CN102551917A - Artificial fallopian tube and preparation method thereof - Google Patents
Artificial fallopian tube and preparation method thereof Download PDFInfo
- Publication number
- CN102551917A CN102551917A CN2011104011675A CN201110401167A CN102551917A CN 102551917 A CN102551917 A CN 102551917A CN 2011104011675 A CN2011104011675 A CN 2011104011675A CN 201110401167 A CN201110401167 A CN 201110401167A CN 102551917 A CN102551917 A CN 102551917A
- Authority
- CN
- China
- Prior art keywords
- artificial
- tube
- oviduct
- braided tube
- fallopian tube
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Landscapes
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Abstract
The invention relates to an artificial fallopian tube and a preparation method thereof. The artificial fallopian tube is a polyester fiber weaving tube, a fluororesin layer is arranged on the inner layer of the weaving tube, and a degradable polymer coating membrane containing anti-adhesion medicine is located at a port of the weaving tube. The preparation method includes (1), weaving polyester fibers into the polyester fiber weaving tube and leading the polyester fiber weaving tube to be in heat setting at the temperature ranging from 140 DEG C to 160 DEG C; (2), coating acrylic ester emulsion containing fluoride on the inner layer of the weaving tube, and then drying the inner layer of the weaving tube to obtain the weaving tube with the fluororesin layer inside; and (3), preparing anti-adhesion medicine and the degradable polymer into solution, coating the solution onto a horn-shaped mold, obtaining horn-shaped membranes after drying, respectively placing the horn-shaped membranes into two horn mouth ends, and obtaining the artificial fallopian tube via hot pressing. The artificial fallopian tube can replace a part, which is blocked and necrotic, of a fallopian tube, is connected to the original fallopian tube so as to guarantee that ova pass through the fallopian tube smoothly; and a suture opening is high in mechanical strength, so that the artificial fallopian tube is not easy to be torn off.
Description
Technical field
The invention belongs to medical department of obstetrics and gynecology field, particularly a kind of artificial oviduct and preparation method thereof.
Background technology
At present, in the infertility that causes by women's pathologic problems, there is considerable part to stop up by fallopian tube adhesion and cause.The generation of adhesion mainly is that the serious inflammation of fallopian tube causes.Adhesion also do not stop up fully before, can adopt method such as anti support to come Film with Preventing Adhesion to stop up.For the patient that fallopian tube adhesion is stopped up, just be difficult to get through again.
Artificial oviduct is to have the artificial organ that cover, an end are equipped with check valve by the end that natural rubber is made; In order to replace fallopian tube hypoplasia, cornua uteri adenomyoma or because of bacterial infection etc. causes the fallopian tube that stops up, the research work of artificial oviduct is also very immature at present.
Summary of the invention
Technical problem to be solved by this invention provides a kind of artificial oviduct and preparation method thereof, and this fallopian tube can substitute and stop up downright bad part fallopian tube, is linked into former fallopian tube position to guarantee the current smoothness of ovum; It is big to sew up mouthful mechanical strength, is difficult for tearing.
A kind of artificial oviduct of the present invention, said artificial oviduct are the polyster fibre braided tube, and the braided tube internal layer is a fluororesin layer, and the degradable polymer coated film that contains the anti medicine is positioned at the port of braided tube.
The specification of said polyster fibre is 6～300d/2～100F.
Said polyster fibre braided tube mid diameter is 2～3mm, horn mouth diameter 2～3mm, and length is 2～3mm.
Said fluororesin is formed by fluorine-containing acrylic acid ester emulsion drying.
The weight ratio of said anti medicine and degradable polymer is 1～3: 97～99.
Said anti medicine is chitosan or humic acids.
Said degradable polymer is the copolymer of one or more formations in polylactic acid, polycaprolactone, the poly butyric ester.
The method for preparing of a kind of artificial oviduct of the present invention comprises:
(1) polyster fibre is woven into the polyster fibre braided tube, in 140～160 ℃ of thermal finalizations;
(2), the braided tube of fluororesin layer is arranged in dry then the obtaining with the above-mentioned braided tube internal layer of fluorine-containing acrylic acid ester emulsion brushing;
(3) be 1～3: 97～99 for anti medicine and degradable polymer wiring solution-forming with weight ratio, be applied on the trumpet-shaped mould, dry must horn-like film, put into two bell-mouthed ends to horn-like film respectively, get artificial oviduct through hot pressing.
The polyster fibre braided tube is foolproof material, has been used for artificial cardiovascular manufacturing.Fluor resin coating has good lubricity and chemistry, biologically inert, is a foolproof material.Internal layer also scribbles the degradable polymer that contains the anti medicine at oviducal two ends of the present invention; This coated film is slightly extended pipe; Degradable polymer is progressively degraded in vivo; Discharge the anti medicine when excreting, can prevent sewing up the interface obstruction new because of hamartoplasia causes.
Beneficial effect
(1) the present invention can substitute and stop up downright bad part fallopian tube, is linked into former fallopian tube position to guarantee the current smoothness of ovum;
(2) characteristics of the present invention are that stitching mouthful mechanical strength is big, are difficult for tearing; Inside pipe wall is lubricated to travel forward with favourable ovum, uses the women of artificial oviducal former salpingemphraxis, can become pregnant with the same intrauterine at oneself of normal women.
Description of drawings
Fig. 1 is a structural representation of the present invention; Wherein 1 is the polyster fibre braided tube, and 2 is fluororesin layer, and 3 for containing the degradable polymer coated film of anti medicine.
The specific embodiment
Below in conjunction with specific embodiment, further set forth the present invention.Should be understood that these embodiment only to be used to the present invention is described and be not used in the restriction scope of the present invention.Should be understood that in addition those skilled in the art can do various changes or modification to the present invention after the content of having read the present invention's instruction, these equivalent form of values fall within the application's appended claims institute restricted portion equally.
Use the polyster fibre of 50d/10F to be woven into mid diameter and be 5mm as 2mm, horn mouth diameter; Length is the polyster fibre braided tube of 25mm; Under 150 ℃ of temperature, finalize the design, the acrylic acid ester emulsion brushing braided tube internal layer that reuse is fluorine-containing has the braided tube of fluororesin layer in dry then the obtaining.To trumpet-shaped mould, it is 2: 98 horn-like film that drying obtains humic acids and polycaprolactone, puts into two flare end to two these films respectively, obtains artificial oviduct through hot pressing with the solution coat that contains 2 gram humic acidss, 98 gram polycaprolactones.
Use the polyster fibre of 6d/100F to be woven into mid diameter and be 6mm as 3mm, horn mouth diameter; Length is the polyster fibre braided tube of 30mm; Under 140 ℃ of temperature, finalize the design, the acrylic acid ester emulsion brushing braided tube internal layer that reuse is fluorine-containing has the braided tube of fluororesin layer in dry then the obtaining.To trumpet-shaped mould, it is 1: 99 horn-like film that drying obtains humic acids and polylactic acid, puts into two flare end to two these films respectively, obtains artificial oviduct through hot pressing with the solution coat that contains 1 gram humic acids, 99 gram polylactic acid.
Embodiment 3
Use the polyster fibre of 300d/2F to be woven into mid diameter and be 6mm as 3mm, horn mouth diameter; Length is the polyster fibre braided tube of 24mm; Under 160 ℃ of temperature, finalize the design, the acrylic acid ester emulsion brushing braided tube internal layer that reuse is fluorine-containing has the braided tube of fluororesin layer in dry then the obtaining.To trumpet-shaped mould, it is 3: 97 horn-like film that drying obtains chitosan and poly butyric ester, puts into two flare end to two these films respectively, obtains artificial oviduct through hot pressing with the solution coat that contains 3 gram chitosan, 97 gram poly butyric esters.
Embodiment 4
Use the polyster fibre of 15d/60F to be woven into mid diameter and be 5mm as 2mm, horn mouth diameter; Length is the polyster fibre braided tube of 30mm; Under 145 ℃ of temperature, finalize the design, the acrylic acid ester emulsion brushing braided tube internal layer that reuse is fluorine-containing has the braided tube of fluororesin layer in dry then the obtaining.To trumpet-shaped mould, it is 3: 97 horn-like film that drying obtains humic acids and poly butyric ester, puts into two flare end to two these films respectively, obtains artificial oviduct through hot pressing with the solution coat that contains 3 gram humic acidss, 97 gram poly butyric esters.
Claims (8)
1. artificial oviduct, it is characterized in that: said artificial oviduct is the polyster fibre braided tube, and the braided tube internal layer is a fluororesin layer, the degradable polymer coated film that contains the anti medicine is positioned at the port of braided tube.
2. a kind of artificial oviduct according to claim 1 is characterized in that: the specification of said polyster fibre is 6～300d/2～100F.
3. a kind of artificial oviduct according to claim 1 is characterized in that: said polyster fibre braided tube mid diameter is 2～3mm, horn mouth diameter 2～3mm, and length is 2～3mm.
4. a kind of artificial oviduct according to claim 1 is characterized in that: said fluororesin is formed by fluorine-containing acrylic acid ester emulsion drying.
5. a kind of artificial oviduct according to claim 1 is characterized in that: the weight ratio of said anti medicine and degradable polymer is 1～3: 97～99.
6. according to claim 1 or 5 described a kind of artificial oviducts, it is characterized in that: said anti medicine is chitosan or humic acids.
7. according to claim 1 or 5 described a kind of artificial oviducts, it is characterized in that: said degradable polymer is the copolymer of one or more formations in polylactic acid, polycaprolactone, the poly butyric ester.
8. the method for preparing of an artificial oviduct comprises:
(1) polyster fibre is woven into the polyster fibre braided tube, in 140～160 ℃ of thermal finalizations;
(2), the braided tube of fluororesin layer is arranged in dry then the obtaining with the above-mentioned braided tube internal layer of fluorine-containing acrylic acid ester emulsion brushing;
(3) be 1～3: 97～99 for anti medicine and degradable polymer wiring solution-forming with weight ratio, be applied on the trumpet-shaped mould, dry must horn-like film, put into two bell-mouthed ends to horn-like film respectively, get artificial oviduct through hot pressing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110401167.5A CN102551917B (en) | 2011-12-06 | 2011-12-06 | Artificial fallopian tube and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110401167.5A CN102551917B (en) | 2011-12-06 | 2011-12-06 | Artificial fallopian tube and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102551917A true CN102551917A (en) | 2012-07-11 |
| CN102551917B CN102551917B (en) | 2015-06-03 |
Family
ID=46399411
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201110401167.5A Expired - Fee Related CN102551917B (en) | 2011-12-06 | 2011-12-06 | Artificial fallopian tube and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102551917B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112535767A (en) * | 2019-09-20 | 2021-03-23 | 江苏启灏医疗科技有限公司 | Preparation method of fallopian tube scaffold |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3343248A1 (en) * | 1983-11-30 | 1985-06-05 | Mohamed Naim Dr.med. 3000 Hannover Saymé | Implant as substitute for a fallopian tube whose function is disturbed |
| US4574000A (en) * | 1984-08-24 | 1986-03-04 | Hunter Stephen K | Artificial fallopian tube |
| CN1300579A (en) * | 2001-02-12 | 2001-06-27 | 周星 | Artificial intracavity duct |
| CN2617333Y (en) * | 2003-04-25 | 2004-05-26 | 杜永义 | Articial multi-use implantation tube |
| CN2726573Y (en) * | 2004-07-02 | 2005-09-21 | 山东省计划生育科学技术研究所 | Restorable memory alloy silicone rubber oviduct cork |
| CN1897990A (en) * | 2003-12-22 | 2007-01-17 | 株式会社I.S.T. | Medical tube and its manufacturing method |
| CN2870771Y (en) * | 2006-03-07 | 2007-02-21 | 王哲 | Utering tube interstitialis stand and holder |
-
2011
- 2011-12-06 CN CN201110401167.5A patent/CN102551917B/en not_active Expired - Fee Related
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3343248A1 (en) * | 1983-11-30 | 1985-06-05 | Mohamed Naim Dr.med. 3000 Hannover Saymé | Implant as substitute for a fallopian tube whose function is disturbed |
| US4574000A (en) * | 1984-08-24 | 1986-03-04 | Hunter Stephen K | Artificial fallopian tube |
| CN1300579A (en) * | 2001-02-12 | 2001-06-27 | 周星 | Artificial intracavity duct |
| CN2617333Y (en) * | 2003-04-25 | 2004-05-26 | 杜永义 | Articial multi-use implantation tube |
| CN1897990A (en) * | 2003-12-22 | 2007-01-17 | 株式会社I.S.T. | Medical tube and its manufacturing method |
| CN2726573Y (en) * | 2004-07-02 | 2005-09-21 | 山东省计划生育科学技术研究所 | Restorable memory alloy silicone rubber oviduct cork |
| CN2870771Y (en) * | 2006-03-07 | 2007-02-21 | 王哲 | Utering tube interstitialis stand and holder |
Non-Patent Citations (3)
| Title |
|---|
| 刘静等: "进口医用可吸收缝合线做支架用于输卵管子宫角植入术的体会", 《中国计划生育学杂志》, vol. 11, no. 7, 31 December 2003 (2003-12-31), pages 435 - 2 * |
| 张辉等: "腐植酸铈的抑菌作用", 《中国稀土学报》, vol. 16, no. 3, 31 December 1998 (1998-12-31), pages 97 * |
| 张雅萍等: "甲壳胺影响变形链球菌粘附力的研究", 《中国微生态学杂志》, vol. 13, no. 5, 31 October 2001 (2001-10-31), pages 269 - 270 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112535767A (en) * | 2019-09-20 | 2021-03-23 | 江苏启灏医疗科技有限公司 | Preparation method of fallopian tube scaffold |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102551917B (en) | 2015-06-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101078134B (en) | Preparation of natural material/polymer material coaxial electrostatic spinning nano fibre | |
| Gao et al. | High-strength hydrogel-based bioinks | |
| CN107280718B (en) | Folding and unfolding rigidity-variable instrument arm for natural orifice surgery | |
| CN101234041A (en) | Atrial septal defect plugging device knitted by degradable material | |
| JP2005046184A (en) | Catheter with extender | |
| CN111000661B (en) | Composite artificial blood vessel and preparation method thereof | |
| CN112472361B (en) | Anti-bending artificial blood vessel and preparation method thereof | |
| CN102551917B (en) | Artificial fallopian tube and preparation method thereof | |
| CN106955411A (en) | A kind of new uropoiesis and digestive endoscope zebra superslide seal wire | |
| CN102580171B (en) | Bronchus flap and manufacturing method thereof | |
| Tran et al. | Bio-inspired barbed microneedle for skin adhesion with interlocking mechanics | |
| CN101234042B (en) | Method for knitting degradable heart atrial septal defect plugging device | |
| CN204106256U (en) | A kind of fibrous membrane/yarn count frame of the novel nano for graft of trachea | |
| CN104473706B (en) | Biodegradable composite type tubular urethral stent and preparation method | |
| CN103429280A (en) | Use of medical implant as adhesion barrier | |
| CN208492200U (en) | A kind of injecting glue closure left auricle of heart device of the front end with closure sacculus | |
| CN115068700B (en) | Multifunctional composite abdominal wall hernia repair patch and preparation method thereof | |
| CN109481828A (en) | A kind of novel seal wire and its application | |
| CN218792630U (en) | Anti-bending artificial blood vessel | |
| CN110124102A (en) | Method of the preparation for the doughnut conduit and its bundle structure object of neural restoration | |
| CN101244293A (en) | Jack-in inside and outside wall dual structure polytetrafluoroethylene artificial bile duct and preparation | |
| CN207370969U (en) | A kind of new uropoiesis and digestive endoscope zebra superslide seal wire | |
| CN106827379A (en) | The production technology of sandwich developing line | |
| CN204618494U (en) | A kind of degradable composite tubular urethra rack | |
| JP2007289634A (en) | Bioabsorbable tube and its manufacturing method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20150603 Termination date: 20171206 |