CN102552729A - Medicament for treating mesangial proliferative glomerulonephritis - Google Patents
Medicament for treating mesangial proliferative glomerulonephritis Download PDFInfo
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- CN102552729A CN102552729A CN2012100341651A CN201210034165A CN102552729A CN 102552729 A CN102552729 A CN 102552729A CN 2012100341651 A CN2012100341651 A CN 2012100341651A CN 201210034165 A CN201210034165 A CN 201210034165A CN 102552729 A CN102552729 A CN 102552729A
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Abstract
The invention discloses a medicament for treating mesangial proliferative glomerulonephritis. The medicament consists of the following Chinese medicines in parts by weight: 8-9 parts of astragalus, 1-2 part of notoginseng root, 2-3 parts of yerbadetajo herb, 2-3 parts of rehmannia root, 1-2 parts of Chinese angelica, 1-2 parts of donkey-hide gelatin, 2-3 parts of spreading hedyotis herb, 2-3 parts of cogongrass rhizome, 2-3 parts of motherwort herb, 1-2 parts of Chinese atractylodes, 1-2 parts of rhubarb, 1-2 parts of indian buead, 1-2 parts of oriental waterplantain rhizome, 1-2 parts of prepared rehmannia rhizome, 2-3 parts of glossy privet fruit and 1-2 parts of south dodder seed and yerbadetajo herb. The medicament disclosed by the invention is a pure Chinese medicinal preparation, has a good curative effect, remarkable action, small side effect and rich medicament sources, does not cause other pathological changes easily, is easy and convenient for preparing, and can be used for treating mesangial proliferative glomerulonephritis.
Description
Technical field
The present invention relates to a kind of nephritis of treating, particularly a kind of medicine of treatment mesangial proliferative glomerulonephritis of pure Chinese medicine.
Background technology
Mesangial proliferative glomerulonephritis; It is a pathological diagnosis; It is characterized by under the light microscopic glomerule be the diffusivity proliferation of mesangial cells with or mesentery substrate increase, and blood capillary is normal, itself can divide into two big types of IgA nephropathy and non-IgA nephropathy according to the immunopathogenesis performance.Wherein IgA nephropathy has become independently renal glomerular disease type, and remaining is referred to as non-IgA mesangial proliferative nephritis, is called for short mesangial proliferative nephritis.The type nephritis is about 1/4 or 1/3 of China's primary glomerulonephritis disease; Accounting for about 1/2 of nephrotic syndrome, is the histological type of the modal primary glomerulopathy of China, its most onset concealments; Clinical serves as main performance with edema, lumbago, weak, albuminuria, hematuria etc.; Can betide any age, see with teenager more, male's case is a little more than the women.The most renal functioies of their early stage are normal, later stage part patient cause renal function deterioration.At present this disease of treatment in, western drug is a lot, but unsatisfactory curative effect, and add other chemicals in the Western medicine, side effect is big, causes other pathological changes easily, should not take for a long time.
Summary of the invention
The present invention be directed to the big defective of western medicine disease side effect, a kind of medicine of evident in efficacy and treatment mesangial proliferative glomerulonephritis that make for pure Chinese medicine is provided.
Realize that above-mentioned purpose adopts following technical scheme: a kind of medicine of treating mesangial proliferative glomerulonephritis, this medicine is made up of following parts by weight of Chinese traditional medicine: Radix Astragali 8-9 part, Radix Notoginseng 1-2 part, Herba Ecliptae 2-3 part, Radix Rehmanniae 2-3 part, Radix Angelicae Sinensis 1-2 part, Colla Corii Asini 1-2 part, Herba Hedyotidis Diffusae 2-3 part, Rhizoma Imperatae 2-3 part, Herba Leonuri 2-3 part, Radix Rubiae 1-2 part, Radix Et Rhizoma Rhei 1-2 part, Poria 1-2 part, Rhizoma Alismatis 1-2 part, Radix Rehmanniae Preparata 1-2 part, Fructus Ligustri Lucidi 2-3 part, Semen Cuscutae 1-2 part, Herba Ecliptae 1-2 part, Cortex Eucommiae 1-2 part.
As preferably, this medicine is made up of following parts by weight of Chinese traditional medicine: 9 parts of the Radixs Astragali, 2 parts of Radix Notoginseng, 3 parts of Herba Ecliptaes, 3 parts in the Radix Rehmanniae, 2 parts of Radix Angelicae Sinensis, 2 parts in Colla Corii Asini, 3 parts of Herba Hedyotidis Diffusaes, 3 parts of Rhizoma Imperataes, 3 parts of Herba Leonuris, 2 parts in Radix Rubiae, 2 parts of Radix Et Rhizoma Rhei, 2 parts in Poria, 2 parts of Rhizoma Alismatis, 2 parts in Radix Rehmanniae Preparata, 3 parts of Fructus Ligustri Lucidi, 2 parts of Semen Cuscutae, 2 parts of Herba Ecliptaes, 2 parts of the Cortexs Eucommiae.
Grind to form after each drug component mixes according to weight portion during fine powder incapsulates, make every medicament capsule that contains 1 gram medicated powder.
Compare with existing therapeutic modality, the disclosed this medicine of the present invention is a pure Chinese medicinal preparation, good drug efficacy, effect obviously, side effect is little, is difficult for causing other pathological changes, and is simple for production, the medicine source is abundant, reaches the effect of treatment mesangial proliferative glomerulonephritis,
The pharmacological action of various medicines among the present invention:
The Radix Astragali: QI invigorating astringency inducing;
Radix Notoginseng: removing stasis to stop bleeding, the analgesic therapy of invigorating blood circulation;
Herba Ecliptae, Radix Rehmanniae, Radix Angelicae Sinensis, Colla Corii Asini: nourishing the liver and kidney, clearing away heat and cooling blood hemostasis
Herba Hedyotidis Diffusae: heat-clearing and toxic substances removing, dampness removing is treating stranguria;
Rhizoma Imperatae, Herba Leonuri, Radix Rubiae: removing heat from blood and promoting blood circulation hemostasis;
Radix Et Rhizoma Rhei: cleanse internal organs, weed out the old and bring forth the new, strengthen metabolism, but and blood circulation promoting and blood stasis dispelling;
Poria: promoting diuresis with drugs of tasteless flavour also can be calmed the nerves;
Rhizoma Alismatis: dampness removing heat;
Radix Rehmanniae Preparata: enriching blood and replenishing vital essence, nourishing the kidney and liver;
Fructus Ligustri Lucidi, Semen Cuscutae, Herba Ecliptae, the Cortex Eucommiae: liver and kidney tonifying.
The specific embodiment
Below in conjunction with embodiment the present invention is done further description.
The medicine of the disclosed this treatment mesangial proliferative glomerulonephritis of the present invention is made up of following parts by weight of Chinese traditional medicine: Radix Astragali 8-9 part, Radix Notoginseng 1-2 part, Herba Ecliptae 2-3 part, Radix Rehmanniae 2-3 part, Radix Angelicae Sinensis 1-2 part, Colla Corii Asini 1-2 part, Herba Hedyotidis Diffusae 2-3 part, Rhizoma Imperatae 2-3 part, Herba Leonuri 2-3 part, Radix Rubiae 1-2 part, Radix Et Rhizoma Rhei 1-2 part, Poria 1-2 part, Rhizoma Alismatis 1-2 part, Radix Rehmanniae Preparata 1-2 part, Fructus Ligustri Lucidi 2-3 part, Semen Cuscutae 1-2 part, Herba Ecliptae 1-2 part, Cortex Eucommiae 1-2 part.
As preferred version: this medicine is made up of following parts by weight of Chinese traditional medicine: the Radix Astragali 90 grams, Radix Notoginseng 20 grams, Herba Ecliptae 30 grams, the Radix Rehmanniae 30 grams, Radix Angelicae Sinensis 20 grams, Colla Corii Asini 20 grams, Herba Hedyotidis Diffusae 30 grams, Rhizoma Imperatae 30 grams, Herba Leonuri 30 grams, Radix Rubiae 20 grams, Radix Et Rhizoma Rhei 20 grams, Poria 20 grams, Rhizoma Alismatis 20 grams, Radix Rehmanniae Preparata 20 grams, Fructus Ligustri Lucidi 30 grams, Semen Cuscutae 20 grams, Herba Ecliptae 20 grams, the Cortex Eucommiae 20 grams.
The weight portion of the Chinese medicine ingredients in this medicine can also be: the Radix Astragali 80 grams, Radix Notoginseng 10 grams, Herba Ecliptae 20 grams, the Radix Rehmanniae 20 grams, Radix Angelicae Sinensis 10 grams, Colla Corii Asini 10 grams, Herba Hedyotidis Diffusae 20 grams, Rhizoma Imperatae 20 grams, Herba Leonuri 20 grams, Radix Rubiae 10 grams, Radix Et Rhizoma Rhei 10 grams, Poria 10 grams, Rhizoma Alismatis 10 grams, Radix Rehmanniae Preparata 10 grams, Fructus Ligustri Lucidi 20 grams, Semen Cuscutae 10 grams, Herba Ecliptae 10 grams, the Cortex Eucommiae 10 grams.
The weight portion of the Chinese medicine ingredients in this medicine can also be: the Radix Astragali 85 grams, Radix Notoginseng 18 grams, Herba Ecliptae 22 grams, the Radix Rehmanniae 26 grams, Radix Angelicae Sinensis 16 grams, Colla Corii Asini 14 grams, Herba Hedyotidis Diffusae 24 grams, Rhizoma Imperatae 25 grams, Herba Leonuri 26 grams, Radix Rubiae 18 grams, Radix Et Rhizoma Rhei 18 grams, Poria 15 grams, Rhizoma Alismatis 17 grams, Radix Rehmanniae Preparata 15 grams, Fructus Ligustri Lucidi 26 grams, Semen Cuscutae 18 grams, Herba Ecliptae 15 grams, the Cortex Eucommiae 15 grams.
Grind to form after each drug component mixes according to weight portion during fine powder incapsulates, make every medicament capsule that contains 1 gram medicated powder.
Instructions of taking: warm water takes after the meal, and every day three times, each 55 restrain totally.Taking medicine to make the state of an illness take a turn for the better to some extent in 2-4 week, and part patient 4-6 can fully recover weekend.
Clinical observation result of the test of the present invention:
Case load 162 examples, wherein 96 examples are organized in treatment, matched group 66 examples.
Physical data, treatment are organized 96 examples, male's 56 examples, women's 40 examples, age 13-64 year, disease time 0.4 year-6 years.
Matched group 66 examples, male's 36 examples, women's 30 examples, age 14-55 year, disease time: 0.5 year-6 years.
Treatment group and matched group curative effect compare:
The treatment group:
Example number: 96 examples
The routine number of fully recovering: 45 examples
Produce effects example number: 28 examples
Effective routine number: 16 examples
Invalid routine number: 6 examples
Dead routine number: 1 example (dying from renal failure)
Total effective routine number: 89 examples, total effective rate 92.7%
Matched group:
Example number: 66 examples
The routine number of fully recovering: 12 examples
Produce effects example number: 16 examples,
Effective routine number: 18 examples
Invalid routine number: 17 examples
Dead routine number: 3 examples (dying from renal failure)
Total effective routine number: 46 examples, total effective rate 69.7%
Treatment group and matched group have significant difference.
In 11.2 weeks of average course of treatment of treatment group, in 11.8 weeks of average course of treatment of matched group, both differed for 0.6 week.
Model case:
Example 1, field, the woman, 15 years old, the student of Yutian County suffered from mesangial proliferative glomerulonephritis 0.5 year, failed to cure through multi-treatment, and the back is with of the present invention day clothes 3 times, and each 5, took for 6 weeks, the basic healing so far recurred.
Example 2, Lee, 29 years old, the man, people from Ninghe County, Tianjin suffered from mesangial proliferative glomerulonephritis 1 year, took the present invention, day clothes 3 times, each 5, the 3-4 week state of an illness of taking medicine takes a turn for the better to some extent, takes for 9 weeks altogether and cures.
Example 3, in certain, the man, 42 years old, people from Yutian County suffered from mesangial proliferative glomerulonephritis 4 years, fail to cure through multi-treatment, after take the present invention, day clothes 3 times, were taken for 11 weeks and are cured, so far recurrence by each 5.
More than disclosedly be merely specific embodiment of the present invention, but the present invention is not limited thereto, any those skilled in the art can think variation, all should drop within protection scope of the present invention.
Claims (3)
1. medicine of treating mesangial proliferative glomerulonephritis; It is characterized in that this medicine is made up of following parts by weight of Chinese traditional medicine: Radix Astragali 8-9 part, Radix Notoginseng 1-2 part, Herba Ecliptae 2-3 part, Radix Rehmanniae 2-3 part, Radix Angelicae Sinensis 1-2 part, Colla Corii Asini 1-2 part, Herba Hedyotidis Diffusae 2-3 part, Rhizoma Imperatae 2-3 part, Herba Leonuri 2-3 part, Radix Rubiae 1-2 part, Radix Et Rhizoma Rhei 1-2 part, Poria 1-2 part, Rhizoma Alismatis 1-2 part, Radix Rehmanniae Preparata 1-2 part, Fructus Ligustri Lucidi 2-3 part, Semen Cuscutae 1-2 part, Herba Ecliptae 1-2 part, Cortex Eucommiae 1-2 part.
2. the medicine of treatment mesangial proliferative glomerulonephritis according to claim 1; It is characterized in that this medicine is made up of following parts by weight of Chinese traditional medicine: 9 parts of the Radixs Astragali, 2 parts of Radix Notoginseng, 3 parts of Herba Ecliptaes, 3 parts in the Radix Rehmanniae, 2 parts of Radix Angelicae Sinensis, 2 parts in Colla Corii Asini, 3 parts of Herba Hedyotidis Diffusaes, 3 parts of Rhizoma Imperataes, 3 parts of Herba Leonuris, 2 parts in Radix Rubiae, 2 parts of Radix Et Rhizoma Rhei, 2 parts in Poria, 2 parts of Rhizoma Alismatis, 2 parts in Radix Rehmanniae Preparata, 3 parts of Fructus Ligustri Lucidi, 2 parts of Semen Cuscutae, 2 parts of Herba Ecliptaes, 2 parts of the Cortexs Eucommiae.
3. the medicine of treatment mesangial proliferative glomerulonephritis according to claim 1 is characterized in that, grinds to form after each drug component mixes according to weight portion during fine powder incapsulates, and makes every medicament capsule that contains 1 gram medicated powder.
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| CN2012100341651A CN102552729B (en) | 2012-02-16 | 2012-02-16 | Medicament for treating mesangial proliferative glomerulonephritis |
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| CN2012100341651A CN102552729B (en) | 2012-02-16 | 2012-02-16 | Medicament for treating mesangial proliferative glomerulonephritis |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103028056A (en) * | 2012-12-04 | 2013-04-10 | 肖毅峰 | Frequently-drank tea-substituting traditional Chinese medicine preparation for treating kidney diseases |
| CN103961582A (en) * | 2014-05-23 | 2014-08-06 | 申立红 | Traditional Chinese medicine composition for treating nephritis, and preparation and preparation method thereof |
| CN105395936A (en) * | 2015-12-03 | 2016-03-16 | 青岛市市立医院 | Pharmaceutical composition for treating mesangial proliferative nephritis and application of pharmaceutical composition |
-
2012
- 2012-02-16 CN CN2012100341651A patent/CN102552729B/en not_active Expired - Fee Related
Non-Patent Citations (2)
| Title |
|---|
| 伍新林等: "系膜增生性肾小球肾炎的中医药研究综述", 《中药材》 * |
| 吕勇: "中医药治疗系膜增生性肾小球肾炎的研究进展", 《安徽中医学院学报》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103028056A (en) * | 2012-12-04 | 2013-04-10 | 肖毅峰 | Frequently-drank tea-substituting traditional Chinese medicine preparation for treating kidney diseases |
| CN103961582A (en) * | 2014-05-23 | 2014-08-06 | 申立红 | Traditional Chinese medicine composition for treating nephritis, and preparation and preparation method thereof |
| CN103961582B (en) * | 2014-05-23 | 2017-10-13 | 申立红 | Treat the Chinese medicine composition and its preparation and preparation method of ephritis |
| CN105395936A (en) * | 2015-12-03 | 2016-03-16 | 青岛市市立医院 | Pharmaceutical composition for treating mesangial proliferative nephritis and application of pharmaceutical composition |
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| CN102552729B (en) | 2013-07-31 |
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