CN102784124A - Cefuroxime axetil composition freeze-dried orally disintegrating tablets and preparation method thereof - Google Patents
Cefuroxime axetil composition freeze-dried orally disintegrating tablets and preparation method thereof Download PDFInfo
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- CN102784124A CN102784124A CN2012103014331A CN201210301433A CN102784124A CN 102784124 A CN102784124 A CN 102784124A CN 2012103014331 A CN2012103014331 A CN 2012103014331A CN 201210301433 A CN201210301433 A CN 201210301433A CN 102784124 A CN102784124 A CN 102784124A
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Abstract
The invention provides cefuroxime axetil composition freeze-dried orally disintegrating tablets and a preparation method of the orally disintegrating tablets, relates to the field of a medicine and a medicine preparation method technology and mainly solves the problems in the prior art that the cefuroxime axetil preparation is poor in curative effect and not suitable for children and the patients who are difficult to swallow. The cefuroxime axetil composition freeze-dried orally disintegrating tablets are prepared from the following components by weight: 25-50% of cefuroxime axetil, 25-75% of mannitol, 2-4% of gelatin, 0.1-0.15% of trichlorosucrose and 42-67% of tertiary butanol-water. The cefuroxime axetil composition freeze-dried orally disintegrating tablets prepared by the above components are easy in preparation process, and simple in components, and mainly meet the administration requirements of children and the patients who are difficult to swallow; moreover, the cefuroxime axetil composition freeze-dried orally disintegrating tablets have the advantages of being fast to disintegrate, convenient to take, and good in taste; and the tablets take effect quickly and are fully absorbed, and the first pass effect of the liver is avoided.
Description
Technical field:
The present invention relates to the method for preparing technical field of medicine and medicine, relate in particular to a kind of CEFUROXIME AXETIL composition freeze-drying oral cavity disintegration tablet and preparation method thereof.
Background technology:
The CEFUROXIME AXETIL chemical name is: (6R, 7R)-7-[2-furyl (methoxyimino) acetylamino]-3-carbamyl oxygen methyl-8-oxo-5-thia-1-azabicyclo [4.2.0] oct-2-ene-2-carboxylic acid, 1-acetoxyl group ethyl ester.C20H22N4O10S, molecular weight 510.48 is prone to dissolve in acetone, and is insoluble in water.Its chemical structural formula is:
CEFUROXIME AXETIL is the esterification preparation of second generation cephalosporin cefuroxime, and its effect of cefuroxime that generates is decomposed for esterase in oral back in intestinal mucosa and blood.Have has a broad antifungal spectrum, antibacterial activity is strong, and gram-positive microorganism and gram-negative micro-organism are all had good antibacterial activity, and is highly stable and side effect is little to beta-lactamase.But CEFUROXIME AXETIL is a lipophilic compound, and poorly water-soluble is met water and gathered group; Raw material is to wet, the equal instability of heat; Existing dosage form mainly contains tablet, dispersible tablet, capsule, dry suspension, and the patient that regular dosage form such as tablet and capsule etc. are not suitable for child, gerontal patient and dysphagia takes, and the little hardship of CEFUROXIME AXETIL mouthfeel, in mouth, chews to loose oral mucosa is had slight zest; Make the patient produce negation, reduced the compliance of patient's clinical application medication.
So still lack at present and press for a kind of like this cefuroxime ester formulation, its preparation technology is simple, component is simple.The oral absorption rate is high, and taking convenience, delicious is specially adapted to child, old age, is unable to leave the bed, the severely-disabled patient, and swallows inconvenient patient's medication.
Summary of the invention:
The object of the invention is to overcome the defective of prior art, need not water when a kind of taking is provided, and need not to chew; Fast CEFUROXIME AXETIL composition freeze-drying oral cavity disintegration tablet of disintegration rate and preparation method thereof in the oral cavity; This method preparation condition is gentle, is easy to control, is fit to industrialized great production.
For realizing the object of the invention, technical scheme realizes through following mode:
A kind of cefuroxime ester composition, the prescription of said composition is made up of principal agent and accessory drugs, and wherein principal agent is a CEFUROXIME AXETIL; Accessory drugs comprises skeleton agent, forming agent, correctives; Mannitol is selected in described skeleton agent for use, and described forming agent is selected gelatin for use, and described correctives is selected sucralose for use.
A kind of cefuroxime ester composition is characterized in that, said composition comprises following component and component quantity ratio:
The preferred ingredient quantity ratio of said each component of cefuroxime ester composition is:
Another object of the present invention provides a kind of CEFUROXIME AXETIL composition freeze-drying oral cavity disintegration tablet that contains above-mentioned cefuroxime ester composition.This freeze-dry orally disintegrating tablet component is simple, need not water when taking, and need not to chew; Disintegration time was no more than for 2 seconds in human oral cavity, and is rapid-action, the intestinal less residue; Absorb fully, side effect is low, and mouthfeel is good; Be particularly suitable for the infant patient and take, be prepared from following component and component quantity ratio:
The preferred ingredient quantity ratio of each component of preparation CEFUROXIME AXETIL composition freeze-drying oral cavity disintegration tablet is:
A further object of the present invention provides a kind of method for preparing of CEFUROXIME AXETIL composition freeze-drying oral cavity disintegration tablet; This method for preparing as solvent, can be accelerated the rate of sublimation of medicine with the tertiary butanol and water cosolvent, shortens lyophilization cycle; Increase dissolubility, stability, promote the crystallization of medicine.
For realizing a further object of the present invention, a kind of method for preparing of CEFUROXIME AXETIL composition freeze-drying oral cavity disintegration tablet adopts following technical scheme:
A) CEFUROXIME AXETIL with recipe quantity is dissolved in the tert-butyl alcohol of recipe quantity, and stirring and dissolving continues to stir at normal temperatures, preparation solution a;
B) mannitol, the sucralose with recipe quantity is dissolved in the purified water of prescription with pure water total amount 70%-80%, preparation solution b;
C) again the gelatin of recipe quantity and xanthan gum are dissolved in the purified water of prescription water consumption 20%-30%, are heated to dissolving fully, preparation solution c;
D) merge two kinds of solution that above-mentioned steps a, step b obtain and become solution d, and stir, mixed then solution is cooled to below 5 ℃;
E) mix a, two kinds of solution of d, and stir, regulate pH value to 6.0-6.5 with sodium bicarbonate;
F) according to CEFUROXIME AXETIL composition freeze-drying oral cavity disintegration tablet specification, confirm loading amount after, the medicinal liquid that merges is moved in the drug-containing dish by loading amount; And put into freeze drying box; Medicinal liquid is carried out freezing, (cryogenic temperature is-20 ℃--50 ℃), evacuation is dry, and (baking temperature is at 0 ℃-5 ℃; Vacuum-more than the 0.09MPa), control moisture be no more than 1.0%;
G) treat CEFUROXIME AXETIL composition freeze-drying oral cavity disintegration tablet drying after, in household freezer, seal;
H) cut drug-containing dish after the medicament that freezes is taken out freeze drying box, and carry out finished product packing.
Described CEFUROXIME AXETIL composition freeze-drying oral cavity disintegration tablet specification is 125mg/ sheet, 250mg/ sheet.
Formulated relevant monitoring method to the disintegration rate of CEFUROXIME AXETIL composition freeze-drying oral cavity disintegration tablet:
Disintegration
According to inspection technique disintegration (two appendix ⅹ of Chinese Pharmacopoeia version in 2010 A); The stainless steel shaft of hanging basket through the upper end hung on the metal rack; Immerse in the 1000ml beaker; And screen cloth fills temperature and is 37 ℃ ± 1 ℃ water apart from beaker bottom 25mm in the beaker when regulating the hanging basket position it being descended, when regulating height of water level hanging basket being risen screen cloth in the underwater 15mm place.
Except as otherwise herein provided, get 6 groups of test samples (every group of dosage is 250mg), put respectively in the glass tubing of above-mentioned hanging basket, add baffle plate, start disintegration tester and check, each sheet all should all disintegrates in 1.1 seconds.Result such as following table:
Dosage equates, the disintegration time and the medicine of different cefuroxime axetil tablets reach peak concentration
The disintegration rate that can find out CEFUROXIME AXETIL composition freeze-drying oral cavity disintegration tablet of the present invention from above experimental result is faster than CEFUROXIME AXETIL ordinary tablet.
CEFUROXIME AXETIL composition freeze-drying oral cavity disintegration tablet in the oral cavity, run into after the saliva can be in two seconds rapidly disintegrate, no grittiness, good mouthfeel, swallow easily, to the oral mucosa nonirritant.
The selected adjuvant of CEFUROXIME AXETIL composition freeze-drying oral cavity disintegration tablet all is adjuvants of suitable this tablet of preparation; Because the water solublity of CEFUROXIME AXETIL is very poor, we adopt the tertiary butanol and water cosolvent as solvent in technology, are insoluble in the CEFUROXIME AXETIL of water with tert-butyl alcohol dissolving; With other adjuvants of purified water dissolving; Both mix with suitable ratio then, are dissolved the clear and bright cosolvent of water solublity and liposoluble substance jointly, use this technology to have multiple advantage.
The first, tert-butyl alcohol freezing point is high, just can freeze at normal temperatures, with also passable after water mixes, just can solidify in the subzero several years; And tert-butyl alcohol vapour pressure is high, helps distillation, so use the tertiary butanol and water cosolvent can shorten freeze-drying time as solvent, the obtained freeze-drying product still keeps porous simultaneously.
The second, the tert-butyl alcohol and water can be with any mixed, and the medicine that will be insoluble in water like this is dissolved in the tert-butyl alcohol, can strengthen stability of drug.
The 3rd, the crystalline state that adds affiliation change water of the tert-butyl alcohol, and then the drug crystallization state that is dissolved in the water is changed, and improving freezing point, rate of sublimation improves greatly.
The 4th, tert-butyl alcohol toxicity is low, and less residue after the lyophilizing, and this just guarantees the safety of medication.
Because CEFUROXIME AXETIL composition freeze-drying oral cavity disintegration tablet of the present invention is main in order to satisfy child's medication demand, in prescription, has added the correctives sucralose.In traditional production application, aspartame flavour mouthfeel is pretty good, but is prone to decompose instability; Cyclamate, glucide safety receive dispute to a certain degree, and are prone to produce the back bitterness.And the sucralose sweet feel is very near sucrose, and is very stable, safe to heat, acid, alkali.Simultaneously, sucralose is not utilized by the dental caries pathogenic bacteria, can reduce pathogenic bacteria in the oral cavity, and the acid amount of generation and streptococcus cell effectively play the dental caries effect in the adhesion of dental surface, and useful especially teenager teeth is healthy; The sucralose good stability can long term storage, and in freezing dry process, can not be damaged, and is fit to industrial applications.
Advantage of the present invention:
The first, the tablet disintegrate is rapid, and drug effect is fast.CEFUROXIME AXETIL composition freeze-drying oral cavity disintegration tablet of the present invention is disintegrate rapidly in 2 seconds in mouth, is beneficial to the rapid stripping of medicine, shortens dissolution time, accelerates to absorb, and liver first-pass effect is little, makes its performance curative effect fast.
The second, drug absorption is abundant.CEFUROXIME AXETIL composition freeze-drying oral cavity disintegration tablet of the present invention is disintegrate fully in the oral cavity, makes the absorption of medicine more abundant, helps improving bioavailability of medicament like this.
Three, taking convenience, mouthfeel is good.CEFUROXIME AXETIL composition freeze-drying oral cavity disintegration tablet of the present invention needn't be used water delivery service, and saliva can make its complete disintegrate, and no foreign body sensation in mouthful is owing to wherein add the compliance that the sweet child of helping of suitable correctives cool taste flavor takes medicine.Compare with liquid preparation and dosage advantage accurately arranged.
Four, avoid the first pass effect of liver: because CEFUROXIME AXETIL composition freeze-drying oral cavity disintegration tablet of the present invention rapidly disintegrate in mouth except that major part gets into the gastrointestinal tract with swallowing act, also has the considerable part trans-oral to absorb, thereby rapid-action, first pass effect is little.
The specific embodiment:
For technological means, creation characteristic that the present invention is realized, reach purpose and effect and be easy to understand and understand, below in conjunction with specific embodiment, further set forth the present invention.
Embodiment 1
With the 125mg/ sheet is that example prepares CEFUROXIME AXETIL composition freeze-drying oral cavity disintegration tablet,
Prescription: 1000 amounts
The CEFUROXIME AXETIL of recipe quantity is dissolved in the tert-butyl alcohol (among the solution a) of recipe quantity, and stirring and dissolving continues to stir at normal temperatures, and mannitol, the sucralose of recipe quantity is dissolved in the purified water (solution b) of prescription with purified water total amount 70%-80%; Gelatin with recipe quantity is dissolved in the purified water (solution c) of prescription water consumption 20%-30% again, is heated to dissolving fully; Merge above-mentioned b, two kinds of solution of c are solution d, and stir, mixed then solution is cooled to below 5 ℃.Mix a, two kinds of solution of d, and stir, regulate pH to 5.5-6.5 with sodium bicarbonate; According to CEFUROXIME AXETIL composition freeze-drying oral cavity disintegration tablet specification, confirm loading amount after, with the medicinal liquid after merging by in the loading amount packing drug-containing dish; And put into freeze drying box, medicinal liquid is carried out freezing, treat CEFUROXIME AXETIL composition freeze-drying oral cavity disintegration tablet drying after; In freeze drying box, seal, take out back cutting, packing.
Embodiment 2
With the 125mg/ sheet is that example prepares CEFUROXIME AXETIL composition freeze-drying oral cavity disintegration tablet,
Prescription: 1000 amounts
The CEFUROXIME AXETIL of recipe quantity is dissolved in the tert-butyl alcohol (among the solution a) of recipe quantity, and stirring and dissolving continues to stir at normal temperatures, and mannitol, the sucralose of recipe quantity is dissolved in the purified water (solution b) of prescription with purified water total amount 70%-80%; Gelatin with recipe quantity is dissolved in the purified water (solution c) of prescription water consumption 20%-30% again, is heated to dissolving fully; Merge above-mentioned b, two kinds of solution of c are solution d, and stir, mixed then solution is cooled to below 5 ℃.Mix a, two kinds of solution of d, and stir, regulate pH to 5.5-6.5 with sodium bicarbonate; According to CEFUROXIME AXETIL composition freeze-drying oral cavity disintegration tablet specification, confirm loading amount after, with the medicinal liquid after merging by in the loading amount packing drug-containing dish; And put into freeze drying box, medicinal liquid is carried out freezing, treat CEFUROXIME AXETIL composition freeze-drying oral cavity disintegration tablet drying after; In freeze drying box, seal, take out back cutting, packing.
Embodiment 3
With the 125mg/ sheet is that example prepares CEFUROXIME AXETIL composition freeze-drying oral cavity disintegration tablet,
Prescription: 1000 amounts
The CEFUROXIME AXETIL of recipe quantity is dissolved in the tert-butyl alcohol (among the solution a) of recipe quantity, and stirring and dissolving continues to stir at normal temperatures, and mannitol, the sucralose of recipe quantity is dissolved in the purified water (solution b) of prescription with purified water total amount 70%-80%; Gelatin with recipe quantity is dissolved in the purified water (solution c) of prescription water consumption 20%-30% again, is heated to dissolving fully; Merge above-mentioned b, two kinds of solution of c are solution d, and stir, mixed then solution is cooled to below 5 ℃.Mix a, two kinds of solution of d, and stir, regulate pH to 5.5-6.5 with sodium bicarbonate; According to CEFUROXIME AXETIL composition freeze-drying oral cavity disintegration tablet specification, confirm loading amount after, with the medicinal liquid after merging by in the loading amount packing drug-containing dish; And put into freeze drying box, medicinal liquid is carried out freezing, treat CEFUROXIME AXETIL composition freeze-drying oral cavity disintegration tablet drying after; In freeze drying box, seal, take out back cutting, packing.
More than show and described ultimate principle of the present invention, principal character and advantage of the present invention.The technical staff of the industry should understand; The present invention is not restricted to the described embodiments; That describes in the foregoing description and the description is merely preference of the present invention, is not used for limiting the present invention, under the prerequisite that does not break away from spirit and scope of the invention; The present invention also has various changes and modifications, and these variations and improvement all fall in the scope of the invention that requires protection.The present invention requires protection domain to be defined by appending claims and equivalent thereof.
Claims (6)
1. a cefuroxime ester composition is characterized in that, said composition comprises following component and component quantity ratio:
2. cefuroxime ester composition according to claim 1 is characterized in that, the preferred ingredient quantity ratio of said each component of cefuroxime ester composition is:
3. a CEFUROXIME AXETIL composition freeze-drying oral cavity disintegration tablet that contains the said compositions of claim 1 is characterized in that, is prepared from following component and component quantity ratio:
4. CEFUROXIME AXETIL composition freeze-drying oral cavity disintegration tablet according to claim 3 is characterized in that, the preferred ingredient quantity ratio of each component of preparation CEFUROXIME AXETIL composition freeze-drying oral cavity disintegration tablet is:
5. the method for preparing of the said CEFUROXIME AXETIL composition freeze-drying of claim 3 oral cavity disintegration tablet is characterized in that the concrete steps of this method for preparing are:
A) CEFUROXIME AXETIL with recipe quantity is dissolved in the tert-butyl alcohol of recipe quantity, and stirring and dissolving continues to stir at normal temperatures, preparation solution a;
B) mannitol, the sucralose with recipe quantity is dissolved in the purified water of prescription with pure water total amount 70%-80%, preparation solution b;
C) again the gelatin of recipe quantity and xanthan gum are dissolved in the purified water of prescription water consumption 20%-30%, are heated to dissolving fully, preparation solution c;
D) merge two kinds of solution that above-mentioned steps a, step b obtain and become solution d, and stir, mixed then solution is cooled to below 5 ℃;
E) mix a, two kinds of solution of d, and stir, regulate pH value to 6.0-6.5 with sodium bicarbonate;
F) according to CEFUROXIME AXETIL composition freeze-drying oral cavity disintegration tablet specification, confirm loading amount after, the medicinal liquid that merges is moved in the drug-containing dish by loading amount, and puts into freeze drying box, to medicinal liquid carry out freezing, evacuation is dry, the control moisture is no more than 1.0%;
G) treat CEFUROXIME AXETIL composition freeze-drying oral cavity disintegration tablet drying after, in household freezer, seal;
H) cut drug-containing dish after the medicament that freezes is taken out freeze drying box, and carry out finished product packing.
6. the method for preparing of CEFUROXIME AXETIL composition freeze-drying oral cavity disintegration tablet according to claim 5 is characterized in that: described CEFUROXIME AXETIL composition freeze-drying oral cavity disintegration tablet specification is 125mg/ sheet, 250mg/ sheet.
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| CN2012103014331A CN102784124A (en) | 2012-08-23 | 2012-08-23 | Cefuroxime axetil composition freeze-dried orally disintegrating tablets and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104546765A (en) * | 2014-12-25 | 2015-04-29 | 海南卫康制药(潜山)有限公司 | Cefuroxime composition freeze-dried tablet and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005018618A1 (en) * | 2003-08-23 | 2005-03-03 | Korea United Pharm, Inc | Formulation of stable for moisture absorption and quickly dissolved tablet containing cefuroxime axetil and it's manufacturing process |
| CN1689649A (en) * | 2004-04-30 | 2005-11-02 | 量子高科（北京）研究院有限公司 | Oral cavity quick dissolving preparation and production method thereof |
| CN102579378A (en) * | 2012-02-07 | 2012-07-18 | 海南卫康制药(潜山)有限公司 | Child cefdinir composition freeze-dried oral disintegrating tablet and preparation method thereof |
| CN102614138A (en) * | 2011-01-26 | 2012-08-01 | 量子高科（北京）研究院有限公司 | Oral disintegrating tablet and preparation method thereof |
-
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- 2012-08-23 CN CN2012103014331A patent/CN102784124A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005018618A1 (en) * | 2003-08-23 | 2005-03-03 | Korea United Pharm, Inc | Formulation of stable for moisture absorption and quickly dissolved tablet containing cefuroxime axetil and it's manufacturing process |
| CN1689649A (en) * | 2004-04-30 | 2005-11-02 | 量子高科（北京）研究院有限公司 | Oral cavity quick dissolving preparation and production method thereof |
| CN102614138A (en) * | 2011-01-26 | 2012-08-01 | 量子高科（北京）研究院有限公司 | Oral disintegrating tablet and preparation method thereof |
| CN102579378A (en) * | 2012-02-07 | 2012-07-18 | 海南卫康制药(潜山)有限公司 | Child cefdinir composition freeze-dried oral disintegrating tablet and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104546765A (en) * | 2014-12-25 | 2015-04-29 | 海南卫康制药(潜山)有限公司 | Cefuroxime composition freeze-dried tablet and preparation method thereof |
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Application publication date: 20121121 |