CN102631587B - Chinese herbal medicinal composition for treating condyloma acuminatum and preparation method thereof - Google Patents
Chinese herbal medicinal composition for treating condyloma acuminatum and preparation method thereof Download PDFInfo
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Abstract
The invention provides a Chinese herbal medicinal composition for treating condyloma acuminatum and a preparation method thereof. The composition comprises the following Chinese herbal medicinal raw materials in parts by weight: 20 to 40 parts of bamboo shoot, 20 to 40 parts of climbing groundsel herb, and 10 to 30 parts of whiteflower leadword root. The preparation method comprises the following steps: baking Chinese herbal medicaments; pulverizing or crushing; leaching; concentrating; drying; and mixing to prepare oral solution, granules, tablets, powder and capsules. The Chinese herbal medicinal composition has rich drug sources, simple preparation process and low cost. Clinical tests prove that: the wart stops growing and necrotizes after a patient takes the composition for 10 days; the wart falls and is completely healed after the patient takes the composition for 20 days, protective immunity is generated in the body, and the surface part of the focus is completely repaired; and a critically ill patient can be completely healed when taking less than 50 days, and does not relapse. The effective rate is 92 percent, and the cure rate is 81 percent. The Chinese herbal medicinal composition has quick treatment effect, safety and reliability and no adverse reaction, and has remarkable effects in effectively inhibiting wart growth and complete heal.
Description
Technical field
The invention belongs to Chinese drug preparation technique field, relate to a kind of condyloma acuminatum herbal composite and preparation method for the treatment of.
Technical background
Condyloma acuminatum is to infect by human papillomavirus (HPV) a kind of sexually transmitted disease (STD) causing.In China, be one of topmost sexually transmitted disease (STD), in the middle of sexually transmitted disease (STD), sickness rate ranked second position, the crowd that being apt to occur in property is active, and annual rate of growth surpasses 100%, occupies first of all kinds of sexually transmitted disease (STD)s, and social danger is serious.
The pathogen human papillomavirus (HPV) of primary disease has 70 polytypes, and approximately 10 types can cause condyloma acuminatum (as 6,11,16,18 and 33 types), wherein 11,16,18 likely cancerations of type.Men and women's external genitalia is the most susceptible position.Local visible vegetation after infecting, form is as pimple shape, mamillary, cauliflower form, cockscomb shape etc., and touching difficulty is more.Doctor trained in Western medicine to condyloma acuminatum without specific treatment medicine, the normal antiviral such as interferon, polyinosini, the close buttocks of 5-fluorine urea, imiquimod that use, the more difficult removing focus of medical treatment, mainly with surgical intervention, be main, common method has operative therapy, cryotherapy, laser therapy, fulgerize treatment, micro-wave therapeutic etc., all surgical treatments all can not judge whether to remove totally in art, more difficult Control in recurring, and most of patients need to repeatedly be treated.
Because the special route of transmission of this disease (it is main spreading through sex intercourse), the uncertainty for the treatment of (without specific aim, easily recurrence), and the possibility of canceration, have a strong impact on patient's personal health and love and marriage life, causes great body and mind injury, often has because of the light survivor of ill wish.China has utilized Chinese medicine treatment, as:
Application number CN 201110210335.2, treatment is Chinese medicine composition and preparation method thereof for condyloma acuminatum.Said composition is made the medicament of Orally-administered decoction, powder or piece agent by the crude drug of following weight proportioning: Radix Isatidis 1-3 part, Folium Isatidis 1-3 part, Radix Arnebiae (Radix Lithospermi) 1-3 part, Semen Coicis 1-3 part.Clinical diagnosis condyloma acuminatum 8 examples, female's 5 examples wherein, 20-52 year, disease damage is in nympha per vaginam mouth around 3 examples, labium majus outer skin 2 examples, and disease damage is cauliflower form 3 examples, hillock rash shape 2 examples; Male's 3 examples, 29-57 year, disease damage penis l example, glans penis coronary sulcus and near foreskin 2 examples, disease damage is cauliflower form 2 examples, pimple shape l example.In 8 examples 7 examples all through laser, ionize recidivist after sub or slave A photodynamic therapy.4 weeks recovery from illness 4 examples of clinical effectiveness, 6 weeks recovery from illness 2 examples, 6 weeks above recovery from illness 2 examples.
Application number CN 200410060274.6, the Chinese medicine composition that is used for the treatment of condyloma acuminatum, it is by the formulated capsule of the crude drug of following portions by weight: Herba Galii Teneri 5-100 part, Rhizoma Paridis 50-100 part, Semen Momordicae 30-60 part, Scorpio 30-60 part, Venenum Bufonis 8-20 part, Rhizoma Sparganii 30-60 part, Rhizoma Curcumae 30-60 part, Pseudobulbus Cremastrae seu Pleiones 45-90 part, Semen Coicis 45-60 part, Stigma Croci 20-50 part, Bulbus Fritillariae Thunbergii 50-100 part, Radix Panacis Quinquefolii 50-100 part, Squama Manis 45-90 part.Take each 5 of this capsule, every day 3 times, be 1 course for the treatment of January, connects and controlled for 3 courses for the treatment of.
The existing Chinese medicine composition for the treatment of condyloma acuminatum of more than taking passages, the effect that there is treatment symptom and prevent recurrence, but remain medicine effective slow, the course for the treatment of is long, the problem of recurrence after part treatment, and all unconverted input is clinical.
Summary of the invention
Object of the present invention: the present invention is the understanding to this Anttdisease Mechanism according to modern medicine, defect for its Therapeutic Method, collect many doctor chiefs, in conjunction with the strong medicine proved recipe of strong doctor among the people, the outstanding Chinese herbal medicine of screening clinical efficacy, according to Chinese medicine determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs principle, develop the active drug for the treatment of condyloma acuminatum.
Technical scheme of the present invention:
Treat a condyloma acuminatum herbal composite, comprise following herbal raw material and parts by weight: 20～40 parts, bamboo sprout, 20～40 parts of Herba Senecionis Scandentiss, 10～30 parts of Radix Plumbaginis Zeylanicaes.
Above-described herbal composite, herbal raw material and parts by weight: 30 parts, bamboo sprout, 30 parts of Herba Senecionis Scandentiss, 20 parts of Radix Plumbaginis Zeylanicaes.
Above-described herbal composite comprises oral liquid, granule, tablet, powder and capsule.
The preparation method of above-described treatment condyloma acuminatum herbal composite, is characterized in that:
(1) powder and capsule preparation method: by herbal raw material through screening, washing, fragmentation, lixiviate, filtration, lixiviate again, secondary filter, merge extractive liquid,, concentrating under reduced pressure, be dried, pulverize, mix, sieve and packaging step, or through screening, clean, dry, broken, pulverize, mix and packing;
(2) granule or tablet preparation method: herbal raw material, through screening, washing, dehydration, dry, fragmentation, lixiviate, filtration, lixiviate again, secondary filter, merge extractive liquid,, concentrating under reduced pressure, is dried, pulverizes, mixes, sieves, adopts the pelletize of pharmacy conventional method or film-making, subpackage and outer package.
(3) preparation method of oral liquid: herbal raw material, through screening, washing, dry, coarse crushing, is soaked to l hour, and decocting boils secondary, adds up for the first time the water of 7～8 times of amounts of medicine raw material, decocts l.5～2 hours, filters to obtain decocting liquid; Add up for the second time the water of 6～7 times of amounts of medicine raw material, decoct l～2 hour, filter to obtain decocting liquid, twice decocting liquid mix homogeneously, pack or bottling, in heat-sealing bag, 105 ℃ of high temperature sterilizes, or by the Chinese medicine routine use that is decocted in water for oral dose.
Above-described dry be by herbal raw material or concentrating under reduced pressure clear paste is put into heated-air circulation oven or pressure Reduction Dryer is dry, temperature is controlled at 55～85 ℃, be 2～10h drying time, moisture≤12%.
Above-described lixiviate is that fragmentation or pulverizing herbal raw material are added in pot for solvent extraction, then add 6～8 times of medicinal solvents of herbal raw material, extraction time 2～8h, filter and remove residue obtains solvent extraction liquid, filtering residue is added to 5～6 times of medicinal solvent lixiviates of herbal raw material once again, extraction time 2～5h, filter and remove residue obtains secondary solvent extracting solution.
Above-described concentrating under reduced pressure is that extracted twice liquid is added in concentration pan, and it is 1.10～1.25 clear paste that concentrating under reduced pressure becomes relative density, reclaims solvent and reuses.
Above-described sieving, adopts 60～200 mesh sieves.
Above-described powder, the conventional adjuvant of adapted, every bag of powder weight is 8～10g.
Above-described capsule, each capsule dress powder weight is 0.2～0.5g.
Above-described granule, the conventional adjuvant of adapted, every bag of granule dress powder weight is 8～10 grams.
Above-described tablet, the conventional adjuvant of adapted, every weight is O.2～0.5g.
Above-described pack or bottling, every bag or bottled oral liquid 70～80ml.
Above medicament contains crude drug amount 4～6g, 2～3 times on the one each serving using.
The pharmacology of Chinese herbal medicine that the present invention adopts
Bamboo sprout (Bamboo Shoot) meridian distribution of property and flavor: sweet in the mouth, cold nature, return stomach, lung meridian.Effect with cure mainly: phencyclidine, heat clearing away QI invigorating, removing toxic substances rash.The morbidity of condyloma acuminatum, development and recurrence and cellular immune function lowly have much relations.The crowd of immunologic hypofunction, as malignant tumor, lupus erythematosus, renal transplantation, chemotherapy person, application glucocorticoid person, the probability of Condyloma Acuminata and recurrence is multiplied.In bamboo sprout, the content of vegetable protein, electrolytes and minerals is all very high, contributes to the immunologic function of enhancing body, improves disease resistance ability.
Herba Senecionis Scandentis (Herba Senecionis Scandentis) claim again Herba Hieracii Umbellati, Herba Senecionis Scandentis.Meridian distribution of property and flavor: cold in nature, bitter in the mouth.Effect with cure mainly: heat-clearing and toxic substances removing, improving eyesight, parasite killing, antipruritic.Be usually used in skin eczema, furuncle erysipelas.Herba Senecionis Scandentis all has inhibitory action to staphylococcus aureus, typhoid fever, dysentery, bacillus pyocyaneus etc., with clinical effectiveness judgement, HPV is had and is suppressed and killing action.
Radix Plumbaginis Zeylanicae (Plumbagozeylanica L) claims again false jasmine, house steward, HERBA SENECIONIS SCANDENTIS, bird face horse, white snowflake, thousand Semen Arecaes, shines medicine, day Semen Arecae.Meridian distribution of property and flavor: arduous puckery, temperature, poisonous.Effect with cure mainly: dispel the wind, dissipating blood stasis, removing toxic substances, parasite killing.For Fengshi Guanjie pain, blood stasis amenorrhea, traumatic injury, toxic swelling malignant boil, scabies.With clinical effectiveness judgement, HPV is had to inhibition and killing action and immune induction antivirus action.
Chinese patent medicine advantage of the present invention and good effect:
1, the present invention according to modern medicine the understanding to this Anttdisease Mechanism, for the defect of its Therapeutic Method, collect many doctor chiefs, in conjunction with the strong medicine proved recipe of strong doctor among the people, the outstanding Chinese herbal medicine of screening clinical efficacy, according to Chinese medicine determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs principle, develops the active drug for the treatment of condyloma acuminatum.Major function is heat clearing and damp drying, righting toxic removing.Be applicable to various HPV and infect, and outbreak repeatedly, or send out in oral cavity, the condyloma acuminatum at the position such as urethra, cervix uteri, crissum.
2, Drug therapy approach is scientific and reasonable, can pass through general action, for any symptom, appears or the effectively treatment of sightless focus enforcement of hiding.
3, crude drug source is abundant, and preparation technology is simple, and cost is low, has the stronger market competitiveness, and economic benefit and social benefit are better.
4, adopt this condyloma acuminatum herbal composite to the whole nation 49 routine Condyloma acuminatum clinical trials.Wherein 19 routine patients about 10 days for oral administration, can be observed the variable color of wart body, part stops growing and downright bad, and 12 routine patients are taken orally to about the 20th day, and downright bad wart body comes off, and focus surface recovery is to normal skin; 6 patients are taken orally to about the 30th day, and downright bad wart body comes off, and focus surface recovery is to normal skin.In patient with severe symptoms, 3 examples are taken and can be fully recovered for approximately 50 days.The for oral administration wart body that has no of 4 routine patients changes, and the 5 routine patients rear section wart body that takes a turn for the better fails to come off always.Clinical trial proof obvious effective rate reaches 92%, cure rate 81%, and its treatment is effective fast, safe and reliable, has no adverse reaction, and can effectively suppress wart bulk-growth, and most patients can thoroughly cure.
The specific embodiment
Below in conjunction with embodiment, the present invention is described in further detail, listed embodiment is only the present invention is described and is never limited to the present invention.
One, preparation method
Embodiment 1: the preparation of powder
(1) herbal raw material and parts by weight:
20 kilograms, bamboo sprout, 30 kilograms of Herba Senecionis Scandentiss, 16 kilograms of Radix Plumbaginis Zeylanicaes.
(2) preparation method:
Herbal raw material is screened respectively, the rejecting Chinese herbal medicine that goes mouldy, after the visible foreign material of the branch and leaf that weed a garden, stone and clod, rinse dehydration, crude drug is put into respectively to heated-air circulation oven dries, temperature is controlled at 2 ℃, 80 soil, and baking time is 2 hours, and raw material Chinese herbal medicine moisture reaches 11%, with pulverizer, pulverize respectively, 120 orders that sieve after mix homogeneously, then every bag of subpackage powder weight is 10 grams, and outer package obtains powder product.
Embodiment 2: the preparation of tablet
(1) herbal raw material, adjuvant and parts by weight:
23 kilograms, bamboo sprout, 35 kilograms of Herba Senecionis Scandentiss, 20 kilograms of Radix Plumbaginis Zeylanicaes, 8 kilograms of modified starches, 5 kilograms of calcium hydrogen phosphate, 2 kilograms of Polyethylene Glycol and consumption are the ethanol of 10 times of raw material Chinese herbal medicine gross weight umbers.
(2) preparation method:
Raw material Chinese herbal medicine is screened respectively, the rejecting Chinese herbal medicine that goes mouldy, branch and leaf weed a garden, the visible foreign material after washing of stone and clod, crude drug is put into respectively to heated-air circulation oven dries, temperature is controlled at 2 ℃, 70 soil, baking time is 2.5 hours, raw material Chinese herbal medicine moisture reaches 10%, with adding after crusher in crushing in pot for solvent extraction, then the ethanol that adds 6 times of herbal raw materials, room temperature lixiviate 6h, filter and remove residue obtains extracting solution, the alcohol steep that filtering residue is added to 4 times of herbal raw materials more once, filter and remove residue obtains secondary raffinate, merge extractive liquid, it is 1.25 clear paste that concentrating under reduced pressure becomes relative density, at 65 ℃ of drying under reduced pressure, pulverize, add pharmaceutic adjuvant, 120 orders sieve after mix homogeneously, then conventional method film-making, every weight of tablet is that 0.5g obtains tablet, subpackage and outer package tablet product.Recovery ethanol is reused.
Embodiment 3: the preparation of granule
(1) herbal raw material, adjuvant and parts by weight:
35 kilograms, bamboo sprout, 35 kilograms of Herba Senecionis Scandentiss, 25 kilograms of Radix Plumbaginis Zeylanicaes, 6 kilograms, dextrin, 7 kilograms of calcium hydrogen phosphate, 5 kilograms of silicon dioxide and consumption are the ethanol of 8 times of raw material Chinese herbal medicine gross weight umbers.
(2) preparation method:
Herbal raw material is screened respectively, the rejecting Chinese herbal medicine that goes mouldy is rejected, branch and leaf weed a garden, the visible foreign material after washing of stone and clod, dehydration, crude drug is put into respectively to heated-air circulation oven dries, temperature is controlled at 2 ℃, 75 soil, baking time is 2 hours, raw material Chinese herbal medicine moisture reaches 10%, with adding after crusher in crushing in pot for solvent extraction, then the ethanol that adds 5 times of raw material Chinese herbal medicine, room temperature lixiviate 8h, filter and remove residue obtains extracting solution, the alcohol steep that filtering residue is added to 3 times of herbal raw materials more once, time 12h, filter and remove residue obtains secondary raffinate, merge extractive liquid, it is 1.20 clear paste that concentrating under reduced pressure becomes relative density, at 55 ℃ of drying under reduced pressure, pulverize, add other raw material, 100 orders sieve after mix homogeneously, then conventional method pelletize, every bag of subpackage granule weight is 10 grams, outer package obtains granule product.Recovery ethanol is reused.
Embodiment 4: the preparation of oral liquid
(1) herbal raw material and parts by weight:
25 kilograms, bamboo sprout, 25 kilograms of Herba Senecionis Scandentiss, 15 kilograms of Radix Plumbaginis Zeylanicaes.
(2) preparation method:
Herbal raw material is screened respectively, reject the Chinese herbal medicine that goes mouldy, after the visible foreign material of the branch and leaf that weed a garden, stone and clod, soak l hour, decocting boils secondary, adds up for the first time the water of 7 times of amounts of medicine raw material, decocts l.5 hour, filters to obtain decocting liquid; Add up for the second time the water of 6 times of amounts of medicine raw material, decoct l.5 hour, filter to obtain decocting liquid, twice decocting liquid mix homogeneously, every packed 80ml, in heat-sealing bag, 105 ℃ of high temperature sterilizes, for taking.
Two, clinical effectiveness
Adopt this condyloma acuminatum herbal composite to the whole nation 49 routine patients with condyloma acuminatum clinical trials, patient introduces subjects, make every patient sex, age, telephone number, address, disease, make a definite diagnosis hospital, make a definite diagnosis the time, treat, clinical trial beginning and ending time, video rash be disconnected, the itemized record such as clinical trial result.Male's 18 examples wherein, at 24～46 years old age, disease damage occurs in penis 4 examples, and lower foreskin and crissum are cauliflower form 14 examples; Women's 31 examples, 20～39 years old age.Disease damage occurs in around labium majus, nympha and vaginal orifice, is cauliflower form 25 examples, is pimple shape 6 examples.In these cases, there is the recurrence after laser external treatment, the healing of taking medicine of 23 examples; There are the treatments such as 14 example processes are fulgerized, enlightening Soviet Union pin, Herba Tubocapsici Anomali ointment without positive effect.Adopt this condyloma acuminatum herbal composite treatment, wherein 19 routine patients about 10 days for oral administration, can be observed the variable color of wart body, part stops growing and downright bad, and 12 routine patients are taken orally to about the 20th day, and downright bad wart body comes off, and focus surface recovery is to normal skin; 6 patients are taken orally to about the 30th day, and downright bad wart body comes off, and focus surface recovery is to normal skin.In patient with severe symptoms, 3 examples are taken and can be fully recovered for approximately 50 days.The for oral administration wart body that has no of 4 routine patients changes, and the 5 routine patients rear section wart body that takes a turn for the better fails to come off always.Clinical trial proof obvious effective rate reaches 92%, cure rate 81%, and its treatment is effective fast, safe and reliable, has no adverse reaction, and can effectively suppress wart bulk-growth, and most patients can thoroughly cure.
Model case:
Not * *, man, 27 years old.Within 2007, be diagnosed as condyloma acuminatum in urethra, in Fusui County * hospital, through antiviral therapies such as laser and interferon, polyinosini, wart body is eliminated, and after two weeks, recurs.Examined afterwards this preparation for oral administration, treat the 5th day wart body black dull by red stain, and treated and start to come off for the 10th day, and treated and come off completely for the 20th day, skin smooth, so far there are no recurs.
Lu *, female, 25 years old.Patient with severe symptoms.In October, 2011, Guangzhou * hospital made a definite diagnosis, and disease is nympha inner side, rear associating, vaginal orifice many places vegetation, and cervix uteri has two place's projections.Through fulgerizing, the treatment such as enlightening Soviet Union pin, Herba Tubocapsici Anomali ointment, recurrence, turns that Hubei * hospital is continuous to be controlled all without improvement.Take this preparation in January, 2012, treat the 17th day wart body and start to come off, the 40th day wart body major part of medication treatment comes off, and the 60th day wart body of medication treatment skin smooth that comes off is completely as usual.
Yellow * *, female, 24 years old.Patient with severe symptoms.In December, 2011 is made a definite diagnosis, and through antiviral therapies such as laser therapy and interleukins, only a few days just recurs again, take this preparation in February, 2012, treat the 21st day wart body and start to come off, the 50th day wart body major part of medication treatment comes off, and the 60th day wart body of medication treatment skin smooth that comes off is completely as usual.
King *, man, 28 years old.Within 2006, suffer from condyloma acuminatum, occurring in YIN part of the body stem coronary sulcus, is cauliflower form granulation.Examine in January, 2007, and acetic acid white test is positive.Take the wart body variable color in the 5th day of this preparation for treating and come off, treat after the 10th day and come off completely totally, skin smooth, consolidates and takes medicine 20 days, does not send out so far again.
Beam *, man, 43 years old.Suffer from condyloma acuminatum in July, 2005, October is after certain private outpatient service external medication wart body disappears.Examine the 5th day wart body of this preparation for treating for oral administration November and start variable color, treat and start to come off for the 10th day, treat and within the 20th day, come off totally, consolidate medication and do not send out again after one month.
Side * *, man, 39 years old.Suffer from condyloma acuminatum in April, 2004 and examine, see that coronary sulcus goes out the large wart body of a Semen Glycines.Through this preparation for treating wart body on the 5th for oral administration, come off, treat and come off completely for 15th, after treatment 5 days, does not send out again.
Beam * *, man, 35 years old.Suffer from condyloma acuminatum in June, 2004.Through this preparation for treating wart body on the 5th for oral administration, disappear, not pedicure journey is sent out in JIUYUE after drug withdrawal voluntarily again, then takes the recovery from illness on the 20th of this preparation for treating, does not send out again.
Liu * *, man, 28 years old.In May, 2009, Heilungkiang * hospital made a definite diagnosis, and disease is crissum and anal canal coronary sulcus cauliflower.Once adopt laser external treatment three times, sprayed interferon and treatment by Chinese herbs is all recurred.In December, 2011 is through this preparation for oral administration, treat that wart body on the 5th stops growing, necrosis, take treatment after the 12nd day downright bad wart body come off and entirely heal, without rebound phenomenon.
Week *, man, 24 years old.In May, 2011, deeply instruct * hospital made a definite diagnosis, and disease is penis and anal canal coronary sulcus cauliflower.Once used wart enlightening escharotica, adopted laser external treatment, took Chinese medicine orally and all recur.In December, 2011 is through this preparation for treating for oral administration, and wart body stopped growing on 1, necrosis, take treatment after the 10th day downright bad wart body come off complete, without rebound phenomenon.
Once *, man, 33 years old.In December, 2011 Jiangxi * hospital makes a definite diagnosis, and through looking into disease, is that glans penis and lower foreskin place have 3 white wart bodies, and it is positive that HPV checks, at local hospital laser with have Western medicine, has used within three days, stop, and within ten days, arrives afterwards fire-fighting hospital administration ten days, without positive effect.Take this preparation for treating in January, 2012 after the 6th day, the blackening of wart body.Take treatment after the 10th day downright bad wart body come off complete more, without rebound phenomenon.
Lee *, female, 27 years old.In December, 2011 Henan * hospital makes a definite diagnosis, and disease is that uterine cavity, large nympha inner side and crissum have wart and the cauliflower form pimple differing in size.Through fulgerizing, the treatment such as enlightening Soviet Union pin, Herba Tubocapsici Anomali ointment, recurrence, turns that Hubei * hospital is continuous to be controlled all without improvement.In December, 2011 is taken 4 days wart bodies of this preparation for treating and is started to come off, and 10 days wart bodies of medication treatment come off completely, and focus surface portion is repaired complete completely, without rebound phenomenon.
Patient's real connection mode, refers to examination as to substances reference material.
Claims (7)
1. a treatment condyloma acuminatum herbal composite, is characterized in that: its crude drug is comprised of the Chinese medicine of following weight portion: 20～40 parts, bamboo sprout, 20～40 parts of Herba Senecionis Scandentiss, 10～30 parts of Radix Plumbaginis Zeylanicaes.
2. treatment condyloma acuminatum herbal composite according to claim 1, is characterized in that: its crude drug is comprised of the Chinese medicine of following weight portion: 30 parts, bamboo sprout, 30 parts of Herba Senecionis Scandentiss, 20 parts of Radix Plumbaginis Zeylanicaes.
3. the preparation method for the treatment of condyloma acuminatum herbal composite according to claim 1, is the preparation method of oral liquid, granule, tablet, powder and capsule, it is characterized in that:
(1) powder and capsule preparation method: by 10～30 parts of screenings respectively of 20～40 parts, the parts by weight bamboo sprout of each herbal raw material, 20～40 parts of Herba Senecionis Scandentiss, Radix Plumbaginis Zeylanicae, washing, fragmentation, then adopts pharmacy conventional method to mix lixiviate, filters, lixiviate again, secondary filter, merge extractive liquid,, concentrating under reduced pressure, dry, pulverize, mix, sieve and pack, or by 20～40 parts, the parts by weight bamboo sprout of each herbal raw material, 20～40 parts of Herba Senecionis Scandentiss, 10～30 parts of screenings respectively of Radix Plumbaginis Zeylanicae, clean, dry, fragmentation, pulverize, mix and packing;
(2) granule or tablet preparation method: by 10～30 parts of screenings respectively of 20～40 parts, the parts by weight bamboo sprout of each herbal raw material, 20～40 parts of Herba Senecionis Scandentiss, Radix Plumbaginis Zeylanicae, washing, dehydration, dry, fragmentation, then mixes lixiviate, filter lixiviate again, secondary filter, merge extractive liquid,, concentrating under reduced pressure, dry, pulverize, mix, sieve, adopt pharmacy conventional method pelletize or film-making, subpackage and outer package;
(3) preparation method of oral liquid: by 20～40 parts, the parts by weight bamboo sprout of each herbal raw material, 20～40 parts of Herba Senecionis Scandentiss, 10～30 parts of screenings respectively of Radix Plumbaginis Zeylanicae, washing, dry, coarse crushing, then mixing and water adding soaks l hour, and decocting boils secondary, adds up for the first time the water of 7～8 times of amounts of medicine raw material, decoct l.5～2 hours, filter to obtain decocting liquid; Add up for the second time the water of 6～7 times of amounts of medicine raw material, decoct l～2 hour, filter to obtain decocting liquid, twice decocting liquid mix homogeneously, pack or bottling, in heat-sealing bag, 105 ℃ of high temperature sterilizes, or by the Chinese medicine routine use that is decocted in water for oral dose.
4. the preparation method for the treatment of condyloma acuminatum herbal composite according to claim 3, it is characterized in that: described dry be by herbal raw material or concentrating under reduced pressure clear paste is put into heated-air circulation oven or pressure Reduction Dryer is dry, temperature is controlled at 55～85 ℃, be 2～10h drying time, moisture≤12%.
5. the preparation method for the treatment of condyloma acuminatum herbal composite according to claim 3, it is characterized in that: described lixiviate is that fragmentation or pulverizing herbal raw material are added in pot for solvent extraction, then add 6～8 times of medicinal solvents of herbal raw material, extraction time 2～8h, filter and remove residue obtains solvent extraction liquid, filtering residue is added to 5～6 times of medicinal solvent lixiviates of herbal raw material once again, extraction time 2～5h, filter and remove residue obtains secondary solvent extracting solution.
6. the preparation method for the treatment of condyloma acuminatum herbal composite according to claim 3, it is characterized in that: described concentrating under reduced pressure is that extracted twice liquid is added in concentration pan, it is 1.10～1.25 clear paste that concentrating under reduced pressure becomes relative density, reclaims solvent and reuses.
7. the preparation method for the treatment of condyloma acuminatum herbal composite according to claim 3, is characterized in that: described sieving is to adopt 60～200 mesh sieves.
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| CN102631587A (en) | 2012-08-15 |
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