CN102552742A - Medicine for treating scapulohumeral periarthritis and rheumatism - Google Patents
Medicine for treating scapulohumeral periarthritis and rheumatism Download PDFInfo
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- CN102552742A CN102552742A CN2012100069544A CN201210006954A CN102552742A CN 102552742 A CN102552742 A CN 102552742A CN 2012100069544 A CN2012100069544 A CN 2012100069544A CN 201210006954 A CN201210006954 A CN 201210006954A CN 102552742 A CN102552742 A CN 102552742A
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Abstract
The invention relates to a medicine, in particular to a medicine for treating scapulohumeral periarthritis and rheumatism. The medicine is characterized by being prepared from the following Chinese herbal medicines in part by weight: 9 to 11 parts of incised notopterygium, 9 to 11 parts of divaricate scaposhnikovia root, 45 to 55 parts of atractylodes lancea, 9 to 11 parts of clematis root, 9 to 11 parts of gentiana macrophylla, 18 to 22 parts of asarum, 9 to 11 parts of angelica dahurica, 9 to 11 parts of ligusticum chuanxiong, 9 to 11 parts of cinnamon, 18 to 22 parts of rice bean, 18 to 22 parts of cyathula officinalis, 18 to 22 parts of teasel, 18 to 22 parts of herba taxilli, 9 to 11 parts of gensing, 18 to 22 parts of licorice, 9 to 11 parts of coix seed and 2 to 3 parts of indomethacin. The invention has the advantages that: the medicine has effects of dispelling wind and eliminating dampness and diminishing inflammation and relieving pain, a unique curative effect on the scapulohumeral periarthritis and good therapeutic effects on sciatica, the rheumatism and rheumatoid arthritis. The invention has the characteristics that: the medicine is easy to take, quick in response, low in cost and short in curative time, does not have toxic or side effects and relieves the pain of patients; and the medicine provides conditions for treating persistent ailments such as the scapulohumeral periarthritis, rheumatoid arthritis and the like and relieving pain of patients.
Description
Technical field
The present invention relates to a kind of medicine, promptly a kind of medicine of treating scapulohumeral periarthritis and rheumatism.
Background technology
Scapulohumeral periarthritis is also claimed scapulohumeral periarthritis or shoulder joint surrounding tissue inflammation, is a kind of person in middle and old age's commonly encountered diseases.Mainly show as soft tissue generation aseptic inflammations such as muscle around the shoulder joint, tendon, ligament, synovial membrane, joint capsule, hyperemia is arranged, ooze out, changes such as edema, adhesion, cause shoulder arthralgia and functional disorder.The cause of disease of scapulohumeral periarthritis is still indeterminate, has that acute and chronic trauma is said, joint shortage activity is said, the age is said or the like saying, and therefore, many clinically is main with symptomatic treatment.Pulika commonly used is because of carrying out pain spot blocking with prednisone, or in take anti-inflammation analgesic, methods such as the acupuncture of employing, massage are also arranged.Though above-mentioned therapy has certain curative effect, how not obvious effect is, mainly to alleviate misery, waits for that spontaneous recovery is main.
Though motherland's medical science has difference to the understanding of scapulohumeral periarthritis, trend towards the theory that wind-cold damp pathogen is invaded the meridians that stagnate more, claim that this disease is " shoulder leaks out ", often adopts relaxing muscles and tendons and activating QI and blood in the collateral, blood-activating stasis-removing kind Chinese medicine, the effect of visible treating both the principal and secondary aspects of a disease., sum up owing to lack, many prescriptions only spread among the people with the form of proved recipe, and how incomplete or lost.
Summary of the invention
The objective of the invention is extensively collecting on the basis of folk remedy, adopt modern technologies to carry out Analysis and Screening, propose a kind of scapulohumeral periarthritis to be had significant curative effect, and usage is simple, produce effects is fast, and cost is low, the Chinese medicine that therapeutic effect is good.
Above-mentioned purpose is realized by following technical scheme: develop a kind of medicine of treating scapulohumeral periarthritis and rheumatism, be characterized in: this medicine is to be processed by following bulk drugs: Rhizoma Et Radix Notopterygii 9-11 part, windproof 9-11 part, Rhizoma Atractylodis 45-55 part; Radix Clematidis 9-11 part, Radix Gentianae Macrophyllae 9-11 part, Herba Asari 18-22 part, Radix Angelicae Dahuricae 9-11 part; Rhizoma Chuanxiong 9-11 part, Cortex Cinnamomi 9-11 part, Semen Phaseoli 18-22 part, Radix Cyathulae 18-22 part; Radix Dipsaci 18-22 part, Herba Taxilli 18-22 part, Radix Codonopsis 9-11 part; Radix Glycyrrhizae 18-22 part, Semen Coicis 9-11 part, indometacin 2-3 part.
This medicine is to be processed by following bulk drugs: 10 parts of Rhizoma Et Radix Notopterygiis, windproof 10 parts, 50 parts of Rhizoma Atractylodis, 10 parts of Radix Clematidis, 10 parts of Radix Gentianae Macrophyllae; 10 parts of Herba Asaris, 10 parts of the Radixs Angelicae Dahuricae, 10 parts of Rhizoma Chuanxiongs, 10 parts of Cortex Cinnamomis; 20 parts of Semen Phaseolis, 20 parts of Radix Cyathulaes, 20 parts of Radix Dipsacis, 20 parts of Herba Taxillis; 10 parts of Radix Codonopsis, 20 parts in Radix Glycyrrhizae, 10 parts of Semen Coiciss, 2.6 parts of indometacin.
The manufacturing approach of said medicine is: get Rhizoma Et Radix Notopterygii 100 grams, windproof 100 grams, Rhizoma Atractylodis 500 grams, Radix Clematidis 100 grams, Radix Gentianae Macrophyllae 100 grams, Herba Asari 200 grams, the Radix Angelicae Dahuricae 100 grams; Rhizoma Chuanxiong 100 grams, Cortex Cinnamomi 100 grams, Semen Phaseoli 200 grams, Radix Cyathulae 200 grams, Radix Dipsaci 200 grams, Herba Taxilli 200 grams; Radix Codonopsis 100 grams, Radix Glycyrrhizae 200 grams, Semen Coicis 100 grams, indometacin 26 grams, except that indometacin, all the other crude drug are ground into fine powder; Sieve,, use water pill, per 10 heavy 2 grams, polishing, dry getting final product with the indometacin mixing.
The method for using of said medicine is: oral, a 13-15 grain 2-3 time on the one, is used water delivery service.
The invention has the beneficial effects as follows: have expelling wind and removing dampness, the effect of anti-inflammatory analgetic has unique curative effect to scapulohumeral periarthritis, and sciatica, rheumatism, rheumatoid arthritis are also had significant curative effect.And it is simple to have usage, and produce effects is fast, and cost is low, and treatment time is short, and the patient suffering is few, and characteristics such as have no side effect are pertinacious diseases such as treatment scapulohumeral periarthritis and rheumatic arthritis, alleviate patient's misery, and condition is provided.
The specific embodiment
Through collecting Mongolian medicine's interrelated data and folk remedy in the arrangement,, pathology understanding and Therapeutic Principle have been confirmed in conjunction with modern medical theory and method.Think that scapulohumeral periarthritis is by the affection of exogenous wind-cold damp, have due to the intrinsic heat in holding concurrently.Wind-cold damp pathogen is invaded the flesh table, the strongly fragrant Wei Yang that holds back, and inaccessible space between skin and muscles, the retardance meridians, QI-blood circulation is not smooth, so disease is seen fever with aversion to cold, the flesh table is lossless, have a headache stiffness of the nape, the miserable pain of limbs; In intrinsic heat is arranged, so bitter taste is little thirsty; White or the little Huang of tongue, floating pulse are the hold concurrently evidences of interior-heat of exterior syndrome.So it is main adopting the dispersing wind-cold damp, the clear interior-heat of holding concurrently is the Therapeutic Principle who assists.On this basis, the experiment screening through a large amount of has formed the prescription scheme.
Rhizoma Et Radix Notopterygii is arduous warm in nature in the side, the exterior cold of loosing, and wind-damp dispelling, sharp joint, stopping numbness pain is for controlling the key medicine of sun wind-cold damp pathogen at table, so be monarch drug.Windproof suffering is sweet warm in nature, is the profit agent in the wind medicine, expelling wind and removing dampness, and dispersing cold for relieving pain: Rhizoma Atractylodis are arduous and warm, but merit diaphoresis damp eliminating is the main medicine of the Taiyin cold-dampness of dispelling; Radix Clematidis is warm in nature and acrid in the mouth is salty, wind-damp dispelling, the meridian dredging, expectorant saliva, the hypochondriac lump of loosing; Radix Gentianae Macrophyllae is bitter flat, wind-damp dispelling, clearing away damp-heat, stopping numbness pain; Four medicines are harmonious, and assist the notopterygium wind dispelling cold expelling, and removing damp and stopping pain is to be ministerial drug.Herba Asari, the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Cortex Cinnamomi expelling wind and cold, diffusing impediment and relieving pain, the kind SHAO YIN headache that ends of Herba Asari wherein, the Radix Angelicae Dahuricae are arrogated to oneself and are separated YANG MING headache, and Rhizoma Chuanxiong is longer than and is ended few positive headache due to JUE YIN disorder, and Cortex Cinnamomi is arrogated to oneself dispersing cold for relieving pain, promoting blood circulation; Semen Phaseoli property sugariness is flat, inducing diuresis to remove edema, the joint dysphoria with smothery sensation of dispelling; The Herba Taxilli invigorating the liver and kidney, bone and muscle strengthening is dispeled the wind; The Radix Dipsaci bone and muscle strengthening; The Radix Cyathulae invigorating the liver and kidney, bone and muscle strengthening; The Semen Coicis spleen invigorating that is slightly cold, heat clearing away; Radix Codonopsis sweet in the mouth property is put down invigorating the spleen and replenishing QI, and spleen invigorating is promoted the production of body fluid, and can prevent all strong article impairment of body fluid of hot warm-dryness syndrome; More than ten medicines all be adjuvant drug.The Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription is for making.Ten Six-element compatibilities can be ruled wind-cold damp pathogen, can take into account the coordination the exterior and the interior again, become the diaphoresis damp eliminating altogether, dispersing cold for relieving pain, and the agent of the clear interior-heat of holding concurrently can be accepted the effect of basis for medical treatment.Indometacin then can be subdued inflammation, and alleviating pain plays the effect that takes stopgap measures.Through the many cases clinical trial certificate, all inflammation shapes of medication one all back porches can be alleviated, and continue to take the effect that can play radical cure.Simultaneously, patient's readme symptom that many cases have sciatica, rheumatism, rheumatoid arthritis concurrently is clearly better, and surely belongs to the effect that this medicine should have.
The concocting method and the dosage form of this prescription are a lot, as fry in shallow oil process after soup is directly obeyed, concentrated honeyed pill or powder etc. all can, but adopt the method for making of commonly using of mongolian medicine, i.e. powder crushing process and with water pill, drug effect is more obvious, so be recommend method.Only lift four kinds of embodiment below:
First kind of embodiment: get 9 parts of Rhizoma Et Radix Notopterygiis by weight, windproof 9 parts, 45 parts of Rhizoma Atractylodis, 9 parts of Radix Clematidis, 9 parts of Radix Gentianae Macrophyllae; 18 parts of Herba Asaris, 9 parts of the Radixs Angelicae Dahuricae, 9 parts of Rhizoma Chuanxiongs, 9 parts of Cortex Cinnamomis; 18 parts of Semen Phaseolis, 18 parts of Radix Cyathulaes, 18 parts of Radix Dipsacis, 18 parts of Herba Taxillis; 9 parts of Radix Codonopsis, 18 parts in Radix Glycyrrhizae, 9 parts of Semen Coiciss, 2 parts of indometacin.Except that indometacin, all the other crude drug are ground into fine powder, sieve, and with the indometacin mixing, use water pill, polishing, dry getting final product.
Second kind of embodiment: get 11 parts of Rhizoma Et Radix Notopterygiis by weight, windproof 11 parts, 55 parts of Rhizoma Atractylodis, 11 parts of Radix Clematidis, 11 parts of Radix Gentianae Macrophyllae; 22 parts of Herba Asaris, 11 parts of the Radixs Angelicae Dahuricae, 11 parts of Rhizoma Chuanxiongs, 11 parts of Cortex Cinnamomis; 22 parts of Semen Phaseolis, 22 parts of Radix Cyathulaes, 22 parts of Radix Dipsacis, 22 parts of Herba Taxillis; 11 parts of Radix Codonopsis, 22 parts in Radix Glycyrrhizae, 11 parts of Semen Coiciss, 3 parts of indometacin.Except that indometacin, all the other crude drug are ground into fine powder, sieve, and with the indometacin mixing, use water pill, polishing, dry getting final product.
The third embodiment: get 11 parts of Rhizoma Et Radix Notopterygiis by weight, windproof 9 parts, 45 parts of Rhizoma Atractylodis, 9 parts of Radix Clematidis, 9 parts of Radix Gentianae Macrophyllae; 18 parts of Herba Asaris, 10 parts of the Radixs Angelicae Dahuricae, 11 parts of Rhizoma Chuanxiongs, 10 parts of Cortex Cinnamomis; 20 parts of Semen Phaseolis, 18 parts of Radix Cyathulaes, 20 parts of Radix Dipsacis, 18 parts of Herba Taxillis; 9 parts of Radix Codonopsis, 18 parts in Radix Glycyrrhizae, 11 parts of Semen Coiciss, 2 parts of indometacin.Except that indometacin, all the other crude drug are ground into fine powder, sieve, and with the indometacin mixing, use water pill, polishing, dry getting final product.
The 4th kind of embodiment: get Rhizoma Et Radix Notopterygii 100 grams by weight, windproof 100 grams, Rhizoma Atractylodis 500 grams, Radix Clematidis 100 grams, Radix Gentianae Macrophyllae 100 grams, Herba Asari 200 grams, the Radix Angelicae Dahuricae 100 grams; Rhizoma Chuanxiong 100 grams, Cortex Cinnamomi 100 grams, Semen Phaseoli 200 grams, Radix Cyathulae 200 grams, Radix Dipsaci 200 grams, Herba Taxilli 200 grams; Radix Codonopsis 100 grams, Radix Glycyrrhizae 200 grams, Semen Coicis 100 grams, indometacin 26 grams, except that indometacin, all the other crude drug are ground into fine powder; Sieve,, use water pill, per 10 heavy 2 grams, polishing, dry getting final product with the indometacin mixing.
Character: these article are the yellowish-brown watered pill, little suffering of distinguishing the flavor of.
Function cures mainly: expelling wind and removing dampness, anti-inflammatory analgetic.Be used for scapulohumeral periarthritis, sciatica, rheumatism, rheumatoid arthritis.
Usage and dosage: oral, a 13-15 grain 2-3 time on the one, is used warm water delivery service.
Untoward reaction: do not find as yet.
Points for attention: these article be used for wind and cold hold under the arm wet, in hot and suffocating card is arranged, the careful usefulness of anemopyretic cold or damp-heat syndrome.
The experiment situation:
1. toxicity test
(1) anxious poison test.According to the pertinent regulations of study of tcm new drug, to the median lethal dose(LD 50) (LD of mouse stomach administration
50) carried out test determination, but do not measure LD
50, therefore carried out mtd test.The result: to mouse stomach, none death of mice in seven days is put to death each internal organs of mice anatomic observation and is not found toxic reaction by 500 times of adult's per weight clinical daily dosage, and administration group and control group mice do not have any difference.
(2) long term toxication.Use the Wistar rat and will test medicine and be set at high, medium and low three dosage, by body weight for humans 70kg, daily dosage calculated for 0.15g/kg/ day, and the dosage by 80 times, 40 times and 20 times is an experimental group respectively, and other establishes the normal matched group of raising.Gastric infusion 90 days, 180 days and the drug withdrawal of part animal were observed the influence to rat each item physiology, biochemical indicator after 10 days continuously.Experimental result shows: gave the rat continuous oral 180 days with various dose, food-intake and the growth promoter (body weight gain) of rat all do not had influence.Liver function and renal function are not all found the overt toxicity effect.Routine blood test, blood are biochemical, urine is biochemical and bone marrow sheet etc. all do not seen obvious influence, between each group with matched group no significant difference relatively.
2. clinical experiment: since 2008; According to Ye Shunbin chief editor's " surgery " (People's Health Publisher published in 1996) and the relevant diagnostic criteria and the treatment standards such as " traditional Mongolian medicines " of " Chinese Medicine encyclopedia "; The how tame hospital in the locality; Under the voluntary situation of patient, scapulohumeral periarthritis patient 72 examples are controlled in examination.Wherein, medication one all readme remission persons reach 42%, and symptom readme disappearance person reaches 74% around the medication, thinks that not having effect person is 14%, and the readme total effective rate reaches 86%, can cooperate to carry out the limbs person taking exercise and have better effect.In the middle of the above-mentioned patient, hold concurrently and suffer from sciatica person 16 people, readme remission person 9 people account for 56% after the medication, and transference cure person 5 people account for 31%, and total effective rate reaches 87%.Hold concurrently and suffer from rheumatism, rheumatoid arthritis person's 33 examples, readme remission person 15 people reach 45%, and transference cure person 11 people reach 33%, and total effective rate reaches 78%.The curative effect of relevant sciatica, rheumatism, rheumatoid arthritis is being carried out deep research at present.
Claims (4)
1. medicine of treating scapulohumeral periarthritis and rheumatism, it is characterized in that: said medicine is to be processed by following bulk drugs: Rhizoma Et Radix Notopterygii 9-11 part, windproof 9-11 part, Rhizoma Atractylodis 45-55 part, Radix Clematidis 9-11 part; Radix Gentianae Macrophyllae 9-11 part, Herba Asari 18-22 part, Radix Angelicae Dahuricae 9-11 part, Rhizoma Chuanxiong 9-11 part, Cortex Cinnamomi 9-11 part; Semen Phaseoli 18-22 part, Radix Cyathulae 18-22 part, Radix Dipsaci 18-22 part, Herba Taxilli 18-22 part; Radix Codonopsis 9-11 part, Radix Glycyrrhizae 18-22 part, Semen Coicis 9-11 part, indometacin 2-3 part.
2. the medicine of treatment scapulohumeral periarthritis according to claim 1 and rheumatism is characterized in that: said medicine is to be processed by following bulk drugs: 10 parts of Rhizoma Et Radix Notopterygiis, windproof 10 parts, 50 parts of Rhizoma Atractylodis, 10 parts of Radix Clematidis; 10 parts of Radix Gentianae Macrophyllae, 10 parts of Herba Asaris, 10 parts of the Radixs Angelicae Dahuricae, 10 parts of Rhizoma Chuanxiongs, 10 parts of Cortex Cinnamomis; 20 parts of Semen Phaseolis, 20 parts of Radix Cyathulaes, 20 parts of Radix Dipsacis, 20 parts of Herba Taxillis; 10 parts of Radix Codonopsis, 20 parts in Radix Glycyrrhizae, 10 parts of Semen Coiciss, 2.6 parts of indometacin.
3. the medicine of treatment scapulohumeral periarthritis according to claim 1 and rheumatism is characterized in that: the manufacturing approach of said medicine is: get Rhizoma Et Radix Notopterygii 100 grams, windproof 100 grams, Rhizoma Atractylodis 500 grams, Radix Clematidis 100 grams; Radix Gentianae Macrophyllae 100 grams, Herba Asari 200 grams, the Radix Angelicae Dahuricae 100 grams, Rhizoma Chuanxiong 100 grams, Cortex Cinnamomi 100 grams; Semen Phaseoli 200 grams, Radix Cyathulae 200 grams, Radix Dipsaci 200 grams, Herba Taxilli 200 grams, Radix Codonopsis 100 grams; Radix Glycyrrhizae 200 grams, Semen Coicis 100 grams are ground into fine powder, sieve, with indometacin 26 gram mixings; Use water pill, per 10 heavy 2 grams, polishing, dry getting final product.
4. the medicine of treatment scapulohumeral periarthritis according to claim 3 and rheumatism is characterized in that: the method for using of said medicine is: oral, and a 13-15 grain, 2-3 time on the one.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103301231A (en) * | 2013-06-21 | 2013-09-18 | 刘云 | Plant chemome formula used by rheumatoid arthritis patients |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1218675A (en) * | 1997-12-04 | 1999-06-09 | 李明伟 | Tongbi ointment for relieving obstruction |
| CN101254286A (en) * | 2008-04-01 | 2008-09-03 | 李西爱 | Chinese medicinal composition for curing wind dampness and rheumatoid |
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2012
- 2012-01-11 CN CN 201210006954 patent/CN102552742B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1218675A (en) * | 1997-12-04 | 1999-06-09 | 李明伟 | Tongbi ointment for relieving obstruction |
| CN101254286A (en) * | 2008-04-01 | 2008-09-03 | 李西爱 | Chinese medicinal composition for curing wind dampness and rheumatoid |
Non-Patent Citations (1)
| Title |
|---|
| 方勇飞等: "中药成方制剂中风湿病相关方剂数据库的建立与处方分析", 《中国药房》, vol. 14, no. 11, 30 November 2003 (2003-11-30), pages 667 - 670 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103301231A (en) * | 2013-06-21 | 2013-09-18 | 刘云 | Plant chemome formula used by rheumatoid arthritis patients |
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