CN102526624A - Chinese medicinal preparation for treating mild cognitive impairment - Google Patents
Chinese medicinal preparation for treating mild cognitive impairment Download PDFInfo
- Publication number
- CN102526624A CN102526624A CN2012100284254A CN201210028425A CN102526624A CN 102526624 A CN102526624 A CN 102526624A CN 2012100284254 A CN2012100284254 A CN 2012100284254A CN 201210028425 A CN201210028425 A CN 201210028425A CN 102526624 A CN102526624 A CN 102526624A
- Authority
- CN
- China
- Prior art keywords
- parts
- filtering residue
- mild cognitive
- cognitive impairment
- radix
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a Chinese medicinal preparation for treating mild cognitive impairment. The Chinese medicinal preparation is prepared from the following Chinese herbal medicines in part by weight: 10 to 20 parts of acorus gramineus, 8 to 12 parts of curcuma aromatica, 8 to 12 parts of uniflower swisscentaury root, 8 to 12 parts of sargentg loryvine stem, 15 to 25 parts of tuckahoe, 8 to 12 parts of Chinese angelica, 25 to 35 parts of polygonatum and 8 to 12 parts of earthworm. The Chinese medicinal preparation is mainly used for treating mild cognitive impairment; the Chinese medicinal preparation is orally taken, a dose every time, and three times every day; and three months constitute a treatment course. Clinical research proves that the Chinese medicinal preparation has an obvious curative effect on mild cognitive impairment, does not have toxic and side effects on liver, kidney function, digestive system and hematopoietic system, and can be safely taken.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation of treating mild cognitive impairment.
Background technology
Mild cognitive impairment (MCI) is the transitive state between normal aging and the dementia; It is the dull-witted crowd's of Alzheimer, vascular dementia and other types high risk factor; Research report over-65s crowd's prevalence of dementia is 6.7%; Serious threat is to quality of life of old people, and its pathogenic factor is unclear fully as yet, thinks that at present oxidative stress etc. is the key factor in the mild cognitive impairment incidence and development process.At present, lack the effective medicine of this disease.
Summary of the invention
To above-mentioned prior art, the invention provides a kind of Chinese medicine preparation of treating mild cognitive impairment.
The present invention realizes through following technical scheme:
A kind of Chinese medicine preparation of treating mild cognitive impairment is processed by following bulk drugs: 10～20 parts of Rhizoma Acori Graminei, 8～12 parts of Radix Curcumaes; 8～12 parts of Radix Rhapontici, 8～12 parts of Caulis Sargentodoxae, 15～25 parts in Poria; 8～12 parts of Radix Angelicae Sinensis, 25～35 parts of Rhizoma Polygonatis, 8～12 parts of Pheretimas.
Preferably, process: Rhizoma Acori Graminei 15g, Radix Curcumae 10g, Radix Rhapontici 10g, Caulis Sargentodoxae 10g, Poria 20g, Radix Angelicae Sinensis 10g, Rhizoma Polygonati 30g, Pheretima 10g by following crude drug.
A kind of method for preparing of treating the Chinese medicine preparation of mild cognitive impairment, step is following:
(1) get Rhizoma Acori Graminei, Radix Angelicae Sinensis, mix, vapor distillation gets volatile oil and medicinal residues II, in volatile oil, adds beta-schardinger dextrin-(in right amount), gets Benexate Hydrochloride I;
(2) get Radix Rhapontici, Pheretima, Caulis Sargentodoxae, mix, add the ethanol of 8 times of amounts (quality multiple), soak 2h; Filter, must filtrate and filtering residue, in filtering residue, add the ethanol of 6 times of amounts (quality multiple) again, soak 2h; Cross and filter filtrating and filtering residue III, merge twice filtrating, subsequent use;
(3) get Radix Curcumae, Poria and Rhizoma Polygonati and mix, mix with medicinal residues II, filtering residue III again, add the water of 10 times of amounts (quality multiple), soak 50min; Filter, must filtrate and filtering residue, in filtering residue, add the water of 3 times of amounts (quality multiple) again, filter; Must filtrate and filtering residue, merge filtrating twice, subsequent use;
(4) filtrating in combining step (2) and the step (3), through concentrating under reduced pressure, drying, pulverize fine powder, fine powder mixes with Benexate Hydrochloride I then, processes granule, tablet or capsule and gets final product.
Chinese medicine preparation of the present invention cures mainly mild cognitive impairment; During treatment, oral, each potion (consumption of the crude drug of potion is with reference to preferred prescription), every day 3 times, 3 months is a course of treatment.
In motherland's medical science mild cognitive impairment belonged to categories such as " dementia ", " dementia ", " literary composition is silly "; And think that deficiency of marrow-reservoir, the resistance of brain network numbness, refreshing machine apraxia are its main pathogenesis; Mostly pathology character is the time of deficiency in origin and excess in superficiality; Deficiency in origin is cloudy smart, deficiency of qi and blood, and mark is real to be that gas, blood, expectorant, stasis of blood internal resistance are in brain.Therefore expectorant, the stasis of blood, heat are the very big pathological factors of harm in the MCI incidence and development process; The resistance of brain network numbness is the main pathological basis in the MCI incidence and development process; Therefore the present invention establishes waking up the patient from unconsciousness by clearing away heat, disperse blood stasis and dredge collateral is the main method of treatment of MCI; Instruct at this that developing Chinese medicine preparation of the present invention (cephalocathartic intelligence-raising granules) is used to treat mild cognitive impairment down, its prescription foundation as follows:
Rhizoma Acori Graminei is got by the side, the Radix Curcumae acrid in the mouth is had one's ideas straightened out and is monarch.The Rhizoma Acori Graminei acrid in the mouth, tepor is gone into the heart, liver, stomach warp, has the eliminating phlegm of having one's ideas straightened out, the effect of vital energy regualting and blood circulation-promoting, because of it goes into heart channel, can happy key, beneficial intelligence, tranquilizing mind, hearing-improing and eyesight improving, therefore clinically be commonly used to treat disease such as forgetful, insomnia; Its treatment expectorant heat is hoodwinked key clearly, and normal and Radix Curcumae mutual reinforcement between are usefulness, the Radix Curcumae acrid in the mouth, and little hardship is returned liver, the heart, lung meridian, has regulating qi to disperse stagnation, the merit of heart fire-clearing upset-relieving, the heat that clears away heart-fire and key are happily controlled blood stasis and are reduced phlegm turbidly, and two medicines are shared, are main with the eliminating turbid pathogen with aromatics inducing resuscitation.Modern pharmacological research is found the Aging that Rhizoma Acori Graminei can protect brain to cause because of anoxia; Improve the memory that anoxia causes and consolidate obstacle; And can improve brain norepinephrine energy, cholinergic nerve function and regulate 5-hydroxy tryptamine level in the brain and treat and the damaged related senile amnesia of choline nerve conduction; Its water decoction-alcohol sedimentation liquid has the intelligence of increasing, promotes memory to obtain, improves amnemonic effect.Its volatile oil has tangible calmness, the excretory effect of facilitating digestion liquid.Radix Curcumae can reduce the content of plasma fibrinogen, reduces plasma cholesterol and content of triglyceride, alleviates the arteriosclerosis degree.
With Radix Rhapontici, Caulis Sargentodoxae, Poria, when being classified as minister.Radix Rhapontici, Caulis Sargentodoxae heat clearing away collateral dredging help the merit of Radix Curcumae heat clearing away circulation of qi promoting; The auxiliary Rhizoma Acori Graminei invigorating the spleen for dissipating phlegm of Poria is had one's ideas straightened out; Chinese Angelica blood replonishing is invigorated blood circulation, and strengthens the removing heat from blood and promoting blood circulation collateral dredging effect of Radix Curcumae and Caulis Sargentodoxae.The Radix Rhapontici bitter in the mouth is salty, has the merit of heat clearing away, dredge the meridian passage.Modern pharmacological research finds that Radix Rhapontici has atherosclerosis and antioxidation, and peroxide, OH are all had effect; To organizing lipid peroxidation that effect is arranged; Rat monoamine oxidase B activity there is inhibitory action; Influential to the animal immune effect.The Caulis Sargentodoxae bitter in the mouth is flat, has heat clearing and blood circulation promoting collateral dredging effect, and modern pharmacological research finds that it has the enhancing anti-anoxia ability, and is also influential to platelet aggregation simultaneously.Poria property slightly sweet flavor is flat, goes into the heart, lung, spleen channel, has eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, the effect of mind tranquilizing and the heart calming.Often use with the Rhizoma Acori Graminei compatibility at the turbid key of hoodwinking clearly of treatment expectorant, modern pharmacological research finds that Poria has the effect of calmness, diuresis, alleviation smooth muscle spasm.Radix Angelicae Sinensis is warm in nature, sweet in the mouth, suffering.Return liver, the heart, spleen channel.The merit that having enriches blood invigorates blood circulation, modern pharmacological research find that Radix Angelicae Sinensis powder 1.5g/kg has the blood fat reducing effect to rat and rabbit experiment property hyperlipidemia, and its effect for reducing blood fat is not owing to hinder due to the absorption of cholesterol.Contain the food of 5% Radix Angelicae Sinensis powder and be equivalent to Radix Angelicae Sinensis oil and other extract of this amount, the aortic disease of experimental arteriosclerosis rat is had certain protective role.Its effective ingredient sodium ferulate has anticoagulant and anti thrombotic action.In addition, have antioxidation and the effect of removing free radical when giving back, Radix Angelicae Sinensis pours into the cerebral tissue MDA after to cerebral anoxia, ischemia again and increases the obvious suppression effect is arranged.Contained ferulic acid has direct minimizing H2O2 content, and combines with membrane phospholipid acyl ethanolamine, through direct elimination free radical, and the infringement of antagonism radical pair tissues such as inhibited oxidation reaction and radical reaction.
Rhizoma Polygonati is sweet, flat, returns lung, spleen, kidney channel.Have the nourishing kidney lung moistening, the invigorating the spleen and replenishing QI effect, it is smart to get the dirty the moon of its tonifying the lung spleen kidney three, and anti-bitter cold impairment of YIN is an adjuvant drug.Modern pharmacological research finds that the Rhizoma Polygonati decoct is oral, can make the active increase of mouse liver superoxide dismutase, and myocardium lipofuscin content is descended; And can make mouse red blood cell film Na+, the K+-ATP enzymatic activity improves; And have blood pressure lowering, and blood sugar lowering, blood fat reducing prevents atherosclerosis, slow down aging and effect such as antibiotic.
Pheretima is salty-cold, and the heat clearing away collateral dredging is good at walking to scurry and inducting the medicines into affected channel is a messenger drug.
Full side's giving consideration to both the incidental and fundamental, reinforcement and elimination in combination has the effect of waking up the patient from unconsciousness by clearing away heat, disperse blood stasis and dredge collateral Fructus Alpiniae Oxyphyllae, makes expectorant hot clearly, and the brain network must be logical and increase the marrow Fructus Alpiniae Oxyphyllae.
Chinese medicine preparation of the present invention shows through clinical research, and it has significant curative effect to mild cognitive impairment, and liver, kidney merit, digestive system and hemopoietic system are all had no side effect, and takes safety.
The specific embodiment
Below in conjunction with embodiment the present invention is further described.
The Chinese medicine preparation of embodiment 1 preparation treatment mild cognitive impairment
Prescription is: Rhizoma Acori Graminei 15g, Radix Curcumae 10g, Radix Rhapontici 10g, Caulis Sargentodoxae 10g, Poria 20g, Radix Angelicae Sinensis 10g, Rhizoma Polygonati 30g, Pheretima 10g.
Method for preparing is following:
(1) get Rhizoma Acori Graminei, Radix Angelicae Sinensis, mix, vapor distillation gets volatile oil and medicinal residues II, in volatile oil, adds beta-schardinger dextrin-(20g), gets Benexate Hydrochloride I;
(2) get Radix Rhapontici, Pheretima, Caulis Sargentodoxae, mix, add the ethanol of 8 times of amounts, soak 2h, filter, must filtrate and filtering residue, in filtering residue, add the ethanol of 6 times of amounts again, soak 2h, cross and filter filtrating and filtering residue III, merge twice filtrating, subsequent use;
(3) get Radix Curcumae, Poria and Rhizoma Polygonati and mix, mix with medicinal residues II, filtering residue III again, add 10 times of water gagings, soak 50min, filter, must filtrate and filtering residue, in filtering residue, add 3 times of water gagings again, filter, must filtrate and filtering residue, merge filtrating twice, subsequent use;
(4) filtrating in combining step (2) and the step (3), through concentrating under reduced pressure, drying, pulverize fine powder, fine powder mixes with Benexate Hydrochloride I then, processes granule.
The Chinese medicine preparation of embodiment 2 preparation treatment mild cognitive impairments
Prescription is: Rhizoma Acori Graminei 20g, Radix Curcumae 12g, Radix Rhapontici 8g, Caulis Sargentodoxae 8g, Poria 25g, Radix Angelicae Sinensis 12g, Rhizoma Polygonati 25g, Pheretima 8g.
Method for preparing is following:
(1) get Rhizoma Acori Graminei, Radix Angelicae Sinensis, mix, vapor distillation gets volatile oil and medicinal residues II, in volatile oil, adds beta-schardinger dextrin-(20g), gets Benexate Hydrochloride I;
(2) get Radix Rhapontici, Pheretima, Caulis Sargentodoxae, mix, add the ethanol of 8 times of amounts, soak 2h, filter, must filtrate and filtering residue, in filtering residue, add the ethanol of 6 times of amounts again, soak 2h, cross and filter filtrating and filtering residue III, merge twice filtrating, subsequent use;
(3) get Radix Curcumae, Poria and Rhizoma Polygonati and mix, mix with medicinal residues II, filtering residue III again, add 10 times of water gagings, soak 50min, filter, must filtrate and filtering residue, in filtering residue, add 3 times of water gagings again, filter, must filtrate and filtering residue, merge filtrating twice, subsequent use;
(4) filtrating in combining step (2) and the step (3), through concentrating under reduced pressure, drying, pulverize fine powder, fine powder mixes with Benexate Hydrochloride I then, processes granule.
The Chinese medicine preparation of embodiment 3 preparation treatment mild cognitive impairments
Prescription is: Rhizoma Acori Graminei 10g, Radix Curcumae 8g, Radix Rhapontici 12g, Caulis Sargentodoxae 12g, Poria 15g, Radix Angelicae Sinensis 8g, Rhizoma Polygonati 35g, Pheretima 12g.
Method for preparing is following:
(1) get Rhizoma Acori Graminei, Radix Angelicae Sinensis, mix, vapor distillation gets volatile oil and medicinal residues II, in volatile oil, adds beta-schardinger dextrin-(20g), gets Benexate Hydrochloride I;
(2) get Radix Rhapontici, Pheretima, Caulis Sargentodoxae, mix, add the ethanol of 8 times of amounts, soak 2h, filter, must filtrate and filtering residue, in filtering residue, add the ethanol of 6 times of amounts again, soak 2h, cross and filter filtrating and filtering residue III, merge twice filtrating, subsequent use;
(3) get Radix Curcumae, Poria and Rhizoma Polygonati and mix, mix with medicinal residues II, filtering residue III again, add 10 times of water gagings, soak 50min, filter, must filtrate and filtering residue, in filtering residue, add 3 times of water gagings again, filter, must filtrate and filtering residue, merge filtrating twice, subsequent use;
(4) filtrating in combining step (2) and the step (3), through concentrating under reduced pressure, drying, pulverize fine powder, fine powder mixes with Benexate Hydrochloride I then, processes granule.
Clinical data:
One, physical data
1 diagnostic criteria
1.1 Western medicine diagnose standard
Adopt the MCI diagnostic criteria of propositions such as Petersen also to revise: 1. subjectivity has the main suit of memory impairment; There is the evidence of mild cognitive functional lesion in objective determination; Like the above schooling 25-27 branch in MMSE scoring middle school, the 21-24 of primary school branch, illiteracy 18-20 branch; 2. overall cognitive function is normal; 3. activity of daily living keeps normal basically; 4. memory impairment has surpassed the expected value according to age and education degree; 5. do not reach dementia degree as yet.
1.2 tcm diagnosis standard
" the dull-witted clinical research guideline of new Chinese medicine treatment " with Ministry of Health of the People's Republic of China's promulgation is foundation, and card belongs to expectorant thermal resistance key card and syndrome of qi stagnation and blood stasis.
Expectorant thermal resistance key card: primary symptom: hypophrenia, heaviness of the head as if it were tightly bandaged, indigestion and loss of appetite gastral cavity expand, the abundant expectoration salivation.
Inferior disease: look stiff, reticent few speech, obesity, slow movement, limbs are stranded vexed not hungry, the nausea nausea of heavy, gastral cavity or see lethargy or see manic uneasiness, red tongue, yellow and greasy fur, slippery and rapid pulse.
Syndrome of qi stagnation and blood stasis: primary symptom: hypophrenia, headache as thorn, the lip onyx is livid purple.
Inferior disease: look quietly, few vigorously of few words or restlessness, speaking incoherently, inarticulateness, dim complexion, scaly dry skin, afternoon night low grade fever, cardiopalmus, be insomnia, purplish tongue or have ecchymosis petechia, Sublingual venation purple dark, stringy pulse or puckery.
1.3 test case standard
(1) meets the diagnostic criteria of above-mentioned doctor trained in Western medicine vascular mild cognitive impairment.Serious dementia degree evaluation is with reference to the clinical dementia evaluation form.
(2) meet the heat-transformation of the above-mentioned traditional Chinese medical science expectorant stasis of blood, on disturb the dialectical standard of key pattern of syndrome clearly.
1.4 get rid of the case standard
(1) do not meet case and include standard person in.
(2) can not anti-receptor to this treatment.
(3) noncooperationist's (referring to cooperate diet control maybe can not treat and the person of affecting the treatment) and psychotic by the regulation medication.
(4) other can cause the disease of cognitive impairment, like malignant tumor, abnormal thyroid function, syphilis, and the patient of serious anemia.
(5) once used similar Drug therapy in 30 days in the past, as took the medicine of relevant or phase antagonism, the curative effect of medicine is difficult to judgement person.
Two, observational technique
1 group technology: the simple randomization method of dividision into groups.
2 observation index
(1) safety indexes:
1. general health check-up project: comprise height, body weight, growth, nutrition, blood pressure etc.
2. blood, urine, stool routine examination are treated forward and backward respectively the inspection 1 time.
3. liver, renal function, electrocardiogram is treated forward and backward respectively the inspection 1 time.
4. untoward reaction: observation has or not uncomfortable sensation after taking this medicine, and combines blood, urine, stool routine examination regulating liver-QI, renal function, Electrocardioscopy, observes this medicine and has no side effect.
(2) health giving quality index:
1. forward and backward respectively the evaluation 1 time of simple and easy mental status examination table (MMSE) treatment.
3. Therapeutic Method:
The treatment group is taken Chinese medicine preparation, embodiment 1 preparation, each potion, every day 3 times.Matched group is taken nimodipine tablet, each 30mg, every day 3 times.Two groups are all treated 3 months is 1 course of treatment, finishes back statistics curative effect the course of treatment.
4. statistical analysis technique: adopt the SPSS10.0 statistical analysis software to carry out statistical procedures.Measurement data is expression with
, adopts the t check.Enumeration data is used X
2Check.
Three, efficacy assessment standard
With reference in " the new Chinese medicine clinical research guideline " of Ministry of Health of the People's Republic of China promulgation about " the clinical research guideline of new Chinese medicine treatment dementia " content; According to the variation of clinical symptoms, sign and objective indicator, formulate following criterion of therapeutical effect:
1. comprehensive therapeutic effect criterion:
(1) clinic control: symptom and sign disappears or basic the disappearance, and other objective determination index is normal basically, therapeutic index >=90%;
(2) produce effects: sings and symptoms obviously improves, and other objective determination index is normal basically, therapeutic index >=60%;
(3) effective: sings and symptoms alleviates to some extent, but not obvious, and other objective determination index has improvement, therapeutic index >=30%;
(4) invalid: sings and symptoms does not have change or increases the weight of, and other objective determination index is not seen improvement, therapeutic index＜30%.
Four: clinical data:
1. case is originated: select to meet vascular mild cognitive impairment patient 120 examples altogether from year JIUYUE in January, 2004 to 2009, be divided into treatment at random and organize 60 examples, matched group 60 examples.All case all derives from Shandong Traditional Chinese Medicine University's second Affiliated Hospital's Neurology Clinic (and being in hospital) patient.
2. physical data and grouping:
Be divided into two groups by the table of random number method.60 examples are organized in treatment, male's 38 examples, women's 22 examples; In age 60-75 year, average 62.7 years old, be dextromanuality; Schooling university 18 examples, middle school 22 examples, primary school's 16 examples, illiteracy's 4 examples; Matched group 60 examples, male's 30 examples, women's 30 examples in age 60-75 year, average 62.9 years old, are dextromanuality; Schooling university 17 examples, middle school 23 examples, primary school's 17 examples, illiteracy's 3 examples; Two groups of physical data are through statistical analysis (X
2Check), there was no significant difference, (P＞0.05) has comparability.(seeing table 1～4).
Table 1 liang group age distribution is (example) relatively
Annotate: through X 2 test, X
2=0.67, P＞0.05, two group age distribution is compared, and no significant difference has comparability.
Table 2 liang group schooling is (example) relatively
Annotate: through X 2 test, X
2=0.51, P＞0.05, two group schooling compares, and no significant difference has comparability.
Table 3 liang group risk factor is (example) relatively
Annotate: through X 2 test, X
2=0.61, P＞0.05, two group risk factor compares, and no significant difference has comparability.
Table 4 liang group state of an illness size scale is (example)
Annotate: through X 2 test, X
2=0.45, P＞0.05, the two group state of an illness distributes relatively, and no significant difference has comparability.
Five, efficacy analysis
The MMSE score value compares (seeing table 5) before and after (one) two group of treatment
The MMSE score value relatively before and after the table 5 liang group treatment
Annotate: relatively preceding with the treatment of this group: * represents P＜0.01; With after the treatment of control group relatively: # represents P＜0.01
(3) two groups of comprehensive therapeutic effects compare (seeing table 6):
Table 6 liang group comprehensive therapeutic effect is (example) relatively
Annotate: through X 2 test, X
2=0.62, P＞0.05, two group comprehensive therapeutic effect compares, and there were significant differences in P＜0.01.
Six, untoward reaction
The treatment group is observed 60 examples altogether; Do not see gastrointestinal reaction and other untoward reaction in patient's drug administration process; All patients have a blood test before and after medication, urinate, just routine, liver, renal function are all no abnormal; Explain that Chinese medicine preparation of the present invention (cephalocathartic Fructus Alpiniae Oxyphyllae mixture) all has no side effect to liver, kidney merit, digestive system and hemopoietic system, takes safety.
Claims (3)
1. a Chinese medicine preparation of treating mild cognitive impairment is characterized in that: processed by following bulk drugs: 10～20 parts of Rhizoma Acori Graminei, 8～12 parts of Radix Curcumaes; 8～12 parts of Radix Rhapontici, 8～12 parts of Caulis Sargentodoxae, 15～25 parts in Poria; 8～12 parts of Radix Angelicae Sinensis, 25～35 parts of Rhizoma Polygonatis, 8～12 parts of Pheretimas.
2. a kind of Chinese medicine preparation of treating mild cognitive impairment according to claim 1 is characterized in that: processed by following bulk drugs: 15 parts of Rhizoma Acori Graminei, 10 parts of Radix Curcumaes; 10 parts of Radix Rhapontici, 10 parts of Caulis Sargentodoxae, 20 parts in Poria; 10 parts of Radix Angelicae Sinensis, 30 parts of Rhizoma Polygonatis, 10 parts of Pheretimas.
3. claim 1 or 2 described a kind of method for preparinies of treating the Chinese medicine preparation of mild cognitive impairment, it is characterized in that: step is following:
(1) get Rhizoma Acori Graminei, Radix Angelicae Sinensis, mix, vapor distillation gets volatile oil and medicinal residues II, in volatile oil, adds beta-schardinger dextrin-, gets Benexate Hydrochloride I;
(2) get Radix Rhapontici, Pheretima, Caulis Sargentodoxae, mix, add the ethanol of 8 times of amounts, soak 2h, filter, must filtrate and filtering residue, in filtering residue, add the ethanol of 6 times of amounts again, soak 2h, cross and filter filtrating and filtering residue III, merge twice filtrating, subsequent use;
(3) get Radix Curcumae, Poria and Rhizoma Polygonati, mix, mix with medicinal residues II, filtering residue III again, add 10 times of water gagings, soak 50min, filter, must filtrate and filtering residue, in filtering residue, add 3 times of water gagings again, filter, must filtrate and filtering residue, merge filtrating twice, subsequent use;
(4) filtrating in combining step (2) and the step (3), through concentrating under reduced pressure, drying, pulverize fine powder, fine powder mixes with Benexate Hydrochloride I then, processes granule, tablet or capsule and gets final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100284254A CN102526624B (en) | 2012-02-09 | 2012-02-09 | Chinese medicinal preparation for treating mild cognitive impairment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100284254A CN102526624B (en) | 2012-02-09 | 2012-02-09 | Chinese medicinal preparation for treating mild cognitive impairment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102526624A true CN102526624A (en) | 2012-07-04 |
| CN102526624B CN102526624B (en) | 2013-11-06 |
Family
ID=46335444
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012100284254A Expired - Fee Related CN102526624B (en) | 2012-02-09 | 2012-02-09 | Chinese medicinal preparation for treating mild cognitive impairment |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102526624B (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101130005A (en) * | 2007-09-13 | 2008-02-27 | 尹克华 | Traditional Chinese medicine for treating blahs aypnia after hepatocerebral apoplexy |
| CN101143189A (en) * | 2006-09-15 | 2008-03-19 | 山东步长制药有限公司 | Traditional Chinese medicinal composition for treating hyperlipemia and its preparation method and quality control method |
| CN101780245A (en) * | 2010-01-19 | 2010-07-21 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine composition for treating senile dementia and preparation method thereof |
| CN101954031A (en) * | 2010-10-07 | 2011-01-26 | 山东省千佛山医院 | Medicament for treating vascular dementia and preparation method |
-
2012
- 2012-02-09 CN CN2012100284254A patent/CN102526624B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101143189A (en) * | 2006-09-15 | 2008-03-19 | 山东步长制药有限公司 | Traditional Chinese medicinal composition for treating hyperlipemia and its preparation method and quality control method |
| CN101130005A (en) * | 2007-09-13 | 2008-02-27 | 尹克华 | Traditional Chinese medicine for treating blahs aypnia after hepatocerebral apoplexy |
| CN101780245A (en) * | 2010-01-19 | 2010-07-21 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine composition for treating senile dementia and preparation method thereof |
| CN101954031A (en) * | 2010-10-07 | 2011-01-26 | 山东省千佛山医院 | Medicament for treating vascular dementia and preparation method |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102526624B (en) | 2013-11-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106214964A (en) | Traditional Chinese medicine for soothing nerves preparation | |
| CN105232976B (en) | Composition for preventing or/and treating sub-health | |
| CN102813870B (en) | Chinese herbal compound preparation used for treating alcoholism and gout and preparation method and application thereof | |
| CN100579556C (en) | Preparation method of Chinese medicinal capsule for treating apoplexy | |
| CN1320912C (en) | Mind easing oral liquor with gen-seng and lily bulb | |
| CN102698077A (en) | Traditional Chinese medicine composition for treating sub-health | |
| CN103585449B (en) | For treating migrainous Chinese medicine composition | |
| CN102772611A (en) | Traditional Chinese medicine composition and preparation method and application thereof | |
| CN105434679A (en) | Traditional Chinese medicine health-care preparation for reducing weight and slimming | |
| CN101194982B (en) | Antidepressive Chinese medicine composition and method of preparing the same | |
| CN101195003B (en) | Proprietary Chinese medicine for treating apoplexy and sequela | |
| CN100382837C (en) | A medicine for treating children's excessive blink, hyperkinetic syndrome and Tottre's syndrome and method for preparing same | |
| CN114224998A (en) | Traditional Chinese medicine composition for treating spleen-kidney yang deficiency type functional dyspepsia, preparation and application | |
| CN102526624B (en) | Chinese medicinal preparation for treating mild cognitive impairment | |
| CN101991829B (en) | Medicament for treating stomach illness | |
| CN101244139B (en) | Chinese medicine composition for prevention or adjuvant therapy of cardiovascular disease and method of preparing the same | |
| CN105998752B (en) | A kind of Chinese medicine composition for the treatment of of vascular dementia | |
| CN105194352B (en) | A kind of Chinese medicine composition and preparation method thereof improving learning and memory | |
| CN116059302B (en) | Traditional Chinese medicine composition for treating gastrointestinal motility diseases and preparation method and application thereof | |
| CN109758559A (en) | A kind of Chinese medicine composition and its preparation method and application for treating chronic fatigue syndrome | |
| CN113413445B (en) | Composition and preparation method and application thereof | |
| CN102727730B (en) | Traditional Chinese medicinal compound preparation for treating male infertility and its preparation method | |
| CN100571722C (en) | Treatment is suffered from a deficiency of the kidney and the pharmaceutical composition of climacteric syndrome and preparation method thereof | |
| CN100406035C (en) | Chinese medicine preparation for treating protrasion of lumbar intervertebral disc | |
| CN1981837B (en) | Chinese-medicinal composition for adjusting human-body viscera function |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20131106 Termination date: 20150209 |
|
| EXPY | Termination of patent right or utility model |