CN102600488B - 中枢神经系统的显像 - Google Patents

中枢神经系统的显像 Download PDF

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Publication number
CN102600488B
CN102600488B CN2012100777571A CN201210077757A CN102600488B CN 102600488 B CN102600488 B CN 102600488B CN 2012100777571 A CN2012100777571 A CN 2012100777571A CN 201210077757 A CN201210077757 A CN 201210077757A CN 102600488 B CN102600488 B CN 102600488B
Authority
CN
China
Prior art keywords
vivo imaging
imaging agent
compound
precursor
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2012100777571A
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English (en)
Chinese (zh)
Other versions
CN102600488A (zh
Inventor
P·A·琼斯
I·威尔逊
V·莫里森-艾夫森
C·琼斯
J·伍德克拉夫特
A·杰克逊
D·怀恩
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare Ltd
Original Assignee
GE Healthcare Ltd
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Publication date
Application filed by GE Healthcare Ltd filed Critical GE Healthcare Ltd
Publication of CN102600488A publication Critical patent/CN102600488A/zh
Application granted granted Critical
Publication of CN102600488B publication Critical patent/CN102600488B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN2012100777571A 2008-02-29 2009-02-26 中枢神经系统的显像 Expired - Fee Related CN102600488B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US3244208P 2008-02-29 2008-02-29
GB0803729.3 2008-02-29
US61/032,442 2008-02-29
GBGB0803729.3A GB0803729D0 (en) 2008-02-29 2008-02-29 Imaging the central nervous system

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN2009801067913A Division CN101970017B (zh) 2008-02-29 2009-02-26 中枢神经系统的显像

Publications (2)

Publication Number Publication Date
CN102600488A CN102600488A (zh) 2012-07-25
CN102600488B true CN102600488B (zh) 2013-11-20

Family

ID=39315680

Family Applications (3)

Application Number Title Priority Date Filing Date
CN2012100777571A Expired - Fee Related CN102600488B (zh) 2008-02-29 2009-02-26 中枢神经系统的显像
CN2009801067913A Expired - Fee Related CN101970017B (zh) 2008-02-29 2009-02-26 中枢神经系统的显像
CN2012100777139A Expired - Fee Related CN102600487B (zh) 2008-02-29 2009-02-26 中枢神经系统的显像

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN2009801067913A Expired - Fee Related CN101970017B (zh) 2008-02-29 2009-02-26 中枢神经系统的显像
CN2012100777139A Expired - Fee Related CN102600487B (zh) 2008-02-29 2009-02-26 中枢神经系统的显像

Country Status (6)

Country Link
US (1) US20110027178A1 (https=)
EP (1) EP2247316B1 (https=)
JP (1) JP2011513277A (https=)
CN (3) CN102600488B (https=)
GB (1) GB0803729D0 (https=)
WO (1) WO2009106564A2 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0906274D0 (en) * 2009-04-09 2009-05-20 Ge Healthcare Ltd Imaging the central nervous system
GB0917611D0 (en) * 2009-10-08 2009-11-25 Ge Healthcare Ltd Automated radiosynthesis

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007141267A1 (en) * 2006-06-06 2007-12-13 Glaxo Group Limited N- (phenylmethyl) -2- (1h-pyraz0l-4-yl) acetamide derivatives as p2x7 antagonists for the treatment of pain, inflammation and neurodegeneration

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9704546D0 (sv) * 1997-12-05 1997-12-05 Astra Pharma Prod Novel compounds
EP1495031A1 (en) * 2002-04-16 2005-01-12 Pharmacia & Upjohn Company LLC Labeled oxazinocarbazoles as diagnostic agents
WO2004038374A2 (en) * 2002-10-24 2004-05-06 Merck & Co., Inc. Alkyne derivatives as tracers for metabotropic glutamate receptor binding
PA8591801A1 (es) * 2002-12-31 2004-07-26 Pfizer Prod Inc Inhibidores benzamidicos del receptor p2x7.
US20080228069A1 (en) * 2003-12-01 2008-09-18 Mediphysics, Inc. Novel Differential Imaging Method
PL2029178T3 (pl) * 2006-06-21 2012-08-31 Ge Healthcare Ltd Produkty radiofarmaceutyczne
CA2655675A1 (en) * 2006-07-06 2008-01-10 Glaxo Group Limited Substituted n-phenylmethyl -5-oxo-proline-2-amides as p2x7-receptor antagonists and their methods of use
WO2008064432A1 (en) * 2006-12-01 2008-06-05 The University Of Sydney Polycyclic molecular compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007141267A1 (en) * 2006-06-06 2007-12-13 Glaxo Group Limited N- (phenylmethyl) -2- (1h-pyraz0l-4-yl) acetamide derivatives as p2x7 antagonists for the treatment of pain, inflammation and neurodegeneration

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
《Characterization of a selective and potent antagonist of human P2X(7) receptors, AZ11645373》;Stokes L, et. al.;《Br J Pharmacol.》;20061209;第149卷(第7期);880-7 *
《Negative and positive allosteric modulators of the P2X(7) receptor》;Michel AD, Chambers LJ, Walter DS.;《Br J Pharmacol.》;20071210;第153卷(第4期);737-750 *
《Structure-activity relationship studies on a series of novel,substituted 1-benzyl-5-phenyltetrazole P2X7 antagonists 》;Nelson DW, et. al.;《J Med Chem.》;20060101;第49卷(第12期);3659-66 *
Michel AD, Chambers LJ, Walter DS..《Negative and positive allosteric modulators of the P2X(7) receptor》.《Br J Pharmacol.》.2007,第153卷(第4期),737-750.
Nelson DW, et. al..《Structure-activity relationship studies on a series of novel,substituted 1-benzyl-5-phenyltetrazole P2X7 antagonists 》.《J Med Chem.》.2006,第49卷(第12期),3659-66.
Stokes L, et. al..《Characterization of a selective and potent antagonist of human P2X(7) receptors, AZ11645373》.《Br J Pharmacol.》.2006,第149卷(第7期),880-7.

Also Published As

Publication number Publication date
WO2009106564A3 (en) 2010-03-25
CN102600487B (zh) 2013-11-20
GB0803729D0 (en) 2008-04-09
CN101970017A (zh) 2011-02-09
JP2011513277A (ja) 2011-04-28
US20110027178A1 (en) 2011-02-03
CN101970017B (zh) 2012-05-23
EP2247316A2 (en) 2010-11-10
WO2009106564A2 (en) 2009-09-03
CN102600488A (zh) 2012-07-25
CN102600487A (zh) 2012-07-25
EP2247316B1 (en) 2013-11-06

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CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20131120

Termination date: 20140226