandrel up-down form, plunger type piston, self-tightening guiding pressure head rise ring,, pre-sealed ring, linear steering post rail, linear guide pillar or linear guides are arranged in the arranged outside of plunger type piston, be combined with the steel ball collar that leads at the ultra-high pressure cylinder mouth.The invention solves existing superhigh pressure technique in using, the small test apparatus structure is heavy, voltage regulation result is relatively poor, tastes with discrimination phase, restricted, the troublesome poeration of the strong trial stretch of multiple pressure more.This test type adopts the self sealss of novel combination skeleton; The more needs of High Voltage use have been realized; Provide a kind of simple in structure; Program control, the automanual UHV (ultra-high voltage) screw mandrel of the better full-automatic electronic of sealing effectiveness up-down form test type, it is required to satisfy 300Mpa-600Mpa pressure intensity testing, WATER AS FLOW MEDIUM, oil.
Aforesaid a kind of 600Mpa screw mandrel lift UHV (ultra-high voltage) test unit, working pressure can freely be set to 600mpa pressure from 300mpa, comprises column, top cover transmission case, linear guide pillar or linear guides, elevating screw, plunger type piston, steel ball guiding ring set.
Aforesaid a kind of 600Mpa screw mandrel lift UHV (ultra-high voltage) test unit, is characterized in that ultra-high pressure cylinder: also comprise: high pressure big piston, high pressure cylinder, linear guide pillar guide rail, guiding pressure head, combined frame self sealss, base.
Aforesaid a kind of 600Mpa screw mandrel lift UHV (ultra-high voltage) test unit can increase many of column even numbers at cylinder diameter, volume under requiring, and bears the axial force security framework that superelevation pressure is produced with top cover transmission case, base, composition.The top cover transmission case is fixedly connected the plunger type piston and is gone up and down by screw mandrel.
Aforesaid a kind of 600Mpa screw mandrel lift UHV (ultra-high voltage) test unit is stablized circumferential displacement by linear guide pillar guide rail when the plunger type piston descends, the guiding pressure head accurately gets into ultra-high pressure cylinder along steel ball guiding ring set.Annex electronic program command pressure source work this moment, but required automatic control operation electronic settings all.
Aforesaid a kind of 600Mpa screw mandrel lift UHV (ultra-high voltage) test unit, it is characterized in that: the arranged outside of full-automatic, semi-automatic screw mandrel up-down plunger type piston has linear guide pillar guide rail to guarantee vertical concentricity.Ultra-high pressure cylinder cylinder muzzle closes steel ball guiding ring set guide post plug formula piston, and correct nothing skew gets into ultra-high pressure cylinder.
Aforesaid a kind of 600Mpa screw mandrel lift UHV (ultra-high voltage) test unit is characterized in that: screw mandrel goes up and down.Along with requiring to change by independent screw mandrel up-down, holding capacity can change the even number symmetric offset spread into, for example 2 screw mandrels, 4 screw mandrels.
Aforesaid a kind of 600Mpa screw mandrel lift UHV (ultra-high voltage) test unit is characterized in that: the said plunger type piston tip circle outside is connected with linear guide pillar guide rail.
Aforesaid a kind of 600Mpa screw mandrel lift UHV (ultra-high voltage) test unit is characterized in that: said linear guide pillar guide rail has guide pillar and two kinds of forms of guide rail to select the verticality between seating plane and the guide pillar for use: below 0.02/100; Seat is the FC250 material up and down.
Aforesaid a kind of 600Mpa screw mandrel lift UHV (ultra-high voltage) test unit, it is characterized in that: said combined frame self sealss are the big clearance seal element of V-type UHV (ultra-high voltage).
Aforesaid a kind of 600Mpa screw mandrel lift UHV (ultra-high voltage) test unit is characterized in that: but said ultra-high pressure cylinder is fixedly connected maintain and replace with the high pressure big piston.
The invention has the beneficial effects as follows:
600Mpa UHV (ultra-high voltage) screw mandrel lift UHV (ultra-high voltage) test unit of the present invention; The pressure of 300Mpa-600 Mpa can be provided; The small test device structure heaviness, the voltage regulation result that have solved in the existing superhigh pressure technique application are relatively poor, taste with discrimination restricted, the troublesome poeration of the strong trial stretch of phase multiple pressure more.Can satisfy that each big-and-middle universities and colleges teaches, scientific research, product development, the technological innovation of biological, medicine, Chinese herbal medicine and food engineering provide the research test platform.Can do killing bacteria, saccharomycete, mould, the experiment of the bad variation that general high temperature sterilization brings is for Chinese development ultra high pressure liquid technical application, develop new product and contribute.
Description of drawings
Fig. 1 is a 600Mpa monofilament bar lift UHV (ultra-high voltage) test unit synoptic diagram;
Fig. 2 is 600Mpa UHV (ultra-high voltage) plunger type piston and hermetically-sealed construction wiring layout.
Embodiment
Below in conjunction with accompanying drawing the present invention is done further description.
Shown in Fig. 1-2; A kind of 600Mpa screw mandrel lift UHV (ultra-high voltage) test unit comprises column 1, top cover transmission case 2, elevating screw 3, plunger type piston 4, steel ball guiding ring set 5, ultra-high pressure cylinder 6, it is characterized in that: also comprises: high pressure big piston 7, high pressure cylinder 8, linear guide pillar guide rail 9, guiding pressure head 10, combined frame self sealss 11, base 12.
Go up and down 3 to flexibly connect at the top of plunger type piston 4 and screw mandrel, arranged outside has linear guide pillar guide rail 9, is sheathed with steel ball guiding ring set 5 at the cylinder mouth of ultra-high pressure cylinder 6, and guiding UHV (ultra-high voltage) plunger type piston 3 is correct not to be had skew and get into ultra-high pressure cylinders.
During design, ultra-high pressure cylinder 6 adopts high-strength stainless steel material and 35-45 chrome molybdenum high-strength structure steel hot cover process, P
B=σ
s 1nk (2- ) plunger type piston 4 employing 17-4PH stainless steel materials.
During the work of 600Mpa screw mandrel lift UHV (ultra-high voltage) test unit; When plunger type piston 4 goes up and down 3 up-downs with screw mandrel; Guarantee vertical with ultra-high pressure cylinder 6 cylinder mouths by linear guide pillar guide rail 9; Make steel ball guiding ring set 5, guiding UHV (ultra-high voltage) plunger type piston 3 guarantees reliability and security that UHV (ultra-high voltage) plunger type piston uses.
600Mpa screw mandrel lift UHV (ultra-high voltage) test unit of the present invention institute application experiment is in extensive range, has to be applied in following field:
1, under inactivation of virus 200~400Mpa UHV (ultra-high voltage), can combine by the inner non-covalent bond of break virus membrane structure.Make between the film capsomere and disintegrate, space structure changes, Conformation Transition, and biologically active changes, thereby makes virus
Particle looses is infectious.But UHV (ultra-high voltage) does not destroy covalent bond, so the single subunit of antigen is not destroyed, and has kept immunogenicity constant.Can obtain do not have infectiousness and constant, the complete virion of immunogenicity with the method.
2, produce the traditional vaccine method of producing of vaccine, all adopt heating power and chemical treatment inactivation of viruses, there is very big drawback in these methods.For example inactivated influenza virus vaccine, traditional preparation process method are chemical method.It uses chemical reagent formalin-inactivated virus, is prone to make the virus surface particle impaired, influences the immunogenicity of vaccine.
3, handle the viral inactivation treatment that the existing at present several different methods of blood plasma is applied to blood product, as: pasteur's method, S/D method, serge blue luminescence method etc.But existing these methods all have certain defective.The S/D method is only effective to the virus that lipid envelope is arranged, and before transfusing blood to patient, must inactivator thoroughly be removed.
4, biological extraction can not only promote chemical reaction under the UHV (ultra-high voltage) state, can also change surface state, molecules align and the physical property of some materials.Superelevation pressure energy fast reaction speed in the biological extraction process shortens extraction time, improves product yield.
5, in the process, a lot of physiologically active ingredients are to responsive to temperature in bio-pharmaceuticals technology in bio-pharmaceuticals, and like aloe, balsam pear, spirulina, sea cucumber extract etc., in case temperature surpasses 60 ℃, its active component is promptly destroyed, and therefore is inappropriate for high-temperature sterilization; Adopt the UHV (ultra-high voltage) low temperature sterilization can guarantee fully that active component does not go to pot.
6, Chinese medicine produce the traditional handicraft of Chinese medicine be fried and the extraction.But a lot of crude drugs are to responsive to temperature, and 30% property of medicine is affected under the high temperature, adopt ultra high pressure treatment technology moment explosion vegetable cell, can intactly keep original composition, improve curative effect.
7, the sterilization of medicine equipment generally adopts high-pressure steam sterilization, and the pre-heating temperature elevation running time is long, adopts the superhigh pressure liquid sterilization, but real time operation, and the time is short, and is convenient.
8, the Treating Liquor of wine, yellow rice wine, grape wine etc. all need store a period of time and make the wine liquid sweet-smelling that becomes soft, and this often needs the time in several years.Use UHV (ultra-high voltage) and urge old technology, can shorten the storage time greatly, under the UHV (ultra-high voltage) effect; Water and alcohol quicken to form and form and system; Simultaneously also promote chemical reactions such as a series of oxidations, reduction, esterification and condensation, reduced sudden and violent peppery, towards nose and pungency, make taste soft, the sweet-smelling that becomes.For example yellow rice wine kept 20 minutes under ultra-high pressure condition, and fragrance increases 15-20%, was equivalent to store the effect of storage more than 16 months.
The comparison of ultra-high pressure sterilization technology and traditional sterilization technology:
1, superhigh pressure technique and traditional heat treated food comparison advantage are:
Ultra high pressure treatment can not make physical characteristicss such as food color change, and can not produce peculiar smell, after the ultra high pressure treatment; The gelatinization state and the heat treated of the sex change of protein and starch are different, and ultra high pressure treatment can keep original local flavor of food, are cold sterilization; Make food sterilizing reach even, instantaneous, efficient, and lower than the heating power consumption, for example; Japan Suntory Ltd. adopts container sterilization, and beer liquid can kill 99.99% Escherichia coli through HIGH PRESSURE TREATMENT.2, superhigh pressure technique and traditional chemical treatment food comparison advantage are: do not need in food, to add chemical substance; Overcome of the harmful effect of the product of material effect generation in chemical reagent and the microbial cell to the human body generation; Also avoided chemical reagent residual in the food negative effect, guaranteed edible safety human body.Chemical reagent uses frequent, can make thalline produce resistance, and bactericidal effect weakens, and ultra-high pressure sterilization is a disposable bactericidal, and is obvious to the thalline action effect.
3, the process characteristic of ultrahigh-pressure sterilization technology: the disinfection equipment of super high pressure food and general high-tension apparatus do not have the difference of essence, and just pressure medium is different, is generally water.Because the water capacity is prone to obtain, cost is low, the without explosion danger of comparing with gas, energy consumption is little.Usually pressure is 100~600MPa, and treatment process is to boost → three processes of pressurize → release, and charging usually, discharging are that discontinuous mode is produced.Most biologies promptly can be dead through the above pressurized treatments of 100MPa.
More than show and described ultimate principle of the present invention, principal character and advantage.The technician of the industry should understand; The present invention is not restricted to the described embodiments; That describes in the foregoing description and the instructions just explains principle of the present invention; Under the prerequisite that does not break away from spirit and scope of the invention, the present invention also has various changes and modifications, and these variations and improvement all fall in the scope of the invention that requires protection.The present invention requires protection domain by appending claims and equivalent circle thereof, especially screw mandrel lifting structure form.
Claims (9)
1. 600Mpa screw mandrel lift UHV (ultra-high voltage) test unit; Working pressure can freely be set to 600mpa pressure from 300mpa; Comprise column (1), top cover transmission case (2), elevating screw (3), plunger type end socket (4), steel ball guiding ring set (5), ultra-high pressure cylinder (6); It is characterized in that: also comprise: high pressure big piston (7), high pressure cylinder (8), linear guide pillar guide rail (9), guiding pressure head (10), combined frame self sealss (11), base (12); By rigidity column (1) (many of even numbers), forms the security framework that bears UHV (ultra-high voltage) strong production axial force with top cover transmission case (2), base (12), the flexible connection of elevating screw (3) and plunger type piston (4).
2. in top cover transmission case (2), be provided with transmission topworks, elevating screw (3) plunger type piston (4) is gone up and down on request.
3., plunger type piston (4) stablizes circumferential displacement when descending by linear guide pillar guide rail (9); Guiding pressure head (10) accurately gets into ultra-high pressure cylinder (6) along steel ball guiding ring set (5); Accessory kit electronic program system directive this moment pressure source supercharging work, but required automatic control operation electronic settings all.
4. a kind of 300Mpa-600Mpa screw mandrel lift UHV (ultra-high voltage) test unit according to claim 1 is characterized in that: full-automatic, semi-automatic screw mandrel goes up and down (3), the top margin arranged outside of plunger type piston (4) has linear guide pillar guide rail (9) to guarantee vertical concentricity.
5. ultra-high pressure cylinder (6) cylinder mouth is sheathed with the correct nothing skew of steel ball guiding ring set (5) guiding UHV (ultra-high voltage) plunger type piston (3) and gets into ultra-high pressure cylinder (6).
6. a kind of 300Mpa-600Mpa screw mandrel lift UHV (ultra-high voltage) test unit according to claim 2 is characterized in that: ultra-high pressure cylinder (6) baseplane and plane, high pressure big piston (7) top are connected up and down.
7. a kind of 300Mpa-600Mpa screw mandrel lift UHV (ultra-high voltage) test unit according to claim 3 is characterized in that: said plunger type piston (4) the tip circle outside is connected with linear guide pillar guide rail (9).
8. a kind of 300Mpa-600Mpa screw mandrel lift UHV (ultra-high voltage) test unit according to claim 5 is characterized in that: said linear guide pillar guide rail (9) has guide pillar and two kinds of forms of guide rail to select for use.
9. a kind of 300Mpa-600Mpa screw mandrel lift UHV (ultra-high voltage) test unit according to claim 8 is characterized in that: said ultra-high pressure cylinder (6) is the outer hot jacket 35CrMo-45 high-strength alloy structural steel of 17-4PH stainless steel material.
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Citations (5)
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---|---|---|---|---|
JPH0866799A (en) * | 1994-08-30 | 1996-03-12 | Murata Mach Ltd | Hydraulic punch press |
KR200200910Y1 (en) * | 2000-04-27 | 2000-10-16 | 주식회사삼주기계 | Hydraulic press |
CN1488405A (en) * | 2003-08-15 | 2004-04-14 | 天津市森淼生物工程技术有限公司 | Integrated superhigh pressure biological treating apparatus |
CN200945253Y (en) * | 2006-09-01 | 2007-09-12 | 天津市华泰森淼生物工程技术有限公司 | Plate and frame type super pressure biological treatment equipment |
CN103033595A (en) * | 2012-03-24 | 2013-04-10 | 雷鉴源 | 600Mpa lead screw lifting type ultrahigh pressure testing device |
-
2012
- 2012-03-26 CN CN2012100807859A patent/CN102645515A/en active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
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JPH0866799A (en) * | 1994-08-30 | 1996-03-12 | Murata Mach Ltd | Hydraulic punch press |
KR200200910Y1 (en) * | 2000-04-27 | 2000-10-16 | 주식회사삼주기계 | Hydraulic press |
CN1488405A (en) * | 2003-08-15 | 2004-04-14 | 天津市森淼生物工程技术有限公司 | Integrated superhigh pressure biological treating apparatus |
CN200945253Y (en) * | 2006-09-01 | 2007-09-12 | 天津市华泰森淼生物工程技术有限公司 | Plate and frame type super pressure biological treatment equipment |
CN103033595A (en) * | 2012-03-24 | 2013-04-10 | 雷鉴源 | 600Mpa lead screw lifting type ultrahigh pressure testing device |
Non-Patent Citations (2)
Title |
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宋吉昌: "食品超高压保鲜技术理论及实验研究", 《中国优秀硕士学位论文全文数据库 工程科技Ⅰ辑》 * |
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Application publication date: 20120822 |