CN102525980A - Children cetirizine hydrochloride composition - Google Patents
Children cetirizine hydrochloride composition Download PDFInfo
- Publication number
- CN102525980A CN102525980A CN2012100290753A CN201210029075A CN102525980A CN 102525980 A CN102525980 A CN 102525980A CN 2012100290753 A CN2012100290753 A CN 2012100290753A CN 201210029075 A CN201210029075 A CN 201210029075A CN 102525980 A CN102525980 A CN 102525980A
- Authority
- CN
- China
- Prior art keywords
- cetirizine hydrochloride
- children
- freeze
- solution
- oral cavity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a children cetirizine hydrochloride composition, relating to the technical field of medicinal preparations. The children cetirizine hydrochloride composition is composed of a main medicine and adjuvants in a formula and is characterized in that the main medicine is cetirizine hydrochloride and the adjuvants comprise a skeleton agent, a forming agent and a flavoring agent, wherein mannitol is selected as the skeleton agent, gelatin is selected as the forming agent, and sucralose is selected as the flavoring agent; and the proportions of the main medicine and the adjuvants in terms of the total weight of the formula are as follows: 25wt% of cetirizine hydrochloride, 75-79wt% of mannitol, 2-4wt% of gelatin, and 0.1-0.15wt% of sucralose. The invention further provides a freeze-dried orally disintegrating tablet of the children cetirizine hydrochloride composition and a preparation method of the freeze-dried orally disintegrating tablet, wherein the freeze-dried orally disintegrating tablet comprises simple components, is taken without water and chewing, disintegrates in the oral cavity of a human body within 2 seconds, has the advantages of high effect-taking speed, fewer intestinal tract residue, absorption sufficiency, low side effect and good mouthfeel, and is particularly suitable for being taken by infants and babies.
Description
Technical field
The present invention relates to technical field of medicine, be specifically related to a kind of children's's cetirizine hydrochloride compositions and contain children's's cetirizine hydrochloride composition freeze-drying oral cavity disintegration tablet that above-mentioned composition processes and preparation method thereof.
Background technology
Cetirizine hydrochloride is a kind of H1 receptor antagonist of strong effect, in the oral entering body, rapidly with target cell membrane on histamine H1-receptor combine blocking histamine activation target cell.Cetirizine does not have tangible cholinolytic and antiserotonergic effect.Under normal dose, be difficult for seeing through blood brain barrier.These article can suppress the histamine transmission of allergy initial stage, reduce the active mediator release with the allergy later stage of the migration of inflammatory cell, thus to delay-action stage allergy also effective.These article are H1 receptor antagonists of a kind of high selectivity, and not finding so far has pair cardiac electrical activity to produce harmful effect.Cetirizine hydrochloride is a second filial generation H1 antihistaminic, is the optionally oral strong effect anti-allergic drug of long lasting tool.The H1 receptor antagonist has good antiallergic action, is usually used in allergic rhinitis, allergic skin pruritus, conjunctivitis etc.It is few and can tolerate that cetirizine hydrochloride has a good anti-allergic effects side reaction.
The cetirizine hydrochloride structural formula is following:
The cetirizine hydrochloride common formulations of listing has at present: ordinary tablet, dry suspension, dispersible tablet, chewable tablet, granule, capsule, pressing port cavity disintegrating tablet etc.Wherein tablet is extrusion forming, and disintegrate is slower, and bioavailability is lower, and the part patient difficulty of swallowing, particularly takes very inconvenient for child patient.Oral cavity disintegration tablet has taking convenience, needn't use water delivery service, and absorption is fast, bioavailability is high, and side effect is low.Given this, the present invention is proposed.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of composition simple, easily manufactured, rapid-action children's's cetirizine hydrochloride compositions and contain children's's cetirizine hydrochloride composition freeze-drying oral cavity disintegration tablet that above-mentioned composition processes and preparation method thereof.
Technical problem to be solved by this invention adopts following technical scheme to realize.
A kind of children's's cetirizine hydrochloride compositions, the prescription of said composition is made up of principal agent and accessory drugs, it is characterized in that: wherein principal agent is a cetirizine hydrochloride, and accessory drugs includes skeleton agent, forming agent, correctives;
Mannitol is selected in described skeleton agent for use, and described forming agent is selected gelatin for use, and described correctives is selected sucralose for use;
Wherein principal agent and accessory drugs by weight the prescription total amount in shared ratio be:
Another object of the present invention provides a kind of children's's cetirizine hydrochloride composition freeze-drying oral cavity disintegration tablet that contains above-mentioned children's's cetirizine hydrochloride compositions, and this freeze-dry orally disintegrating tablet component is simple, need not water when taking; Need not to chew, disintegration time was no more than for 2 seconds in human oral cavity, and is rapid-action; Intestinal is residual few, absorbs fully, and side effect is low; Mouthfeel is good, is particularly suitable for the infant patient and takes.
A kind of children's's cetirizine hydrochloride composition freeze-drying oral cavity disintegration tablet that contains above-mentioned children's's cetirizine hydrochloride compositions, it is characterized in that: it is prepared from following components by weight proportion:
Said children's's cetirizine hydrochloride composition freeze-drying oral cavity disintegration tablet specification is 5mg/ sheet, 10mg/ sheet.
A further object of the present invention provides a kind of method for preparing of children's's cetirizine hydrochloride composition freeze-drying oral cavity disintegration tablet; This method for preparing with the tertiary butanol and water cosolvent as solvent; Can accelerate the distillation cycle of medicine, shorten lyophilization cycle, increase the cetirizine hydrochloride dissolving; Strengthen medicine stability, promote the crystallization of medicine.
For realizing a further object of the present invention, a kind of method for preparing of children's's cetirizine hydrochloride composition freeze-drying oral cavity disintegration tablet adopts following technical scheme:
A) cetirizine hydrochloride with recipe quantity is dissolved in the tert-butyl alcohol of recipe quantity, and stirring and dissolving continues to stir at normal temperatures, preparation solution a;
B) with recipe quantity mannitol, sucralose be dissolved in the purified water of prescription with purified water total amount 70%-80%, prepare solution b;
C) again the gelatin of recipe quantity is dissolved in the purified water of prescription water consumption 20%30%, is heated to dissolving preparation solution c fully;
D) merge above-mentioned b, two kinds of solution of c become solution d, and stir, mixed then solution is cooled to below 5 ℃;
E) mix a, two kinds of solution of d, and stir, regulate pH value to 6.0-6.5 with sodium bicarbonate;
E) according to children's's cetirizine hydrochloride composition freeze-drying oral cavity disintegration tablet specification; After confirming loading amount, the medicinal liquid after merging is moved in the drug-containing dish by loading amount, and put into freeze drying box; Medicinal liquid is carried out freezing (cryogenic temperature is-20 ℃-50 ℃); Evacuation dry (baking temperature is at 0 ℃-5 ℃, vacuum-more than the 0.09MPa), the control moisture is no more than 1.0%;
F) treat children's's cetirizine hydrochloride composition freeze-drying oral cavity disintegration tablet drying after, in freeze drying box, seal;
G) cut drug-containing dish after the medicament that freezes is taken out freeze drying box, and carry out finished product packing.
Formulated relevant detection method to the disintegration rate of children's's cetirizine hydrochloride composition freeze-drying oral cavity disintegration tablet:
1, disintegration
According to inspection technique disintegration (two appendix xA of Chinese Pharmacopoeia version in 2010); The stainless steel shaft of hanging basket through the upper end hung on the metal rack; Immerse in the 1000ml beaker; And screen cloth fills temperature and is 37 ℃ ± 1 ℃ water apart from beaker bottom 25mm in the beaker when regulating the hanging basket position it being descended, when regulating height of water level hanging basket being risen screen cloth in the underwater 15mm place.
Except as otherwise herein provided, get 4 groups of test samples (every group of dosage is 150mg), put respectively in the glass tubing of above-mentioned hanging basket, add baffle plate, start disintegration tester and check.The result is as shown in the table.
Dosage equates, the disintegration time of different cetirizine hydrochloride tablets
To children's's cetirizine hydrochloride composition freeze-drying oral cavity disintegration tablet of the present invention and the common pressing port cavity disintegrating tablet of cetirizine hydrochloride comparative determination, children's's cetirizine hydrochloride composition freeze-drying oral cavity disintegration tablet disintegration time of the present invention is significantly shorter than the common compacting oral cavity disintegration tablet of cetirizine hydrochloride as stated above.
Children's's cetirizine hydrochloride composition freeze-drying oral cavity disintegration tablet in the oral cavity, run into after the saliva can be in 2 seconds rapidly disintegrate, no grittiness, good mouthfeel, swallow easily, to the oral mucosa nonirritant.
The selected adjuvant of children's's cetirizine hydrochloride composition freeze-drying oral cavity disintegration tablet all is the adjuvants that are suitable for this tablet of preparation.According to discovering; The water solublity of cetirizine hydrochloride is very poor, and we adopt the tertiary butanol and water cosolvent as solvent in technology, is insoluble in the cetirizine hydrochloride of water with tert-butyl alcohol dissolving; With other adjuvants of purified water dissolving; Both mix with suitable ratio then, are dissolved the clear and bright cosolvent of water solublity and liposoluble substance jointly, use this technology to have multiple advantage.
First because the freezing point of the tert-butyl alcohol is high, just can freeze at normal temperatures, and also can just can solidify in the subzero several years after water mixes; And tert-butyl alcohol vapour pressure is high, and the vapour pressure height helps distillation, so use the tertiary butanol and water cosolvent can shorten freeze-drying time as solvent, the obtained freeze-drying product still keeps porous simultaneously.
Second tert-butyl alcohol and water can be with any mixed, and the medicine that will be insoluble in water like this is dissolved in the tert-butyl alcohol, can strengthen stability of drug.
The 3rd tert-butyl alcohol add the crystalline state that affiliation changes water, and then the drug crystallization state that is dissolved in the water is changed, improve freezing point, rate of sublimation improves greatly,
The 4th tert-butyl alcohol toxicity is low, and after the lyophilizing residual quantity seldom, the safety of the drug use that this just guarantees.
Because children's's cetirizine hydrochloride composition freeze-drying oral cavity disintegration tablet of the present invention is main in order to satisfy infant and child's medication demand, in prescription, has added the correctives sucralose.In traditional production application, aspartame flavour mouthfeel is pretty good, but is prone to decompose instability; Cyclamate, glucide safety receive dispute to a certain degree, and are prone to produce the back bitterness; The sucralose sweet feel is very near sucrose, and is very stable, safe to heat, acid, alkali.Simultaneously, sucralose is not utilized by the dental caries pathogenic bacteria, can reduce pathogenic bacteria in the oral cavity, and the acid amount of generation and streptococcus cell effectively play the dental caries effect in the adhesion of dental surface, and useful especially teenager teeth is healthy; The sucralose good stability can long term storage, and in freezing dry process, can not be damaged; Sweet taste is pure, and is similar with the sucrose sweet taste, can as some other intense sweeteners, can not produce sense of bitter back and abnormal flavour; Low price, more cheap under the identical sugariness than sucrose, be fit to industrial applications.
The present invention has following beneficial effect:
First disintegrate is rapid, and drug effect is fast.Children's's cetirizine hydrochloride composition freeze-drying oral cavity disintegration tablet of the present invention is disintegrate rapidly in 2 seconds in mouth, is beneficial to the rapid stripping of medicine, shortens dissolution time, accelerates to absorb, and makes its performance curative effect fast.
Second drug absorption is abundant.Children's's cetirizine hydrochloride composition freeze-drying oral cavity disintegration tablet of the present invention is disintegrate fully in the oral cavity, can in the oral cavity, just begin to absorb, and makes the absorption of medicine more abundant, helps improving bioavailability of medicament like this.
The 3rd taking convenience, mouthfeel is good.Children's's cetirizine hydrochloride composition freeze-drying oral cavity disintegration tablet of the present invention needn't be used water delivery service; Saliva can make its complete disintegrate; Be particularly useful for the patient of old man, children's's dysphagia and the inconvenient person that fetches water takes medicine; Owing to wherein add the compliance that the sweet child of helping of suitable correctives cool taste flavor takes medicine, solve the problem that it is difficult that infant is taken medicine again.Compare with liquid preparation and have that dosage advantage accurately, the present invention can guarantee in time the taking of medicine, dosage is accurate and curative effect is rapid.
The specific embodiment
For technological means, creation characteristic that the present invention is realized, reach purpose and effect and be easy to understand and understand, below in conjunction with specific embodiment, further set forth the present invention.
Embodiment 1
With the 10mg/ sheet is that example prepares children's's cetirizine hydrochloride composition freeze-drying oral cavity disintegration tablet,
Prescription: 1000 amounts
Preparation technology:
With the cetirizine hydrochloride of recipe quantity be dissolved in recipe quantity the tert-butyl alcohol (solution a) in, stirring and dissolving at normal temperatures continues to stir, with recipe quantity mannitol, sucralose be dissolved in the purified water (solution b) of prescription with purified water total amount 70%-80%; Gelatin with recipe quantity is dissolved in the purified water (solution c) of prescription water consumption 20%-30% again, is heated to dissolving fully; Merge above-mentioned b, two kinds of solution of c become solution d, and stir, mixed then solution is cooled to below 5 ℃.Mix a, two kinds of solution of d, and stir, regulate pH value to 6.0-6.5 with sodium bicarbonate.According to children's's cetirizine hydrochloride composition freeze-drying oral cavity disintegration tablet specification, confirm loading amount after, the medicinal liquid after merging is moved in the drug-containing dish by loading amount, and puts into freeze drying box, medicinal liquid is carried out freezing, evacuation is dry, the control moisture is no more than 1.0%; After treating children's's cetirizine hydrochloride composition freeze-drying oral cavity disintegration tablet drying, in freeze drying box, seal; Cut drug-containing dish after the medicament that freezes taken out freeze drying box, and carry out finished product packing.
Embodiment 2
With the 10mg/ sheet is that example prepares children's's cetirizine hydrochloride composition freeze-drying oral cavity disintegration tablet,
Prescription: 1000 amounts
Preparation technology:
With the cetirizine hydrochloride of recipe quantity be dissolved in recipe quantity the tert-butyl alcohol (solution a) in, stirring and dissolving at normal temperatures continues to stir, with recipe quantity mannitol, sucralose be dissolved in the purified water (solution b) of prescription with purified water total amount 70%-80%; Gelatin with recipe quantity is dissolved in the purified water (solution c) of prescription water consumption 20%-30% again, is heated to dissolving fully; Merge above-mentioned b, two kinds of solution of c become solution d, and stir, mixed then solution is cooled to below 5 ℃.Mix a, two kinds of solution of d, and stir, regulate pH value to 6.0-6.5 with sodium bicarbonate.According to children's's cetirizine hydrochloride composition freeze-drying oral cavity disintegration tablet specification, confirm loading amount after, the medicinal liquid after merging is moved in the drug-containing dish by loading amount, and puts into freeze drying box, medicinal liquid is carried out freezing, evacuation is dry, the control moisture is no more than 1.0%; After treating children's's cetirizine hydrochloride composition freeze-drying oral cavity disintegration tablet drying, in freeze drying box, seal; Cut drug-containing dish after the medicament that freezes taken out freeze drying box, and carry out finished product packing.
Embodiment 3
With the 10mg/ sheet is that example prepares children's's cetirizine hydrochloride composition freeze-drying oral cavity disintegration tablet,
Prescription: 1000 amounts
Preparation technology:
With the cetirizine hydrochloride of recipe quantity be dissolved in recipe quantity the tert-butyl alcohol (solution a) in, stirring and dissolving at normal temperatures continues to stir, with recipe quantity mannitol, sucralose be dissolved in the purified water (solution b) of prescription with purified water total amount 70%-80%; Gelatin with recipe quantity is dissolved in the purified water (solution c) of prescription water consumption 20%-30% again, is heated to dissolving fully; Merge above-mentioned b, two kinds of solution of c become solution d, and stir, mixed then solution is cooled to 5 ℃ once.Mix a, two kinds of solution of d, and stir, regulate pH value to 6.0-6.5 with sodium bicarbonate.According to children's's cetirizine hydrochloride composition freeze-drying oral cavity disintegration tablet specification, confirm loading amount after, the medicinal liquid after merging is moved in the drug-containing dish by loading amount, and puts into freeze drying box, medicinal liquid is carried out freezing, evacuation is dry, the control moisture is no more than 1.0%; After treating children's's cetirizine hydrochloride composition freeze-drying oral cavity disintegration tablet drying, in freeze drying box, seal; Cut drug-containing dish after the medicament that freezes taken out freeze drying box, and carry out finished product packing.
More than show and described ultimate principle of the present invention and principal character and advantage of the present invention.The technical staff of the industry should understand; The present invention is not restricted to the described embodiments; That describes in the foregoing description and the description just explains principle of the present invention; Under the prerequisite that does not break away from spirit and scope of the invention, the present invention also has various changes and modifications, and these variations and improvement all fall in the scope of the invention that requires protection.The present invention requires protection domain to be defined by appending claims and equivalent thereof.
Claims (3)
1. children's's cetirizine hydrochloride compositions, the prescription of said composition is made up of principal agent and accessory drugs, it is characterized in that: wherein principal agent is a cetirizine hydrochloride, and accessory drugs includes skeleton agent, forming agent, correctives;
Mannitol is selected in described skeleton agent for use, and described forming agent is selected gelatin for use, and described correctives is selected sucralose for use;
Wherein principal agent and accessory drugs by weight the prescription total amount in shared ratio be:
2. children's's cetirizine hydrochloride composition freeze-drying oral cavity disintegration tablet that contains claim 1 or 2 described children's's cetirizine hydrochloride compositionss, it is characterized in that: described freeze-dry orally disintegrating tablet is prepared from following components by weight proportion:
3. children's's cetirizine hydrochloride composition freeze-drying oral cavity disintegration tablet, it is characterized in that: described method for preparing adopts following technical scheme:
A) cetirizine hydrochloride with recipe quantity is dissolved in the tert-butyl alcohol of recipe quantity, and stirring and dissolving continues to stir at normal temperatures, preparation solution a;
B) with recipe quantity mannitol, sucralose be dissolved in the purified water of prescription with purified water total amount 70%-80%, prepare solution b;
C) again the gelatin of recipe quantity is dissolved in the purified water of prescription water consumption 20%-30%, is heated to dissolving preparation solution c fully;
D) merge above-mentioned b, two kinds of solution of c become solution d, and stir, mixed then solution is cooled to below 5 ℃;
E) mix a, two kinds of solution of d, and stir, regulate pH value to 6.0-6.5 with sodium bicarbonate;
seals in freeze drying box after treating children's's cetirizine hydrochloride composition freeze-drying oral cavity disintegration tablet drying;
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210029075 CN102525980B (en) | 2012-02-07 | 2012-02-07 | Children cetirizine hydrochloride composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210029075 CN102525980B (en) | 2012-02-07 | 2012-02-07 | Children cetirizine hydrochloride composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102525980A true CN102525980A (en) | 2012-07-04 |
| CN102525980B CN102525980B (en) | 2013-05-22 |
Family
ID=46334814
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201210029075 Active CN102525980B (en) | 2012-02-07 | 2012-02-07 | Children cetirizine hydrochloride composition |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102525980B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102784122A (en) * | 2012-08-23 | 2012-11-21 | 海南卫康制药(潜山)有限公司 | Isoniazid composition freeze-dried orally disintegrating tablet and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101310711A (en) * | 2007-05-24 | 2008-11-26 | 海南高升医药科技开发有限公司 | Levo-cetirizine hydrochloride orally disintegrating tablets and preparation method thereof |
| WO2008152067A1 (en) * | 2007-06-12 | 2008-12-18 | Alk-Abelló A/S | An allergen dosage form comprising an antihistamine |
| CN102038654A (en) * | 2009-10-15 | 2011-05-04 | 山东方明药业股份有限公司 | Cetirizine hydrochloride orally disintegrating tablets and preparation method thereof |
-
2012
- 2012-02-07 CN CN 201210029075 patent/CN102525980B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101310711A (en) * | 2007-05-24 | 2008-11-26 | 海南高升医药科技开发有限公司 | Levo-cetirizine hydrochloride orally disintegrating tablets and preparation method thereof |
| WO2008152067A1 (en) * | 2007-06-12 | 2008-12-18 | Alk-Abelló A/S | An allergen dosage form comprising an antihistamine |
| CN102038654A (en) * | 2009-10-15 | 2011-05-04 | 山东方明药业股份有限公司 | Cetirizine hydrochloride orally disintegrating tablets and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 张毅等: "口腔速崩片的研究进展及临床应用", 《职业与健康》, vol. 27, no. 19, 31 October 2011 (2011-10-31), pages 2254 - 2256 * |
| 李标等: "口腔崩解片的研究进展", 《中国医院用药评价与分析》, vol. 9, no. 2, 28 February 2009 (2009-02-28), pages 159 - 160 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102784122A (en) * | 2012-08-23 | 2012-11-21 | 海南卫康制药(潜山)有限公司 | Isoniazid composition freeze-dried orally disintegrating tablet and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102525980B (en) | 2013-05-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102579378B (en) | Child cefdinir composition freeze-dried oral disintegrating tablet and preparation method thereof | |
| CN102631336B (en) | Freeze-drying orally disintegrating tablet with vitamin K1 composition for infants and preparation method for freeze-drying orally disintegrating tablet | |
| CN104784157A (en) | Stable Montelukast oral film preparation | |
| CN102525978B (en) | Children amoxicillin-potassium clavulanate composition | |
| CN104922143A (en) | EGCG (epigallocatechin gallate) and chitosan oligosaccharide composition as well as preparation method and application thereof | |
| CN102600119A (en) | Pediatric acetaminophen composition | |
| CN102772383A (en) | Azithromycin composition freeze-dried orally disintegrating tablet and preparation method thereof | |
| CN102525980B (en) | Children cetirizine hydrochloride composition | |
| CN102784119A (en) | Roxithromycin composition freeze-dried orally disintegrating tablets and preparation method thereof | |
| CN102525979B (en) | Infant ibuprofen composition | |
| WO2016086557A1 (en) | Vitamin d calcium composition chewing tablet and preparation method thereof | |
| CN104780907A (en) | Medicinal lozenge based on ibuprofen sodium dihydrate | |
| CN102614212B (en) | Freeze-dried orally disintegrating tablets of pediatric ribavirin composition, and preparation method thereof | |
| CN102940610A (en) | Vitamin B6 composition freeze-drying orally disintegrating tablets and preparation method thereof | |
| CN102784121A (en) | Levofloxacin composition freeze-dried orally disintegrating tablets and preparation method thereof | |
| CN102648899B (en) | Child cefalexin composition | |
| CN102600153B (en) | Pediatric compound anisodamine hydrobromide and chlorpheniramine maleate freeze-dried orally disintegrating tablets and manufacturing method thereof | |
| CN102784122A (en) | Isoniazid composition freeze-dried orally disintegrating tablet and preparation method thereof | |
| CN105250227A (en) | Citric acid caffeine freeze-dried powder and preparation method thereof | |
| CN102784124A (en) | Cefuroxime axetil composition freeze-dried orally disintegrating tablets and preparation method thereof | |
| CN103239478A (en) | Calcium carbonate milk composition freeze-dried orally disintegrating tablets, and preparation method thereof | |
| CN104490814A (en) | Zinc gluconate composition chewable tablets and preparation method thereof | |
| CN102784118A (en) | Fosfomycin calcium composition freeze-dried orally disintegrating tablets and preparation method thereof | |
| CN102784126A (en) | Rifampicin composition freeze-dried orally disintegrating tablet and preparation method thereof | |
| CN101427999B (en) | Frusemide oral solution and method of producing the same |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |