CN102526139A - Artificial vaginal solution and preparation method thereof - Google Patents
Artificial vaginal solution and preparation method thereof Download PDFInfo
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- CN102526139A CN102526139A CN2012100420102A CN201210042010A CN102526139A CN 102526139 A CN102526139 A CN 102526139A CN 2012100420102 A CN2012100420102 A CN 2012100420102A CN 201210042010 A CN201210042010 A CN 201210042010A CN 102526139 A CN102526139 A CN 102526139A
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- seed oil
- squalene
- tween
- arlacel
- artificial vagina
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Abstract
The invention discloses an artificial vaginal solution and a preparation method thereof, and relates to the field of medicinal preparation. The artificial vaginal solution consists of fluid substrate and an additive, wherein the fluid substrate comprises one or more than one of seabuckthorm seed oil, mint oil and squalene; the additive comprises one or more than one of vitamin B complex, tween-80 and span-80. The preparation method comprises steps of weighing, emulsifying and sterilizing. The artificial vaginal solution has the functions of sterilization and disinfection, skin oxidation resistance, no toxic or side effect and no irritation, can be used for effectively solving the problem of skin aging caused by oxygen radical, and is a natural drug with good development prospect. Massive pharmacological experiments indicate that the seabuckthorm seed oil can be externally applied to skin and vagina mucosa, and has good effects of sterilizing and disinfecting, diminishing inflammation and relieving pains, and resisting oxidation and aging.
Description
Technical field
The present invention relates to field of pharmaceutical preparations, be specifically related to a kind of artificial vagina liquid and preparation method thereof.
Background technology
Along with the increasing and be widely used of synthetic and semi-synthetic antibiotics, the bacterial drug resistance problem is on the rise in recent years, and adverse effect constantly increases, and development cost are expensive.Therefore, from Chinese crude drug, seeking exploitation pure natural antibacterial raw material is a very feasible way of potentialization, and modern pharmacological research shows that Fructus Hippophae has broad-spectrum antibacterial antibacterial action.
On the other hand, think that at present the free radical accumulated damage is the major reason of skin aging, and experimental result shows the effectively aging of skin due to the antagonism D-galactose of the present invention; When increasing the skin SOD vigor; Obviously reduce old and feeble skin MDA content, so the present invention can improve the skin antioxidase activity, through stimulating fibroblastic vigor of old and feeble skin; Promote collagen protein synthesis, the effect of performance anti aging effect.
Summary of the invention
The purpose of this invention is to provide a kind of artificial vagina liquid and preparation method thereof.
Technical scheme of the present invention is achieved in that a kind of artificial vagina liquid, is made up of fluid matrix and additive.
A kind of artificial vagina liquid of the present invention, described fluid matrix is made up of in Fructrs Hippophae seed oil, Oleum menthae, the Squalene one or more; Described additive is made up of in compound vitamin B, tween 80, the Arlacel-80 one or more.
A kind of artificial vagina liquid of the present invention; In mass fraction, it consists of: Fructrs Hippophae seed oil 10-50 part, Oleum menthae 10-50 part, Squalene 10-30 part, compound vitamin B 0.3-1 part, tween 80 1-5 part, Arlacel-80 1-5 part, add water to 1000 parts.
A kind of artificial vagina liquid of the present invention; In mass fraction, it consists of: Fructrs Hippophae seed oil 20-30 part, Oleum menthae 17-25 part, Squalene 9-13 part, compound vitamin B 0.45-0.57 part, tween 80 1-2 part, Arlacel-80 1-2 part, add water to 1000 parts.
The present invention is a pure water in described water.
A kind of method for preparing of artificial vagina liquid has the following steps: weigh (1): under the room temperature, take by weighing Fructrs Hippophae seed oil, Oleum menthae, Squalene, compound vitamin B aqueous solution, tween 80, Arlacel-80, the water of formula ratio; (2) emulsifying: after Fructrs Hippophae seed oil, Oleum menthae, Squalene mixing, add compound vitamin B aqueous solution, tween 80, Arlacel-80 after weighing, after emulsifying, centrifugal 10-30 minute, process oil-in-water emulsion; (3) sterilization: sterilization is 10-30 minute under 120 ℃-130 ℃ condition, promptly gets artificial vagina liquid.
The invention has the beneficial effects as follows: the present invention is that primary raw material is made into the spray that can be applied to vagina with Fructrs Hippophae seed oil, compound vitamin B, Oleum menthae and Squalene.The present invention has the function of sterilizing, anti-skin oxidation, and has no side effect nonirritant.Simultaneously can effectively solve the skin aging problem that oxygen-derived free radicals causes, be a kind of crude drug with better DEVELOPMENT PROSPECT.A large amount of pharmacological evaluation show that Fructrs Hippophae seed oil can be used for skin and vaginal mucosa outward, have the effect of sterilizing, anti-inflammatory analgetic, oxidation-resisting and caducity preferably.
The specific embodiment
Embodiment 1
Formed (100ml) as follows through optimizing prescriptions: Fructrs Hippophae seed oil 2.0g; Oleum menthae 1.7g; Squalene 0.9g; Compound vitamin B 45mg; Tween 80 0.1g; Arlacel-80 0.1g adds pure water to 100ml.
Under the room temperature; Fructrs Hippophae seed oil, Oleum menthae, Squalene are mixed by prescription; Add respectively and weigh back compound vitamin B aqueous solution, tween 80, Arlacel-80 after emulsifying, with the rotating speed of 3500n/min centrifugal 15 minutes, process oil-in-water emulsion; Under 120 ℃-130 ℃ condition, sterilized 15 minutes at last, promptly get artificial vagina liquid.
Embodiment 2
Formed (100ml) as follows through optimizing prescriptions: Fructrs Hippophae seed oil 3.0g; Oleum menthae 2.5g; Squalene 1.3g; Compound vitamin B 57mg; Tween 80 0.2g; Arlacel-80 0.2g adds pure water to 100ml.
Under the room temperature; Fructrs Hippophae seed oil, Oleum menthae, Squalene are mixed by prescription; Add respectively and weigh back compound vitamin B aqueous solution, tween 80, Arlacel-80 after emulsifying, with the rotating speed of 3500n/min centrifugal 15 minutes, process oil-in-water emulsion; Under 120 ℃-130 ℃ condition, sterilized 10 minutes at last, promptly get artificial vagina liquid.
Embodiment 3
Formed (100ml) as follows through optimizing prescriptions: Fructrs Hippophae seed oil 2.5g; Oleum menthae 2.0g; Squalene 1.1g; Compound vitamin B 50mg; Tween 80 0.15g; Arlacel-80 0.15g adds pure water to 100ml.
Under the room temperature; Fructrs Hippophae seed oil, Oleum menthae, Squalene are mixed by prescription; Add respectively and weigh back compound vitamin B aqueous solution, tween 80, Arlacel-80 after emulsifying, with the rotating speed of 3500n/min centrifugal 15 minutes, process oil-in-water emulsion; Under 120 ℃-130 ℃ condition, sterilized 30 minutes at last, promptly get artificial vagina liquid.
The above; Be merely the preferable specific embodiment of the present invention; But protection scope of the present invention is not limited thereto; Any technical staff who is familiar with the present technique field is equal to replacement or change according to technical scheme of the present invention and inventive concept thereof in the technical scope that the present invention discloses, all should be encompassed within protection scope of the present invention.
Claims (6)
1. an artificial vagina liquid is characterized in that: be made up of fluid matrix and additive.
2. a kind of artificial vagina liquid according to claim 1 is characterized in that: described fluid matrix is made up of in Fructrs Hippophae seed oil, Oleum menthae, the Squalene one or more; Described additive is made up of in compound vitamin B, tween 80, the Arlacel-80 one or more.
3. a kind of artificial vagina liquid according to claim 2; It is characterized in that: in mass fraction, it consists of: Fructrs Hippophae seed oil 10-50 part, Oleum menthae 10-50 part, Squalene 10-30 part, compound vitamin B 0.3-1 part, tween 80 1-5 part, Arlacel-80 1-5 part, add water to 1000 parts.
4. a kind of artificial vagina liquid according to claim 3; It is characterized in that; In mass fraction, it consists of: Fructrs Hippophae seed oil 20-30 part, Oleum menthae 17-25 part, Squalene 9-13 part, compound vitamin B 0.45-0.57 part, tween 80 1-2 part, Arlacel-80 1-2 part, add water to 1000 parts.
5. a kind of artificial vagina liquid according to claim 3 is characterized in that described water is pure water.
6. the method for preparing of an artificial vagina liquid is characterized in that, has the following steps: weigh (1): under the room temperature, take by weighing Fructrs Hippophae seed oil, Oleum menthae, Squalene, compound vitamin B aqueous solution, tween 80, Arlacel-80, the water of formula ratio; (2) emulsifying: after Fructrs Hippophae seed oil, Oleum menthae, Squalene mixing, add compound vitamin B aqueous solution, tween 80, Arlacel-80 after weighing, after emulsifying, centrifugal 10-30 minute, process oil-in-water emulsion; (3) sterilization: sterilization is 10-30 minute under 120 ℃-130 ℃ condition, promptly gets artificial vagina liquid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100420102A CN102526139A (en) | 2012-02-23 | 2012-02-23 | Artificial vaginal solution and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100420102A CN102526139A (en) | 2012-02-23 | 2012-02-23 | Artificial vaginal solution and preparation method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN102526139A true CN102526139A (en) | 2012-07-04 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012100420102A Pending CN102526139A (en) | 2012-02-23 | 2012-02-23 | Artificial vaginal solution and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114259555A (en) * | 2021-12-31 | 2022-04-01 | 宁夏医科大学总医院 | Chinese and western medicine combined compound preparation and application thereof |
Citations (6)
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|---|---|---|---|---|
| CN1077373A (en) * | 1993-04-06 | 1993-10-20 | 王师舜 | Sex emollient disinfectant |
| CN1100652A (en) * | 1994-04-13 | 1995-03-29 | 王志理 | Xilu liquid for treating wart |
| CN1106691A (en) * | 1994-11-21 | 1995-08-16 | 中国医学科学院西安分院医药生物技术研究所 | Medicine for regulating endocrine function of woman |
| CN1433314A (en) * | 1999-12-30 | 2003-07-30 | 密执安州立大学董事会 | Antimicrobial compositions and methods of use |
| CN101455715A (en) * | 2008-11-13 | 2009-06-17 | 陕西东泰制药有限公司 | Suppository for treating gynecologic diseases and preparation method thereof |
| CN102309710A (en) * | 2010-07-09 | 2012-01-11 | 李正全 | Lotion special for female |
-
2012
- 2012-02-23 CN CN2012100420102A patent/CN102526139A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1077373A (en) * | 1993-04-06 | 1993-10-20 | 王师舜 | Sex emollient disinfectant |
| CN1100652A (en) * | 1994-04-13 | 1995-03-29 | 王志理 | Xilu liquid for treating wart |
| CN1106691A (en) * | 1994-11-21 | 1995-08-16 | 中国医学科学院西安分院医药生物技术研究所 | Medicine for regulating endocrine function of woman |
| CN1433314A (en) * | 1999-12-30 | 2003-07-30 | 密执安州立大学董事会 | Antimicrobial compositions and methods of use |
| CN101455715A (en) * | 2008-11-13 | 2009-06-17 | 陕西东泰制药有限公司 | Suppository for treating gynecologic diseases and preparation method thereof |
| CN102309710A (en) * | 2010-07-09 | 2012-01-11 | 李正全 | Lotion special for female |
Non-Patent Citations (2)
| Title |
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| 贾慧: "复方沙棘籽油栓联合甲硝锉片治疗细菌性阴道病", 《中国中医药》 * |
| 陈俊宁: "角鲨烯的临床应用价值", 《上海医药》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114259555A (en) * | 2021-12-31 | 2022-04-01 | 宁夏医科大学总医院 | Chinese and western medicine combined compound preparation and application thereof |
| CN114259555B (en) * | 2021-12-31 | 2024-05-31 | 宁夏医科大学总医院 | Combined preparation for traditional Chinese medicine and western medicine and application thereof |
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Application publication date: 20120704 |