CN102614369A - Medicinal composition for treating arrhythmia, and preparation method thereof - Google Patents
Medicinal composition for treating arrhythmia, and preparation method thereof Download PDFInfo
- Publication number
- CN102614369A CN102614369A CN201110028714XA CN201110028714A CN102614369A CN 102614369 A CN102614369 A CN 102614369A CN 201110028714X A CN201110028714X A CN 201110028714XA CN 201110028714 A CN201110028714 A CN 201110028714A CN 102614369 A CN102614369 A CN 102614369A
- Authority
- CN
- China
- Prior art keywords
- radix
- preparation
- rhizoma nardostachyos
- add
- plumula nelumbinis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a medicinal composition for treating arrhythmia, and a preparation method thereof. The medicinal composition is prepared from lotus plumule, Panax Notoginseng, Nardostachyos Root and Rhizome, Radix Ophiopogonis, Lopatherum Herb and licorice according to a certain weight ration. The medicinal composition which can be prepared to form any oral preparations has the arrhythmia treating function.
Description
Technical field
The present invention relates to ARR pharmaceutical composition of a kind of treatment and preparation method thereof, belong to technical field of Chinese medicine.
Background technology
Arrhythmia is meant rhythm of the heart origin position, cardiac frequency and the rhythm and pace of moving things and conduction of impulse etc., and each is unusual, clinical manifestation for nervous, uncomfortable in chest, suppress breathe heavily, dizziness, pulse frequency is too fast, mistake is slow or uneven etc.Premature beat (premature beat, premature beat) is one of common arrhythmia, by the origin position of systolia ectopica, can be divided into four kinds of hole property, room property, chamber handing-over property, chamber property, and is wherein maximum with ventricular premature contraction.Say that from the traditional Chinese medical science angle arrhythmia belongs to categories such as " cardiopalmus ", " palpitation with a distress feeling ", " thoracic obstruction ", " pained " of the traditional Chinese medical science, many, internal damage by the excessive seven emotions deficient owing to the internal organs negative and positive of qi and blood, qi depression to blood stasis reciprocal action cause become homeless foster, heart arteries and veins mistake of the heart and freely cause.In the last few years; The Chinese medicine arrhythmia is clinical and experimentation has all obtained significant curative effect, and untoward reaction is few, can be interrupted for a long time and take medicine; Have the curative effect of consolidation, prevent recurrence and whole body adjustment and strong effect, the treatment by Chinese herbs arrhythmia has boundless development prospect.
Summary of the invention
The object of the present invention is to provide a kind of new pharmaceutical composition, said composition has the effect of heat clearing away mind calming, promoting blood circulation to remove obstruction in the collateral, supplementing QI and nourishing YIN, is used to treat arrhythmia.
Another object of the present invention provides the method for preparing of aforementioned pharmaceutical compositions.
The present invention realizes through following technical scheme:
Medicament selection Plumula Nelumbinis of the present invention, Radix Notoginseng, Radix Ophiopogonis, Radix Glycyrrhizae make up, and make each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat arrhythmia.
Select for use Plumula Nelumbinis to be because Plumula Nelumbinis is bitter, cold, have clearing away heart-fire for tranquillization, restoring normal coordination between the heart and kidney, the effect of unsmoothing the sperm and stopping bleeding, pharmacological research shows that Plumula Nelumbinis alkaloid has blood pressure lowering, the arrhythmia isoreactivity.Nelumbine has antiarrhythmic effect preferably; Can significantly resist the Cavia porcellus arrhythmia that rat that aconitine brings out and ouabain bring out; Also can prevent due to the epinephrine generation of quivering of Cavia porcellus chamber; Rat ventricular due to can also irritating again resisting myocardial ischemia, (-)-Neferine can suppress the self-disciplining of sinuatrial node slow reacting cell and delay the chamber conduction; The Radix Notoginseng temperature, sweet, little hardship has dissipating blood stasis hemostasis, the effect of subduing swelling and relieving pain, relevant pharmacologically active shows, Radix Notoginseng can reduce myocardial oxygen consumption, improves myocardial ischemia, arrhythmia.Notoginseng preparations ability coronary artery dilating, coronary blood flow increasing, Radix Notoginseng total arasaponins (PNS) can increase the myocardial nutritional flow amount, improves myocardium microcirculation, obviously reduces myocardial oxygen consumption; PNS also is proved to be the basis of Radix Notoginseng treatment ischemic heart desease.PNS all has obvious antagonism to several kinds of experimental arrhythmia models (arrhythmia that mice ventricular fibrillation, barium chloride and the aconitine that chloroform brings out brings out), and its mechanism of action possibly produce through the effect of antagonism calcium; Radix Ophiopogonis is sweet; Little hardship is slightly cold, and has YIN nourishing and the production of body fluid promoting; The effect that lung moistening clears away heart-fire; Relevant pharmacological action shows that Radix Ophiopogonis extract has tangible function of resisting myocardial ischemia and is certain dose-effect relationship, and injection discovered that rats by intraperitoneal injection Radix Liriopes injection has sexually revised tangible preventive effect to Acute Myocardial Ischemia in Rats; Radix Ophiopogonis total polysaccharides and ophiopogon root total saponin (60g crude drug/kg; Ig) all can increase mouse cardiac muscle nutritional blood flow amount to some extent, and demonstrate certain dose-effect relationship, Radix Ophiopogonis total saponins is the effective ingredient of antiarrhythmic effect; Intravenous injection 10mg/kg Radix Ophiopogonis total saponins can prevent or resist the arrhythmia of being brought out by chloroform-epinephrine (rabbit), BaCh (rat) and aconitine (rat), and makes the ventricular arrhythmia incidence rate behind the ligation coronary artery 24h reduce to (57 ± 7) % by (87 ± 8) %; Radix Glycyrrhizae is sweet, and temperature has and strengthens the spleen and stomach; The effect of Yiqi and vein recovery, modern pharmacological research show that Radix Glycyrrhizae total flavones can resist rat and the mice arrhythmia that aconitine, BaCl2, coronary ligation and CaCl2-Ach mixed liquor bring out; The arrhythmia that ability antagonism aconitine, chloroform, ouabain bring out, liquorice beverage dissolubility total flavones can reduce the generation of free radical indirectly, suppresses the damage that free radical causes; Fall MDA content, the contractility of protection cardiac muscle has tangible activity against myocardial ischemia.Full side's heat clearing away mind calming, promoting blood circulation to remove obstruction in the collateral, supplementing QI and nourishing YIN can be taken for a long time, for treating ARR effective prescription.
In order to reach better therapeutic, medicine of the present invention also makes up with Radix Et Rhizoma Nardostachyos, the bamboo heart.
Select for use Radix Et Rhizoma Nardostachyos to be because Radix Et Rhizoma Nardostachyos is hot, sweet, temperature; Have regulating QI to relieve pain, the effect of relieving stagnation and activating the spleen, pharmacological research shows; The Radix Et Rhizoma Nardostachyos ligroin extraction has significant curative effect to the mice arrhythmia that chloroform, barium chloride bring out; Ethyl acetate extract has certain curative effect, and its effective ingredient mainly is present in petroleum ether and the ethyl acetate extract, and valerone has antiarrhythmic effect; The Radix Et Rhizoma Nardostachyos alcohol extract has the antagonism barium chloride to bring out the rat arrhythmia and chloroform-adrenal gland brings out the ARR effect of rabbit, and the refractory stage that can prolong the rabbit isolated atria.Behind the rabbit vein injection Radix Et Rhizoma Nardostachyos water extract-alcohol precipitation liquid, ventricular premature beat significantly reduces; The bamboo heart has the relieving restlessness of clearing away heart-fire; The effect of relieving heat and thirst, its pharmacological effect report is less, but the bamboo heart and Folium Bambusae ingredient are similar; Bibliographical information Folium Bambusae effective ingredient Folium Bambusae total flavones has the significant protection effect to the myocardial cell of anoxia-induced apoptosis; The dog experimental myocardial infarction is had protective effect, and Folium Bambosae extract can significantly reduce the oxygen consumption of cardiac muscle, increases the coronary flow of heart; Increase the blood supply oxygen supply of cardiac muscle, significantly suppress the inductive platelet aggregation of AA and bring into play function of resisting myocardial ischemia preferably.
The consumption of drug component of the present invention also draws through groping in a large number to sum up, and the consumption of each component is for all to have better curative effect in the following weight parts scope:
Plumula Nelumbinis 2-6 part, Radix Notoginseng 3-9 part, Radix Ophiopogonis 3-12 part, Radix Glycyrrhizae 1.5-9 part.
Be preferably: Plumula Nelumbinis 4-6 part, Radix Notoginseng 4-7 part, Radix Ophiopogonis 3-7 part, Radix Glycyrrhizae 2-6 part.
Can also add Radix Et Rhizoma Nardostachyos 3-6 part, bamboo heart 3-12 part in the medicine of the present invention.
Each amounts of components of medicine of the present invention is preferably: Plumula Nelumbinis 4-6 part, Radix Notoginseng 4-7 part, Radix Et Rhizoma Nardostachyos 4-6 part, Radix Ophiopogonis 3-7 part, bamboo heart 3-7 part, Radix Glycyrrhizae 2-6 part.
The preferred Radix Glycyrrhizae Preparata of Radix Glycyrrhizae.
Can be among the present invention with crude drug pulverize mix homogeneously; Perhaps said bulk drugs is added water or Different concentrations of alcohol extraction respectively; The extracting solution concentrate drying gets crude extract; Or employing process for purification; For example, decoction and alcohol sedimentation technique, organic solvent extractionprocess, column chromatography, carbon dioxide supercritical extraction method, steam distillation are made with extra care and are obtained extract;
When stating medicine in the use, both can adopt with the medicine that is equivalent to said weight proportion is that raw material cleans respectively, dry, pulverize, mix the granule or the powder that obtain meeting preparation requirement granularity and directly take.Also can adopt with the medicine that is equivalent to said weight proportion relation is that raw material adds pharmaceutic adjuvant through suitably handling the back, is made into various preparations as required.Be prepared into by the above-mentioned raw materials medicine in the process of preparation, the above-mentioned raw materials medicine can adopt following method to handle: add water or Different concentrations of alcohol respectively and extract, the extracting solution concentrate drying gets crude extract; Or adopt further that alcohol deposition method, water returns molten method, organic solvent extractionprocess, flocculent precipitation, column chromatography one or more unite use carry out after suitably refining extract; Adoptable concrete operations and/or method for using when above-mentioned effective medicinal ingredient is extracted; Both can be that ingredient with described each proportional quantities is a raw material; Extract decomposite mode behind its effective medicinal ingredient respectively, also can adopt each medicine material by said proportional quantities to mix after the mode of co-extracted again.Adopt different extraction means, equipment and actual conditionses such as required desirable or best extraction temperature, solvent load, extraction time, extraction time when extracting, then can be according to practical situation through test by screening with find.
Better bring into play drug effect for each raw material that makes this medicine, preferably adopt decoction and alcohol sedimentation technique to extract.But can not be used to limit protection scope of the present invention.
The method for preparing of preferred medicine activity component of the present invention is:
A) take by weighing each crude drug Plumula Nelumbinis, Radix Notoginseng, Radix Ophiopogonis, Radix Glycyrrhizae;
B) above four Chinese medicine material adds 8-12 times of water gaging, decocts each 1-2 hour 2-4 time; Filter, relative density was the clear paste of 1.16-1.20 when filtrating was concentrated into 60 ℃, put coldly, added ethanol to determining alcohol 60%-80%; Placement is spent the night, and draws supernatant, and relative density is the thick paste of 1.30-1.35 when being concentrated into 60 ℃; Drying, powder becomes fine powder, prepares the active component of medicine of the present invention.
If also make up with Radix Et Rhizoma Nardostachyos, the bamboo heart, its preparation method is:
A) take by weighing each crude drug Plumula Nelumbinis, Radix Notoginseng, Radix Et Rhizoma Nardostachyos, Radix Ophiopogonis, the bamboo heart, Radix Glycyrrhizae;
B) above Six-element medical material adds 8-12 times of water gaging, decocts each 1-2 hour 2-4 time; Filter, relative density was the clear paste of 1.16-1.20 when filtrating was concentrated into 60 ℃, put coldly, added ethanol to determining alcohol 60%-80%; Placement is spent the night, and draws supernatant, and relative density is the thick paste of 1.30-1.35 when being concentrated into 60 ℃; Drying, powder becomes fine powder, prepares the active component of medicine of the present invention.
Wherein, preparation of drug combination method of the present invention can also be: Radix Et Rhizoma Nardostachyos extracting in water volatile oil, and volatile oil carries out cyclodextrin inclusion compound, and clathrate is dry, pulverizes subsequent use; Extracting solution and medicinal residues are subsequent use; Plumula Nelumbinis, Radix Notoginseng, Radix Ophiopogonis, the bamboo heart, Radix Glycyrrhizae and Radix Et Rhizoma Nardostachyos medicinal residues add water or Different concentrations of alcohol is extracted, and merge said extracted liquid, filter, and filtrating is concentrated into thick paste, and drying is pulverized; Add Radix Et Rhizoma Nardostachyos cyclodextrin clathrate and extract powder, mixing prepares the active component of medicine of the present invention.
The active component of medicine of the present invention can directly be used as medicine and take or add that acceptable auxiliary is prepared into required preparation by common process on the pharmaceutics.As can process the oral drugs of solid preparation forms such as tablet commonly used (dispersible tablet, effervescent tablet, oral cavity disintegration tablet, buccal tablet, chewable tablet, effervescent tablet), capsule (hard capsule, soft capsule), granule, pill (drop pill), powder, also can process the oral drugs of liquid preparation forms such as syrup, oral liquid; Can also process the external used medicine of external preparation forms such as unguentum, gel, ointment, cataplasma, emplastrum, liniment, lotion, liniment.Therefore, except that effective ingredient, can also contain pharmaceutically acceptable adjuvant in this pharmaceutical composition.
Adjuvant described here can be different according to different preparations, like diluent commonly used in solid preparations such as tablet, capsule, granule, disintegrating agent, excipient, binding agent, lubricant, surfactant, filler etc.; The surfactant of in liquid preparation forms such as syrup, oral liquid, using always, diluent, antiseptic, stabilizing agent, correctives, thickening agent, fluidizer etc.; The medicinal oleaginous base of in external preparation forms such as gel, ointment, using always, aqueous matrix, antiseptic, antioxidant, wetting agent, Percutaneous absorption enhancer, surfactant etc.
Its adjuvant commonly used such as starch; Lactose; Dextrin; Icing Sugar; Microcrystalline Cellulose; Mannitol; Xylitol; Polyethylene Glycol; Calcium sulfate; Calcium hydrogen phosphate; Calcium carbonate; Modified starch; Sorbitol; Polyvidon; Heavy Magnesium Carbonate; Sodium carboxymethyl cellulose; Hydroxypropyl methylcellulose; Methylcellulose; Ethyl cellulose; Carboxymethylstach sodium; Hydroxypropyl cellulose; 30 POVIDONE K 30 BP/USP 30; Kaolin; Pregelatinized Starch; Magnesium stearate; Pulvis Talci; Micropowder silica gel; Stevioside; Betanin; Aspartame; Glycyrrhizin; Saccharin sodium; Citric acid; Sodium bicarbonate; Sodium carbonate; Carrageenan; Agar; Gelatin; Sodium alginate; Xanthan gum; Guar gum; Tragcanth; Arabic gum; Locust bean gum; POLY-karaya; Stearic acid; Glyceryl monostearate; Polyacrylamide; Cross linked sodium polyacrylate; Polyvinyl alcohol; Carbomer; Sorbic acid; Potassium sorbate; Ethyl hydroxybenzoate; Benzyl alcohol; Nipalgin; Thimerosal; Dimethyl sulfoxide; Azone; Triethanolamine; Sodium hydroxide; Glycerol; Propylene glycol; BHT; BHA; Sodium lauryl sulphate; Tweens; Spans etc.
For preparation above-mentioned, preferred tablet:
Tablet adopts following method preparation:
Get Plumula Nelumbinis, Radix Notoginseng, Radix Et Rhizoma Nardostachyos, Radix Ophiopogonis, the bamboo heart, 8-12 times of water gaging of Radix Glycyrrhizae adding, decoct 2-4 time, each 1-2 hour, filter; Filtrating when being concentrated into 60 ℃ relative density be the clear paste of 1.16-1.20, put coldly, add ethanol to determining alcohol 60%-80%, placement is spent the night; Draw supernatant, relative density is the thick paste of 1.30-1.35 when being concentrated into 60 ℃, drying, and powder becomes fine powder; It is an amount of to add low-substituted hydroxypropyl cellulose, micropowder silica gel, microcrystalline Cellulose, and mixing is with the 70%-95% alcohol granulation; Add an amount of magnesium stearate mixing, tabletting, the bag film-coat promptly gets.
Above-mentioned method for preparing is only enumerated the present invention's method of obtaining through refining, but should this be interpreted as that method for preparing of the present invention only is limited to above-mentioned cited method.
The present invention is foundation with the theory of Chinese medical science, adopts the above-mentioned active drug prescription that cooperatively interacts, and reaches the effect of heat clearing away mind calming, promoting blood circulation to remove obstruction in the collateral, supplementing QI and nourishing YIN, can take for a long time, for treating ARR effective prescription.
According to foregoing,,, obviously can also make modification, replacement and the change of other various ways according to the ordinary skill knowledge and the customary means of this area not breaking away under the basic fundamental thought prerequisite of the present invention.
The specific embodiment
Below come further to set forth the beneficial effect of Chinese medicine composition according to the invention through Test Example:
1, test material
1.1 medicine
Anthology invention medicine is a drug group, and wherein drug group 1 is processed according to embodiment 1, and drug group 2 is processed according to embodiment 5; Matched group is selected propafenone for use; Concentration all is mixed with 30 times that are equivalent to clinical consumption.
1.2 animal
Wistar rat 250-300g, the male and female dual-purpose.
2, method and result
2.1 Chinese medicine composition of the present invention brings out the influence of rat ventricular to aconitine
Rat divides into groups immediately; Continuous irrigation stomach 7 days; After the last administration 30 minutes, from a side jugular vein intubate, press the aconitine of the speed of 1ug/min behind the 25% urethane 1g/kg intraperitoneal injection of anesthesia from vein input 0.001%; Write down the dosage of each animal generation chamber premature beat (VP), the used aconitine of ventricular tachycardia (VT) respectively, the result sees table 1.
Table 1 Chinese medicine composition of the present invention brings out the influence of rat ventricular to aconitine
Compare * P＜0.05, * * P＜0.01 with the blank group
The result shows, drug group of the present invention 1, drug group 2 all can obviously improve the consumption of rat VP due to the aconitine, VT, and drug group 2 effects are superior to drug group 1.
2.2 Chinese medicine composition of the present invention is to the ARR influence of rat central
The rat random packet, continuous irrigation stomach 7 days, after the last administration 30 minutes; Cut scalp behind 10% the chloral hydrate 300mg/kg intraperitoneal injection of anesthesia; Confirm the body surface symbol of tricorn,, in the bilateral tricorn, respectively inject 0.01% aconitine 20ug with the most advanced and sophisticated boring of eye scissors; Write down the ARR persistent period of each treated animal, the result sees table 2.
Table 2 Chinese medicine composition of the present invention is to the influence of rat ventricular
Compare * P＜0.05, * * P＜0.01 with the blank group
The result shows, drug group of the present invention 1, drug group 2 all can obviously shorten the persistent period of rat ventricular, and the effect of drug group 2 is superior to drug group 1.
2.3 Chinese medicine composition of the present invention brings out the influence of rat ventricular to barium chloride
The rat random packet, continuous irrigation stomach 7 days, after the last administration 30 minutes, chloral hydrate intraperitoneal injection of anesthesia with 6%; It is fixing to lie on the back, and record II lead electrocardiogram is by the barium chloride (8.5ul/s) of femoral vein constant speed injection 0.5%, along with the increase of barium chloride dosage; Heart rate can occur and accelerate, the ST section improves, ventricular premature contraction, short battle array property ventricular tachycardia; Two-way ventricular tachycardia, the ARR barium chloride dosage of animal appears in record, and the result sees table 3.
Table 3 Chinese medicine composition of the present invention brings out the influence of rat ventricular to barium chloride
Compare * P＜0.05, * * P＜0.01 with the blank group
The result shows, drug group of the present invention 1, drug group 2 all can make barium chloride bring out the dosage that ventricular premature contraction and two-way ventricular tachycardia appear in rat obviously to be increased, and the effect of drug group 2 is superior to drug group 1.
3, conclusion
To sum up; Chinese medicine composition of the present invention has antagonism to the zoopery arrhythmia, and the tachycardia of particularly laboratory animal being brought out has tangible intervention effect, and the therapeutic effect of drug group 2 is superior to drug group 1; Compare with the blank group, difference has statistical significance.This shows that Chinese medicine composition of the present invention is excellent to the arrhythmia curative effect.
Below, foregoing of the present invention is done further to specify through the specific embodiment of embodiment form.But should this be interpreted as that the scope of the above-mentioned theme of the present invention only limits to following embodiment.All technology that realizes based on foregoing of the present invention all belong to scope of the present invention.
Embodiment 1
Plumula Nelumbinis 60g Radix Notoginseng 50g 30g Radix Ophiopogonis Radix Glycyrrhizae 30g
Get Plumula Nelumbinis, Radix Notoginseng, Radix Ophiopogonis, 10 times of water gagings of Radix Glycyrrhizae adding, decoct 3 times, each 1.5 hours, filter; Filtrating when being concentrated into 60 ℃ relative density be the clear paste of 1.16-1.20, put coldly, add ethanol to determining alcohol 70%, placement is spent the night; Draw supernatant, relative density is the thick paste of 1.30-1.35 when being concentrated into 60 ℃, drying, and powder becomes fine powder; It is an amount of to add low-substituted hydroxypropyl cellulose, micropowder silica gel, microcrystalline Cellulose, and mixing with 85% alcohol granulation, adds an amount of magnesium stearate; Mixing, tabletting, the bag film-coat promptly gets.
Embodiment 2
Plumula Nelumbinis 40g Radix Notoginseng 60g 75g Radix Ophiopogonis Radix Glycyrrhizae 53g
Get Plumula Nelumbinis, Radix Notoginseng, Radix Ophiopogonis, 8 times of water gagings of Radix Glycyrrhizae adding, decoct 4 times, each 1 hour, filter, relative density was the clear paste of 1.16-1.20 when filtrating was concentrated into 60 ℃; Put coldly, add ethanol to determining alcohol 80%, placement is spent the night, and draws supernatant, and relative density is the thick paste of 1.30-1.35 when being concentrated into 60 ℃; Drying, powder becomes fine powder, adds an amount of dextrin, sucrose, and mixing is with alcohol granulation; Drying, granulate is processed granule, promptly gets.
Embodiment 3
Plumula Nelumbinis 20g Radix Notoginseng 30g 120g Radix Ophiopogonis Radix Glycyrrhizae 90g
Get Plumula Nelumbinis, Radix Notoginseng, Radix Ophiopogonis, 12 times of water gagings of Radix Glycyrrhizae adding, decoct 2 times, each 2 hours, filter; Filtrating when being concentrated into 60 ℃ relative density be the clear paste of 1.16-1.20, put coldly, add ethanol to determining alcohol 60%, placement is spent the night; Draw supernatant, relative density is the thick paste of 1.30-1.35 when being concentrated into 60 ℃, drying, and powder becomes fine powder; Add an amount of dextrin, mixing is processed pill, promptly gets.
Embodiment 4
Plumula Nelumbinis 60g Radix Notoginseng 90g 30g Radix Ophiopogonis Radix Glycyrrhizae 15g
Get Plumula Nelumbinis, Radix Notoginseng, Radix Ophiopogonis, 12 times of water gagings of Radix Glycyrrhizae adding, decoct 2 times, each 2 hours, filter, relative density was the clear paste of 1.16-1.20 when filtrating was concentrated into 60 ℃; Put coldly, add ethanol to determining alcohol 60%, placement is spent the night, and draws supernatant, and relative density is the thick paste of 1.30-1.35 when being concentrated into 60 ℃; Drying, powder becomes fine powder, adds an amount of lactose, mixing; Granulate, drying incapsulates, and promptly gets.
Embodiment 5
Plumula Nelumbinis 60g Radix Notoginseng 50g Radix Et Rhizoma Nardostachyos 50g 30g Radix Ophiopogonis bamboo heart 30g
Radix Glycyrrhizae 30g
Get Plumula Nelumbinis, Radix Notoginseng, Radix Et Rhizoma Nardostachyos, Radix Ophiopogonis, the bamboo heart, 10 times of water gagings of Radix Glycyrrhizae adding, decoct 3 times, each 1.5 hours, filter; Filtrating when being concentrated into 60 ℃ relative density be the clear paste of 1.16-1.20, put coldly, add ethanol to determining alcohol 70%, placement is spent the night; Draw supernatant, relative density is the thick paste of 1.30-1.35 when being concentrated into 60 ℃, drying, and powder becomes fine powder; It is an amount of to add low-substituted hydroxypropyl cellulose, micropowder silica gel, microcrystalline Cellulose, and mixing with 85% alcohol granulation, adds an amount of magnesium stearate; Mixing, tabletting, the bag film-coat promptly gets.
Embodiment 6
Plumula Nelumbinis 40g Radix Notoginseng 60g Radix Et Rhizoma Nardostachyos 45g 75g Radix Ophiopogonis bamboo heart 75g
Radix Glycyrrhizae 53g
Above Six-element, Radix Et Rhizoma Nardostachyos added water extraction volatile oil 8 hours, and water liquid and medicinal residues are subsequent use; Volatile oil is used beta-cyclodextrin inclusion compound, and cold preservation is spent the night, filter, and the filter cake cold drying, it is subsequent use to be ground into fine powder; Add Radix Glycyrrhizae, the bamboo heart, Radix Ophiopogonis 8 times of water gagings, extract 3 times, add the Radix Et Rhizoma Nardostachyos medicinal residues in the time of for the third time, each 1 hour, filter filtrate for later use; Plumula Nelumbinis, Radix Notoginseng add 6 times of amount 70% ethanol, extract 2 times, and each 1.5 hours, merge alcohol extract, reclaim ethanol to there not being the alcohol flavor; Merge with above-mentioned solution, relative density is the clear paste of 1.25-1.30 when being evaporated to 60 ℃, and drying under reduced pressure is ground into fine powder; Add above-mentioned Benexate Hydrochloride and low-substituted hydroxypropyl cellulose, micropowder silica gel, microcrystalline Cellulose is an amount of, mixing, with 85% alcohol granulation, it is an amount of to add magnesium stearate; Mixing, tabletting, the bag film-coat promptly gets.
Embodiment 7
Plumula Nelumbinis 20g Radix Notoginseng 30g Radix Et Rhizoma Nardostachyos 60g 120g Radix Ophiopogonis bamboo heart 30g
Radix Glycyrrhizae 90g
Above Six-element, Radix Et Rhizoma Nardostachyos added water extraction volatile oil 8 hours, and water liquid and medicinal residues are subsequent use; Volatile oil is used beta-cyclodextrin inclusion compound, and cold preservation is spent the night, filter, and the filter cake cold drying, it is subsequent use to be ground into fine powder; All the other five tastes medical materials add 12 times of water gagings, decoct 3 times, add the Radix Et Rhizoma Nardostachyos medicinal residues for the third time; Each 1.5 hours, merging filtrate, relative density is the clear paste of 1.25-1.30 when being evaporated to 60 ℃, drying under reduced pressure; Be ground into fine powder, it is an amount of to add above-mentioned Benexate Hydrochloride and lactose, and mixing is with 95% alcohol granulation; Drying incapsulates, and promptly gets.
Embodiment 8
Plumula Nelumbinis 60g Radix Notoginseng 90g Radix Et Rhizoma Nardostachyos 30g 30g Radix Ophiopogonis bamboo heart 120g
Radix Glycyrrhizae 15g
Get Plumula Nelumbinis, Radix Notoginseng, Radix Et Rhizoma Nardostachyos, Radix Ophiopogonis, the bamboo heart, 10 times of water gagings of Radix Glycyrrhizae adding, decoct 3 times, each 1.5 hours, filter, relative density was the clear paste of 1.16-1.20 when filtrating was concentrated into 60 ℃; Put coldly, add ethanol to determining alcohol 70%, placement is spent the night, and draws supernatant, and relative density is the thick paste of 1.30-1.35 when being concentrated into 60 ℃; Drying, powder becomes fine powder, adds lactose, starch is an amount of, and mixing is granulated; Add an amount of magnesium stearate, mixing, tabletting, the bag film-coat promptly gets.
Embodiment 9
Plumula Nelumbinis 40g Radix Notoginseng 40g Radix Et Rhizoma Nardostachyos 60g 70g Radix Ophiopogonis bamboo heart 70g
Radix Glycyrrhizae 20g
Get Plumula Nelumbinis, Radix Notoginseng, Radix Et Rhizoma Nardostachyos, Radix Ophiopogonis, the bamboo heart, 8 times of water gagings of Radix Glycyrrhizae adding, decoct 4 times, each 1 hour, filter, relative density was the clear paste of 1.16-1.20 when filtrating was concentrated into 60 ℃; Put coldly, add ethanol to determining alcohol 80%, placement is spent the night, and draws supernatant, and relative density is the thick paste of 1.30-1.35 when being concentrated into 60 ℃; Drying, powder becomes fine powder, adds an amount of dextrin, sucrose, and mixing is with alcohol granulation; Drying, granule is processed in arrangement, promptly gets.
Embodiment 10
Plumula Nelumbinis 60g Radix Notoginseng 70g Radix Et Rhizoma Nardostachyos 40g 30g Radix Ophiopogonis bamboo heart 30g
Radix Glycyrrhizae 60g
Get Plumula Nelumbinis, Radix Notoginseng, Radix Et Rhizoma Nardostachyos, Radix Ophiopogonis, the bamboo heart, 12 times of water gagings of Radix Glycyrrhizae adding, decoct 2 times, each 2 hours, filter; Filtrating when being concentrated into 60 ℃ relative density be the clear paste of 1.16-1.20, put coldly, add ethanol to determining alcohol 70%, placement is spent the night; Draw supernatant, relative density is the thick paste of 1.30-1.35 when being concentrated into 60 ℃, drying, and powder becomes fine powder; Add an amount of tartaric acid, sodium bicarbonate, aspartame, xylitol, dehydrated alcohol is granulated, and drying adds magnesium stearate; Mixing, compacting promptly gets effervescent tablet in flakes.
Embodiment 11
Plumula Nelumbinis 50g Radix Notoginseng 55g Radix Et Rhizoma Nardostachyos 50g 50g Radix Ophiopogonis bamboo heart 50g
Radix Glycyrrhizae 40g
Get Plumula Nelumbinis, Radix Notoginseng, Radix Et Rhizoma Nardostachyos, Radix Ophiopogonis, the bamboo heart, 10 times of water gagings of Radix Glycyrrhizae adding, decoct 3 times, each 1.5 hours, filter, relative density was the clear paste of 1.16-1.20 when filtrating was concentrated into 60 ℃; Put coldly, add ethanol to determining alcohol 70%, placement is spent the night, and draws supernatant, and relative density is the thick paste of 1.30-1.35 when being concentrated into 60 ℃; Drying, powder becomes fine powder, adds lactose, starch is an amount of, and mixing is granulated; Add an amount of magnesium stearate, mixing, tabletting, the bag film-coat promptly gets.
Embodiment 12
Plumula Nelumbinis 60g Radix Notoginseng 50g Radix Et Rhizoma Nardostachyos 50g 30g Radix Ophiopogonis bamboo heart 30g
Radix Glycyrrhizae 30g
Get Plumula Nelumbinis, Radix Notoginseng, Radix Et Rhizoma Nardostachyos, Radix Ophiopogonis, the bamboo heart, 10 times of water gagings of Radix Glycyrrhizae adding, decoct 3 times, each 1.5 hours, filter the D101 macroporous adsorbent resin of filtrating; Water elution is used 20% ethanol elution then to colourless, and reuse 75% ethanol elution is collected 75% ethanol elution, concentrating under reduced pressure; Concentrated solution adds n-butanol extraction, and relative density is the thick paste of 1.30-1.35 when being concentrated into 60 ℃, drying, and powder becomes fine powder; It is an amount of to add low-substituted hydroxypropyl cellulose, micropowder silica gel, microcrystalline Cellulose, and mixing with 85% alcohol granulation, adds an amount of magnesium stearate; Mixing, tabletting, the bag film-coat promptly gets.
Embodiment 13
Plumula Nelumbinis 40g Radix Notoginseng 40g Radix Et Rhizoma Nardostachyos 60g 70g Radix Ophiopogonis bamboo heart 70g
Radix Glycyrrhizae 20g
Get Plumula Nelumbinis, Radix Notoginseng, Radix Et Rhizoma Nardostachyos, Radix Ophiopogonis, the bamboo heart, 8 times of water gagings of Radix Glycyrrhizae adding, decoct 4 times, each 1 hour, filter the D101 macroporous adsorbent resin of filtrating; Water elution is used 20% ethanol elution then to colourless, and reuse 80% ethanol elution is collected 80% ethanol elution; Concentrating under reduced pressure, concentrated solution extracts through the carbon dioxide supercritical fluid extraction device, and relative density is the thick paste of 1.30-1.35 when being concentrated into 60 ℃, drying; Powder becomes fine powder, adds an amount of dextrin, sucrose, and mixing is with alcohol granulation; Drying, granule is processed in arrangement, promptly gets.
Claims (11)
1. ARR pharmaceutical composition of treatment is characterized in that it mainly is to be processed by following bulk drugs: Plumula Nelumbinis 2-6 part, Radix Notoginseng 3-9 part, Radix Ophiopogonis 3-12 part, Radix Glycyrrhizae 1.5-9 part.
2. the ARR pharmaceutical composition of a kind of treatment according to claim 1 is characterized in that wherein each raw material medicaments in part by weight is counted: Plumula Nelumbinis 4-6 part, Radix Notoginseng 4-7 part, Radix Ophiopogonis 3-7 part, Radix Glycyrrhizae 2-6 part.
3. pharmaceutical composition according to claim 1 is characterized in that, crude drug also has: Radix Et Rhizoma Nardostachyos 3-6 part, bamboo heart 3-12 part.
4. pharmaceutical composition according to claim 3 is characterized in that, the consumption of crude drug is: Plumula Nelumbinis 4-6 part, Radix Notoginseng 4-7 part, Radix Et Rhizoma Nardostachyos 4-6 part, Radix Ophiopogonis 3-7 part, bamboo heart 3-7 part, Radix Glycyrrhizae 2-6 part.
5. according to each described pharmaceutical composition of claim 1-4, it is characterized in that Radix Glycyrrhizae is a Radix Glycyrrhizae Preparata.
6. according to claim 3 or 4 said preparation of drug combination methods, it is characterized in that it is preparation like this:
A) take by weighing each crude drug Plumula Nelumbinis, Radix Notoginseng, Radix Et Rhizoma Nardostachyos, Radix Ophiopogonis, the bamboo heart, Radix Glycyrrhizae;
B) the direct pulverizing of above-mentioned raw materials medicine obtained medicinal powder; Or adding water or Different concentrations of alcohol extraction respectively, the extracting solution concentrate drying gets crude extract; Or adopt decoction and alcohol sedimentation technique, organic solvent extractionprocess, column chromatography, carbon dioxide supercritical extraction method, steam distillation to make with extra care and obtain extract; Prepare the active component of medicine of the present invention.
7. according to claim 3 or 4 said preparation of drug combination methods, it is characterized in that it is preparation like this:
Radix Et Rhizoma Nardostachyos extracting in water volatile oil, volatile oil carries out cyclodextrin inclusion compound, and clathrate is dry, pulverizes subsequent use; Extracting solution and medicinal residues are subsequent use; Plumula Nelumbinis, Radix Notoginseng, Radix Ophiopogonis, the bamboo heart, Radix Glycyrrhizae and Radix Et Rhizoma Nardostachyos medicinal residues add water or Different concentrations of alcohol is extracted, and merge said extracted liquid, filter, and filtrating is concentrated into thick paste, and drying is pulverized; Add Radix Et Rhizoma Nardostachyos cyclodextrin clathrate and extract powder, mixing prepares the active component of medicine of the present invention.
8. according to claim 6 or 7 described preparation of drug combination methods, it is characterized in that the active component that makes adds or do not add adjuvant processes oral formulations by common process.
9. preparation of drug combination method according to claim 8 is characterized in that described oral formulations is a tablet.
10. preparation of drug combination method according to claim 9 is characterized in that, tablet is preparation like this: get Plumula Nelumbinis, Radix Notoginseng, Radix Et Rhizoma Nardostachyos, Radix Ophiopogonis, the bamboo heart, 8-12 times of water gaging of Radix Glycyrrhizae adding, decoct 2-4 time; Each 1-2 hour, filter, relative density was the clear paste of 1.16-1.20 when filtrating was concentrated into 60 ℃, put cold; Add ethanol to determining alcohol 60%-80%, placement is spent the night, and draws supernatant, and relative density is the thick paste of 1.30-1.35 when being concentrated into 60 ℃; Drying, powder becomes fine powder, and it is an amount of to add low-substituted hydroxypropyl cellulose, micropowder silica gel, microcrystalline Cellulose, mixing; With the 70%-95% alcohol granulation, add an amount of magnesium stearate, mixing; Tabletting, the bag film-coat promptly gets.
11. any described pharmaceutical composition of claim 1-4 is used for the application at preparation treatment cardiac arrhythmia medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110028714.XA CN102614369B (en) | 2011-01-26 | 2011-01-26 | Medicinal composition for treating arrhythmia, and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110028714.XA CN102614369B (en) | 2011-01-26 | 2011-01-26 | Medicinal composition for treating arrhythmia, and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102614369A true CN102614369A (en) | 2012-08-01 |
| CN102614369B CN102614369B (en) | 2014-11-26 |
Family
ID=46554817
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201110028714.XA Active CN102614369B (en) | 2011-01-26 | 2011-01-26 | Medicinal composition for treating arrhythmia, and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102614369B (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103054914A (en) * | 2012-11-23 | 2013-04-24 | 中国人民解放军第三军医大学第二附属医院 | Drug for treating arrhythmia |
| CN104288482A (en) * | 2013-07-16 | 2015-01-21 | 北京因科瑞斯医药科技有限公司 | A traditional Chinese medicine composition for treating cardiovascular disease and a preparing method thereof |
| CN106983797A (en) * | 2016-01-20 | 2017-07-28 | 珠海宝德润生健康科技有限公司 | A kind of composition with blood nourishing function and preparation method thereof |
| CN106983787A (en) * | 2016-01-20 | 2017-07-28 | 珠海宝德润生健康科技有限公司 | It is a kind of to have by composition of stasis of blood function and preparation method thereof |
| CN107019745A (en) * | 2016-01-30 | 2017-08-08 | 珠海宝德润生健康科技有限公司 | A kind of composition with strengthen immunity function and preparation method thereof |
| CN107362236A (en) * | 2016-05-13 | 2017-11-21 | 珠海宝德润生健康科技有限公司 | A kind of composition with auxiliary function for lowering blood pressure and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1408389A (en) * | 2001-09-28 | 2003-04-09 | 杨锡铭 | Traditional Chinese medicine for curing arrhythmia and its preparation |
| CN1814234A (en) * | 2005-11-29 | 2006-08-09 | 袁培荣 | Chinese medicine for treating heart disease |
| CN1970050A (en) * | 2006-12-04 | 2007-05-30 | 南京博善医药技术发展有限公司 | Pharmaceutical composition for treating arrhythmia and preparation process thereof |
| CN101088549A (en) * | 2006-06-14 | 2007-12-19 | 山东步长制药有限公司 | Chinese medicine prepn for treating arrhythmia and its prepn process and quality control method |
| CN101342314A (en) * | 2008-08-27 | 2009-01-14 | 江苏省中医院 | Traditional Chinese medicine for treating cardiovascular disease, preparation method and uses thereof |
-
2011
- 2011-01-26 CN CN201110028714.XA patent/CN102614369B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1408389A (en) * | 2001-09-28 | 2003-04-09 | 杨锡铭 | Traditional Chinese medicine for curing arrhythmia and its preparation |
| CN1814234A (en) * | 2005-11-29 | 2006-08-09 | 袁培荣 | Chinese medicine for treating heart disease |
| CN101088549A (en) * | 2006-06-14 | 2007-12-19 | 山东步长制药有限公司 | Chinese medicine prepn for treating arrhythmia and its prepn process and quality control method |
| CN1970050A (en) * | 2006-12-04 | 2007-05-30 | 南京博善医药技术发展有限公司 | Pharmaceutical composition for treating arrhythmia and preparation process thereof |
| CN101342314A (en) * | 2008-08-27 | 2009-01-14 | 江苏省中医院 | Traditional Chinese medicine for treating cardiovascular disease, preparation method and uses thereof |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103054914A (en) * | 2012-11-23 | 2013-04-24 | 中国人民解放军第三军医大学第二附属医院 | Drug for treating arrhythmia |
| CN104288482A (en) * | 2013-07-16 | 2015-01-21 | 北京因科瑞斯医药科技有限公司 | A traditional Chinese medicine composition for treating cardiovascular disease and a preparing method thereof |
| CN108210715A (en) * | 2013-07-16 | 2018-06-29 | 北京盈科瑞创新医药股份有限公司 | A kind of Chinese medicine composition for treating angiocardiopathy and preparation method thereof |
| CN106983797A (en) * | 2016-01-20 | 2017-07-28 | 珠海宝德润生健康科技有限公司 | A kind of composition with blood nourishing function and preparation method thereof |
| CN106983787A (en) * | 2016-01-20 | 2017-07-28 | 珠海宝德润生健康科技有限公司 | It is a kind of to have by composition of stasis of blood function and preparation method thereof |
| CN107019745A (en) * | 2016-01-30 | 2017-08-08 | 珠海宝德润生健康科技有限公司 | A kind of composition with strengthen immunity function and preparation method thereof |
| CN107362236A (en) * | 2016-05-13 | 2017-11-21 | 珠海宝德润生健康科技有限公司 | A kind of composition with auxiliary function for lowering blood pressure and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102614369B (en) | 2014-11-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102614369B (en) | Medicinal composition for treating arrhythmia, and preparation method thereof | |
| CN103446450B (en) | A kind of composition and method of making the same with alleviating physical fatigue function | |
| WO2019056908A1 (en) | Application method of dendrobium candidum in preparing medicine for treating hypertension | |
| CN101088546A (en) | Heart-benefiting Yixinshu micropill and its prepn process | |
| CN103372054A (en) | Medicament for treating cardiovascular and cerebrovascular diseases and preparation method of medicament | |
| CN101396528B (en) | Traditional Chinese medicine composite preparation for treating wind-heat cold | |
| CN101088542A (en) | Compound Chinese medicine prepn for treating chest obstruction | |
| CN102908513B (en) | Application of traditional Chinese medicine composition in medicine for treating arrhythmia | |
| CN103372053A (en) | Medicinal composition for treating cardiovascular and cerebrovascular diseases and preparation method of medicament | |
| CN111000903A (en) | Traditional Chinese medicine composition for treating blood stasis type coronary heart disease angina and preparation method thereof | |
| CN101099775B (en) | Cardiac and cerebral vascular disease treating medicine | |
| CN101549017B (en) | Traditional Chinese medicine composition for treating arrhythmia and preparation method thereof | |
| CN102579934B (en) | Traditional Chinese medical composition used for treatment of vascular dementia and preparation and application thereof | |
| CN105380993A (en) | Yindanxintai dispersible tablet and preparation method thereof | |
| CN101590102A (en) | A kind of medicine for the treatment of cardiovascular and cerebrovascular disease and preparation method thereof | |
| CN101199606B (en) | Medicament for treating liver disease | |
| CN103385931A (en) | Blood-sugar-lowering medicine composition | |
| CN103800789A (en) | Traditional Chinese medicine composition for invigorating spleen and tonifying kidney and preparing method thereof | |
| JPH02152926A (en) | Brain edema depressant | |
| CN105125616A (en) | Traditional Chinese medicine composition having function of improving anoxia endurance | |
| CN111110756A (en) | Traditional Chinese medicine composition for treating infantile heat asthma and preparation method thereof | |
| CN103800546A (en) | Traditional Chinese medicine composition for invigorating spleen and tonifying qi, and warming yang and tonifying kidney and preparing method thereof | |
| CN108938785B (en) | Traditional Chinese medicine composition for treating cough variant asthma and preparation method thereof | |
| CN1935171A (en) | Medicinal composition and its preparing method | |
| CN104288482A (en) | A traditional Chinese medicine composition for treating cardiovascular disease and a preparing method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: JIANGXI BAISHEN PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: BEIJING INCREASE PHARMACEUTICAL TECHNOLOGY CO., LTD. Effective date: 20150217 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| C53 | Correction of patent of invention or patent application | ||
| CB03 | Change of inventor or designer information |
Inventor after: Shen Chunti Inventor after: Fu Cheng Inventor before: Shen Chunti |
|
| COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: SHEN CHUNTI TO: SHEN CHUNTI FU CHENG Free format text: CORRECT: ADDRESS; FROM: 100088 XICHENG, BEIJING TO: 336000 YICHUN, JIANGXI PROVINCE |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20150217 Address after: 336000 Yuanzhou Jiangxi Pharmaceutical Industrial Park Patentee after: Jiangxi Baishen Pharmaceutical Co.,Ltd. Address before: 100088 Beijing city Xicheng District, New Street No. 2 Tiancheng Technology Building Room 4002-1 B Patentee before: Beijing Increase Pharmaceutical Technology Co., Ltd. |