CN102579761A - Application of traditional Chinese medicine beauty composition in preparation of medicament for adjusting women hormonal equilibrium - Google Patents
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Abstract
The invention provides an application of a traditional Chinese medicine beauty composition in preparation of a medicament for adjusting women hormonal equilibrium. The traditional Chinese medicine beauty composition comprises the following materials in parts by weight: 0.5-4 parts of aloetic powder, 0.5-4 parts of pearl powder, 1-8 parts of fructus lycii, 1-8 parts of radices paeoniae alba, 1-8 parts of radix angelicae sinensis, 1-8 parts of szechwan lovage rhizome, and 1-8 parts of radix astragali. The traditional Chinese medicine beauty composition dose not contain sex hormone active substances, has a comprehensive and systematic adjusting function on sex hormone, displays different biological effects in different age groups and physiological states, is remarkably different from known chemical drugs and known natural drugs (including traditional Chinese medicines), and has a better application prospect.
Description
(1) technical field
The present invention relates to the new purposes of a kind of Chinese medicine cosmetic composition in the medicine of preparation adjusting women hormonal balance.
(2) background technology
Modern society's working woman faces various burdens such as work, study, life, family, and the physical and psychological pressure that is born is big than before, often causes endocrine dysfunction, and then causes the various diseases that do not accommodate.Part child-bearing period women, ovarian dysfunction, the estrogen secretion horizontal abnormality raises, and the uterus estrogen-sensitive improves, and brings out hysteromyoma easily.On the other hand, menopause syndrome has appearred in some women of about 40 years old in advance, and especially the professional women is relatively finer and smoother to the psychological feelings of things, and stress is big, causes endocrine regulation, and then premature ovarian failure occurs.The senilism of ovarian function cause the secreting sex hormones rhythm and pace of moving things and quantity changes, and menoxenia can take place not only, body constitution descends, and also can cause a series of problems such as carcinoma of endometrium, symptoms such as menstruation irregularis, menstrual cycle prolongation, MBV minimizing occur.Present clinical employing hormonal supplementation treatment is the content of an important and a lot of dispute in the climacteric treatment field, and considering and examineing and praise or blame of its pros and cons often makes us at a loss as to what to do.Perimenopausal women uses after the hormone therapy, can effectively improve symptom, improve the quality of living, and prevents some and menopause relevant disease.But as the other medicines treatment, hormone therapy also exists untoward reaction, increases the risk of apoplexy, thrombosis and thromboembolism like the hormone therapy meeting; Possibly increase the risk that the women suffers from dementia, increases diseases such as breast carcinoma and cardiac event.Also have the women because of reason spay or ovary anergies such as tumors, estrogen level acutely descends, and not only causes hectic fever, insomnia, cardio palmus shape, and bone-loss, urinary system infection take place easily, and physiological function significantly fails.
Chinese medicine cosmetic composition of the present invention is made up of seven kinds of Chinese medicines such as Radix Angelicae Sinensis, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Fructus Lycii, the Radix Astragali, Aloe powder, Margarita powder, has the function of functions of removing chloasma.Prescription is set about from consolidating, and has improved the function of each organ of health on the whole.The hot temperature of Radix Angelicae Sinensis in the side, the sun of enriching blood and invigorating blood circulation and nourishing blood, and ability loosening bowel to relieve constipation are transferred Liver and kidney; Enrich blood yin fluid astringing and battalion are received in Radix Paeoniae Alba acid; The hot temperature of Rhizoma Chuanxiong is walked to scurry, and arrogates to oneself the promoting the circulation of blood of invigorating blood circulation, and activating QI to alleviate the depression transfers irritability to dredge the merit of rushing down to satisfy it; The Fructus Lycii nourishing the liver and kidney, benefiting essence-blood, four medicines match, and can play not blood trouble of promoting the circulation of blood, enrich blood and the blood that do not stagnate, and play the moon of supporting the five internal organs and menstruation regulating blood nourishing medicinal, so be applicable to symptom such as women's shallow complexion.In order to strengthen its blood tonification effect, according to the theory of the traditional Chinese medical science " blood is not spontaneous, must must give birth to the medicine of yang-energy, and blood is from prosperous ", so increased the Qi-tonifying drug Radix Astragali to increase the merit of its QI invigorating and blood producing in the side.Therefore the traditional Chinese medical science thinks that Aloe has relieving constipation and removing heat from the liver effect, can coordinate intestine moistening, the defecating feces excretion of Radix Angelicae Sinensis among the we, impels that poisonous and harmful is excremental in the human body intestinal canal in time excretes, thereby improves lusterless complexion and the generation that reduces or eliminates chloasma; Margarita powder is China's tradition rare Chinese medicine; Be cosmetology good merchantable brand commonly used among the people, the effect that has liver heat removing, detoxifcation, granulation promoting, calms the nerves and calm the frightened is according to modern pharmacological research; Margarita powder can suppress the generation of human harmful substance-lipofuscin; And the effect of removing free radical is arranged, therefore can reduce the generation of chloasma faciei, and have certain delaying senility function.Comprehensive we's pharmacological action, can explain we can play invigorate blood circulation, blood tonification effect, the women is had rosy cheeks, chloasma reduces, and plays certain beautification function.
The prescription of cosmetic composition is made up of the plant of dietotherapeutic, and is safe, and the former functions of removing chloasma effect that is used for the women does not appear in the newspapers to the hormonal regulation function of women's each age group for said composition.
(3) summary of the invention
The object of the invention provides the new purposes of Chinese medicine cosmetic composition in the medicine of preparation adjusting women hormonal balance.
The technical scheme that the present invention adopts is:
The application of a kind of Chinese medicine cosmetic composition in the medicine of preparation adjusting women hormonal balance, said Chinese medicine cosmetic composition quality is formed as follows: Aloe powder, 0.5～4 part; 0.5～4 part of Margarita powder; 1～8 part of Fructus Lycii; 1～8 part of the Radix Paeoniae Alba; 1～8 part of Radix Angelicae Sinensis; 1～8 part of Rhizoma Chuanxiong; 1～8 part of the Radix Astragali.
Various hormonal readinesses have different characteristics in all ages and classes section human female; Endocrine disturbance's the form of expression has nothing in common with each other; Chinese medicine cosmetic composition of the present invention all has certain regulating action to all ages and classes section women's sex hormone level, and also there is significant difference in its biological effect.Simultaneously, the Chinese medicine cosmetic composition itself does not have estrogenic activity, has no toxic and side effects, can be used for preventing because the disorderly various diseases that do not accommodate that cause of sex hormone metabolism.
Many about 25～30 years old child-bearing period women take contraceptive for a long time; Or take and contain estrogenic medicine, tonic and face and skin beautifying articles for use, improved body inner estrogen level; Or dietary structure is unreasonable, smoking, drink, women that meat is main high fat diet custom; Or face work family dual-pressure, and be prone to produce depressive emotion, the estrogen secretion amount is increased, all can bring out hysteromyoma.Statistical data shows that present women more than 30 years old has 20% to suffer from hysteromyoma approximately, and sickness rate presents rising trend.Hysteromyoma can cause pelvic congestion and infection, produces adhesion or inflammation, also can impel pathogenic bacterium to invade other uterine cavity organ because of hemorrhage, causes adnexitis, gynecopathy such as pelvic inflammatory inflammation.Hysteromyoma can cause menstrual bleeding too much, and time one is long, just can cause secondary anemia, and when serious, the patient has and malaise, pale complexion, nervous ill symptoms such as breathe hard occur.The muscular tumor tissue compressing fallopian tube inlet in bight, patients with uterine myoma factor palace makes the uterus distortion so that hinders the germ cell implantation, finally causes infertility.In addition, show according to statistics that muscular tumor patient's spontaneous current productive rate is high than ordinary person also, its ratio is 4: 1.Hysteromyoma originally is a benign tumor, but minority also can canceration.Modern medicine thinks that hypothalamus-pituitary function imbalance can improve FSH and LH level, and then stimulates ovary excessive secretion estrogen, and uterus local hormone sensitivity raising simultaneously is the main cause of bringing out hysteromyoma.Therefore, often adopt clinically and replenish androgen, progesterone antagonist medicine and the treatment of estrogen antagonist medicine, but side effect is apparent in view.The Chinese medicine cosmetic composition can significantly reduce child-bearing period animal FSH level, and estrogen secretion is also had certain inhibitory action, and does not improve the sensitivity of uterus to gonadal hormone, thereby helps to reduce the hysteromyoma incidence rate.
On the other hand, the ovary weight of 45～50 years old later climacteric women reduces, function fails gradually and disappear, and estrogen level obviously reduces.Because whole body is organized mostly and the cell of organ pipe contains estrogen receptor; Accept estrogen regulating in various degree; When estrogen decrease; Variation in degeneration or the metabolism will take place in these tissues and organ pipe, and it is uneven to cause a plurality of systems such as nerve, endocrine to occur, and then the symptom of a series of neuroendocrine imbalances occurs.This disease sickness rate is high, and symptom in various degree can appear in 90% women, has a strong impact on personal health and family life quality.Also have one type of crowd who suffers from hysteromyoma and carry out behind ovary (uterus) resection operation also can occur menopause syndrome in advance.Rat body weight significantly increased after the Chinese medicine cosmetic composition can effectively suppress oophorectomize; Suppress metratrophia; Effectively suppress the decline of estradiol (E2) and testosterone (TESTO) level; But progesterone (PROG), FSH (FSH) and lutropin (LH) level are not all had obvious influence, thereby help to delay because the various diseases that do not accommodate that ovarian function decline causes, and under the situation of the complete anergy of ovary, keep estrogen level higher in the body.And the Chinese medicine cosmetic composition itself does not have estrogenic activity.
In sum; Chinese medicine cosmetic composition itself does not contain gonadal hormone appearance active substance; Its regulating action to gonadal hormone is comprehensive, system; And under all ages and classes section and physiological status, show different biological effects, with known chemicals, natural drug (comprising Chinese medicine) significant difference is arranged all.According to modern medical theory, this medicine can be used for reducing the risk that the child-bearing period women suffers from hysteromyoma to the regulating action of gonadal hormone; Also can be used for alleviating the various malaise symptoms of climacteric women; Also can be used for keeping spay (or ovary anergy) women's body inner estrogen level, improve physiological function.
Preferably, said Chinese medicine cosmetic composition quality is formed as follows: Aloe powder, 1 part; 1 part of Margarita powder; 2.5 parts of Fructus Lycii; 2.5 parts of the Radix Paeoniae Albas; 2.5 parts of Radix Angelicae Sinensis; 2.5 parts of Rhizoma Chuanxiongs; 2.5 parts of the Radixs Astragali.
Said Chinese medicine cosmetic composition specifically can be used for preparing the medicine of preventing and treating menopausal syndrome.Said composition has the decline function that suppresses metratrophia and effectively suppress estrogen level to climacteric women; The ability slow down aging; Alleviate the malaise symptoms of climacteric women, like hectic fever, perspiration, cardiopalmus, be prone to the climacteric syndrome of symptoms such as tired, mood change, depressive anxiety, forfeiture interest, work efficiency reduction.In addition, said Chinese medicine cosmetic composition also can be used for preparing the prevention hysteromyoma or treats the medicine of the menoxenia that hormone disturbance causes.
Said medicine can add conventional adjuvant, processes one of following dosage form: tablet, granule, capsule, oral liquid.
Beneficial effect of the present invention is mainly reflected in: Chinese medicine cosmetic composition of the present invention itself does not contain gonadal hormone appearance active substance; Its regulating action to gonadal hormone is comprehensive, system; And under all ages and classes section and physiological status, show different biological effects; With known chemicals, natural drug (comprising Chinese medicine) significant difference is arranged all, have application promise in clinical practice.
(4) description of drawings
Fig. 1 is the expression of Chinese medicine cosmetic composition to estrogen receptor in the uterine cancer cell (ER); A: normal control group, HE * 400, the visible pale brown color positive expression of endometrial epithelial cell; B: model control group, HE * 400, the visible sepia strong positive of endometrial epithelial cell is expressed, and expression increases; C: high dose group, HE * 400, the visible pale brown color positive expression of endometrial epithelial cell;
Fig. 2 is the expression of beauty-care capsule to progesterone receptor in the uterine cancer cell (PR); A: normal control group, HE * 400, the visible pale brown color positive expression of endometrial epithelium; B: model control group, HE * 400, the visible a large amount of pale brown color positive expressions of endometrial epithelium; C: high dose group, HE * 400, the visible pale brown color positive expression of endometrial epithelium.
(5) specific embodiment
Below in conjunction with specific embodiment the present invention is described further, but protection scope of the present invention is not limited in this:
Embodiment 1:
1.1 product prescription and preparation thereof
Prescription:
Extract:
The decocting that Fructus Lycii, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Astragali is added 8 times of quality boils 2 times, decocts 1 hour at every turn, merges 2 times extracting solution, and being concentrated into relative density is 1.25～1.35; Add ethanol and make and contain alcohol amount and reach 63% (v/v), leave standstill the absorption supernatant, filter, reclaim ethanol; Be condensed into extractum, mix one-step palletizing with Margarita powder, Aloe powder; Drying, granulate can further add conventional adjuvant and process tablet, granule, capsule etc.
2.2 the Chinese medicine cosmetic composition is to the influence of ovariectomized rat uterus and gonadal hormone
The female sd inbred rats that to get 50 body weight be 250～285g is divided 5 groups by body weight: normal control group (distilled water 20m Lkg at random
-1), model control group (distilled water 20mLkg
-1), low dose group (Chinese medicine beauty treatment extract 0.72gkg
-1), high dose group (Chinese medicine beauty treatment extract 2.16gkg
-1), 10 every group, except that the normal control group, all the other each groups are all excised bilateral ovaries, postoperative 7 days, and each group is irritated stomach and is given corresponding medicine, once a day, in 8 weeks of successive administration, observes the body weight of respectively organizing rat weekly; Get blood when 4 weeks of administration, 8 weeks; Measure the level of rat blood serum estradiol in menopause (E2), progesterone (PROG), FSH (FSH), lutropin (LH), testosterone (TESTO); Simultaneously; Get the homonymy uterine cancer cell behind 8 week of the administration back execution rat and carry out pathological observation; And measure cervix uteri, subangle uterus root transverse diameter and smooth muscle thickness, understand the sex hormones secretion equilibrated regulating action of Chinese medicine beauty treatment extract, for the clinical practice of Chinese medicine beauty treatment extract provides laboratory reference to the rat in menopause.
Result of the test, compare with the normal control group (1), after the oophorectomize; The model control group rat body weight significantly increases (P＜0.01); Uterus weight and uterus index obviously descend (P＜0.01), the obvious attenuation of Uterus wall, and cervix uteri, subangle uterus transverse diameter and smooth muscle thickness obviously reduce (P＜0.01); Compare with model control group; After giving Chinese medicine beauty treatment extract; The ovariectomized rat body weight has minimizing trend (P＞0.05), and uterus weight and uterus index all obviously improve (P＜0.01, P＜0.05); Uterus wall obviously improves, and cervix uteri, subangle uterus transverse diameter and smooth muscle thickness also have increase trend (P＞0.05); (2) compare with the normal control group, after the oophorectomize, model control group rat blood serum estradiol (E2), progesterone (PROG) and testosterone (TESTO) level obviously descend (P＜0.01), and FSH (FSH) is slightly decline (P＞0.05) also; Compare with model control group; After giving Chinese medicine beauty treatment extract continuously; The estradiol of ovariectomized rat (E2) level significantly improves (P＜0.05); Testosterone (TESTO) level also has rising (P＞0.05), and progesterone (PROG), FSH (FSH) and lutropin (LH) level are not all had obvious influence (P＞0.05).
Above result of the test shows; Rat body weight significantly increased after Chinese medicine beauty treatment extract can effectively suppress oophorectomize; Suppress metratrophia; Effectively suppress the decline of estradiol (E2) and testosterone (TESTO) level, but progesterone (PROG), FSH (FSH) and lutropin (LH) level are not all had obvious influence.
Chinese medicine beauty treatment extract is seen table 1 to the influence of ovariectomized rat sex hormone level; Visible by table 1; Compare with the normal control group, after the oophorectomize, the serum estradiol of model control group rat (E2), progesterone (PROG) and testosterone (TESTO) level be obviously decline (P＜0.01) all; FSH (FSH) level also slightly descends (P＞0.05), and lutropin (LH) level does not then have obvious influence (P＞0.05); After giving Chinese medicine beauty treatment 4 weeks of extract, 8 weeks of high and low dose continuously; Compare with model control group; Estradiol (E2) level of high and low dose group ovariectomized rat significantly improves (P＜0.05); Testosterone (TESTO) level also has rising, but difference not significantly (P＞0.05) does not all have obvious influence (P＞0.05) to progesterone (PROG), FSH (FSH) and lutropin (LH) level.
Table 1: Chinese medicine beauty treatment extract to the influence of oophorectomize hormonal readiness (pg/mL, x ± s, n=10)
Annotate: compare with the normal control group,
△P＜0.05,
△ △P＜0.01; Compare with model control group,
*P＜0.05,
*P＜0.01.
2.3 Chinese medicine beauty treatment extract is to the influence of period of duration rat uterus and gonadal hormone
Getting 40 body weight is the 3 month female SD rats of 250-285g, divides 4 groups at random by body weight: blank group (distilled water 20mLkg
-1), low dose group (Chinese medicine beauty treatment extract 0.72gkg
-1), high dose group (Chinese medicine beauty treatment extract 2.16gkg
-1), 10 every group, each is organized per os filling stomach and gives corresponding medicine; Once a day, in 4 weeks of successive administration, observe the variation of the body weight of rat weekly; And after 4 weeks of administration, get blood; Measure each group test rat blood serum estradiol (E2), progesterone (PROG), FSH (FSH), lutropin (LH), testosterone (TESTO), superoxide dismutase (SOD) and malonaldehyde (MDA) content, get internal organs such as the uterus of respectively organizing rat, ovary, heart, kidney after the execution and weigh, and calculate each organ index; And measure homonymy with more than the cervix uteri at position and the root transverse diameter of subangle uterus, and the skin of getting rat is measured the variation of moisture content of skin.To the influence of period of duration rat uterus and sex hormones secretion experimental data is provided for understanding Chinese medicine beauty treatment extract, for the Chinese medicine extract of improving looks provides laboratory reference in clinical practice.
Result of the test compares with the blank group, and giving Chinese medicine beauty treatment extract (1) continuous 4 weeks does not all have obvious influence (P＞0.05) to the body weight of period of duration rat; But can obviously reduce uterus weight, uterus index, cervix uteri transverse diameter and the subangle cervix uteri transverse diameter (P＜0.05, P＜0.01) of period of duration rat, other organ index of ovary exponential sum is not all had obvious influence (P＞0.05); (2) give Chinese medicine beauty treatment extract continuous 4 weeks and can reduce serum estradiol (E2), FSH (FSH) and lutropin (LH) and testosterone (TESTO) level of period of duration rat, but progesterone (PROG) is not had obviously influence (P＞0.05); (3) continuous 4 all per os are irritated stomaches and are given behind the Chinese medicine beauty treatment extract of high dose period of duration rat blood serum MDA content is had downward trend (P＞0.05), but active and moisture content of skin does not have obvious influence (P＞0.05) to SOD.
Result of the test shows; Chinese medicine beauty treatment extract can reduce uterus weight, uterus index, cervix uteri transverse diameter and the subangle cervix uteri transverse diameter of period of duration rat; Reduce estradiol (E2), FSH (FSH), lutropin (LH) and testosterone (TESTO) level, but progesterone (PROG) level is not had obvious influence; And Chinese medicine beauty treatment extract can improve the ability of removing MDA.Chinese medicine beauty treatment extract is seen table 2 to the influence of period of duration rat sex hormone level
Visible by table 2; Compare with the blank group; After continuous 4 all per os filling stomaches gave the Chinese medicine beauty treatment extract of high and low dose, the serum estradiol of period of duration rat (E2), FSH (FSH) and lutropin (LH) and testosterone (TESTO) level all had decline in various degree, wherein; The FSH of high dose group (FSH) level descends, and there were significant differences (P＜0.01), but progesterone (PROG) level is not had obvious influence (P＞0.05).
Table 2: Chinese medicine beauty treatment extract is to the influence (pg/mL,
n=10) of period of duration hormonal readiness
Annotate: compare with the blank group,
*P＜0.05,
*P＜0.01.
1.4 the discussion of Chinese medicine beauty treatment extract pharmacological mechanism
The female sd inbred rats that to get 50 body weight be 250-285g is divided 5 groups by body weight: normal control group (distilled water 20mLkg at random
-1), model control group (distilled water 20mLkg
-1), low dose group (Chinese medicine beauty treatment extract 0.72gkg
-1), high dose group (Chinese medicine beauty treatment extract 2.16gkg
-1), 10 every group, except that the normal control group; All the other rats are all excised bilateral ovaries, postoperative 7 days, and each group is irritated stomach and is given corresponding medicine; Once a day, successive administration is after 8 weeks, and each organizes rat extracting blood; Measure serum gonadotropin-releasing hormone (GnRH) with the ELISA method, simultaneously rat anesthesia is put to death, get the uterus after the dissection and place 4% formalin fixing; Paraffin Bao Li detects the expression of estrogen receptor (ER), progesterone receptor (PR) in the uterine cancer cell with the SABC method, observes the influence of Chinese medicine beauty treatment extract to the gonadotropin-releasing hormone (GnRH) of ovariectomized rat and estrogen receptor (ER), progesterone receptor (PR).Simultaneously; Detect superoxide dismutase (SOD) and malonaldehyde (MDA) content in the serum; Measure organ index and moisture content of skin such as hypophysis cerebri coefficient; And carry out the test of estrogen dependent cells strain MCF-7 in-vitro multiplication, inquire into the metratrophia mechanism of action that Chinese medicine beauty treatment extract suppresses ovariectomized rat.
Result of the test; (1) compares with the normal control group; After the oophorectomize; Serum gonadotropin-releasing hormone (GnRH) level of model control group rat does not have significant change (P＞0.05), but the hypophysis index obviously descends (P＜0.05), the expression of estrogen receptor in the uterine cancer cell (ER), progesterone receptor (PR) obviously increases; After giving the Chinese medicine beauty treatment extract of high and low dose; Compare with model control group; The hypophysis index of high and low dose group ovariectomized rat obviously improves (P＜0.05), and the estrogen receptor (ER) of serum gonadotropin-releasing hormone (GnRH) level and uterine cancer cell, the expression of progesterone receptor (PR) are not had obvious influence (P＞0.05) yet; (2) compare with the normal control group, after the oophorectomize, adrenal gland's index of model control group rat significantly descends (P＜0.01), and cardiac index, liver index, lungs index, kidney index, cerebral index also all have downward trend (P＞0.05); With model control group relatively, give ovariectomized rat cardiac index behind the Chinese medicine beauty treatment extract, adrenal gland's index significantly raises (P＜0.05), cardiac index, liver index, lungs index, kidney index, adrenal gland's index also have rising (P＞0.05); (3) compare with the normal control group, after the oophorectomize, the activity of SOD in serum of model control group rat obviously descends (P＜0.05), and MDA content obviously raises (P＜0.01), and moisture content of skin obviously reduces (P＜0.05); Compare with model control group, give Chinese medicine beauty treatment extract continuously after 8 weeks, the activity of SOD in serum of ovariectomized rat obviously raises (P＜0.01), and MDA content obviously descends (P＜0.05), and moisture content of skin also has rising trend (P＞0.05); (4) Chinese medicine beauty treatment extract-treated 4d does not have influence to the MCF-7 cell proliferation, and XIANLING GUBAO 80 μ g/mL can significantly promote MCF-7 cell proliferation (P＜0.01) under the similarity condition.
Above result of the test shows; The effect of the no estrogen appearance of Chinese medicine beauty treatment extract own; Expression to the estrogen receptor (ER) in gonadotropin-releasing hormone (GnRH) level and the uterine cancer cell, progesterone receptor (PR) has no significant change, but Chinese medicine beauty treatment extract can effectively suppress the atrophy of internal organs such as rat pituitary after the oophorectomize, the heart, lung, liver, kidney, adrenal gland; Effectively improve body tissue and remove oxygen-derived free radicals and anti peroxidation of lipid ability, reduce lipid peroxidation product content, improve the water content of skin; Chinese medicine beauty treatment extract also can suppress metratrophia; Improve the skin quality; Its mechanism possibly be through hypophysis cerebri, lung, kidney, adrenal gland etc. being organized the protection of internal organs, effectively suppresses the Telatrophy that descends and cause because of gonadal hormone, keeps the physiological function of organizing internal organs; Keep the nutrition of body thereby play, play the effect that improves rat fuselage state after the oophorectomize from inside to outside uterus, skin.
1.4.1 Chinese medicine beauty treatment extract is to ovariectomized rat gonadotropin-releasing hormone (GnRH) and the exponential influence of hypophysis
Chinese medicine beauty treatment extract is seen table 3 to ovariectomized rat gonadotropin-releasing hormone (GnRH) and the influence of hypophysis index
Visible by table 3, to compare with the normal control group, after the oophorectomize, the no significant change of serum gonadotropin-releasing hormone (GnRH) (P＞0.05) of model control group rat is but the hypophysis index obviously descends (P＜0.05); After giving the Chinese medicine beauty treatment extract of high and low dose, compare with model control group, the hypophysis index of high and low dose group ovariectomized rat obviously improves (P＜0.05).
Table 3: Chinese medicine beauty treatment extract is to the influence (
n=10) of the hypophysis coefficient and the gonadotropin-releasing hormone of ovariectomized rat
Annotate: compare with the normal control group,
△P＜0.05,
△ △P＜0.01; Compare with model control group,
*P＜0.05,
*P＜0.01.
1.4.2 Chinese medicine beauty treatment extract is to the influence of ovariectomized rat organ index
Visible by table 4; Compare with the normal control group; After the oophorectomize, adrenal gland's index of model control group rat significantly descends (P＜0.01), and cardiac index, liver index, lungs index, kidney index, cerebral index all also have downward trend; But difference is remarkable (P＞0.05) not, and index and spleen index and thymus index are not all had obvious influence (P＞0.05); Compare with model control group; After giving the Chinese medicine beauty treatment extract of high and low dose; The cardiac index of high and low dose group ovariectomized rat, liver index, lungs index, kidney index, adrenal gland's index all have rising in various degree, wherein high dose group cardiac index and high and low dose group adrenal gland index rising remarkable (P＜0.05).
Table 4: Chinese medicine beauty treatment extract is to the influence (g/kg body weight,
n=10) of ovariectomized rat organ index
Annotate: compare with the normal control group,
△P＜0.05,
△ △P＜0.01; Compare with model control group,
*P＜0.05,
*P＜0.01.
1.4.3 Chinese medicine beauty treatment extract is to the influence of ovariectomized rat SOD activity, MDA content and moisture content of skin
Visible by table 5, to compare with the normal control group, after the oophorectomize, the activity of SOD in serum of model control group rat obviously descends (P＜0.05), and MDA content obviously raises (P＜0.01), and moisture content of skin obviously reduces (P＜0.05); Compare with model control group; The Chinese medicine beauty treatment extract that gives high and low dose continuously is after 8 weeks; The activity of SOD in serum of high and low dose group ovariectomized rat obviously raises (P＜0.01), and MDA content obviously descends (P＜0.05), and moisture content of skin also has rising trend (P＞0.05).
Table 5: Chinese medicine beauty treatment extract is to the influence (
n=10) of ovariectomized rat SOD activity, MDA content and moisture content of skin
Annotate: compare with the normal control group,
△P＜0.05,
△ △P＜0.01; Compare with model control group,
*P＜0.05,
*P＜0.01.
1.4.4 Chinese medicine beauty treatment extract is to the estrogen receptor (ER) of uterine cancer cell, the influence of progesterone receptor (PR)
Visible by Fig. 1 and Fig. 2; Compare with the normal control group; After the oophorectomize, the expression levels of the estrogen receptor of the uterine cancer cell of model control group rat (ER), progesterone receptor (PR) increases, and the Chinese medicine beauty treatment extract that gives high and low dose continuously is after 8 weeks; Compare with model control group, the estrogen receptor (ER) of the uterine cancer cell of high and low dose group ovariectomized rat, the expression of progesterone receptor (PR) do not have obvious influence.
1.4.5 Chinese medicine beauty treatment extract is to the influence of estrogen dependent cells strain MCF-7 in-vitro multiplication
Mtt assay detection Chinese medicine beauty treatment extract compares with the normal control group the result's (seeing table 6) that influences of MCF-7 cells in vitro propagation, and solvent does not have influence to the propagation of MCF-7 cell.Chinese medicine beauty treatment extract-treated 4d does not have influence to the MCF-7 cell proliferation, and XIANLING GUBAO 80 μ g/mL can significantly promote MCF-7 cell proliferation (P＜0.01) under the similarity condition.
Table 6: the influence that Chinese medicine beauty treatment extract is bred the MCF-7 cells in vitro (x ± s)
Annotate:
*P＜0.01vs solvent control group.
Claims (6)
1. the application of Chinese medicine cosmetic composition in the medicine of preparation adjusting women hormonal balance, said Chinese medicine cosmetic composition quality is formed as follows: Aloe powder, 0.5～4 part; 0.5～4 part of Margarita powder; 1～8 part of Fructus Lycii; 1～8 part of the Radix Paeoniae Alba; 1～8 part of Radix Angelicae Sinensis; 1～8 part of Rhizoma Chuanxiong; 1～8 part of the Radix Astragali.
2. application as claimed in claim 1 is characterized in that said Chinese medicine cosmetic composition quality composition as follows: Aloe powder, 1 part; 1 part of Margarita powder; 2.5 parts of Fructus Lycii; 2.5 parts of the Radix Paeoniae Albas; 2.5 parts of Radix Angelicae Sinensis; 2.5 parts of Rhizoma Chuanxiongs; 2.5 parts of the Radixs Astragali.
3. application as claimed in claim 1 is characterized in that said Chinese medicine cosmetic composition is used to prepare the medicine of preventing and treating menopausal syndrome.
4. application as claimed in claim 1 is characterized in that said Chinese medicine cosmetic composition is used to prepare the medicine that prevents hysteromyoma.
5. application as claimed in claim 1 is characterized in that said Chinese medicine cosmetic composition is used to prepare the medicine of the menoxenia that the treatment hormone disturbance causes.
6. like the described application of one of claim 1～5, it is characterized in that said medicine processes one of following dosage form: tablet, granule, capsule, oral liquid.
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| CN2012100520613A CN102579761A (en) | 2012-03-01 | 2012-03-01 | Application of traditional Chinese medicine beauty composition in preparation of medicament for adjusting women hormonal equilibrium |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103494949A (en) * | 2013-10-07 | 2014-01-08 | 李艳辉 | Chinese herbal medicine for treating uterine fibroid and preparation method of Chinese herbal medicine |
| CN103990082A (en) * | 2013-09-24 | 2014-08-20 | 无棣县中心医院 | Traditional Chinese medicine for treating gynecological inflammation and manufacturing method thereof |
| CN110974899A (en) * | 2019-12-13 | 2020-04-10 | 姜涛 | Moxibustion column for dispelling cold and manufacturing method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101229276A (en) * | 2008-01-14 | 2008-07-30 | 北京中科雍和医药技术有限公司 | Body-building, face-recruiting and skin-moistening medicinal granules and preparing method thereof |
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2012
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101229276A (en) * | 2008-01-14 | 2008-07-30 | 北京中科雍和医药技术有限公司 | Body-building, face-recruiting and skin-moistening medicinal granules and preparing method thereof |
Non-Patent Citations (1)
| Title |
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| 小美: "让中药为美丽加分", 《医药保健杂志》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103990082A (en) * | 2013-09-24 | 2014-08-20 | 无棣县中心医院 | Traditional Chinese medicine for treating gynecological inflammation and manufacturing method thereof |
| CN103494949A (en) * | 2013-10-07 | 2014-01-08 | 李艳辉 | Chinese herbal medicine for treating uterine fibroid and preparation method of Chinese herbal medicine |
| CN103494949B (en) * | 2013-10-07 | 2015-07-15 | 李艳辉 | Chinese herbal medicine for treating uterine fibroid and preparation method of Chinese herbal medicine |
| CN110974899A (en) * | 2019-12-13 | 2020-04-10 | 姜涛 | Moxibustion column for dispelling cold and manufacturing method thereof |
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Application publication date: 20120718 |