CN102600051B - 一种义齿清洁片 - Google Patents
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Abstract
本发明涉及一种义齿清洁片，它是由下述重量配比的物质制成：金银花3-5份、紫花地丁5-15份、连翘1-5份、五味子4-8份、佩兰1-5份、杜仲3-7份、马齿苋5-11份、蛇床子3-5份和药学上可接受的载体。本发明所述的义齿清洁片具有优良去垢杀菌效果，能广泛应用于临床。
Description
技术领域
本发明涉及口腔领域，具体来说涉及一种义齿清洁片。
背景技术
义齿比真牙更易附着细菌，沉积污垢，色素，形成结石，严重影响配戴义齿患者的口腔卫生。据报道戴全口或半口义齿的病人约有65％患义齿性口炎，这是由于义齿不清洁对口腔粘膜造成的创伤，特别是白色念珠菌所致。
发明内容
本发明的目的是提供一种义齿清洁片。
为了实现本发明的目的，本发明提供一种义齿清洁片，它是由下述重量配比的物质制成：金银花3-5份、紫花地丁5-15份、连翘1-5份、五味子4-8份、佩兰1-5份、杜仲3-7份、马齿苋5-11份、蛇床子3-5份和药学上可接受的载体。
优选地，所述的义齿清洁片是由下述重量配比的物质制成：金银花4份、紫花地丁10份、连翘2份、五味子5份、佩兰2份、杜仲4份、马齿苋7份、蛇床子4份和药学上可接受的载体。
药学上可接受的载体包括但不限于：粘合剂、芳香剂、抗氧化剂、稳定剂、药学上可接受的溶剂、崩解剂、药学上可接受的助溶剂等等。所述药学上可接受的载体的用量可以由本领域技术人员通过常规方法来确定。
本发明所述的义齿清洁片具有优良去垢杀菌效果，能广泛应用于临床。
具体实施方式
以下通过具体实施方式的描述对本发明作进一步说明，但这并非是对本发明的限制，本领域技术人员根据本发明的基本思想，可以做出各种修改或改进，但是只要不脱离本发明的基本思想，均在本发明的范围之内。
实施例1：本发明分散片的制备
称取金银花40克、紫花地丁100克、连翘20克、五味子50克、佩兰20克、杜仲40克、马齿苋70克、蛇床子40克和水800毫升，置于密封的烧瓶内。在90℃的水浴下加热3小时，过滤，收集滤液，浓缩至干。粉碎，过80目筛，加入微晶纤维素20克、交联羧甲基纤维素钠10克、乳糖20克和硬脂酸镁3克，混合均匀，直接进行粉末压片，压制成100片。
实验例1去垢试验
取实施例1中制备的分散片两片，放入100毫升水中，在3分钟内，所述分散片完全崩解。使用玻璃棒搅拌均匀，静置为澄清清洁液。
义齿脏度分级标准：I级，假牙某一部分可见散在的茶渍，烟渍和污垢；II级，假牙各部分均有块状的烟渍、茶渍、污垢或结石；III级，假牙各部分均有大片或整个假牙均有烟渍、茶渍，污垢或结石。
收集具有烟茶渍，污垢和结石的义齿50件，用自来水刷洗后进行脏度分级，其中I级16例，II级12例，III级22例。然后分别浸泡在清洁液中，浸泡2h，取出后用棉签擦洗，观察其去垢效果。
去垢效果的评价标准：用棉签擦洗清洁液浸泡后的义齿，根据去除色渍、污垢效果分为“+++”(轻擦即可去除)，“++”(反复轻擦可去除)，“+”(用力擦洗可去除)。
经过检查，所有义齿的去垢效果均符合“+++”的标准。
实验例2杀菌试验
取实施例1中制备的分散片两片，放入100毫升水中，在3分钟内，所述分散片完全崩解。使用玻璃棒搅拌均匀，静置为澄清清洁液。
收集义齿10例，浸于无菌生理盐水中1h，洗刷下义齿上的细菌，用生理盐水稀释成103/ml菌悬液。取103/ml菌悬液0.01ml接种于皿琼脂培养基内，置于37℃温箱中24h，鉴定为常见口腔正常菌，将菌悬液与清洁液1∶1(体积)混合30min，分别取出0.01ml于皿培养基内划线接种，发现，菌悬液与清洁液1∶1混合30min内即可杀灭细菌，无菌斑形成。
Claims (1)
1.一种义齿清洁片，其特征在于它是由下述重量配比的物质按照下列方法制成：称取金银花40克、紫花地丁100克、连翘20克、五味子50克、佩兰20克、杜仲40克、马齿苋70克、蛇床子40克和水800毫升，置于密封的烧瓶内；在90℃的水浴下加热3小时，过滤，收集滤液，浓缩至干；粉碎，过80目筛，加入微晶纤维素20克、交联羧甲基纤维素钠10克、乳糖20克和硬脂酸镁3克，混合均匀，直接进行粉末压片，压制成100片。
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103040685B (zh) * | 2012-12-31 | 2014-05-14 | 英敏霞 | 义齿清洁液 |
| CN103393587B (zh) * | 2013-08-20 | 2015-10-07 | 苏成帅 | 一种义齿清洁剂的制备方法 |
| CN106377487A (zh) * | 2016-09-29 | 2017-02-08 | 青岛海之源智能技术有限公司 | 一种义齿清洁片及其制备方法 |
| CN113509416B (zh) * | 2021-07-13 | 2023-04-25 | 无限极（中国）有限公司 | 一种具有增强过氧化氢酶活力的组合物及其在化妆品中的应用 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1087813A (zh) * | 1993-10-06 | 1994-06-15 | 杨云平 | 固体方便牙膏片及其制造方法 |
| CN1337222A (zh) * | 2000-08-07 | 2002-02-27 | 雷学军 | 一种含天然药物的白齿牙粉 |
| CN1416803A (zh) * | 2002-10-26 | 2003-05-14 | 张德成 | 口洁液 |
-
2012
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1087813A (zh) * | 1993-10-06 | 1994-06-15 | 杨云平 | 固体方便牙膏片及其制造方法 |
| CN1337222A (zh) * | 2000-08-07 | 2002-02-27 | 雷学军 | 一种含天然药物的白齿牙粉 |
| CN1416803A (zh) * | 2002-10-26 | 2003-05-14 | 张德成 | 口洁液 |
Non-Patent Citations (4)
| Title |
|---|
| 5 种义齿清洁剂对白色念珠菌生物膜清洁效果的比较;张燕萍 等;《口腔医学研究》;20110531;第27卷(第5期);第368-371页 * |
| 中药义齿黏膜调理剂的临床初步应用;冯剑桥 等;《哈尔滨医科大学学报》;20080831;第42卷(第4期);第424-426页 * |
| 冯剑桥 等.中药义齿黏膜调理剂的临床初步应用.《哈尔滨医科大学学报》.2008,第42卷(第4期),第424-426页. |
| 张燕萍 等.5 种义齿清洁剂对白色念珠菌生物膜清洁效果的比较.《口腔医学研究》.2011,第27卷(第5期),第368-371页. |
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