CN102634449A - Viral aerosol collecting and enriching instrument - Google Patents
Viral aerosol collecting and enriching instrument Download PDFInfo
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- CN102634449A CN102634449A CN201210089458XA CN201210089458A CN102634449A CN 102634449 A CN102634449 A CN 102634449A CN 201210089458X A CN201210089458X A CN 201210089458XA CN 201210089458 A CN201210089458 A CN 201210089458A CN 102634449 A CN102634449 A CN 102634449A
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/06—Nozzles; Sprayers; Spargers; Diffusers
Abstract
The invention relates to a viral aerosol collecting and enriching instrument which comprises a framework, a gas feeder, a gas outlet unit nozzle and a collection unit pipe. The gas feeder is used for collecting gas samples to be detected and inputting the gas samples to the gas outlet unit nozzle through a gas pipe. The gas outlet unit nozzle and the collection unit pipe are both arranged on the framework, the collection unit pipe is detachably arranged below the gas outlet unit nozzle, and testing liquid with virus capturing immunomagnetic beads is arranged on the collection unit pipe. The gas samples are sprayed into the collection unit pipe through the gas outlet unit nozzle in a rotary mode. The testing liquid absorbs aerosol contained in the gas to be detected, and virus carried by the gas to be detected is captured through the virus immunomagnetic beads. According to the invention, bio-aerosol in the air can be effectively captured, and virus microbial samples can be specifically enriched, therefore, the viral aerosol collecting and enriching instrument is especially suitable for monitoring virus pathogens in environmental air.
Description
Technical field
The present invention relates to a kind of viral aerosol and gather enriching apparatus, viral beneficiation technologies is effectively gathered and integrated to bioaerosol to dock the integrated apparatus that follow-up virus detects in particularly a kind of ambient air.
Background technology
At present; Most of epidemics are mainly caused by virus infection; And with respiratory tract be main route of transmission virus infection since its propagate mode of infection easily; Propagation causes serious public health event to take place fast very easily at short notice, and infection of SARS, high pathogenic avian influenza and new H1N1virus in recent years and popular institute cause that the mankind or the serious Health hazard of animal and international concern are exactly case history; Sending out the virus type bio-terrorism factor through aerosol also is the mentioned guard key content of counter terrorism expert.In addition, non-Respirovirus also can cause infecting and the incident propagated also takes place frequently through aerosol infection or through the laboratory mishandle, and is therefore very urgent and necessary to aerocolloidal virus monitor research in the environment.But; Because traditional biological aerosol acquisition instrument or device counterpart detection method mainly are applicable to bacterium, Mycophyta pathogenic agent, cause the monitoring of viral aerosol aspect to be restricted; The operation of monitoring virus is inconvenient, susceptibility is poor; The serious study on monitoring present situation in the current transmissible disease of incompatibility field has restricted pathogenic agent monitoring requirements in the environment, and new virus class sampling thief has become one of this field current research focus.
Because virus belongs to noncellular microorganism, must rise in value by dependent cells ability reproducible, particle little (nano level), the air dilution causes reasons such as concentration is low, and it can detected level be a difficult problem that Respirovirus in the ambient air is collected always.Obviously; Viral impinger answers emphasis to be directed against the aerosol particle of breathing output; Research shows, the aerosol particle majority of human airway movable (comprise cough, sneeze, talk and breathing etc.) generation is less than 1 μ m (Edwards et al, 2004); The influenza virus relevant with respiratory activity then mainly is distributed in (Fabian et al, 2008) in the 0.3-1 μ m aerosol particle.Therefore, existing air sampler is to high greater than 1 μ m particle collection efficiency, and it is on the low side to gather viral aerosol particle efficient, and lacking specific aim is one of the main reasons.Most prior biological aerosol samplers are not specific for viral aerosol setting, collect spectrum width, not too are fit to collect viral sample, typical reason can conclude following some:
L) little or working hour of sampling thief flow short, be difficult to collect the air sample of q.s, with the minimum that guarantees that enough virus detects;
2) the aerosol particle collection effciency is on the low side, and especially the aerosol particle collection effciency of pattern of sub-micron level is low;
3) particle removal in the trapping medium and concentration technique deficiency cause inefficiency problem;
4) trapping medium is to the insufficient technical problem of subsequent detection method applicability;
5) be directed against the poor operability of virus monitor, or lack the portability setting that meets the scene.
The important commercialization air sampler collection virus comparative analysis research that is directed against of foreign latest shows (Fabian et al; Indoor Air 2009; 19:433-441); Comprise SKC biosamper biological sampling device, Teflon air strainer, gelatin filter and CCI impact type collector the commercialization biological sampling device of totally four kinds of emphasis carried out comparative analysis, its conclusion is exactly: novel aerosol virus sampling thief needs research; Existing commercialization biological sampling device lacks efficient for virus collection and infectious maintenance aspect; Should pay close attention to the collection effciency and the optimization aspect of collecting liquid phase medium in viral aerosol particle diameter stage.Except some external military project units have carried out viral aerosol monitors and detect based on anti-bio-terrorism demand; Shang Weijian is specifically designed to the air virus monitor enrichment instrument of sensitive sites such as big assembly, vehicles enclosed space or medical institutions; Especially sampling and monitoring device and the supporting virus to nano level virus concentrates highly sensitive, the specific detection device development of formation; Also have many aspects such as sampling efficiency, thickening efficiency and simplicity that relate to improve demand, many distances are still arranged apart from actual application value.
The air microorganism sampler that uses in the present domestic public health field environmental monitoring is broadly divided into three major types: air microbe is captured on solid medium or other adhesion surface; Be collected in the nutritive medium; Be collected in aspects such as filter membrane or other filtrates; The commercialization air microorganism sampler of this type all is primarily aimed at microbial aerosol collections such as micron order bacterium, and pattern of sub-micron level particle collecting efficiency is on the low side.Owing to the nano-scale particle characteristics of virus and such as pathogenic agent height variability such as influenza viruses; Partial virus increment concentration of different virus respiratory tract and discharge mode are different; Different virus detects factors such as means are variant; For the collection of virion with handle the specific aim research that all lacks system, corresponding sample collecting apparatus does not have viral beneficiation technologies integration yet, and viral detection sensitivity has much room for improvement; Be connected also with follow-up detection technique and be left to be desired, do not see and integrate virus collection in the air sampling rig of enrichment.Simultaneously; Environmental quality requirement based on the air virus monitor; Existing biological sampling device makes sampling apparatus not meet actual requirement combining that the vehicles, biocontainment laboratory or animal rearing field etc. are airtight relatively specially, aspect the small space characteristics, also lacking portable, easy and specificity.
Summary of the invention
In order to solve the existing problem of prior art, the present invention provides a kind of and gathers the device with enrichment to viral aerosol, particularly about effective collection of bioaerosol Virus Sample in the ambient air and integrate the integrated apparatus of viral enrichment.
Be to realize above-mentioned purpose, the invention provides that a kind of viral aerosol gathers that the enrichment appearance comprises framework, air feeder, the unit spray head of giving vent to anger and collecting unit pipe; Said air feeder is used to collect gas sample to be detected, and through pneumatic tube said gas sample is input in the unit spray head of giving vent to anger; Said unit spray head and the collecting unit Guan Jun of giving vent to anger is arranged on the framework, and the dismountable below that is arranged on the said unit spray head of giving vent to anger of said collecting unit pipe is provided with test fluid in it; Said gas sample is injected in the said collecting unit pipe through the unit spray head rotation of giving vent to anger, and absorbs the aerosol that is contained in the gas to be measured through said test fluid wherein.
Further; The said unit spray head of giving vent to anger is a cylindrical chamber; Its bottom surface is provided with some jet outlets; Some said jet outlets are uniformly distributed with respect to the axis of the unit spray head of giving vent to anger, and the axis of some jet outlets all spatially is separated by with the axis of the unit spray head of giving vent to anger, and with respect to said axis to oblique below inclination set angle.
Further, the quantity of said jet outlet is more than or equal to 3.
Further, said bottom surface is the face that protrudes downwards.
Further, said some jet outlets are positioned at sustained height in vertical direction.
Further, the container of said collecting unit pipe for constituting by cylinder and the circular cone tube that is arranged on said cylinder below, the capacity of said circular cone tube part is more than or equal to 15ml.
Further, said collection enriching apparatus also comprises enrichment unit frame, said enrichment unit frame comprise can the realization level and the pipe support that rotates freely of vertical direction be arranged on the flexible fastening jump ring that is used for fixing said collecting unit pipe on the pipe support; After collecting unit pipe bracing or strutting arrangement detected and finishes, said collecting unit pipe was set on the enrichment unit frame.
Further, said enrichment unit frame also comprises the magnetic devices that is arranged on said pipe support bottom.
Further, the outer wall of said collecting unit pipe is provided with the bayonet socket that matches with said flexible fastening jump ring.
Further, said test fluid is the test fluid that has the virus immunity magnetic bead; And catch the virus of gas-entrained to be measured through said virus immunity magnetic bead.
It is to collect aerosol through employing gas-liquid mixed mode that the viral aerosol that is limited among the present invention is gathered its principle of enrichment appearance, and in test fluid, drops into the virus that immunomagnetic beads is caught gas-entrained to be measured.This device comprises give vent to anger unit spray head and two integral parts of collecting unit pipe; Be combined to form complete air sampling and viral enrichment instrument, simple in structure, operation link links up, is easy to implement; Its pathogenic agent enrichment mode is docked simply with existing virusology detection method; Especially dock with viral molecular biology detection method commonly used, can extra process directly get into the nucleic acid extraction detection step of cause of disease, time saving and energy saving.In addition, the unit spray head of giving vent to anger among the present invention, collecting unit pipe and three major partss of enrichment unit frame also can be used to complete the standalone feature that each one has separately.
Description of drawings
Fig. 1 gathers enrichment appearance structural representation for the present invention;
Fig. 2 is a kind of unit spray head structural representation of giving vent to anger;
Fig. 3 is second kind of unit spray head structural representation of giving vent to anger;
Fig. 4 is the another kind unit spray head structural representation of giving vent to anger;
Fig. 5 is a collecting unit tubular construction synoptic diagram;
Fig. 6 is connected sectional view for the collecting unit pipe with the unit spray head of giving vent to anger;
Fig. 7 is an enrichment unit shelf structure synoptic diagram.
Embodiment
As shown in Figure 1, viral aerosol is gathered the enrichment appearance and is comprised framework 1, air feeder, the unit spray head of giving vent to anger 3, collecting unit pipe 4 and enrichment unit frame 5.And with the user mode of gathering enriching apparatus set upper and lower to, promptly collecting unit pipe 4 is positioned at the below of the unit spray head 3 of giving vent to anger.Wherein air feeder comprises off-gas pump and pneumatic tube 2, pneumatic tube 2 with the gas delivery to be measured of off-gas pump suction in the unit spray head 3 of giving vent to anger, again by jet outlet 7 ejections.The unit spray head of giving vent to anger 3 is cylindrical chamber, and the face that preferably outwards protrude its bottom surface 6 can be piece or is rule or irregular curved surface or planes such as cone surface, pyramidal surface; Shown in Fig. 2-4; Also be provided with some jet outlets 7 on the bottom surface 6 of the unit spray head of giving vent to anger 3, some jet outlets 7 are uniformly distributed with respect to the axis of the unit spray head 3 of giving vent to anger, and preferably are positioned at sustained height in vertical direction; The axis of some jet outlets 7 all spatially is separated by with the axis of the unit spray head 3 of giving vent to anger; And with respect to this axis to oblique below inclination set angle, the quantity of jet outlet 7 is no less than 3, preferably 3-6.The advantage of this set mode of jet outlet 7 is following: jet outlet 7 directly is processed on the bottom surface, and is easy to process, and can guarantee that the emission direction of gas is constant in the ejection process.Jet outlet number is many, and jet outlet conduit is short, is difficult for stopping up, and is easy to clean; Jet-stream wind evenly forms the tangential gas flow of same surperficial downward direction, forms the downward motivating force of rotation fully, and the rotation of driving liquid level is also risen, and around jet outlet, forms semicircle camber parcel liquid level, realizes complete gas-liquid mixed and aerocolloidal comprehensive collection.
Like Fig. 5, shown in 6, the container of collecting unit pipe 4 for constituting by cylinder 8 and the circular cone tube 9 that is arranged on cylinder 8 belows, cylinder 8 open upper end, the big end of lower end and conically shaped 9 joins.The inwall top of cylinder 8 is provided with screw socket so that dock with the unit spray head 3 of giving vent to anger, or through other modes with give vent to anger 3 dismountable connections of unit spray head.On the outer wall of collecting unit pipe 4, also be provided with inside simple depression bayonet socket 10, be used for the collecting unit pipe is fixedly installed on enrichment unit frame 5, this bayonet socket preferably is arranged on cylinder 8 and circular cone tube 9 junctions.Collecting unit pipe conically shaped partly is mainly used in deposits collection solution, and conically shaped partially liq capacity is for being no less than 15ml.This structure of collecting unit pipe 4 can guarantee the q.s test fluid so that fully mix with big scale of construction air sample, otherwise can't realize effective gas-liquid mixed or owing to test fluid is evaporated very soon and caused the aerosol loss.Test fluid can be the test fluid that has the virus immunity magnetic bead; And catch the virus of gas-entrained to be measured through the virus immunity magnetic bead.
As shown in Figure 7, enrichment unit frame 5 is the pipe support that can rotate freely in level and vertical direction, and pipe support is suitable for reading to be provided with the bayonet socket 10 that flexible fastening jump ring 11 is used to dock the collecting unit pipe.Flexible fastening jump ring 11 can be when realizing fixedly the collecting unit pipe, and craft at any time pick and place collecting unit pipe 4.The pipe support bottom is provided with magnetic devices 12, and magnetic devices 12 can be fixed permanent magnet etc., and the pipe support size needs and collecting unit pipe 4 couplings.As shown in Figure 1, enrichment unit frame 5 is arranged on the lower end of framework 1, can it be taken in the framework 1 through horizontally rotating pipe support, or screw out in use, so that fixing collecting unit pipe 4.Rotating pipe support in vertical direction can pour out the liquid in the collecting unit pipe 4.Enrichment unit frame 5 also can be independent of framework 1 setting in addition, but its structure and function are constant.
During test, the viral aerosol among the present invention is gathered the enrichment appearance be arranged in the zone to be measured, off-gas pump starts; With gas suction to be measured, and be input in the unit spray head 3 of giving vent to anger, and be ejected in the test fluid in the collecting unit pipe 4 by the some jet outlet 7 that is arranged on its bottom surface 6 through pneumatic tube 2; Because some jet outlets 7 are positioned on the equal height of bottom surface 6, and its outlet is all towards oblique below, so; Gas to be detected ejection simultaneously in collecting unit pipe 4 by its ejection; Form swirling eddy, drive the test fluid rotation in the collecting unit pipe 4, liquid level is risen; Realization is to spraying into the liquid arc parcel of air-flow; Make the gas to be measured of all collections can be ejected into the test fluid surface fully, and continue to be mixed in the test fluid of rotation, and then realize aerocolloidal effective seizure and collection in air and test fluid high efficient mixed and the air.After gas collecting finishes; Collecting unit pipe 4 is taken off from the unit spray head 3 of giving vent to anger; And collecting unit pipe 4 fixed placement are left standstill on enrichment unit frame 5, after magnetic bead all adheres at the bottom of the pipe of collecting unit pipe 4 in the test solution to be measured through magneticaction, vertical direction rotation pipe support; Can test fluid be poured out, and the magnetic bead of enrichment virus is retained in the pipe end is used for next step virus and detects.
The advantage that the viral aerosol of the present invention is gathered the enrichment appearance is following: the design of the unit spray head of 1, giving vent to anger meets the physics cyclone principle; The air-flow of collecting can realize that with the circular arc type of follow-up generation parcel liquid level gas-liquid fully contacts, and the tested test solution of different-grain diameter aerosol particle that contains in the gas to be measured that guarantees to be gathered is fully gathered; 2, the layout of the same cavity of some unit spray head of giving vent to anger, short duct makes the unit spray head of giving vent to anger be difficult for stopping up, and is easy to clean; 3, the collecting unit pipe is the combined shaped cavity of cylinder and circular cone; After can guaranteeing the rotation of air stream drives liquid level on the one hand; The liquid upper space forms big arc-shaped concave, and to realize the abundant parcel to tuyere, guarantee gas is effectively gathered and mixed; The tip of circular cone lower end is designed with and is beneficial to the small volume that holds follow-up concentrated magnetic bead on the other hand, is convenient to reclaim; 4, the collecting unit pipe is equipped with bigger liquid sample capacity; Can guarantee the collection of big air flow quantity after the air stream drives and mix with the effective of test fluid; Also directly add virus in the test fluid and catch immunomagnetic beads, in gas-liquid mixed, realize the virus in the aerosol is caught; 5, but enrichment unit frame is folded with for the horizontal vertical direction, conveniently is incorporated in the apparatus, and the pipe support bottom is a fixed permanent magnet, is convenient to contact magnetic bead realization enrichment in the pipe with the tapered bottom end of collecting unit pipe tapered segment.
Claims (10)
1. a viral aerosol is gathered the enrichment appearance, it is characterized in that, said collection enriching apparatus comprises framework, air feeder, the unit spray head of giving vent to anger and collecting unit pipe; Said air feeder is used to collect gas sample to be detected, and through pneumatic tube said gas sample is input in the unit spray head of giving vent to anger; Said unit spray head and the collecting unit Guan Jun of giving vent to anger is arranged on the framework, and the dismountable below that is arranged on the said unit spray head of giving vent to anger of said collecting unit pipe is provided with test fluid in it; Said gas sample is injected in the said collecting unit pipe through the unit spray head rotation of giving vent to anger, and absorbs the aerosol that is contained in the gas to be measured through said test fluid wherein.
2. gather the enrichment appearance according to viral aerosol described in the right 1; It is characterized in that; The said unit spray head of giving vent to anger is a cylindrical chamber, and its bottom surface is provided with some jet outlets, and some said jet outlets are uniformly distributed with respect to the axis of the unit spray head of giving vent to anger; The axis of some jet outlets all spatially is separated by with the axis of the unit spray head of giving vent to anger, and with respect to said axis to oblique below inclination set angle.
3. gather the enrichment appearance according to right 2 said viral aerosols, it is characterized in that the quantity of said air outlet is more than or equal to 3.
4. gather the enrichment appearance according to viral aerosol described in the right 2, it is characterized in that, said bottom surface is the face that protrudes downwards.
5. gather the enrichment appearance according to viral aerosol described in the right 2, it is characterized in that said some jet outlets are positioned at sustained height in vertical direction.
6. gather the enrichment appearance according to viral aerosol described in the right 1, it is characterized in that, the container of said collecting unit pipe for constituting by cylinder and the circular cone tube that is arranged on said cylinder below, the capacity of said circular cone tube part is more than or equal to 15ml.
7. gather the enrichment appearance according to viral aerosol described in the right 1; It is characterized in that; Said collection enriching apparatus also comprises enrichment unit frame, said enrichment unit frame comprise can the realization level and the pipe support that rotates freely of vertical direction be arranged on the flexible fastening jump ring that is used for fixing said collecting unit pipe on the pipe support; After collecting unit pipe bracing or strutting arrangement detected and finishes, said collecting unit pipe was set on the enrichment unit frame.
8. gather the enrichment appearance according to viral aerosol described in the right 7, it is characterized in that, said enrichment unit frame also comprises the magnetic devices that is arranged on said pipe support bottom.
9. gather the enrichment appearance according to viral aerosol described in the right 7, it is characterized in that the outer wall of said collecting unit pipe is provided with the bayonet socket that matches with said flexible fastening jump ring.
10. gather the enrichment appearance according to viral aerosol described in the right 1, it is characterized in that said test fluid is the test fluid that has the virus immunity magnetic bead; And catch the virus of gas-entrained to be measured through said virus immunity magnetic bead.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 201210089458 CN102634449B (en) | 2012-03-30 | 2012-03-30 | Viral aerosol collecting and enriching instrument |
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| CN 201210089458 CN102634449B (en) | 2012-03-30 | 2012-03-30 | Viral aerosol collecting and enriching instrument |
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| CN102634449A true CN102634449A (en) | 2012-08-15 |
| CN102634449B CN102634449B (en) | 2013-11-06 |
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| CN104498356A (en) * | 2014-12-26 | 2015-04-08 | 杭州师范大学 | Device for collecting atmospheric particulates in cell culture medium |
| CN105733934A (en) * | 2016-02-23 | 2016-07-06 | 中国检验检疫科学研究院 | Electromagnetic excitation magnetic bead rotary type microbiological aerosol collecting and enriching instrument |
| CN109022252A (en) * | 2018-08-01 | 2018-12-18 | 杭州富集生物科技有限公司 | A kind of high efficiency large volume bottom magnetic StrongmenGroup acquisition means |
| CN110411921A (en) * | 2019-08-26 | 2019-11-05 | 中国检验检疫科学研究院 | Bioaerosol detection device and detection method |
| CN112557364A (en) * | 2020-12-11 | 2021-03-26 | 天津市职业大学 | Intelligent indoor air quality virus detection system and detection method |
| CN112683753A (en) * | 2020-12-10 | 2021-04-20 | 华桥生物工程科技有限公司 | Automatic detector and system for microbial droplet aerosol |
| CN112779318A (en) * | 2020-12-22 | 2021-05-11 | 樱拓（上海）生物科技有限公司 | Method, application and device for automatically detecting microorganisms |
| CN114018658A (en) * | 2021-11-09 | 2022-02-08 | 中国人民解放军总医院第五医学中心 | Air sample collector for regional infectious disease investigation equipment |
| CN114032173A (en) * | 2022-01-11 | 2022-02-11 | 至美时代生物智能科技(北京)有限公司 | Closed air sampling bottle |
| CN114088476A (en) * | 2021-10-21 | 2022-02-25 | 上海交通大学 | Aerosol virus collecting and enriching device and method with self-adaptive collecting control |
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| CN112779318A (en) * | 2020-12-22 | 2021-05-11 | 樱拓（上海）生物科技有限公司 | Method, application and device for automatically detecting microorganisms |
| CN114088476A (en) * | 2021-10-21 | 2022-02-25 | 上海交通大学 | Aerosol virus collecting and enriching device and method with self-adaptive collecting control |
| CN114088476B (en) * | 2021-10-21 | 2022-11-04 | 上海交通大学 | Aerosol virus collecting and enriching device and method with adaptive collection control |
| CN114018658A (en) * | 2021-11-09 | 2022-02-08 | 中国人民解放军总医院第五医学中心 | Air sample collector for regional infectious disease investigation equipment |
| CN114032173A (en) * | 2022-01-11 | 2022-02-11 | 至美时代生物智能科技(北京)有限公司 | Closed air sampling bottle |
| CN114032173B (en) * | 2022-01-11 | 2022-03-15 | 至美时代生物智能科技(北京)有限公司 | Closed air sampling bottle |
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Effective date of registration: 20171228 Address after: The Poplar Street of Hangzhou city in Zhejiang province 310018 Hangzhou economic and Technological Development Zone No. 6 Street No. 452 Building 2 room A2409 Patentee after: Hangzhou enrichment biotechnology Co Ltd Address before: 100025 No. 3, Gaobeidian North Road, Beijing, Chaoyang District Patentee before: Chinese Academy of Inspection and Quarantine |