CN102600526B - Intelligent micropump for switching between insulin infusion and glucagon infusion - Google Patents
Intelligent micropump for switching between insulin infusion and glucagon infusion Download PDFInfo
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- CN102600526B CN102600526B CN 201210061773 CN201210061773A CN102600526B CN 102600526 B CN102600526 B CN 102600526B CN 201210061773 CN201210061773 CN 201210061773 CN 201210061773 A CN201210061773 A CN 201210061773A CN 102600526 B CN102600526 B CN 102600526B
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Abstract
The invention discloses an intelligent micropump for switching between insulin infusion and glucagon infusion, belonging to the technical field of electrical equipment. The intelligent micropump can effectively stabilize the blood sugar of a patient in a safe range, and can be widely applied to type 1, type 2, special type and gestational diabetic patients. In the application, an intelligent method for simultaneously infusing insulin and glucagon based on a switching control theory is designed. The intelligent micropump for switching between the insulin infusion and the glucagon infusion is composed of a public motor, a needle and two independent sets of medicine storage and infusion systems; in a normal mode, the insulin is infused to the patient, and in a special mode, the glucagon is infused to the patient by switching the infusion system. The original function of capability of infusing one treatment medicine only is expanded that two different treatment medicaments can be respectively infused. Therefore, compared with the prior art, the multi-functional micropump has the characteristics of high integration, high safety and the like, and can distinctly improve the control effect of blood sugar.
Description
Technical field
This new micro pump relates to be a kind of can be at regular time and quantity in the human body the portable injection device of insulin injection and glucagon, can help diabetics in whole day, to keep the blood glucose of safety and stability, belong to medical instruments field, specifically refer to the automaton of a kind of reusable infusion of insulin and glucagon.
Background technology
Along with the raising of living standard and the deterioration of environment, diabetes become the important diseases of serious harm human health day by day.The diabetics number that China has made a definite diagnosis becomes the in the world maximum country of diabetics up to 9,240 ten thousand people, and sickness rate that is to say that up to 9.7% just having 1 among per 10 adults is diabetics.As everyone knows, diabetes are a kind of fatal diseases.That diabetes become is blind, the main cause of renal failure and lower extremity amputation, also is that cardiovascular complication causes dead principal element.Diabetes are human the fourth-largest causes of the death, and the death toll that diabetes cause accounts for 6.8% of total death toll, have every year nearly 4,000,000 people to die from diabetes and complication thereof.The health care expense in the annual whole world 11.6% is used for the treatment of diabetes and complication thereof.
Blood sugar level surpassed 7.5mmol/L (mM every liter) when the symptom of diabetes was the sky stomach, or was 11mmol/L in 2 hours after the meal.The main cause that develops complications is the hyperglycemia (blood sugar concentration is higher than 10mmol/L) that diabetes cause.For blood sugar lowering concentration, type 1 diabetes patient and the treatment of part type 2 diabetes mellitus needs of patients exogenous insulin.At present, state-of-the-art therapy is to wear insulin pump, one day 24 hours continuous infusions.
Also do not have so far a kind of method that can fundamentally cure diabetes, therefore just become the main method for the treatment of diabetes by the blood glucose in the control human body.In order to simulate the insulin secretion rule of healthy human body, the insulin pump infusion therapy comprises two kinds of patterns: bolus insulin and basis amount insulin.Basis amount insulin is used for compensating the blood glucose that human body self produces.Bolus insulin is mainly used to compensate the impact of diet and proofreaies and correct hyperglycemia.Because diet is difficult to be measured in real time, the infusion bolus insulin needs the participation of user, i.e. the self management of user: user on the feed front and back needs the moment and the size of diet are inputed to insulin pump.The diet size here refers to the content of carbohydrate in the diet.In order accurately to estimate the content of the carbohydrate in the diet, diabetics need to be accepted strict and the food nutrition knowledge education of system.Nonetheless, the estimated bias of diet size also is difficult to avoid, and therefore is easy to produce because insulin is inputted excessive generation postprandial hypoglycemia phenomenon.And have a lot of diabeticss to have hypoglycemia phenomenon at night, and generally night, hypoglycemia all was to occur in one's sleep, was difficult for being discovered.Yet all insulin pumps all can only be inputted insulin at present, patient's blood glucose is lowered, and helpless to the hypoglycemia phenomenon that may occur.
Summary of the invention
This new micro pump this deficiency and defective for existing insulin pump technology have proposed a kind of micropump that can distinguish insulin injection and glucagon, are a kind of intelligent micro pumps of safe, easy, complete function.
A kind of intelligent micro pump that switches infusion of insulin and glucagon, it comprises such as lower member:
A public drive motors is for the power resources that drug storage and infusion system infused drug and piston return are provided;
Separate drug storage and the infusion system of two covers is used for respectively storage and infusion of insulin and glucagon, and it includes respectively the piston of a promotion drug flow;
One is used for realizing the lever and gear wheel structure that duty is changed mutually between above-mentioned two cover systems;
The interface of an input blood sugar monitoring information;
One for the administrative unit that determines to switch between above-mentioned two cover systems; The interface of input blood sugar monitoring information links to each other with administrative unit;
A public syringe needle is used for infused drug;
A twin-channel conduit, be used for connecting two cover drug storage and infusion system and public syringe needles, it is the conduit that contains two parallel channels, and the input port of each passage in the conduit is connected to respectively above-mentioned cover drug storage and an infusion system, and delivery outlet is connected to public syringe needle simultaneously.
Described public drive motors uses micro-driving motor.
Described lever and gear wheel structure comprises the motor gear that is connected with the drive motors output shaft, two drug storage and infusion system gears that are connected respectively to piston in described two cover drug storages and the infusion system, two ends are furnished with the lever and gear wheel appliance stand of two lever and gear wheels; The lever and gear wheel appliance stand can be around its mid point rotation, and when being in reset mode, above-mentioned gear does not all mesh; When in running order, the rotation of lever and gear wheel appliance stand, the lever and gear wheel of lever and gear wheel appliance stand one end respectively with motor gear and liquid storage and the engagement of infusion system gear, electric machine rotation is converted into the rotation of drug storage and infusion system gear, and the lever and gear wheel of the lever and gear wheel appliance stand other end is away from motor gear and another liquid storage and infusion system gear; Be provided with screw thread and drug storage and infusion system engaged gears on the piston of drug storage and infusion system, drug storage and infusion system gear are converted into moving up and down of piston; Rotation by the lever and gear wheel appliance stand realizes the conversion of gear position, so that motor gear drives alone respectively the piston movement of two cover drug storages and infusion system, realizes the switching of two cover system duties.
Described lever and gear wheel appliance stand mid point is fixed, two ends side arrangement magnetic material, location arrangements at corresponding this both sides magnetic material has two with the solenoid of iron core, the solenoid energising produces magnetic field, described magnetic material is produced the effect that attracts or repel, promote the rotation of lever and gear wheel appliance stand.
Be provided with for the draw-in groove that blocks the lever and gear wheel appliance stand that ensures that engagement is stable at each end lever and gear wheel of described lever and gear wheel appliance stand and other gear engagement position.
One side of described drug storage and infusion system gear is provided with light source, opposite side is provided with optical sensor, be provided with through hole on drug storage and the infusion system gear, the light source of through hole both sides and optical sensor equal through hole to the distance of gear rotating shaft just apart from the distance of gear rotating shaft, light source, optical sensor, through hole be jointly for detection of the rotary speed of drug storage and infusion system gear, and then obtain fltting speed and the fluid injection speed of piston.
Blood glucose value is perhaps manually inputted in the interface of described input blood sugar monitoring information and the communication of blood glucose monitoring system CGMS or blood glucose meter.
Administrative unit links to each other with the sensor that detects blood sugar concentration, and the software that contains switching law has been installed in the administrative unit, and switching law software comprises insulin injection module and glucagon injection module; The input of administrative unit is connected to the interface of described optical sensor, described input blood sugar monitoring information, and the control end of administrative unit is connected to described motor, described two solenoids, described light source.
Described public syringe needle is the syringe needle of a two entrance/list outlet, and its two entrances are connected with some passages of described dual pathways conduit respectively.
Place at described each passage of twin-channel conduit and needle hub is separately installed with the micro one-way valve door, the one-way flow of control medicinal liquid.
Clinically, glycemic control is vital task for the treatment of diabetes, and insulin intensive treatment also is widely regarded as the very effective method that blood glucose is controlled, yet insulin intensive treatment has potential risks, insulin can only blood sugar lowering and the blood glucose that can not raise, and does not have effective method patient's blood glucose is risen to rapidly safe scope in case hypoglycemia has appearred in the patient.Switch infusion of insulin and glucagon and can overcome this shortcoming, the co-therapy to the patient implements insulin and glucagon can guarantee the patient is carried out the safety of glycemic control greatly.Because this micropump can be respectively to patient infusion insulin and glucagon, this closed-loop control system is compared with conventional system, can add the handover control system part, namely by automatically switch selecting insulin and glucagon that the patient is carried out glycemic control, and the method in theory also is proved to be than the single insulinize of routine better effect is all arranged in stability or safety.
The present invention can obtain following beneficial effect: this micropump is by switching infusion of insulin and glucagon, the generation that can stop the hypoglycemia event fully, the safety that has greatly improved intensive treatment; This covering device adopts the structure of dual pathways conduit and common syringe needle, under the prerequisite that reduces patient's discomfort, has minimized the in advance mixing situation of two kinds of medicines, has guaranteed curative effect and the onset time of two kinds of medicines; By optimizing switching law, this covering device can keep the steady of blood sugar level to greatest extent, thereby so that diabetics can be avoided the puzzlement of complication all the life; Reasonably switching law can also reduce drug dose to greatest extent, reduces patient's drug cost.
Description of drawings
Fig. 1 is the micropump structural representation.
Fig. 2 is micropump central processing unit and each parts annexation block chart.
Fig. 3 is each power transmitting gear top view of micropump.
Fig. 4 is micropump lever and gear wheel device front view.
Fig. 5 is that micropump lever and gear wheel appliance stand partly contains draw-in groove and solenoid top view.
Fig. 6 is micropump draw-in groove phantom.
Fig. 7 is that micropump lever and gear wheel appliance stand partly contains draw-in groove and solenoid top view and is in top view under certain duty.
Fig. 8 is the enlarged drawing of output duct and injection needle in the micropump.
Fig. 9 is the functional structure chart of micropump decision-making link.
Among the figure: 1 motor, 2 motor gears, 3A lever and gear wheel, the 4B lever and gear wheel, 5 lever and gear wheel appliance stands, 6A drug storage and infusion system gear, 7B drug storage and infusion system gear, 8A drug storage and infusion system medicine storage, 9B drug storage and infusion system medicine storage, 10A drug storage and infusion system output duct, 11B drug storage and infusion system output duct, 12A draw-in groove, 13B draw-in groove, the 14A solenoid, 15B solenoid, 16 optical sensors, 17 light sources, 18 blood sugar monitoring signal ports, 19 micropump central processing units, 20 injection needles, 21 through holes, 22A magnetic material, the 23B magnetic material, 24 draw-in grooves are given prominence to card, 25 springs, 26A drug storage and infusion system output duct check valve, 27B drug storage and infusion system output duct check valve, 28 sensors, 29 micropump administrative units, 30 insulin injection modules, 31 glucagon injection module, 32 infusion units.
The specific embodiment
With reference to accompanying drawing this intelligent micro pump is described in detail.
Fig. 1 is the inside brief configuration figure of micropump, mainly comprise motor 1, motor gear 2, A lever and gear wheel 3, B lever and gear wheel 4, lever and gear wheel appliance stand 5, A drug storage and infusion system gear 6, B drug storage and infusion system gear 7, A drug storage and infusion system medicine storage 8, B drug storage and infusion system medicine storage 9, A drug storage and infusion system output duct 10, B drug storage and infusion system output duct 11, A draw-in groove 12, B draw-in groove 13, A solenoid 14, B solenoid 15, optical sensor 16, light source 17, blood sugar monitoring signal port 18, micropump central processing unit 19, injection needle 20.
Motor 1 is the power source of whole micropump in Fig. 1, the rotation of motor 1 drive motor gear 2, A lever and gear wheel 3 is transfer devices of power with B lever and gear wheel 4, by with the combined effect of lever and gear wheel appliance stand 5, can be with the transmission of power of motor 1 to A drug storage and infusion system gear 6 or B drug storage and infusion system gear 7.Switching on the hardware of lever and gear wheel is by A draw-in groove 12, B draw-in groove 13, A solenoid 14,15 combineds effect of B solenoid realize, by pass into the electric current of different directions in solenoid, can make solenoid produce the magnetic field of opposed polarity, produce the power that attracts or repel with the magnetic material on the lever and gear wheel appliance stand 5, thereby lever and gear wheel appliance stand 5 is swung, cooperates the use of draw-in groove, can be very well micropump is switched to another kind of mode of operation by a kind of mode of operation.Blood sugar monitoring signal port 18 is to be connected for the equipment with some blood glucose Real-Time Monitorings, and the blood glucose value of Real-Time Monitoring is passed to micropump central processing unit 19, forms safer blood glucose closed-loop control system.
Fig. 2 is micropump central processing unit and each parts annexation block chart.As shown in the figure, there is wire to be connected between micropump central processing unit 19 and optical sensor 16, blood sugar monitoring signal port 18, motor 1, A solenoid 14, B solenoid 15, the light source 17, wherein optical sensor 16 is by wire information to be passed to micropump central processing unit 19 with blood sugar monitoring signal port 18, and motor 1, A solenoid 14, B solenoid 15 then are to receive micropump central processing unit 19 by wire to transmit the information and instruction of coming with light source 17.Micropump central processing unit 19 can be realized the switching of micropump different working modes by the instruction that A solenoid 14 and B solenoid 15 are sent, can realize the control of motor gear 2 rotating speeds by the instruction that motor 1 is sent, then realize the control to micropump output drug dose.
Fig. 3 is each power transmitting gear top view of micropump, as shown in the figure, motor 1 passes to A lever and gear wheel 3 with mechanical energy by motor gear 2 under this kind mode of operation, thereby is passed to the normal operation of A drug storage and infusion system gear 6 drive A injecting systems by it again.This moment, the rotation of motor gear 2 was on B drug storage and not impact of infusion system gear 7, so the B injecting systems is in idle state because B lever and gear wheel 4 is in unsettled state.In the time will switching injecting systems, only need on the hardware lever and gear wheel device is rotated to an angle, make B lever and gear wheel 4 be embedded into motor gear 2 and inject in the gear 7 with B, thus the normal operation of drive B injecting systems.Through hole 21 is worked jointly with light source 17 and optical sensor 16 among Fig. 1, light source 17 constantly outwards produces optical signal, and because the existence of A drug storage and infusion system gear 6 is arranged between light source 17 and the optical sensor 16, optical sensor 16 can only just can detect optical signal during by 4 through holes 21 on A drug storage and the infusion system gear 6 at light, whether the cymometer that can receive by calculating optical sensor optical signal is thus calculated A drug storage and infusion system gear 6 slewing rates, thereby can work for detection of A drug storage and infusion system.B drug storage and infusion system are by its light source equally, and optical sensor and through hole detect by same principle.
Fig. 4 is micropump lever and gear wheel device front view, and as shown in the figure, lever and gear wheel appliance stand 5 carries out swing take its midpoint as fulcrum, by with A draw-in groove 12, B draw-in groove 13, A solenoid 14,15 combineds effect of B solenoid realize the switching between two infusion systems.
Fig. 5 is micropump lever and gear wheel appliance stand part top view, mainly comprises A magnetic material 22, B magnetic material 23, and A draw-in groove 12, B draw-in groove 13,, A solenoid 14, B solenoid 15.Lever and gear wheel appliance stand 5 swings up and down take its midpoint as fulcrum, realizes the switching between two infusion systems.
Fig. 6 is micropump draw-in groove phantom, mainly comprises lever and gear wheel appliance stand 5, A draw-in groove 12, and draw-in groove is given prominence to card 24, spring 25.Lever and gear wheel appliance stand 5 is owing to be subject to the impact of the magnetic force of solenoid generation, can in Fig. 5, swing up and down, when lever and gear wheel appliance stand 5 is done the time spent downwards in draw-in groove 12 outer beginnings, can produce the power of both sides to the outstanding card 24 of draw-in groove, when the magnetic force between lever and gear wheel appliance stand 5 and the solenoid during greater than the counteracting force of spring 25, lever and gear wheel appliance stand 5 can be pushed the outstanding card 24 of draw-in groove to both sides, thereby arrives smoothly draw-in groove inside.Will be from draw-in groove out the time when lever and gear wheel appliance stand 5, the principle that adopts is the same, and just the action direction of magnetic force is opposite.
Fig. 7 is that micropump lever and gear wheel appliance stand partly is in the top view under a kind of duty, as shown in the figure, there is certain angle between A solenoid 14 and the lever and gear wheel appliance stand 5, can make like this it gapless identical with lever, under this kind mode of operation, because A draw-in groove 12 can be fixed lever and gear wheel appliance stand 5, therefore when rotating, lever and gear wheel can not cause the phenomenon of waving.
Fig. 8 is the enlarged drawing of output duct and injection needle in the micropump, as shown in the figure, the output duct of micropump is comprised of with B drug storage and infusion system output duct 11 separate A drug storage and infusion system output duct 10, can effectively prevent from like this producing the phenomenon of mutual pollution because two groups of healing potions meet at the conduit place in advance.Seam between A drug storage and infusion system output duct 10 and B drug storage and infusion system output duct 11 and the injection needle 20 has been installed A drug storage and infusion system output duct check valve 26 and B drug storage and infusion system output duct check valve 27, make like this this seam form the infusion system of " two entrances/list outlet ", and owing to the existence of two check valves, can effectively prevent the refluence phenomenon of healing potion.
Fig. 9 is the functional structure chart of micropump decision-making link, and as shown in the figure, this micropump forms the glycemic control system of a closed loop by blood sugar monitoring signal port among Fig. 1 18 and Dynamic Blood Glucose Monitoring equipment (CGMS).Micropump administrative unit 29 is the software section of micropump central processing unit 19 among Fig. 1, has comprised insulin injection module 30 and glucagon injection module 31 on its structure, by judging the blood sugar measured switching of carrying out between the different injection module of CGMS.Micropump is selected insulin injection module 30 under normal mode of operation, the injection by insulin makes patient's blood glucose be reduced to rational scope.Micropump switches to glucagon injection module 31 under special circumstances, by making its blood glucose rise to safe scope to the patient infusion glucagon.Infusion unit 32 correspondences A drug storage and infusion system (A drug storage and the infusion system gear 6 among Fig. 1, A drug storage and infusion system medicine storage 8, A drug storage and infusion system output duct 10, A solenoid 14) with B drug storage and infusion system (B drug storage and infusion system gear 7, B drug storage and infusion system medicine storage 9, B drug storage and infusion system output duct 11, B solenoid 15).The corresponding relation of Fig. 9 and Fig. 1 is as follows, CGMS measures the real time blood sugar value of human body by sensor 28, data communication device is crossed blood sugar monitoring signal port 18 pass to micropump administrative unit 29 (software section of micropump central processing unit 19), micropump administrative unit 29 is by calculating required healing potion kind and dosage of next stage, and the infusion instruction is passed to infusion unit 32.Wherein the infusion instruction has comprised the instruction of infusion kind and infusion velocity instruction, the instruction of infusion kind passes to A solenoid 14 and B solenoid 15, realize that by apply different electric currents to A solenoid 14 and B solenoid 15 lever and gear wheel appliance stand 5 swings, finishing the micropump mode of operation is the selection of medicament kind; The infusion velocity instruction passes to motor 1, it can realize the control to motor gear 2 rotating speeds, and pass to A drug storage and infusion system gear 6 or B drug storage and infusion system gear 7 by A lever and gear wheel 3 or B lever and gear wheel 4, and then realize the micropump infusion velocity is controlled.
The below is described further the work process of this intelligent micro pump.
(1) micropump is in a kind of mode of operation
As shown in Figure 6, suppose that micropump is under the mode of operation of this infusion system, when it works, because the amount of injection is relatively mild, this moment is owing to the counteracting force that lever and gear wheel transmission mechanical energy produces is less, A draw-in groove 12 can overcome this counteracting force fully, thus can disconnect the electric current in the A solenoid 14, with saves energy.Yet when this infusion system need to reset, namely rotate by motor 1 snap back, by A lever and gear wheel 3 mechanical energy is passed to injecting systems, its injection push rod that drives in A drug storage and the infusion system medicine storage 8 is moved backward.This moment be because the rotating speed of A lever and gear wheel 3 comparatively fast can produce a larger counteracting force, might shake off the binding force that A draw-in groove 12 gives and produces and certain wave phenomenon and affect the transmission effect of A lever and gear wheel 3.In view of the situation, can injecting systems need to reset during this period of time in A solenoid 14, pass into electric current, make A solenoid 14 produce a power that attracts each other with A magnetic material 23, simultaneously also can in B solenoid 15, pass into electric current, make it produce a power of repelling each other with B magnetic material 22, can well overcome the larger counteracting force that produces when resetting by the restraining forces of A draw-in groove 12 and the electromagnetic force of electric current generation like this.Among Fig. 2 among through hole 21 and Fig. 1 the common work of light source 17 and optical sensor 16 whether can well detect resetting of injecting systems working properly.
(2) micropump switches to another kind of mode of operation by a kind of mode of operation
Suppose that micropump is under the mode of operation shown in Figure 6, and next need it is switched under the another kind of mode of operation.The first step stops the rotation of motor 1, and A lever and gear wheel 3 also stops operating at this moment, can make it be in a kind of relatively static state and be convenient to switch.Second step passes into reverse current in A solenoid 14, make A solenoid 14 produce a power of mutually repelling with A magnetic material 23, simultaneously also in B solenoid 15, pass into reverse current, make it produce a power that attracts each other with B magnetic material 22, the electromagnetic force that is produced by electric current like this can overcome the restraining forces of A draw-in groove 12, lever and gear wheel appliance stand 5 is ejected from A draw-in groove 12, then snap in the B draw-in groove 13.The 3rd step starter motor 1 by detecting the rotating speed of B injecting systems gear 7, in case it normally begins normal operation, prove good snapping in the B draw-in groove of lever and gear wheel holder part, disconnects the electric current in A solenoid 14 and the B solenoid 15 this moment, with saving electric power.
(3) generation of mode of operation switching signal
As previously mentioned, this new micro pump has also been reserved the blood sugar monitoring signal port, and the mode of operation switching signal can be determined by the blood sugar monitoring signal.In principle, switching law can be conveniently used in this micropump arbitrarily.The present invention only introduces two kinds of switching laws: the proportional-type switching law:
Wherein, G is blood sugar measured; g
1And g
2Be the blood glucose threshold value, such as, g
1Be chosen as 6.7mmol/L (mM every liter), g
2Be chosen as 3.9mmol/L (mM every liter), these threshold values can be adjusted according to practical situation; " attonity " means does not namely need infusion of insulin not need the infusion glucagon yet, and simultaneously, lever and gear wheel appliance stand 5 is put into the position and remained unchanged.
Ratio+derivative-type switching law:
Wherein, G ' is blood sugar concentration about the rate of change of time, so G+kG ' can regard the blood glucose predictive value of k after constantly as; Prediction duration k can elect as between 0-60 minute;
With
Be switching threshold, the prediction duration is different, and switching threshold also should be different.
Apparent as institute in the above description, this new micro pump provides a kind of portable multi-function injection device that can distinguish infusion of insulin and glucagon.In fact, the present invention can be used for any two kinds of medicines that effect is opposite of infusion.Above-described embodiment, the present invention's specific embodiment more preferably just, but those of ordinary skill in the art will recognize, can make various modification, increase and replace the present invention, and not depart from the scope of the present invention and marrow.So common variation and replacement that those skilled in the art carries out in the technical solution of the present invention scope all should be included in protection scope of the present invention.
Claims (9)
1. intelligent micro pump that switches infusion of insulin and glucagon, it is characterized in that: it comprises such as lower member:
A public drive motors is for the power resources that drug storage and infusion system infused drug and piston return are provided;
Separate drug storage and the infusion system of two covers is used for respectively storage and infusion of insulin and glucagon, and it includes respectively the piston of a promotion drug flow;
One is used for realizing the lever and gear wheel structure that duty is changed mutually between above-mentioned two cover systems;
One for the administrative unit that determines to switch between above-mentioned two cover systems; The interface of input blood sugar monitoring information links to each other with administrative unit;
A public syringe needle is used for infused drug;
A twin-channel conduit, be used for connecting two cover drug storage and infusion system and public syringe needles, it is the conduit that contains two parallel channels, and the input port of each passage in the conduit is connected to respectively above-mentioned cover drug storage and an infusion system, and delivery outlet is connected to public syringe needle simultaneously;
The lever and gear wheel structure comprises the motor gear that is connected with the drive motors output shaft, two drug storage and infusion system gears that are connected respectively to piston in described two cover drug storages and the infusion system, and two ends are furnished with the lever and gear wheel appliance stand of two lever and gear wheels; The lever and gear wheel appliance stand can be around its mid point rotation, and when being in reset mode, motor gear, drug storage and infusion system gear, lever and gear wheel all do not mesh; When in running order, the rotation of lever and gear wheel appliance stand, the lever and gear wheel of lever and gear wheel appliance stand one end respectively with motor gear and liquid storage and the engagement of infusion system gear, electric machine rotation is converted into the rotation of drug storage and infusion system gear, and the lever and gear wheel of the lever and gear wheel appliance stand other end is away from motor gear and another liquid storage and infusion system gear; Be provided with screw thread and drug storage and infusion system engaged gears on the piston of drug storage and infusion system, drug storage and infusion system gear are converted into moving up and down of piston; Rotation by the lever and gear wheel appliance stand realizes the conversion of gear position, so that motor gear drives alone respectively the piston movement of two cover drug storages and infusion system, realizes the switching of two cover system duties.
2. micropump according to claim 1 is characterized in that: public drive motors use micro-driving motor.
3. micropump according to claim 1, it is characterized in that: lever and gear wheel appliance stand mid point is fixed, two ends side arrangement magnetic material, location arrangements at corresponding this both sides magnetic material has two with the solenoid of iron core, the solenoid energising produces magnetic field, described magnetic material is produced the effect that attracts or repel, promote the rotation of lever and gear wheel appliance stand.
4. micropump according to claim 1 is characterized in that: be provided with for the draw-in groove that blocks the lever and gear wheel appliance stand that ensures that engagement is stable at each end lever and gear wheel of lever and gear wheel appliance stand and other gear engagement position.
5. micropump according to claim 3, it is characterized in that: a side of drug storage and infusion system gear is provided with light source, opposite side is provided with optical sensor, be provided with through hole on drug storage and the infusion system gear, the light source of through hole both sides and optical sensor equal through hole to the distance of gear rotating shaft just apart from the distance of gear rotating shaft, light source, optical sensor, through hole be jointly for detection of the rotary speed of drug storage and infusion system gear, and then obtain fltting speed and the fluid injection speed of piston.
6. micropump according to claim 1 is characterized in that: micropump also comprises the interface of an input blood sugar monitoring information; Blood glucose value is perhaps manually inputted in the interface of described input blood sugar monitoring information and the communication of blood glucose monitoring system CGMS or blood glucose meter, and administrative unit links to each other with the interface of input blood sugar monitoring information.
7. micropump according to claim 5 is characterized in that: install in the administrative unit and comprise insulin injection module and glucagon injection module; The input of administrative unit is connected to described optical sensor, and the control end of administrative unit is connected to described motor, described two solenoids, described light source.
8. micropump according to claim 1 is characterized in that: described public syringe needle is a syringe needle that two entrance/list exports, and its two entrances are connected with some passages of described dual pathways conduit respectively.
9. micropump according to claim 1, it is characterized in that: the place at described each passage of twin-channel conduit and needle hub is separately installed with the micro one-way valve door, the one-way flow of control medicinal liquid.
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| CN 201210061773 CN102600526B (en) | 2012-03-09 | 2012-03-09 | Intelligent micropump for switching between insulin infusion and glucagon infusion |
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| CN 201210061773 CN102600526B (en) | 2012-03-09 | 2012-03-09 | Intelligent micropump for switching between insulin infusion and glucagon infusion |
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| CN104027867A (en) * | 2014-06-13 | 2014-09-10 | 杨力 | Portable intelligent dual-function diabetes treatment pump |
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| KR102495891B1 (en) * | 2020-03-04 | 2023-02-06 | 이오플로우(주) | Medical liquid control Injection device |
| CN117482325A (en) * | 2021-07-27 | 2024-02-02 | 武汉联影智融医疗科技有限公司 | Insulin glucagon injection device and medical instrument |
| CN114404728A (en) * | 2021-12-30 | 2022-04-29 | 武汉联影智融医疗科技有限公司 | Medicament infusion equipment |
| WO2023070250A1 (en) * | 2021-10-25 | 2023-05-04 | Medtrum Technologies Inc. | Closed-loop artificial pancreas insulin infusion personalized control system |
| CN115252954B (en) * | 2022-07-13 | 2024-01-23 | 天津英诺伟创科技有限公司 | Double-needle infusion device and insulin pump |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201558381U (en) * | 2009-10-10 | 2010-08-25 | 吴伟华 | Novel digital intelligent remotely controllable insulin pump |
| CN201692438U (en) * | 2010-04-20 | 2011-01-05 | 深圳市利泰尔科技有限公司 | Insulin pump for allocating automatic drug administration transmission assembly |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| GB0130284D0 (en) * | 2001-12-19 | 2002-02-06 | Glaxo Group Ltd | Medicament dispenser |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201558381U (en) * | 2009-10-10 | 2010-08-25 | 吴伟华 | Novel digital intelligent remotely controllable insulin pump |
| CN201692438U (en) * | 2010-04-20 | 2011-01-05 | 深圳市利泰尔科技有限公司 | Insulin pump for allocating automatic drug administration transmission assembly |
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| CN102600526A (en) | 2012-07-25 |
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