CN102552793A - Chinese medicinal composition for treating unstable angina pectoris derived from aged coronary heart disease - Google Patents
Chinese medicinal composition for treating unstable angina pectoris derived from aged coronary heart disease Download PDFInfo
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Abstract
The invention discloses a Chinese medicinal composition for treating unstable angina pectoris derived from an aged coronary heart disease. The Chinese medicinal composition consists of the following bulk pharmaceuticals in parts by weight: 20-40 parts of astragalus, 10-20 parts of dangshen, 10-20 parts of red-rooted salvia root, 5-10 parts of sandalwood, 5-10 parts of amomum fruit, 10-15 parts of Chinese thorowax root, 10-15 parts of bitter orange, 10-15 parts of beautiful sweetgum fruit, 10-15 parts of kadsura pepper stem, 10-15 parts of red paeony root, 10-20 parts of Chinese angelica, 10-15 parts of szechuan lovage rhizome, 5-10 parts of dalbergia wood, 10-15 parts of corydalis tuber, 10-20 parts of kudzuvine root, 5-10 parts of liquoric root. The Chinese medicinal composition is easy to prepare; raw materials are readily-available; the bulk pharmaceuticals with different curative effects are selected according to the pathology of angina pectoris; through synergic actions of the medicaments in a formula, the Chinese medicinal composition has the effects of promoting blood circulation to dispel blood and inducing menstruation to relieve menalgia; and the Chinese medicinal composition has a good curative effect on unstable angina pectoris derived from the aged coronary heart disease.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition of the old people's of treatment unstable angina pectoris of coronary heart disease, belong to technical field of Chinese medicines.
Background technology
Angina pectoris is one of modal cardiovascular disease of old people, and along with improving constantly of living standard, old people's health is not noted taking exercise, and present stage, anginal incidence rate was the trend that rises year by year, and more and more rejuvenation.Mainly be because the left ventricle cell causes coronary artery luminal stenosis, arteriosclerosis to blood flow decreased between the coronary artery; Cause coronary artery that the blood supply of heart is reduced, slows down; Make myocardial ischemia, anoxia, increase the weight of the pathological changes of heart, the small artery blood vessel is in contraction, spasticity for a long time; Increased water sodium storage and stayed with herding of peripheral vessels and contract, increased the weight of angina pectoris, bring out the myocardial infarction river.
Angina pectoris is modal cardiovascular system diseases; Unstable angina pectoris (UAP) be since in the arteria coronaria unsettled atheromatous plaque secondary pathological change make the angina pectoris of regional myocardial blood flow due to obviously descending; Be one group of clinical anginal syndrome between stable angina pectoris and acute myocardial infarction, pilosity is born in mid-aged population, if treat untimely reaching; Serious myocardial infarction takes place in regular meeting and heart source property is broken dead, influences patient's life and quality of life.The medicine of treating unstable angina pectoris clinically is varied, takes for a long time with a kind of medicine and can produce drug resistance, and patient's the state of an illness and health is threatened.
Summary of the invention
The invention provides a kind of Chinese medicine composition of treating the aged coronary heart disease UA, this medicine has good therapeutical effect to unstable angina pectoris, and drug dependence is low, and is easy to use.
The present invention realizes through following measure:
A kind of Chinese medicine composition of treating the aged coronary heart disease UA is characterized in that being made up of following bulk drugs: Radix Astragali 20-40 part, Radix Codonopsis 10-20 part, Radix Salviae Miltiorrhizae 10-20 part, Lignum Santali Albi 5-10 part, Fructus Amomi 5-10 part, Radix Bupleuri 10-15 part, Fructus Aurantii 10-15 part, Fructus Liquidambaris 10-15 part, Caulis Piperis Kadsurae 10-15 part, Radix Paeoniae Rubra 10-15 part, Radix Angelicae Sinensis 10-20 part, Rhizoma Chuanxiong 10-15 part, Lignum Dalbergiae Odoriferae 5-10 part, Rhizoma Corydalis 10-15 part, Radix Puerariae 10-20 part, Radix Glycyrrhizae 5-10 part.
In the above-mentioned Chinese medicine composition, preferably form: 30 parts of the Radixs Astragali, 15 parts of Radix Codonopsis, 15 parts of Radix Salviae Miltiorrhizaes, 9 parts in Lignum Santali Albi, 9 parts of Fructus Amomis, 12 parts of Radix Bupleuri, 12 parts of Fructus Aurantiis, 12 parts of Fructus Liquidambaris, 12 parts of Caulis Piperis Kadsuraes, 12 parts of Radix Paeoniae Rubra, 15 parts of Radix Angelicae Sinensis, 12 parts of Rhizoma Chuanxiongs, 9 parts of Lignum Dalbergiae Odoriferaes, 12 parts of Rhizoma Corydalis, 15 parts of Radix Puerariaes, 9 parts in Radix Glycyrrhizae by following bulk drugs.
The method for preparing of medicine of the present invention is: all medicine materials are mixed, and the water that adds the medicine that just submerges decocts, and gets decoction liquor and takes, and takes the potion decoction liquor every day, takes at twice for every dose, and each 2 hours at interval, 7 days was 1 course of treatment.
The inventor has obtained this prescription according to a large amount of experiments and practical experience for many years, and each medicine material effect is following in the prescription:
The Radix Astragali; Nature and flavor are sweet, warm; Return lung, spleen channel; Effect with invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation, be used for that the deficiency of vital energy is weak, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle are difficultly burst, burst for a long time do not hold back, blood deficiency dull yellowish colored skin, interior-heat are quenched one's thirst, chronic nephritis proteinuria, diabetes.
Radix Codonopsis, nature and flavor are sweet, flat, return spleen, lung meridian, have the effect of invigorating the spleen and replenishing QI, spleen invigorating lung benefiting, are used for deficiency of the spleen and lung, the cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency cough, interior-heat quenches one's thirst.
Radix Salviae Miltiorrhizae; Nature and flavor are bitter, be slightly cold; GUIXIN, Liver Channel have stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, an effect of the relieving restlessness that clears away heart-fire, and are used for that menoxenia, amenorrhea dysmenorrhea 、 lumps in the chest and abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection are swollen and ache, dysphoria and insomnia, hepatosplenomegaly, angina pectoris.
Lignum Santali Albi, nature and flavor are hot, warm, return spleen, stomach, the heart, lung meridian, have circulation of qi promoting warming middle-JIAO, appetizing analgesic effect, are used for QI stagnated by cold, chest pain, stomachache, stomachache lack of appetite, coronary heart disease, angina pectoris.
Fructus Amomi, nature and flavor are hot, warm, return spleen, stomach, kidney channel, and removing dampness appetizing, warming spleen and stopping diarrha, the antiabortive effect of regulating the flow of vital energy are used for that turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass are not hungry, Deficiency and coldness of spleen and stomach, vomiting are had loose bowels, pregnancy reactions, frequent fetal movement.
Radix Bupleuri, nature and flavor are bitter, be slightly cold, and return liver, gallbladder meridian, have the effect of reconciling superficies and interior, soothing the liver, yang invigorating, are used for cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, uterine prolapse, proctoptosis.
Fructus Aurantii, nature and flavor are bitter, hot, acid, warm, return spleen, stomach warp, have the stagnate effect of relieving distension of regulating the flow of QI to ease the stomach, row, are used for stopping in the breast side of body stagnation of QI, distension pain, accumulation of food in the stomach and intes tine due to indigestion, the phlegm retention, gastroptosis, proctoptosis, uterine prolapse.
Fructus Liquidambaris, nature and flavor are bitter, flat, return liver, kidney channel, have the effect that dispelling, collateral-activating, diuretic stimulate the menstrual flow, and are used for arthralgia, numbness contracture, edema distension, the few amenorrhea of breast.
Caulis Piperis Kadsurae, nature and flavor are hot, bitter, tepor, return Liver Channel, have the effect of wind-damp dispelling, the meridian dredging, stopping numbness pain, are used for anemofrigid-damp arthralgia, arthrodynia of extremities, execute arteries and veins contracture, joint stuffiness.
Radix Paeoniae Rubra, nature and flavor are bitter, be slightly cold, and return Liver Channel, have the effect of clearing away heat and cooling blood, eliminating stasis to stop pain, are used for maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion tumor, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea 、 mass in the abdomen stomachache, injury from falling down, carbuncle skin infection.
Radix Angelicae Sinensis; Nature and flavor are sweet, hot, warm; Return liver, the heart, spleen channel, having enriches blood invigorates blood circulation, the effect of menstruction regulating and pain relieving, loosening bowel to relieve constipation, is used for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.
Rhizoma Chuanxiong, nature and flavor are hot, warm, return liver, gallbladder, pericardium channel, have the effect of blood-activating and qi-promoting, wind-expelling pain-stopping, are used for menoxenia, amenorrhea dysmenorrhea 、 mass in the abdomen stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.
Lignum Dalbergiae Odoriferae, nature and flavor are hot, warm, return liver, spleen channel, have promoting flow of QI and blood, pain relieving, hemostatic effect, are used for epigastric pain, hypochondriac pain due to stagnation of liverQI, thoracic obstruction twinge, injury from falling down, traumatic hemorrhage.
Rhizoma Corydalis, another name Rhizoma Corydalis, corydalis tuber, rhizoma corydalis, Rhizoma Corydalis, nature and flavor are hot, bitter, warm, return liver, spleen channel, have invigorate blood circulation, promoting the circulation of QI, analgesic effect, be used for the breast side of body, epigastric pain. amenorrhea dysmenorrhea, postpartum stagnation, tumbling and swelling.
Radix Puerariae, nature and flavor are sweet, hot, cool, return spleen, stomach warp, have expelling pathogenic factors from muscles for reducing heat, promote the production of body fluid, rash, yang invigorating antidiarrheal effect, be used for fever caused by exogenous pathogens headache, stiff nape and back, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea, have loose bowels, the hypertension neck pain.
Radix Glycyrrhizae, nature and flavor are sweet, flat, GUIXIN, lung, spleen, stomach warp; Have the effect of invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription, be used for weakness of the spleen and stomach, fatigue and weakness; Shortness of breath and palpitation, cough with copious phlegm, institute's abdomen, the anxious pain of extremity contraction; Carbuncle sore tumefacting virus, cushion toxicity, strong.
The present invention prepares simply, and raw material is easy to get, and has selected the crude drug of different curative effects according to anginal pathology; Synergism through each medicine in the prescription; Played good blood circulation promoting and blood stasis dispelling, the effect of inducing menstruation to relieve menalgia has good therapeutical effect for old people's unstable angina pectoris of coronary heart disease.
The specific embodiment
Through specific embodiment the present invention is further set forth below, should be understood that, following explanation only is in order to explain the present invention, its content not to be limited.
Embodiment 1
Get Radix Astragali 30g, Radix Codonopsis 15g, Radix Salviae Miltiorrhizae 15g, Lignum Santali Albi 9g, Fructus Amomi 9g, Radix Bupleuri 12g, Fructus Aurantii 12g, Fructus Liquidambaris 12g, Caulis Piperis Kadsurae 12g, Radix Paeoniae Rubra 12g, Radix Angelicae Sinensis 15g, Rhizoma Chuanxiong 12g, Lignum Dalbergiae Odoriferae 9g, Rhizoma Corydalis 12 g, Radix Puerariae 15g, Radix Glycyrrhizae 9g; Water decocts, and takes decoction liquor.The decoction liquor instructions of taking is: take potion every day, divide and take for 2 times, child and old man take the circumstances into consideration decrement, and 7 days is 1 course of treatment.
Embodiment 2
Get Radix Astragali 20g, Radix Codonopsis 10g, Radix Salviae Miltiorrhizae 10g, Lignum Santali Albi 5g, Fructus Amomi 5g, Radix Bupleuri 10g, Fructus Aurantii 10g, Fructus Liquidambaris 10g, Caulis Piperis Kadsurae 10g, Radix Paeoniae Rubra 10g, Radix Angelicae Sinensis 10g, Rhizoma Chuanxiong 10g, Lignum Dalbergiae Odoriferae 5g, Rhizoma Corydalis 10 g, Radix Puerariae 10g, Radix Glycyrrhizae 5g; Water decocts, and takes decoction liquor.The decoction liquor instructions of taking is: take potion every day, divide and take for 2 times, child and old man take the circumstances into consideration decrement, and 7 days is 1 course of treatment.
Embodiment 3
Get Radix Astragali 40g, Radix Codonopsis 20g, Radix Salviae Miltiorrhizae 20g, Lignum Santali Albi 10g, Fructus Amomi 10g, Radix Bupleuri 15g, Fructus Aurantii 15g, Fructus Liquidambaris 15g, Caulis Piperis Kadsurae 15g, Radix Paeoniae Rubra 15g, Radix Angelicae Sinensis 20g, Rhizoma Chuanxiong 15g, Lignum Dalbergiae Odoriferae 10g, Rhizoma Corydalis 15 g, Radix Puerariae 20g, Radix Glycyrrhizae 10g; Water decocts, and takes decoction liquor.The decoction liquor instructions of taking is: take potion every day, divide and take for 2 times, child and old man take the circumstances into consideration decrement, and 7 days is 1 course of treatment.
Medicine of the present invention has the effect of blood circulation promoting and blood stasis dispelling, inducing menstruation to relieve menalgia, below through part clinical trial certificate beneficial effect of the present invention.
Clinical trial
1, patient source
Collect the patient that 228 examples suffer from unstable angina pectoris from this city, patient age is all bigger, at 45-80 between year; Mean age is 65.7 years old, and the ill time limit is between 1-20, and average life is 7.1 years; All patients all meet cardiovascular diseases branch of Chinese Medical Association " unstable angina pectoris diagnosis and treatment suggestion ", male patient's 152 examples wherein, female patient 76 examples; Patients with mild 70 examples, moderate patient's 127 examples, severe patient's 31 examples.
2, Therapeutic Method
Above-mentioned patient is equally divided into 4 groups, between each group at aspects such as the state of an illness, sex, ages there are no significant difference.Wherein, preceding 3 groups is the treatment group, and the 4th group is matched group; Treatment group and matched group all adopt conventional therapies such as aspirin, calcium anticaking agents; In addition, the treatment group uses the medicine of the embodiment of the invention 1,2,3 to treat respectively, and matched group uses control drug to treat.Therapeutic Method is: every day taken potion by medicine of the present invention, takes at twice for every dose; Control drug is a sorbitrate, every day 3 times, each 10mg.
3, criterion of therapeutical effect
Produce effects: clinical symptom relief or disappearance, electrocardiogram recovers normal level;
Effectively: clinical symptom relief, the angina pectoris attacks number of times reduces, and l-3 time/week, electrocardiogram S-T reduces, and more than the rise 0.05mV, but does not return to normal level;
Invalid: clinical symptoms does not alleviate or disappears, and the angina pectoris attacks number of times is frequent, and electrocardiogram does not have change.
4, therapeutic outcome
Adopt said method that each group patient is treated, treat 30 days continuously after, statistics patient treatment situation is seen table 1.
Claims (2)
1. a Chinese medicine composition of treating the aged coronary heart disease UA is characterized in that being made up of following bulk drugs: Radix Astragali 20-40 part, Radix Codonopsis 10-20 part, Radix Salviae Miltiorrhizae 10-20 part, Lignum Santali Albi 5-10 part, Fructus Amomi 5-10 part, Radix Bupleuri 10-15 part, Fructus Aurantii 10-15 part, Fructus Liquidambaris 10-15 part, Caulis Piperis Kadsurae 10-15 part, Radix Paeoniae Rubra 10-15 part, Radix Angelicae Sinensis 10-20 part, Rhizoma Chuanxiong 10-15 part, Lignum Dalbergiae Odoriferae 5-10 part, Rhizoma Corydalis 10-15 part, Radix Puerariae 10-20 part, Radix Glycyrrhizae 5-10 part.
2. the Chinese medicine composition of treatment aged coronary heart disease UA according to claim 1 is characterized in that being made up of following bulk drugs: 30 parts of the Radixs Astragali, 15 parts of Radix Codonopsis, 15 parts of Radix Salviae Miltiorrhizaes, 9 parts in Lignum Santali Albi, 9 parts of Fructus Amomis, 12 parts of Radix Bupleuri, 12 parts of Fructus Aurantiis, 12 parts of Fructus Liquidambaris, 12 parts of Caulis Piperis Kadsuraes, 12 parts of Radix Paeoniae Rubra, 15 parts of Radix Angelicae Sinensis, 12 parts of Rhizoma Chuanxiongs, 9 parts of Lignum Dalbergiae Odoriferaes, 12 parts of Rhizoma Corydalis, 15 parts of Radix Puerariaes, 9 parts in Radix Glycyrrhizae.
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| CN102755580A (en) * | 2012-07-16 | 2012-10-31 | 唐山职业技术学院 | Method for preparing chewable tablets of drug for treating unstable angina pectoris |
| CN102755581A (en) * | 2012-07-16 | 2012-10-31 | 唐山职业技术学院 | Pharmaceutical composition for treating unstable angina pectoris |
| CN104922602A (en) * | 2015-07-08 | 2015-09-23 | 于江月 | Traditional Chinese medicine for treating coronary heart disease combination dyslipidemia |
| CN106110133A (en) * | 2016-07-04 | 2016-11-16 | 满纪荣 | A kind of Chinese medicine treating unstable angina pectoris and preparation method thereof |
| CN115252691A (en) * | 2022-08-05 | 2022-11-01 | 长春中医药大学 | Traditional Chinese medicine composition for treating qi stagnation and blood stasis type coronary heart disease angina |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102755580A (en) * | 2012-07-16 | 2012-10-31 | 唐山职业技术学院 | Method for preparing chewable tablets of drug for treating unstable angina pectoris |
| CN102755581A (en) * | 2012-07-16 | 2012-10-31 | 唐山职业技术学院 | Pharmaceutical composition for treating unstable angina pectoris |
| CN102755581B (en) * | 2012-07-16 | 2013-11-06 | 唐山职业技术学院 | Pharmaceutical composition for treating unstable angina pectoris |
| CN102755580B (en) * | 2012-07-16 | 2014-02-19 | 唐山职业技术学院 | Method for preparing chewable tablets of drug for treating unstable angina pectoris |
| CN104922602A (en) * | 2015-07-08 | 2015-09-23 | 于江月 | Traditional Chinese medicine for treating coronary heart disease combination dyslipidemia |
| CN106110133A (en) * | 2016-07-04 | 2016-11-16 | 满纪荣 | A kind of Chinese medicine treating unstable angina pectoris and preparation method thereof |
| CN115252691A (en) * | 2022-08-05 | 2022-11-01 | 长春中医药大学 | Traditional Chinese medicine composition for treating qi stagnation and blood stasis type coronary heart disease angina |
| CN115252691B (en) * | 2022-08-05 | 2023-05-05 | 长春中医药大学 | Traditional Chinese medicine composition for treating qi stagnation and blood stasis type coronary heart disease angina |
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|---|---|
| CN102552793B (en) | 2013-11-13 |
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