CN102552413A - Traditional Chinese medicine mixed volatile oil for energizing and restoring consciousness simultaneously in automobiles and preparation method thereof - Google Patents
Traditional Chinese medicine mixed volatile oil for energizing and restoring consciousness simultaneously in automobiles and preparation method thereof Download PDFInfo
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- CN102552413A CN102552413A CN2010106083404A CN201010608340A CN102552413A CN 102552413 A CN102552413 A CN 102552413A CN 2010106083404 A CN2010106083404 A CN 2010106083404A CN 201010608340 A CN201010608340 A CN 201010608340A CN 102552413 A CN102552413 A CN 102552413A
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Abstract
The invention discloses traditional Chinese medicine mixed volatile oil for energizing and restoring consciousness simultaneously in automobiles and a preparation method thereof. The traditional Chinese medicine mixed volatile oil comprises following materials by weight ratio: 20% to 40% of syzygium aromaticum, 20% to 40% of ligusticum wallichii, 5% to 20% of borneol and 30% to 60% of rhizoma atractylodis. The materials are mixed to extract volatile oil, 5% to 20% of borneol is added, and the volatile oil is obtained after purification. Pharmacodynamics researches find that the traditional Chinese medicine mixed volatile oil has strong effects on nervous centralis excitability, namely restoring consciousness and excitation, and simultaneously the traditional Chinese medicine mixed volatile oil has tong coordinate repression effects on bacteria in air.
Description
Technical field
The present invention relates to a kind of Chinese medicine mixed volatilization oil, relate in particular to a kind of Chinese medicine mixed volatilization oil that is used for refreshment degerming simultaneously in the car and preparation method thereof.
Background technology
Along with growth in the living standard, the increase of domestic vehicle makes that the time of people in private car more and more, but the in-vehicle air pollution of home vehicle, long driving all can make people's dizziness, feel sleepy simultaneously; Occurrence of traffic accident very easily, light property loss then, heavy then personal injury.Present automobile-used perfume can only play and improve abnormal smells from the patient in the car, and joyful person for driving a car's mood can not directly effectively be improved person for driving a car's the mental status.
To have the sachet that makes in smalls dress and different, the embroidery capsule that differs in size of Chinese herbal medicine development of multiple strong aromatic odor and be China and be used for the mode of refreshing oneself the earliest.This mixed volatilization oil can play the refreshment effect, and this mixed volatilization oil has very strong coordinate repression for airborne antibacterial in the car simultaneously.Chemical constitution study shows: Borneolum Syntheticum, main component be sesquiterpenes such as Borneolum Syntheticum, Humuleno, elemene (Huang Weidong, Lv Wuqing. the progress of Borneolum Syntheticum. symposium .1006-4931 (2008) 04-0064-03); The Rhizoma Chuanxiong volatile oil main component is a ligustilide, dihydro-homophthalic lactone (Zhang Dalei, Li Guisheng. the progress of Rhizoma Chuanxiong volatile oil. the time precious traditional Chinese medical science traditional Chinese medicines .1008-0805 (2005) 07-0664-02); The Flos Caryophylli volatile oil main component be eugenol (Fu Zhenxi, Wang Jianqing etc. the extraction process of Flos Caryophylli volatile oil and chemical composition analysis. Anhui agricultural sciences .0517-6611 (2010) 11-05628-03) reason research shows; The Rhzoma Atractylodis Lanceae volatile oil main component be atisine chloride atractydin, atractylone and sagittol (Liu Xiaoning, Hou Fangjie etc. different places of production Rhzoma Atractylodis Lanceae volatile oil characteristic chemical constituent is analyzed. the journal .1000-5005 of Nanjing University of Traditional Chinese Medicine (2009) 01-0051-03).Existing pharmacological research shows: Borneolum Syntheticum has stronger adjusting central nervous excitation property effect, has simultaneously with other drug to share the effect of strengthening curative effect of medication; Vasomotor center, respiratory center and spinal reflex that Rhizoma Chuanxiong has medulla oblongata have excitation; Flos Caryophylli has the effect of inspiring enthusiasm, excite intelligence, has bacteriostasis simultaneously; Rhizoma Atractylodis have the inhibitory action stronger to pathogenic bacterium.In the prior art still no-trump Rhizoma Chuanxiong, Flos Caryophylli and Rhizoma Atractylodis with certain proportion mixed extraction volatile oil after, add mixture that a certain amount of Borneolum Syntheticum purification makes as a kind of bibliographical information that is used for the Chinese medicine mixed volatilization oil of refreshment degerming simultaneously in the car.
Summary of the invention
The technical problem that the present invention will solve provides a kind of method for preparing that is used for Chinese medicine mixed volatilization oil and this Chinese medicine mixed volatilization oil of refreshment degerming simultaneously in the car.
In one aspect of the invention, a kind of Chinese medicine mixed volatilization oil that is used for refreshment degerming simultaneously in the car is provided, forms by the crude drug of following weight ratio: Flos Caryophylli: 20-40%, Rhizoma Chuanxiong: 20-40%, Borneolum Syntheticum: 5-20%, Rhizoma Atractylodis: 15-60%.Can the be direct uncovered volatilization naturally of this mixed volatilization oil onset, the volatile material that also can add a certain amount of adjuvant or other kinds is prepared into nasal formulations, distillate medicinal water and fragrant card with it, wherein is index components with Borneolum Syntheticum, and its content is 10%-30%.
Nasal formulations of the present invention is that comprising of stipulating in the pharmacopeia, nasal drop, nasal spray, nose were with dosage forms such as ointments.
Adjuvant of the present invention is solubilizing agent commonly used, suspending agent, emulsifying agent etc.
Volatile material of the present invention comprise volatile oil, quintessence oil, and part volatile organic compound is arranged.
The method for preparing of mixture of volatile oil disclosed by the invention comprises the following steps:
1. the preparation of volatile oil
(1) pre-treatment: with Flos Caryophylli, Rhizoma Chuanxiong, Rhizoma Atractylodis pulverize separately to 20 order.Above-mentioned mixed-powder is put into baking oven, with 40 ℃ of bakings 8-12 hour.With above-mentioned powder in Flos Caryophylli: the ratio of Rhizoma Chuanxiong: Rhizoma Atractylodis=20-40: 20-40: 30-60 is mixed.
(2) CO2 supercritical extraction: the extraction kettle of the above-mentioned powder that mixes being put into supercritical extraction unit.With the extracting pressure is that 15-25Mpa, extraction temperature are 45-55 ℃, CO
2Flow velocity is 20-30Kg/h, and the time is that 1-2h is that condition extracts, and collects product.
(3) purification: above-mentioned supercritical extraction product by not preceding mixed-powder: Borneolum Syntheticum=80-95: the 20-5 mixing of extraction, is added 3 times to the ethanol of said mixture, under 45 ℃ temperature, stir, filter while hot, reclaim ethanol, promptly get.
2. the preparation of product
This mixed volatilization oil can be directly uncovered, volatilization onset naturally, and also desirable above-mentioned mixed volatilization oil is processed nasal formulations, distillate medicinal water and fragrant card by conventional method, wherein is index components with Borneolum Syntheticum, and its content is 10%-50%.
3. the effect experiment of Chinese medicine mixed volatilization oil
3.1 mixture of volatile oil is to the excitatoty influence of central nervous system
Animal: NIH mice, 40,20 ± 2g, male and female half and half.
Divide into groups and administration: animal is divided into 4 groups at random, and (the crude drug component ratio is respectively: first group: Flos Caryophylli: Rhizoma Chuanxiong: Rhizoma Atractylodis: Borneolum Syntheticum=4: 4: 11: 1 to be respectively the mixed volatilization oil administration group of model group and three kinds of different crude drug proportionings; Second group: Flos Caryophylli: Rhizoma Chuanxiong: Rhizoma Atractylodis: Borneolum Syntheticum=5: 5: 8: 2; The 3rd group: Flos Caryophylli: Rhizoma Chuanxiong: Rhizoma Atractylodis: Borneolum Syntheticum=6: 7: 3: 4; The medical material total amount of crude drug is 5g).After processing mixture of volatile oil respectively by above-mentioned method for preparing, add tween 80, antiseptic is processed spray.Wherein model group is only given the spray that contains tween 80 and antiseptic.
Test in 24-25 ℃ of quiet environment and carry out, first via intranasal application gives spray, after 15 minutes, and every mouse peritoneal injection 50mg/kg pentobarbital sodium.Observe sleep time of occurrence and persistent period.(reaching more than the 1min with the animal righting reflex loss is the sleep sign)
The result sees table 1
Table 1 mixture of volatile oil is to the influence
of mice sleep
Annotate: compare with model group
*, P＜0.05;
*, P＜0.01
Results suggest: this mixed volatilization oil nose administration can significantly resist the time for falling asleep and the persistent period of injection pentobarbital sodium in mice sleep, has the excitability action to the central nervous system.
3.2 bacteriostatic test
Material: staphylococcus aureus, escherichia coli, bacillus pyocyaneus (preservation of microorganism teaching and research room of Shanghai Univ. of Traditional Chinese Medicine).
Get frozen staphylococcus aureus respectively, escherichia coli, the recovery of bacillus pyocyaneus strain, the meat soup nutritional solution increases bacterium, gradient dilution, counting makes every milliliter of bacterium liquid contain the bacterium number 3 * 10
3About, get equivalent bacterium liquid and be inoculated into broth agar culture medium planar surface (every ware 0.1ml) respectively.
To inoculate germy culture dish flat board be placed horizontally at the room (2m * 3m * 2.5mm) diagonal two and central ground, 3 are put in every place, in addition in the room diagonal two vertical wall (2m eminence) respectively to paste 3 germy culture dishs of inoculation with double faced adhesive tape dull and stereotyped.Room temperature is controlled at about 20 ℃.
Volatile oil fumigation liquid sterilization, (the crude drug component ratio is respectively: first group: Flos Caryophylli: Rhizoma Chuanxiong: Rhizoma Atractylodis: Borneolum Syntheticum=4: 4: 11: 1 to get this mixed volatilization oil of different crude drug ratios respectively; Second group: Flos Caryophylli: Rhizoma Chuanxiong: Rhizoma Atractylodis: Borneolum Syntheticum=5: 5: 8: 2; The 3rd group: Flos Caryophylli: Rhizoma Chuanxiong: Rhizoma Atractylodis: Borneolum Syntheticum=6: 7: 3: 4; ) process fumigation liquid, electrical heating makes volatilization fully, and every cubic metre of space amount of consumption of drugs is equivalent to the 1g crude drug, takes out flat board behind the 1h, send 37 ℃ of incubators to cultivate 48h, the counting bacterium colony.
Volatile oil fumigant sterilization, this mixed volatilization oil (ratio as above) of getting different crude drug ratios respectively add the fumigant that the ethanol of two volumes is processed, and light; Every cubic metre of space amount of consumption of drugs is equivalent to the 1g crude drug; Afterburnt 1h takes out dull and stereotyped, send 37 ℃ of incubators to cultivate 48h, the counting bacterium colony.
Matched group does not carry out disinfection, and it is the same to cultivate counting.
Antibacterial percentage rate (%)=(the dull and stereotyped average clump count of matched group-sterilization group flat-plate bacterial colony the number)/dull and stereotyped average clump count of matched group * 100%.
The result sees table 2,3
The antibacterial percentage rate of table 2 volatile oil fumigation liquid
Annotate: compare with model group
*, P＜0.05;
*, P＜0.01
The antibacterial percentage rate of table 3 volatile oil fumigant
Annotate: compare with model group
*, P＜0.05;
*, P＜0.01
Results suggest: fumigation liquid, the fumigant processed by this mixed volatilization oil have the obvious synergistic inhibitory action for staphylococcus aureus, escherichia coli and bacillus pyocyaneus, possibly very strong coordinate repression arranged for airborne antibacterial.
Claims (6)
1. a Chinese medicine mixed volatilization oil that is used for refreshment degerming simultaneously in the car is characterized in that, described Chinese medicine mixed volatilization oil is by following crude drug: Flos Caryophylli, Rhizoma Chuanxiong behind the Rhizoma Atractylodis mixed extraction volatile oil, adds a certain amount of Borneolum Syntheticum, makes behind the purification.
2. the Chinese medicine mixed volatilization oil that is used for refreshment degerming simultaneously in the car as claimed in claim 1; It is characterized in that the Flos Caryophylli of above-mentioned medical material by following weight ratio: 20-40%, the Rhizoma Chuanxiong of 20-40% is behind the Rhizoma Atractylodis mixed extraction volatile oil of 15-60%; Add the Borneolum Syntheticum of 5-20%, make behind the purification.
3. the Chinese medicine mixed volatilization oil that is used for refreshment degerming simultaneously in the car as claimed in claim 1; It is characterized in that preferred medical material is by following weight ratio: 25% Flos Caryophylli, 25% Rhizoma Chuanxiong is behind 45% the Rhizoma Atractylodis mixed extraction volatile oil; The Borneolum Syntheticum of adding 5% makes behind the purification.
4. the Chinese medicine mixed volatilization oil that is used for refreshment degerming simultaneously in the car as claimed in claim 1 is characterized in that passing through CO after above-mentioned medical material mixes
2After the method for supercritical extraction makes volatile oil, add Borneolum Syntheticum, make behind the purification, the method for not getting rid of through vapor distillation, organic reagent extraction and squeezing obtains the oil condition of volatilizing.
5. the method for preparing that is used for the Chinese medicine mixed volatilization oil of refreshment degerming simultaneously in the car as claimed in claim 1 is characterized in that above-mentioned mixed volatilization oil is made by following method: get Flos Caryophylli, Rhizoma Chuanxiong and Rhizoma Atractylodis and pulverize, dry, proportional mixing, CO
2Supercritical extraction adds a certain proportion of Borneolum Syntheticum, adds the ethanol heated and stirred, filters, and reclaims ethanol, promptly gets.
6. the method for using that is used for the Chinese medicine mixed volatilization oil of refreshment degerming simultaneously in the car as claimed in claim 1; It is characterized in that above-mentioned mixed volatilization oil can directly uncoveredly be positioned over around the air outlet in the driver's cabin; Naturally volatilization back onset is not got rid of above-mentioned mixed volatilization oil is processed nasal formulations, distillate medicinal water and fragrant card.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106822506A (en) * | 2017-03-02 | 2017-06-13 | 清华大学 | A kind of Alevaire of effect of overcoming difficulties of refreshing oneself with driving over a long distance |
| CN108721671A (en) * | 2018-06-13 | 2018-11-02 | 李帛昀 | Student's air freshener with functions of refreshing brain and restoring consciousness and preparation method thereof |
| CN113068721A (en) * | 2021-03-26 | 2021-07-06 | 安徽中医药大学 | Self-heating refrigerator bacteriostatic deodorant and preparation method thereof |
-
2010
- 2010-12-23 CN CN2010106083404A patent/CN102552413A/en active Pending
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106822506A (en) * | 2017-03-02 | 2017-06-13 | 清华大学 | A kind of Alevaire of effect of overcoming difficulties of refreshing oneself with driving over a long distance |
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| CN108721671A (en) * | 2018-06-13 | 2018-11-02 | 李帛昀 | Student's air freshener with functions of refreshing brain and restoring consciousness and preparation method thereof |
| CN113068721A (en) * | 2021-03-26 | 2021-07-06 | 安徽中医药大学 | Self-heating refrigerator bacteriostatic deodorant and preparation method thereof |
| CN113068721B (en) * | 2021-03-26 | 2022-06-21 | 安徽中医药大学 | Self-heating refrigerator bacteriostatic deodorant and preparation method thereof |
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Application publication date: 20120711 |