CN102552780B - 一种治疗单纯性牙龈炎的喷雾剂 - Google Patents
一种治疗单纯性牙龈炎的喷雾剂 Download PDFInfo
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Abstract
本发明涉及一种治疗单纯性牙龈炎的喷雾剂，它是由下述重量配比的物质制成：金银花3-5份、丁香5-15份、桔梗1-5份、白芷4-8份、佩兰1-5份、山奈3-7份、陌上菜5-11份、蛇床子3-5份和药学上可接受的载体。本发明所述的治疗单纯性牙龈炎的喷雾剂成分简单明确，消毒效果明显，并且采用喷雾剂剂型来使用，可以更好地治疗单纯性牙龈炎。
Description
技术领域
本发明涉及口腔领域，具体来说涉及一种治疗单纯性牙龈炎的喷雾剂。
背景技术
单纯性牙龈炎是指牙齿组织在致病因素的作用下而发生的急、慢性炎症。医学上将围绕并覆盖在牙齿周围及槽突表面的口腔粘膜称之牙龈。由于几乎每人在一生的某个时期均会发生程度和范围不等的慢性牙龈炎，因此单纯性牙龈炎是人们日常生活中常见的疾病。
发明内容
本发明的目的是提供一种治疗单纯性牙龈炎的喷雾剂。
为了实现本发明的目的，本发明提供一种治疗单纯性牙龈炎的喷雾剂，它是由下述重量配比的物质制成：金银花3-5份、丁香5-15份、桔梗1-5份、白芷4-8份、佩兰1-5份、山奈3-7份、陌上菜5-11份、蛇床子3-5份和药学上可接受的载体。
优选地，所述的治疗单纯性牙龈炎的喷雾剂是由下述重量配比的物质制成：金银花4份、丁香10份、桔梗2份、白芷5份、佩兰2份、山奈4份、陌上菜7份、蛇床子4份和药学上可接受的载体。
喷雾剂是药物研究中开发的新剂型，其中药学上可接受的载体是指进行喷雾剂配制时常规使用的各种载体，这是本领域技术人员容易地意识到的。例如，药学上可接受的载体包括但不限于：抛射剂、芳香剂、抗氧化剂、稳定剂、药学上可接受的溶剂、吸收促进剂、药学上可接受的助溶剂等等。所述药学上可接受的载体的用量可以由本领域技术人员通过常规方法来确定。
本发明所述的治疗单纯性牙龈炎的喷雾剂成分简单明确，消毒效果明显，并且采用喷雾剂剂型来使用，可以更好地治疗单纯性牙龈炎。
具体实施方式
以下通过具体实施方式的描述对本发明作进一步说明，但这并非是对本发明的限制，本领域技术人员根据本发明的基本思想，可以做出各种修改或改进，但是只要不脱离本发明的基本思想，均在本发明的范围之内。
实施例1：本发明喷雾剂的制备
称取金银花40克、丁香100克、桔梗20克、白芷50克、佩兰20克、山奈40克、陌上菜70克、蛇床子40克和水800毫升，置于密封的烧瓶内。在90℃的水浴下加热3小时，过滤，收集滤液，浓缩至400毫升。加入10克吐温-60、3克薄荷油和30毫升丙二醇，混合均匀，消毒，灌入40瓶喷雾器中即得。
实验例
一般资料：
50例患者均符合单纯性牙龈炎的诊断标准(曹采方.牙周病学[M].北京：人民卫生出版社，2000：104，85-87.)，在上、下牙列4个分区中，每个分区至少有5颗牙齿存在；知情同意，能保证进行定期治疗和随访者。排除孕妇及哺乳期妇女，有严重系统性疾病、内分泌疾病、精神性疾病患者，正在进行激素治疗、抗生素治疗者，在过去6周内进行过牙周治疗者，不能合作者。其中男性25例，女性25例；年龄16～47岁。
治疗方案
使用实施例1制备的喷雾剂来进行治疗，使用时每次在患者口腔内均匀喷完1瓶，每天喷3次，连续治疗3天为一个疗程。
疗效标准
菌斑指数(PLI)(Quigley-Hein法)：0分：无菌斑；1分：牙颈部可见点状散在菌斑；2分：牙颈部可见点状菌斑，宽度不超过1mm；3分：菌斑覆盖牙面不超过1/3；4分：菌斑覆盖牙面1/3～2/3；5分：菌斑超过牙面2/3。
龈沟出血指数(SBI)(Mazza法)：0分：正常牙龈；1分：牙龈略有水肿，探针探之不出血；2分：牙龈探诊处呈点状出血；3分：牙龈探诊后出血，出血溢出龈缘；4分：牙龈有自发性出血倾向或溃疡形成。
口臭值(OS)：0分：无口臭；1分：自觉口臭，对话时医生嗅不到；2分：自觉口臭，对话时医生能嗅到；3分：严重口臭，不说话医生也能嗅到。
疗效标准：显效：PLI、SBI、OS均下降，主观症状(牙龈红肿、疼痛)明显改善；有效：PLI、SBI、OS至少有一项下降，主观症状改善；无效：PLI、SBI、OS均无改变，主观症状无改善或加重。
治疗结果
在连续使用3天后，全部患者均符合显效的标准。
Claims (1)
1.一种治疗单纯性牙龈炎的喷雾剂，其特征在于它是由下述重量配比的物质按照下列方法制成：称取金银花40克、丁香100克、桔梗20克、白芷50克、佩兰20克、山奈40克、陌上菜70克、蛇床子40克和水800毫升，置于密封的烧瓶内，在90℃的水浴下加热3小时，过滤，收集滤液，浓缩至400毫升，加入10克吐温-60、3克薄荷油和30毫升丙二醇，混合均匀，消毒，灌入40瓶喷雾器中即得。
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| CN103549623B (zh) * | 2013-10-30 | 2014-12-03 | 寻俭敏 | 一种临床营养上用于食品防腐的喷雾剂 |
| CN105250484A (zh) * | 2015-11-16 | 2016-01-20 | 林立朋 | 一种治疗单纯性牙龈炎的中药组合物 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1475204A (zh) * | 2002-06-30 | 2004-02-18 | 丛繁滋 | 经口、鼻给药的组合物、干粉吸入剂、喷雾剂、喷雾剂辅助制剂及其制备方法 |
| CN101547609A (zh) * | 2006-10-11 | 2009-09-30 | Wm.雷格利Jr.公司 | 包含中药或其提取物的口服递送媒介物 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1475204A (zh) * | 2002-06-30 | 2004-02-18 | 丛繁滋 | 经口、鼻给药的组合物、干粉吸入剂、喷雾剂、喷雾剂辅助制剂及其制备方法 |
| CN101547609A (zh) * | 2006-10-11 | 2009-09-30 | Wm.雷格利Jr.公司 | 包含中药或其提取物的口服递送媒介物 |
Non-Patent Citations (2)
| Title |
|---|
| 刘一梅.自制中药爽口液治疗牙龈炎480例.《淮海医药》.1999,第17卷第67-68页. |
| 自制中药爽口液治疗牙龈炎480例;刘一梅;《淮海医药》;19990930;第17卷;第67页 * |
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