CN102631691A - High-temperature hot water sterilizing process for aerobe fermentation medium or fed-batch material continuous disinfection system and equipment pipeline configuration - Google Patents
High-temperature hot water sterilizing process for aerobe fermentation medium or fed-batch material continuous disinfection system and equipment pipeline configuration Download PDFInfo
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- CN102631691A CN102631691A CN2012100087631A CN201210008763A CN102631691A CN 102631691 A CN102631691 A CN 102631691A CN 2012100087631 A CN2012100087631 A CN 2012100087631A CN 201210008763 A CN201210008763 A CN 201210008763A CN 102631691 A CN102631691 A CN 102631691A
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Abstract
A high-temperature hot water sterilizing process for an aerobe fermentation medium or a fed-batch material continuous disinfection system includes following steps: 1) feeding water in a water sterilizing tank, heating the water, and leading hot water to sterilize pipelines and equipment from a continuous sterilizing pump to a fermenting tank or an inlet valve of a fed-batch tank via a total maintaining tank; 2) leading high-temperature water flowing from a water return valve V11 of the water sterilizing tank to enter a heat exchanger D before entering a return water sterilizing tank, leading the high-temperature water and water flowing out from the water sterilizing tank to be in heat exchange, and increasing the temperature of the water flowing out from the water sterilizing tank; 3) leading high-temperature water flowing out from the heat exchanger D to enter a heat exchanger E to be in heat exchange with replenished water flowing into the water sterilizing tank, and increasing the temperature of inflow water of the water sterilizing tank; and 4) beginning to record circulation time and realizing water sterilizing when the temperature of water flowing out from a heat exchanger A reaches 125-130 DEG C. The high-temperature hot water sterilizing process has the advantages that a constant-pressure water sterilizing technological production process is stable, continuous and reliable, safety of the aerobe fermentation medium or fed-batch material continuous disinfection system is improved, a thermal energy recovery system is used for constant-pressure water sterilizing, thermal energy loss is reduced, and energy consumption is lowered.
Description
Technical field
The present invention relates to the microbe industrial fermentation production field, particularly a kind of aerobic microbiological that is used for adds the Processes and apparatus pipeline configuration that thing continuous sterilization disinfection system (abbreviation continuous sterilizing system) carries out high-temperature-hot-water sterilization (being called for short water at atmospheric pressure disappears) in commercial production to fermentation medium or stream.
Background technology
With the fermentation engineering be the biotechnology of core content today in continuous development; Carry out production by microorganism culturing and related to fields such as medicine, chemical industry, light industry, the energy, environmental protection,, the production technology operation and the equipment design of scale are had higher requirement along with fermentation engineering trend equipment enlarging, efficient and automatization; A wherein very important production link is exactly the process that continuous sterilizing systems such as fermentation medium are carried out disinfection; When particularly making good use of oxygen animalcule and carrying out fermenting and producing, it is that the success or failure of sweat are crucial that the continuous sterilizing system that culture medium and stream are added thing carries out disinfection, if the continuous sterilizing system sterilization is not thorough; Will cause microbiological contamination during the fermentation; Thereby can not guarantee the quality of fermented product, even cause the sweat failure, cause manufacturing enterprise's enormous economic loss.
When fermentation industry manufacturing enterprise added the thing continuous sterilizing system and carries out disinfection fermentation medium or stream, generally the state according to the antibacterial thermal medium was divided into steam (125 ℃～130 ℃) sterilization (being called for short vapour disappears) and high-temperature-hot-water (125 ℃～130 ℃) sterilization (abbreviation water disappears) two type systematics.
The advantage of vapour sterilizing system technology be quick heating, time short, the efficiency of heating surface is high, the operation simple relatively; Shortcoming is the bad control of sterilization temperature, and material residual in equipment and pipeline is prone to fouling, influences the disinfectant effect, is the factor that causes the sweat microbiological contamination.And the advantage of water sterilizing system is that sterilization temperature control is steady; Cleaned equipment and pipeline simultaneously at disinfectant, bactericidal effect is more safe and reliable; Shortcoming is that present domestic fermenting and producing enterprise is when making water sterilizing system technology; Effectively solve the difficult problem of energy recovery and system balancing because fail, before high-temperature water is got back to water pot, in order to keep the balance of system; Can only be through flash distillation and the mode of directly discharging; 125 ℃～130 ℃ high-temperature-hot-water is dropped to below 100 ℃,, cause energy waste so in the circulation disinfecting process, need constantly again the water that water disappears jar to be heated to 125 ℃～130 ℃ with steam.
Characteristics based on above-mentioned two kinds of decontamination systems; Because present domestic fermenting and producing enterprise can't solve and fermentation medium or stream are added the thing continuous sterilizing system carry out the problem that water disappears and exists in the technology; So what most enterprises adopted all is vapour sterilizing system technology; Make have safety, steadily, the water sterilizing system of characteristics such as control but can't be widely used in fermentation industry easily, has restricted the promotion and application of this technology in fermentation industry greatly.And, can reduce energy resource consumption again how in the characteristics that keep the water sterilizing system, this is a topic before proposing of the present invention.
Summary of the invention
The purpose of this invention is to provide and a kind ofly be used for that aerobic microbiological fermentation medium or stream are added thing continuous sterilization disinfection system and carry out high-temperature-hot-water sterilization process and the configuration of equipment pipeline; This technology has the production process operative temperature steadily, continuously, reliably; Improved the safety of system; Control system is simple, and is safe and reliable, easy to operate; Heat energy has carried out efficient recovery, and the water sterilizing system is used widely at fermentation industry, and this technology is particularly useful for existing fermenting and producing enterprise water sterilizing system is undergone technological transformation.
For achieving the above object, the present invention adopts following technical scheme:
Thisly be used for that aerobic microbiological fermentation medium or stream are added thing continuous sterilization disinfection system and carry out the high-temperature-hot-water sterilization process, it may further comprise the steps:
1) the water water inlet that disappears jar; The water that water is disappeared jar directly gets into heat exchanger A through connecting the pump that disappears; Water is heated; Open fermentation tank or stream and add jar charging valve V9 top water discharging valve V10 and the water jar backwater valve V11 that disappears, hot water is kept jar carrying out disinfection from pipeline and the equipment that connects the pump that disappears adds jar to fermentation tank or stream the inlet valve through whole;
2) before backwater disappears jar, be introduced into heat exchanger D from the water jar high-temperature water that back-water valve (BWV) V11 comes out that disappears, carry out heat exchange, improved the water jar leaving water temperature that disappears with the water jar water outlet that disappears;
3) high-temperature water that comes out from heat exchanger D gets into the supplementing water that heat exchanger E and water inlet disappear jar and carries out heat exchange, improved the water inlet water temperature that water disappears jar;
4) when heat exchanger A water outlet water temperature reaches 125 ℃～130 ℃, the opening entry circulation time also carries out water and disappears, and after the water process that disappears was accomplished, water disappeared and jar stops water outlet, makes material get into continuous sterilizing system.
The water that water disappears jar is got to heat exchanger A through connecting the pump that disappears; Make water be warmed up to 125 ℃～130 ℃; High-temperature water adds the feeding pipe of thing through keeping jar the back along culture medium or stream, returns water disappear jar, so circulation before adding jar advancing fermentation tank or stream; Fermentation medium or stream add thing connect disappear before, to carrying out disinfection from pipeline and the equipment that connects the inlet valve that the pump that disappears adds jar to fermentation tank or stream; And the high-temperature water behind the disinfection before backwater disappears jar earlier through heat exchanger D, heat exchanger E, carry out thermal energy exchange with water the disappear water inlet of jar of jar water outlet and water that disappears, return water temperature is reduced to below 100 ℃, fully reclaimed heat energy.
After sterilization is accomplished, close water disappear jar outlet valve and back-water valve (BWV), open material-compound tank bleeder valve and fermentation tank or stream and add a jar inlet valve, begin logistics connected and disappear.
This technology also can be used for many cover fermentation medium continuous sterilizing systems and many cover streams and adds the thing continuous sterilizing system and carry out the water at atmospheric pressure operation that disappears simultaneously.
Advantage of the present invention is: water disappear the production process operative temperature steadily, continuously, reliable, the safety that has improved system is cleaned pipeline, prevents material fouling on equipment tank skin and tube wall, has improved the reliability of continuous sterilizing system; Control system is simple, and is safe and reliable, easy to operate, and heat energy has carried out efficient recovery.This technology is particularly useful for existing fermenting and producing enterprise water sterilizing system is undergone technological transformation.
Description of drawings
Fig. 1: high-temperature-hot-water disinfectant equipment pipeline configuration schematic diagram of the present invention
Among Fig. 1, V1 is an inlet valve, and V2 is an inlet valve, and V3 is the discharging valve, and V4 is a flowing water Valve, and V5 is the charging valve, and V6 is an inlet valve, and V7 is a steam valve, and V8 is an inlet valve, and V9 is the charging valve, and V10 is a water discharging valve, the V11 backwater valve.
The specific embodiment
The equipment pipeline configuration that the present invention is used for the high-temperature-hot-water sterilization process comprises: it comprises: the water jar that disappears, the water jar that disappears is established the two-way water inlet, and one the tunnel meets inlet valve V2; Another termination water pipe of valve V2, another road water inlet is for connecing serial connection one valve V1 on the water pipe, another termination heat exchanger of valve V1 E water inlet; The heat exchanger E outlet water receiving jar water inlet that disappears; The water outlet that disappears jar connects the water inlet of heat exchanger D, and heat exchanger D outlet picks out penstock V4, and the valve V4 other end connects and connects the pump that disappears; Connect the pump inlet that disappears and also connect a charging valve V3, the valve V3 other end connects material-compound tank, connects the pump discharge that disappears and meets an inlet valve V6; The valve V6 other end connects the import of heat exchanger A material channel, and heat exchanger A outlet connects keeps jar, and the outlet of keeping jar meets heat exchanger B; The outlet of heat exchanger B meets heat exchanger C, and heat exchanger C outlet meets charging valve V9, and the valve V9 other end connects fermentation tank or stream adds jar; Valve V9 epimere connects a water discharging valve V10, and the valve V10 other end connects the water jar that disappears; Heat exchanger C outlet meets a backwater valve V11, and the valve V11 other end connects the high-temperature water import of heat exchanger D, and the high-temperature water outlet of heat exchanger D connects the import of heat exchanger E high-temperature water, the water return outlet that heat exchanger E high-temperature water outlet water receiving disappears jar.
Heat exchanger B charging valve 5, this valve one end connects feed pipe, and the other end connects the import of heat exchanger B material channel;
Heat exchanger A admission valve 7, this valve one end connects into jet chimney, and the other end connects the import of heat exchanger steam channel;
Heat exchanger C inlet valve V8, this valve one end connects the cooling water inlet pipe road, and the other end connects the import of spiral-plate heat exchanger C cooling-water duct.
In this configuration, heat exchanger A is used for heating up, and heat exchanger B is used for preheating, and heat exchanger C is used for cooling, can adopt spiral-plate heat exchanger, and described heat exchanger D, heat exchanger E can be independently, also can be two-stage nitration template formula heat exchanger D/E.
The high-temperature-hot-water sterilization process may further comprise the steps:
1) jar inlet valve V1 that disappears that fetches boiling water, the water jar water inlet that disappears;
2) intake water when disappearing jar certain liquid level, open successively water disappear a jar flowing water Valve V4, connect disappear pump, water intaking valve V6, the water that water is disappeared jar directly gets into heat exchanger A through connecting the pump that disappears; Open steam valve V7 simultaneously, make steam get into heat exchanger A, water is heated; Open fermentation tank or stream and add jar inlet valve V9 top float water valve V10 and the water jar back-water valve (BWV) V11 that disappears, make hot water through whole jar and heat exchanger B, the heat exchanger C of keeping, up to inlet valve 9 tops; It is carried out disinfection, and return the water jar that disappears; Cooling water water intaking valve V8, fermentation tank or the stream of material-compound tank bleeder valve V3, heat exchanger B inlet valve V5, heat exchanger C added a jar inlet valve V9 and were closed condition this moment;
3) high-temperature water was introduced into heat exchanger D before backwater disappears jar, exchanged with the water jar water outlet that disappears, and had improved the water jar leaving water temperature that disappears;
4) when high-temperature water gets into heat exchanger, open valve 1, valve-off 2, high-temperature water get into the supplementing water that heat exchanger E section and water inlet disappear jar and carry out heat exchange, have improved the water inlet water temperature that water disappears jar.Fully reclaimed the heat energy of high-temperature water through the secondary exchange;
5) when heat exchanger A water outlet water temperature reaches 125 ℃～130 ℃, the opening entry circulation time;
6) after the water process that disappears was accomplished, valve-off V4, the water jar water outlet that disappears stopped, and Open valve V3 makes material get into continuous sterilizing system simultaneously; Valve-off V11, valve V10 open valve V9, make hot water not backwater disappear jar and enter in the fermentation tank; Valve-off V6 opens valve V5 simultaneously, makes material get into heat exchanger B and carries out preheating; Open valve V8, cooling water gets into heat exchanger C, and material is cooled off, and at this moment the material continuous sterilizing system brings into operation, and pushes up remaining water in the pipeline in the fermentation tank, and the water process that disappears finishes.
Claims (2)
1. one kind is used for that aerobic microbiological fermentation medium or stream are added thing continuous sterilization disinfection system and carries out the high-temperature-hot-water sterilization process, and it is characterized in that: it may further comprise the steps:
1) the water water inlet that disappears jar; The water that water is disappeared jar directly gets into heat exchanger A through connecting the pump that disappears; Water is heated; Open fermentation tank or stream and add jar charging valve V9 top water discharging valve V10 and the water jar backwater valve V11 that disappears, hot water is kept jar carrying out disinfection from pipeline and the equipment that connects the pump that disappears adds jar to fermentation tank or stream the inlet valve through whole;
2) before backwater disappears jar, be introduced into heat exchanger D from the water jar high-temperature water that back-water valve (BWV) V11 comes out that disappears, carry out heat exchange, improved the water jar leaving water temperature that disappears with the water jar water outlet that disappears;
3) high-temperature water that comes out from heat exchanger D gets into the supplementing water that heat exchanger E and water inlet disappear jar and carries out heat exchange, improved the water inlet water temperature that water disappears jar;
4) when heat exchanger A water outlet water temperature reaches 125 ℃～130 ℃, the opening entry circulation time also carries out water and disappears, and after the water process that disappears was accomplished, water disappeared and jar stops water outlet, makes material get into continuous sterilizing system.
2. equipment pipeline configuration that is used for the said high-temperature-hot-water sterilization process of claim 1, it is characterized in that: it comprises: the water jar that disappears, the water jar that disappears is established the two-way water inlet; One the tunnel meets inlet valve V2; Another termination water pipe of valve V2, another road water inlet is for connecing serial connection one valve V1 on the water pipe, another termination heat exchanger of valve V1 E water inlet; The heat exchanger E outlet water receiving jar water inlet that disappears; The water outlet that disappears jar connects the water inlet of heat exchanger D, and heat exchanger D outlet picks out penstock V4, and the valve V4 other end connects and connects the pump that disappears; Connect the pump inlet that disappears and also connect a charging valve V3, the valve V3 other end connects material-compound tank, connects the pump discharge that disappears and meets an inlet valve V6; The valve V6 other end connects the import of heat exchanger A material channel, and heat exchanger A outlet connects keeps jar, and the outlet of keeping jar meets heat exchanger B; The outlet of heat exchanger B meets heat exchanger C, and heat exchanger C outlet meets charging valve V9, and the valve V9 other end connects fermentation tank or stream adds jar; Valve V9 epimere connects a water discharging valve V10, and the valve V10 other end connects the water jar that disappears; Heat exchanger C outlet meets a backwater valve V11, and the valve V11 other end connects the high-temperature water import of heat exchanger D, and the high-temperature water outlet of heat exchanger D connects the import of heat exchanger E high-temperature water, the water return outlet that heat exchanger E high-temperature water outlet water receiving disappears jar.
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| CN201210008763.1A CN102631691B (en) | 2012-01-12 | 2012-01-12 | High-temperature hot water sterilizing process for aerobe fermentation medium or fed-batch material continuous disinfection system and equipment pipeline configuration |
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| CN201210008763.1A CN102631691B (en) | 2012-01-12 | 2012-01-12 | High-temperature hot water sterilizing process for aerobe fermentation medium or fed-batch material continuous disinfection system and equipment pipeline configuration |
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| CN102631691B CN102631691B (en) | 2014-10-29 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109331192A (en) * | 2018-11-07 | 2019-02-15 | 肇庆市天臻生物化工技术有限公司 | A kind of efficient, full nutrition protection continuous sterilization system and technique |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090152183A1 (en) * | 2005-11-02 | 2009-06-18 | Packaged Environmental Solutions Pty Ltd. | Disinfection System Improvements |
| CN201782983U (en) * | 2010-09-14 | 2011-04-06 | 北京东方诚益通工业自动化技术有限公司 | Superheated water sterilizing device for fermentation equipment |
| CN201791122U (en) * | 2010-09-14 | 2011-04-13 | 北京东方诚益通工业自动化技术有限公司 | Automatic control device for continuous sterilization of fermentation base material |
| CN202019699U (en) * | 2011-03-30 | 2011-11-02 | 鹿泽海 | Novel high efficiency dual triple-connected-tank sterilization kettle |
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2012
- 2012-01-12 CN CN201210008763.1A patent/CN102631691B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090152183A1 (en) * | 2005-11-02 | 2009-06-18 | Packaged Environmental Solutions Pty Ltd. | Disinfection System Improvements |
| CN201782983U (en) * | 2010-09-14 | 2011-04-06 | 北京东方诚益通工业自动化技术有限公司 | Superheated water sterilizing device for fermentation equipment |
| CN201791122U (en) * | 2010-09-14 | 2011-04-13 | 北京东方诚益通工业自动化技术有限公司 | Automatic control device for continuous sterilization of fermentation base material |
| CN202019699U (en) * | 2011-03-30 | 2011-11-02 | 鹿泽海 | Novel high efficiency dual triple-connected-tank sterilization kettle |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109331192A (en) * | 2018-11-07 | 2019-02-15 | 肇庆市天臻生物化工技术有限公司 | A kind of efficient, full nutrition protection continuous sterilization system and technique |
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