CN102526189B - Chinese medicinal composition for treating angina pectoris - Google Patents
Chinese medicinal composition for treating angina pectoris Download PDFInfo
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Abstract
The invention discloses a Chinese medicinal composition for treating angina pectoris, and relates to the technical field of Chinese medicines. The Chinese medicinal composition is prepared from 10 to 40 weight parts of rosewood heart wood, 20 to 40 weight parts of sandalwood, 10 to 30 weight parts of the root of red-rooted salvia, 8 to 25 weight parts of angelica, 10 to 30 weight parts of szechuan lovage rhizome, 5 to 20 weight parts of ganoderma lucidum, 10 to 30 weight parts of leech and 5 to 24 weight parts of borneol. The Chinese medicinal composition has a special curative effect on the angina pectoris, and particularly has a remarkable curative effect on stable angina pectoris.
Description
Technical field
The invention belongs to the Chinese medicine technical field, be specifically related to a kind of Chinese medicine composition for the treatment of angina pectoris.
Background technology
Along with the raising of China's living standards of the people, the change of life pattern and dietary structure, the coronary disease patient who belongs to " affluenza " is more and more, as the angina pectoris of coronary heart disease cardinal symptom and pathological changes type, in cardiovascular outpatient service nothing to be surprised at.Angina pectoris is pressed property pain from the literal strand that can be understood as heart, and it is the clinical symptoms that the coronary insufficiency owing to the nutrition heart occurs.
Coronary heart disease heart stricture of vagina pain, the traditional Chinese medical science is referred to as " thoracic obstruction ", and it is clinical mainly to show as suffocating pain over the chest, shortness of breath and palpitation, very then chest pain waits to the bone, be a kind of commonly encountered diseases and frequently-occurring disease, the patient is in the majority with middle-aged and elderly people, as treat untimely, but normal secondary myocardial infarction and even broken dead.The traditional Chinese medical science thinks that the etiology and pathology of angina pectoris mostly is " imbalance of YIN and YANG, mechanism of qi be contrary to cause disorderly that painstaking effort tiredly stagnate, blockage of the cardiac vessels, stagnation of QI and blood may bring about pain ".In have through " a Ling Shu Miraculous Pivot or Divine Axis five pathogenic factors piece of writing " ' Bu Zaixin, then sick in pain " say; " opinion when element is asked the internal organs method " pointed out, " heart patient, chest pain, discomfort and fullness in the hypochondrium, pain over the hypochondrium, pain between breast back of the body shoulder is given as security, pain in the medial sides of both arms." " Ling Shu Miraculous Pivot or Divine Axis faint disease a piece of writing " says: " benefit is very bitterly in action for precordial pain with cold limbs, pain in the heart." " angina pectoris, bluish colour of the limbs extending up to the elbows and knees, very pained, onset of disease in the morning and dying in the evening, onset of disease in the evening and dying in the next morning." also claim in " golden plaque outline obstruction of qi in the chest and cardialgia lose heart abnormal pulse card control ": " and the thoracic obstruction for sick, dyspnea and expectoration, the pain over the chest and back is losed heart." " thoracic obstruction must not crouch chest pain radiating to the back " etc.These are all very similar to the clinical manifestation of angina pectoris, and the visible tired resistance of painstaking effort is the main morbidity base reason of this disease.According to statistics, whole world every year because of the number of angina pectoris death more than ten million, it has seriously endangered human particularly health and the life of mid-aged population.At present the Western medicine for the treatment of coronary heart disease mainly is nitrate compound, B receptor blocking agent and calcium antagonist etc., and these medicines can only relief of symptoms, is difficult to effect a permanent cure, and certain toxic and side effects is arranged; And in the present clinical practice of the traditional Chinese medical science the used Chinese patent medicine for the treatment of angina pectoris such as FUFANG DANSHEN PIAN, DANQI PIAN etc. also exist mostly medication not comprehensively, curative effect is low, onset is slow defective, and toward contact need with multiple medicine drug combination.Though the action intensity of the single target spot of Chinese medicine is lower than Western medicine, its multipath, many target spots, dynamically wholistic therapy, characteristic that toxic and side effects is little then are far from Western medicine and can reach, and the Comprehensive Treatment effect of the Chinese patent medicine of determined curative effect will surpass Western medicine.But the conventional treatment by Chinese herbs time is long, is difficult to fundamentally cure coronary heart disease.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine composition that can treat angina pectoris effectively.
A kind of Chinese medicine composition for the treatment of angina pectoris of the present invention is made by following weight portion raw material: Lignum Dalbergiae Odoriferae 10-40 part, Lignum Santali Albi 20-40 part, Radix Salviae Miltiorrhizae 10-30 part, Radix Angelicae Sinensis 8-25 part, Rhizoma Chuanxiong 10-30 part, Ganoderma 5-20 part, Hirudo 10-30 part, Borneolum Syntheticum 5-24 part.
Further preferably, a kind of Chinese medicine composition for the treatment of angina pectoris of the present invention is made by following weight portion raw material: Lignum Dalbergiae Odoriferae 10-20 part, Lignum Santali Albi 20-30 part, Radix Salviae Miltiorrhizae 15-25 part, Radix Angelicae Sinensis 10-20 part, Rhizoma Chuanxiong 20-30 part, Ganoderma 10-20 part, Hirudo 20-30 part, Borneolum Syntheticum 5-15 part.
Most preferred, a kind of Chinese medicine composition for the treatment of angina pectoris of the present invention is made by following weight portion raw material: 20 parts of Lignum Dalbergiae Odoriferaes, 30 parts in Lignum Santali Albi, 20 parts of Radix Salviae Miltiorrhizaes, 20 parts of Radix Angelicae Sinensis, 25 parts of Rhizoma Chuanxiongs, 10 parts of Ganodermas, 20 parts of Hirudos, 10 parts of Borneolum Syntheticums.
Chinese medicine composition technology of the present invention simply need not to mention alcohol extraction process by water, directly is pulverized and mixed evenly routinely preparation process and is prepared into peroral dosage form and gets final product.
Described peroral dosage form is liquid oral dosage form or oral dosage form, is preferably oral dosage form, and described oral dosage form is tablet, granule, capsule, soft capsule, pill;
Aforementioned dosage form is preferably capsule or pill; Most preferably be capsule.
The preparation method of capsule of the present invention is as follows:
According to the present invention's prescription, weighting raw materials material Lignum Dalbergiae Odoriferae, Lignum Santali Albi, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Ganoderma, Hirudo, Borneolum Syntheticum clean, dry;
With above-mentioned pulverizing medicinal materials, cross sieve No. five, insert capsule after the sterilization No. 0, namely.
The preparation method of pill of the present invention is as follows:
According to the present invention's prescription, weighting raw materials material Lignum Dalbergiae Odoriferae, Lignum Santali Albi, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Ganoderma, Hirudo, Borneolum Syntheticum clean, dry;
With above-mentioned pulverizing medicinal materials, cross sieve No. five; Sterilization, the binding agent that the adding preparation process is used always preparation technology routinely is prepared into pill, and every about 2g of pastille namely gets pill of the present invention.
According to theory of Chinese medical science " heart governing blood and vessels ", " heart master yang-energy " is so angina pectoris pathogeny and deficiency of heart-QI relation are most close.A little less than the motive incentive force, painstaking effort addiction resistance and cause painedly, this just need be aided with the method that invigorates vital energy and reinforce the heart and treat based on the blood circulation and channel invigorating pain relieving.
Chinese medicine composition of the present invention, it is further to improve to change to form on the basis of secret prescription handed down in the family from generation to generation, more is applicable to the angina pectoris patient, has done the clinical practice of experience secret recipe for many years, cures example surplus the case 200, effective percentage is more than 90%.The present invention can also be used for the treatment of coronary atherosclerotic heart disease and myocardial infarction except patient with angina pectoris is had the specially good effect.
The present invention's prescription: Radix Salviae Miltiorrhizae, bitter little, cold, the accent blood of invigorating blood circulation, the double blood that nourishes heart, tranquilizing the mind." detailed outline " claims it " to invigorate blood circulation logical percardium ", so to removing the resistance of the heart arteries and veins stasis of blood, the especially chief." detailed outline " said: " Radix Salviae Miltiorrhizae breaks stagnated blood, mends fresh blood, the big class Radix Angelicae Sinensis of its merit, Radix Rehmanniae, Radix Paeoniae ", " Bencao Jingshu " also said: " obey sharp people's QI invigorating for a long time, that nourishes blood tests also ".Radix Salviae Miltiorrhizae simply, merit four things of holding concurrently, logical just not cutting down mended and blood stasis dispelling, pain relieving is also good, use for extremely.Lignum Dalbergiae Odoriferae, Xin Wen, promoting flow of QI and blood, blood-activating analgetic, the QI and blood reason of holding concurrently, the anti-Radix Astragali is mended and is stopped up gas again, in please spleen, promoting flow of QI and blood is with being to help to make.Lignum Santali Albi is warm in nature, acrid in the mouth, and in the feasible temperature, the appetizing pain relieving.Be used for QI stagnated by cold, chest pain, stomachache, stomachache lack of appetite; Coronary heart disease, angina pectoris.Radix Angelicae Sinensis, warm in nature, sweet in the mouth, suffering.Return liver, the heart, spleen channel, it can be enriched blood, and can invigorate blood circulation again, both can stimulate the menstrual flow, again can be active.Rhizoma Chuanxiong, another name Rhizoma Chuanxiong " book on Chinese herbal medicine ", blood circulation promoting and blood stasis dispelling; Activating QI to alleviate the depression; Wind-expelling pain-stopping; " book on Chinese herbal medicine converges and says ": rhizome of chuanxiong Qiong, the up head, following regulating menstruation water, middle relieving stagnation, gas medicine in the blood.Taste by Radix Angelicae Sinensis and made, Fei Dizhi blood is meritorious, and control gas also god test also.All cold expelling wet, go pathogenic wind, the disease that makes eye bright, separate wind syndrome of head, except before hypochondriac pain, the fetus nourishing, benefit puerperal, poly-, the blood of lump in the abdomen knot closes not all right, sufferings skin infection, carbuncle cold and heat, flaccidity of the lower limbs flaccidity syndrome and arthralgia syndrome, the stepping back of swelling and ache again, and can control it.Ganoderma, feeble QI perfume (or spice), bitter and puckery flavor, GUIXIN, lung, liver, kidney channel.Cure mainly asthenia, cough, asthma, insomnia, dyspepsia, malignant tumor etc.Animal pharmacology shows experiment: Ganoderma has inhibitory action to nervous system, and blood circulation has blood pressure lowering and strengthens the effect of cardiac contractile force, and respiratory system is had phlegm-dispelling functions, in addition, also has hepatoprotective, improves immunologic function, antibioticly waits effect.Hirudo, salty in the mouth, hardship, property is flat, and is slightly poisonous.Return Liver Channel.The benefaction of gas raw meat is gone into blood and is broken diffusing." herbal classic ": " main by closing stagnant blood, blood stasis, the moon, the removing blood stasis abdominal mass is gathered, loss of fecundity, dredging water passages." Borneolum Syntheticum, property is arduous, cool logical all keys, and the stagnated fire of loosing, removing nebula makes eye bright, reducing swelling and alleviating pain.Control the apoplexy locked mouth, the calentura coma, infantile convulsion expectorant fan, deafness with qi stagnation, sore throat, aphtha, otitis media, carbuncle, hemorrhoid, order is the nebula film also, enterobiasis." Haiyao Bencao, Oversea Materia Medica ": " external oculopathy eye in main, three worms are controlled five hemorrhoid, make eye bright relieving palpitation, secret essence." above all medicine 5 usefulness, collaborative mutually, the merit that play the blood circulation and channel invigorating pain relieving altogether, invigorates vital energy and reinforce the heart.
The used Chinese medicinal herbs crude drug of the present invention all can traditional Chinese medical science pharmacy be bought.
Chinese medicine composition of the present invention can be according to patient age, and the difference of body weight and health status can give the consumption of each 2-3g respectively, and every day 3 times, warm water takes.10 days courses for the treatment of, 2-3 can fully recover the course for the treatment of.
Chinese medicine composition of the present invention is on the basis of secret prescription handed down in the family from generation to generation, through inventor's exploration for many years, reduced the Chinese medicine taking dose, reduced the stimulation of medicine to the intestines and stomach, avoid Chinese medicine to decoct the inconvenience that brings simultaneously, researched and developed the capsule formulation of this Chinese medicine composition by rational compatibility.Chinese medicine composition compatibility science of the present invention, curative effect is rapid, has activating blood circulation to dissipate blood stasis, promoting the circulation of QI to relieve pain, vital base and primordial QI consolidating, the effect of Yin Yang balancing.To the coronary heart disease with qi deficiency and blood stasis angina pectoris, have advantages such as instant effect, short treating period, cure rate height, expense are few.
For further investigating clinical efficacy and the safety of medicine of the present invention, select 200 routine cardiovascular and cerebrovascular disease cases that the curative effect of medicine of the present invention is carried out clinical observation.
200 routine MethodsThe cases enrolled all meet the diagnostic criteria of cardiovascular and cerebrovascular disease, make a definite diagnosis through the CT of hospital above county level, nuclear magnetic resonance, NMR, rheoencephalogram, electrocardiogram and various laboratory examination.Coronary atherosclerotic heart disease (coronary heart disease) 70 examples, myocardial infarction 50 examples, angina pectoris 80 examples.Male's 118 examples, women's 82 examples.The oldest 70 years old, minimum 39 years old.39～48 years old 42 examples, 49～59 years old 59 example, 60～70 years old 99 example.
Above case all gives the capsule of the embodiment of the invention 1, every day 3 times, each 3～6, oral meal.10 days is a course for the treatment of, takes 2～3 courses for the treatment of continuously.
Curative effect determinate standard: according to country " clinical diagnosis is according to curing the improvement standard ".
Cure: after treating 2～3 courses for the treatment of, the positive sign of symptom and objective determination disappears, and has recovered normal work and viability, observes continuously and does not have recurrence more than 3 years.
Yu changes: after treating 2～3 courses for the treatment of, the positive Signs of symptom and objective determination and cardinal symptom disappear, and have recovered certain work and self care ability, observe continuously and do not have recurrence more than 2 years.
Invalid: through treat 2 the course for the treatment of symptom and sign do not have obvious improvement.
Observe therapeutic effect according to criterion of therapeutical effect and see Table l.
Table 1 medicine composite for curing cardiovascular pathological changes 200 routine curative effect statistics of the present invention
By 200 routine cardiovascular and cerebrovascular vessel patient's clinical practices medicine capsule of the present invention is treated, and long term follow-up checking efficacy result, cure rate 82.5% obtained, the significant curative effect of total effective rate 96%.Wherein patient with angina pectoris was got cure rate 90% especially, the significant curative effect of total effective rate 98.7%.
The specific embodiment
Now by the present invention of following FORMULATION EXAMPLE more detailed description, but do not limit the present invention in any form.
EXAMPLE l: weighting raw materials material Lignum Dalbergiae Odoriferae 20g, Lignum Santali Albi 30g, Radix Salviae Miltiorrhizae 20g, Radix Angelicae Sinensis 20g, Rhizoma Chuanxiong 25g, Ganoderma 10g, Hirudo 20g, Borneolum Syntheticum 10g; Dry, pulverize, cross sieve No. five, capsule is inserted in sterilization then No. 0, adorns about 0. 5g, namely gets capsule of the present invention for every.
Embodiment 2: weighting raw materials material Lignum Dalbergiae Odoriferae 10g, Lignum Santali Albi 30g, Radix Salviae Miltiorrhizae 15g, Radix Angelicae Sinensis 10g, Rhizoma Chuanxiong 20g, Ganoderma 10g, Hirudo 10g, Borneolum Syntheticum 5g; Dry, pulverize, cross sieve No. five, capsule is inserted in sterilization then No. 0, adorns about 0. 5g, namely gets capsule of the present invention for every.
Embodiment 3: weighting raw materials material Lignum Dalbergiae Odoriferae 40g, Lignum Santali Albi 40g, Radix Salviae Miltiorrhizae 10g, Radix Angelicae Sinensis 8g, Rhizoma Chuanxiong 10g, Ganoderma 20g, Hirudo 20g, Borneolum Syntheticum 20g; Dry, pulverize, cross sieve No. five, capsule is inserted in sterilization then No. 0, adorns about 0. 5g, namely gets capsule of the present invention for every.
Embodiment 4: weighting raw materials material Lignum Dalbergiae Odoriferae 14g, Lignum Santali Albi 20g, Radix Salviae Miltiorrhizae 25g, Radix Angelicae Sinensis 14g, Rhizoma Chuanxiong 30g, Ganoderma 20g, Hirudo 20g, Borneolum Syntheticum 8g; Dry, sieve is crossed in pulverizing No. five, sterilization, and the binding agent that the adding preparation process is used always preparation technology routinely is prepared into pill, and every about 2g of pastille namely gets pill of the present invention.
Embodiment 5: weighting raw materials material Lignum Dalbergiae Odoriferae 10g, Lignum Santali Albi 20g, Radix Salviae Miltiorrhizae 20g, Radix Angelicae Sinensis 16g, Rhizoma Chuanxiong 20g, Ganoderma 12g, Hirudo 20g, Borneolum Syntheticum 10g; Dry, sieve is crossed in pulverizing No. five, sterilization, and the binding agent that the adding preparation process is used always preparation technology routinely is prepared into pill, and every about 2g of pastille namely gets pill of the present invention.
Embodiment 6: weighting raw materials material Lignum Dalbergiae Odoriferae 20g, Lignum Santali Albi 30g, Radix Salviae Miltiorrhizae 20g, Radix Angelicae Sinensis 20g, Rhizoma Chuanxiong 25g, Ganoderma 10g, Hirudo 20g, Borneolum Syntheticum 10g; Dry, sieve is crossed in pulverizing No. five, sterilization, and the binding agent that the adding preparation process is used always preparation technology routinely is prepared into pill, and every about 2g of pastille namely gets pill of the present invention.
Claims (4)
1. a Chinese medicine composition for the treatment of angina pectoris is characterized in that being made by the raw material of following weight portion: 20 parts of Lignum Dalbergiae Odoriferaes, 30 parts in Lignum Santali Albi, 20 parts of Radix Salviae Miltiorrhizaes, 20 parts of Radix Angelicae Sinensis, 25 parts of Rhizoma Chuanxiongs, 10 parts of Ganodermas, 20 parts of Hirudos, 10 parts of Borneolum Syntheticums.
2. the Chinese medicine composition for the treatment of angina pectoris as claimed in claim 1, it is characterized in that: described Chinese medicine composition is peroral dosage form.
3. the Chinese medicine composition for the treatment of angina pectoris as claimed in claim 2, it is characterized in that: described peroral dosage form is capsule.
4. the Chinese medicine composition for the treatment of angina pectoris as claimed in claim 2, it is characterized in that: described peroral dosage form is pill.
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| CN105796838A (en) * | 2016-04-23 | 2016-07-27 | 包晓娜 | Traditional Chinese medicine composition for treating angina |
| CN109602866A (en) * | 2019-01-31 | 2019-04-12 | 舒虹 | A kind of Chinese medicine composition that treating coronary heart disease, preparation, preparation method and applications |
| CN112716992A (en) * | 2021-01-26 | 2021-04-30 | 山西晋康风湿病医院有限公司 | Traditional Chinese medicine composition for treating coronary heart disease and preparation method thereof |
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| CN1081890A (en) * | 1993-02-17 | 1994-02-16 | 中国人民解放军第二炮兵西安中医多学科研究所 | The prescription and the production method of treatment angina pectoris coronary heart disease medicine |
| EP1388344A1 (en) * | 2002-07-31 | 2004-02-11 | Tianjin Tasly Pharmaceutical Co., Ltd., China | Composition comprising Salvia Miltiorrhizae, Ginseng, Borneol for treating heart disease, and cerebrovascular diseases |
| CN1517122A (en) * | 2003-10-28 | 2004-08-04 | 温先敏 | Medicine for treating coronary heart disease and its preparation method |
| US20050142229A1 (en) * | 2003-12-29 | 2005-06-30 | Jiao Gong | Pharmaceutical activity and manufacturing method of the four-plant-derived coronary blood flow enhancing agent |
| CN101711837A (en) * | 2008-10-06 | 2010-05-26 | 王德刚 | Traditional Chinese medicine preparation for treating coronary heart diseases and angina pectoris |
| TW201117839A (en) * | 2009-11-20 | 2011-06-01 | Tianjin Tasly Pharmaceutical | Drop pill for treating coronary heart disease and manufacture method thereof |
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2012
- 2012-02-20 CN CN 201210037984 patent/CN102526189B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1081890A (en) * | 1993-02-17 | 1994-02-16 | 中国人民解放军第二炮兵西安中医多学科研究所 | The prescription and the production method of treatment angina pectoris coronary heart disease medicine |
| EP1388344A1 (en) * | 2002-07-31 | 2004-02-11 | Tianjin Tasly Pharmaceutical Co., Ltd., China | Composition comprising Salvia Miltiorrhizae, Ginseng, Borneol for treating heart disease, and cerebrovascular diseases |
| CN1517122A (en) * | 2003-10-28 | 2004-08-04 | 温先敏 | Medicine for treating coronary heart disease and its preparation method |
| US20050142229A1 (en) * | 2003-12-29 | 2005-06-30 | Jiao Gong | Pharmaceutical activity and manufacturing method of the four-plant-derived coronary blood flow enhancing agent |
| CN101711837A (en) * | 2008-10-06 | 2010-05-26 | 王德刚 | Traditional Chinese medicine preparation for treating coronary heart diseases and angina pectoris |
| TW201117839A (en) * | 2009-11-20 | 2011-06-01 | Tianjin Tasly Pharmaceutical | Drop pill for treating coronary heart disease and manufacture method thereof |
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