CN102512703A - Medicinal dressing and preparation method thereof - Google Patents
Medicinal dressing and preparation method thereof Download PDFInfo
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- CN102512703A CN102512703A CN2012100060200A CN201210006020A CN102512703A CN 102512703 A CN102512703 A CN 102512703A CN 2012100060200 A CN2012100060200 A CN 2012100060200A CN 201210006020 A CN201210006020 A CN 201210006020A CN 102512703 A CN102512703 A CN 102512703A
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Abstract
The invention provides a preparation method for a medicinal dressing. The method comprises the following the steps of: (a) pretreating a substrate, wherein the substrate is selected from a pigskin biological dressing or an amniotic membrane biological dressing or carbon fiber medical cloth, and the pretreatment comprises a process of drying the substrate; (b) in a vacuum environment, compounding nanometer silver particles on the substrate with a physical vapor deposition method; and (c) putting the substrate compounded with the nanometer silver particles into medical iodine for soaking. The invention further discloses a medical dressing. By using the method, clean nanometer silver particles with certain depths can be obtained on the substrate, and the obtained medical dressing has strong sterilizing and bacteriostasis functions and high slow release property.
Description
Technical field
The present invention relates to a kind of medical dressing and preparation method thereof, relate in particular to a kind of medical dressing that is compounded with nano-Ag particles and preparation method thereof.
Background technology
In recent years, the medical dressing that in burn wound's treatment technology, is widely used is like Corii Sus domestica biological dressing, amniotic membrane biological dressing, carbon cloth etc.The physicochemical property of Corii Sus domestica biological dressing and structure and human body skin are similar, and with low cost, are widely used as the burn medical dressing.Yet Corii Sus domestica does not have initiatively anti-infection ability, becomes the place of breed bacteria easily.Therefore, the homemade cream of the general employing of traditional treatment external use burn treating medicine has strong bactericidal action like free Ag+ in the Sulfadiazine Silver Cream, thereby plays convergence and antibacterial and promote the effect that cell is grown.But the repeatability that the problem that this type of cream exists is batch, the uniformity of active ion, slow-releasing etc. are relatively poor.
Silver nano-grain is widely used in medical material with its unique anti-microbial property; There are some researches show: nanometer silver second of bactericidal activity row in all metals; It all has staphylococcus aureus common in the effect, particularly burn wound, escherichia coli, bacillus pyocyaneus, Candida albicans that stronger bactericidal action is all arranged to gram positive bacteria, gram negative bacteria, fungus.Therefore, nanometer silver and biological dressing are carried out compoundly will effectively improving its treatment function.
Along with the development of nanotechnology, the medical dressing that contains nanometer silver engenders, is that carrier is processed antiseptic dressing with the gauze how; The report that composite nano silver on medical dressing is also arranged; As, report such as Jing Hongxia [Chinese public health volume o. 11th November the 26th in 2010, P1355]: adopt AgNO
3And HNO
3Mixed solution on Corii Sus domestica, prepare the Ag nano-particle.But this method is a kind of chemical method, more or less can be in medical dressing more residual chemical substances, unfavorable to follow-up use clinically.
Summary of the invention
Deficiency to prior art; The technical problem that the present invention solves is to provide a kind of medical dressing and preparation method thereof; Utilize this method can on base material, obtain clean and nano-Ag particles that have certain depth; The medical dressing that is obtained has stronger antibacterial, bacteriostasis, and has slow-releasing preferably.
For solving the problems of the technologies described above, technical scheme of the present invention is achieved in that a kind of method for preparing of medical dressing, especially, comprises the steps:
(a) base material is carried out pretreatment, said base material is selected from Corii Sus domestica biological dressing or amniotic membrane biological dressing or the medical cloth of carbon fiber, and said pretreatment comprises carries out exsiccant process to said base material;
(b) under vacuum environment, through physical gas-phase deposite method composite nano silver granule on base material;
The base material that (c) will be compounded with nano-Ag particles is placed in the medical iodine tincture and soaks, and obtains medical dressing.
Preferably, in the method for preparing of above-mentioned medical dressing, the pretreatment of said base material comprises the process that base material is flattened.
Preferably, in the method for preparing of above-mentioned medical dressing, in the said step (b), the physical vacuum deposition process is a magnetron sputtering method.
Preferably, in the method for preparing of above-mentioned medical dressing, the power of magnetron sputtering is 30～300 watts, and the time is 0～60 second.
Preferably, in the method for preparing of above-mentioned medical dressing, said step (b) specifically describes and is:
(1) base material with silver-colored target and pretreatment completion is positioned in the vacuum chamber;
(2) vacuum chamber is carried out evacuation, the air pressure in the control vacuum chamber is at first pressure;
(3) open the radio-frequency power supply preheating, logical argon is controlled at 3～5Pa with gas pressure in vacuum, the beginning magnetron sputtering;
(4) after sputter is accomplished, close radio-frequency power supply, stop to supply argon, to carrying out evacuation in the vacuum chamber and control air pressure at second pressure, it is indoor to feed nitrogen to vacuum then, treats that air pressure reaches after 1 atmospheric pressure, takes out base material.
Preferably, in the method for preparing of above-mentioned medical dressing, said first pressure is less than 10
-2Pa, said second pressure is less than 10
-3Pa.
Preferably, in the method for preparing of above-mentioned medical dressing, the time that said base material soaks in medical iodine tincture is more than 24 hours.
The invention also discloses a kind of medical dressing, said medical dressing is to obtain according to above-mentioned method for preparing.
The invention discloses a kind of medical dressing and preparation method thereof, it is under vacuum environment, to adopt physical gas-phase deposite method composite nano silver granule on base material, and then obtains medical dressing.Because this method for preparing is under vacuum environment, to carry out, and adopt physical means, so the nano-Ag particles that obtains is relatively cleaner; Through physical gas-phase deposite method, make nano-Ag particles on base material, be evenly distributed, and on base material, form certain degree of depth, so improve the slow-releasing of medical dressing; Be compounded with the medical dressing of nano-Ag particles, have stronger antibacterial and bacteriostasis; Simultaneously, Corii Sus domestica biological dressing or amniotic membrane biological dressing biologically active, and also soft, easy and wound is fitted.
Description of drawings
In order to be illustrated more clearly in the technical scheme in the embodiment of the invention; The accompanying drawing of required use is done to introduce simply in will describing embodiment below; Obviously, the accompanying drawing in describing below only is some embodiments of the present invention, for those of ordinary skills; Under the prerequisite of not paying creative work, can also obtain other accompanying drawing according to these accompanying drawings.
Fig. 1 is the structural representation of medical dressing in the specific embodiment of the invention;
Fig. 2 is the photo of medical dressing when different sputtering time in the specific embodiment of the invention;
Fig. 3 is the X-ray diffraction spectrum of medical dressing in the specific embodiment of the invention;
Fig. 4 is the photo of medical dressing under ultramicroscope in the specific embodiment of the invention.
The specific embodiment
In order further to understand the present invention, below in conjunction with embodiment the preferred embodiment of the invention is described, describe just to further specifying feature and advantage of the present invention but should be appreciated that these, rather than to the restriction of claim of the present invention.
The embodiment of the invention provides a kind of method for preparing of medical dressing, comprises the steps:
(a) base material is carried out pretreatment, said base material is selected from Corii Sus domestica biological dressing or amniotic membrane biological dressing or the medical cloth of carbon fiber, and said pretreatment comprises carries out exsiccant process to said base material;
(b) under vacuum environment, through physical gas-phase deposite method composite nano silver granule on base material;
The base material that (c) will be compounded with nano-Ag particles is placed in the medical iodine tincture and soaks, and obtains medical dressing.
This method for preparing is under vacuum environment, to carry out, and adopts physical means, thereby has avoided the pollution of chemical substance, and the nano-Ag particles of acquisition is relatively cleaner.
Through physical gas-phase deposite method, make nano-Ag particles on base material, be evenly distributed, and on base material, form certain degree of depth, improved the slow-releasing of medical dressing.The raising of slow-releasing can alleviate medical and nursing work person's workload, has reduced patient's dressing change frequency simultaneously, greatly reduces patient's misery.
Base material preferably adopts Corii Sus domestica biological dressing or amniotic membrane biological dressing.The physicochemical property of Corii Sus domestica biological dressing or amniotic membrane biological dressing and structure and human body skin are similar, and with low cost, are widely used as the burn medical dressing.
The pretreatment of base material comprises base material is flattened and exsiccant process.Flatten and in sputter procedure, to make silver-colored uniform particles ground beat surface at base material; Drying is preferably drawn water to base material under the vacuum high-temperature environment, the process of drawing water can forvacuum indoor carry out or other drying equipment in carry out, purpose is to prevent that the base material that contains moisture from causing damage to equipment in sputter procedure.The preprocessing process of base material can also comprise the disinfectant process.
Physical vapour deposition (PVD) (Physical Vapor Deposition; PVD) technique table is shown under the vacuum condition; Adopt physical method; Material source-solid or liquid surface are gasificated into gaseous atom, molecule or partial ionization become ion, and, have the technology of the thin film of certain specific function in the substrate surface deposition through low-pressure gas (or plasma) process.The main method of physical vapour deposition (PVD) has: vacuum evaporation, magnetron sputtering plating, arc-plasma plating, ion film plating and molecular beam epitaxy etc.
In the embodiment of the invention, physical gas-phase deposite method is preferably magnetron sputtering method.The power of magnetron sputtering is 30～300 watts, and the time is 0～60 second.In other embodiments, also can adopt methods such as vacuum evaporation, arc-plasma plating, ion film plating and molecular beam epitaxy.
Nano-Ag particles all has stronger bactericidal action to staphylococcus aureus common in the burn wound, escherichia coli, bacillus pyocyaneus, Candida albicans.Have stronger antibacterial and bacteriostasis so be compounded with the medical dressing of nano-Ag particles.
Preferably, in the method for preparing of above-mentioned medical dressing, said step (b) specifically describes and is:
(1) base material with silver-colored target and pretreatment completion is positioned in the vacuum chamber;
(2) vacuum chamber is carried out evacuation, the air pressure in the control vacuum chamber is at first pressure;
(3) open the radio-frequency power supply preheating, logical argon is controlled at 3～5Pa with gas pressure in vacuum, the beginning magnetron sputtering;
(4) after sputter is accomplished, close radio-frequency power supply, stop to supply argon, to carrying out evacuation in the vacuum chamber and control air pressure at second pressure, it is indoor to feed nitrogen to vacuum then, treats that air pressure reaches after 1 atmospheric pressure, takes out the base material that is compounded with nano-Ag particles.
First pressure is preferably less than 10
-2Pa, second pressure is preferably less than 10
-3Pa.
Preferably, base material time of in medical iodine tincture, soaking was preferably more than 24 hours.After the substrate passed pretreatment, moisture is drained, and after magnetron sputtering is accomplished, through it is immersed in the iodine tincture, can also play germ-resistant effect simultaneously so that base material absorbs water and returns to softish state.
The degree of depth of the size of nano-Ag particles and implantation base material can be regulated through the power of control magnetron sputtering; The content of nano-Ag particles can be regulated through the time of control sputter.
The embodiment of the invention also provides a kind of medical dressing, and this medical dressing is to obtain according to above-mentioned method for preparing.
Join shown in Figure 1ly, medical dressing comprises two-layer, is respectively nano-Ag particles layer 1 and base material 2, and nano-Ag particles layer 1 part at least is implanted in the base material 2.Because nano-Ag particles forms certain degree of depth at substrate surface; So improved the slow-releasing of silver ion, make medical dressing have longer service time, alleviated medical and nursing work person's workload; Reduce patient's dressing change frequency simultaneously, alleviated patient's misery greatly.
In order to further specify technical scheme of the present invention; Below in conjunction with embodiment the preferred embodiment of the invention is described; Describe just to further specifying feature and advantage of the present invention but should be appreciated that these, rather than to the restriction of claim of the present invention.
The method for preparing of medical dressing is following:
(1) the Corii Sus domestica biological dressing is flattened, and it is indoor to put into the forvacuum of magnetron sputtering apparatus, opens the mechanical pump evacuation 30 minutes, the moisture in the Corii Sus domestica biological dressing is drawn out of;
(2) open the magnetron sputtering apparatus power supply, logical cooling water, vacuum chamber is opened in inflation in the vacuum chamber, and the high-purity silver target is installed, and lays the good Corii Sus domestica biological dressing of pretreatment, the sealed vacuum chamber;
(3) open mechanical pump, to carrying out evacuation in the vacuum chamber, control vacuum chamber internal gas pressure is opened molecular pump, pumping high vacuum to 10 then below 5Pa
-2Below the Pa;
(4) opened the radio frequency source preheating 5～15 minutes, logical argon transfers to 3～5Pa with gas pressure in vacuum, beginning sputter, 30～300 watts of adjustable power scopes, sputter 0-60 second;
(5) treat that sputter is accomplished after, close radio-frequency power supply, stop to supply argon, be evacuated to 10-3Pa, close extract system, it is indoor to feed nitrogen to vacuum then, treats that air pressure reaches after 1 atmospheric pressure, opens vacuum chamber, takes out the Corii Sus domestica biological dressing;
The Corii Sus domestica biological dressing that (6) will be compounded with nano-Ag particles is put into medical iodine tincture immersion 24 hours, obtains medical dressing.
Join shown in Figure 2ly, medical dressing is the photo under different sputtering times respectively.The medical dressing that is compounded with nano-Ag particles of method for preparing is used for bacteriostatic test, and the medical dressing that under different sputtering times, obtains all has stronger bacteriostasis; And place and still can suppress breeding and the growth of antibacterial on the surface in many days, explain that the stability of prepared medical dressing and slow-releasing are better.
Join shown in Figure 3ly, be the X-ray diffraction spectrum of the medical dressing that obtained; Join shown in Figure 4ly, be the photo of medical dressing under scanning electron microscope that is obtained.
In sum, the invention discloses a kind of medical dressing and preparation method thereof, it is under vacuum environment, to adopt physical gas-phase deposite method composite nano silver granule on base material, and then obtains medical dressing.The invention also discloses a kind of medical dressing.Because this method for preparing is under vacuum environment, to carry out, and adopt physical means, so the nano-Ag particles that obtains is relatively cleaner; Through physical gas-phase deposite method, make nano-Ag particles on base material, be evenly distributed, and on base material, form certain degree of depth, so improve the slow-releasing of medical dressing; Simultaneously, be compounded with the medical dressing of nano-Ag particles, have stronger antibacterial and bacteriostasis.
The explanation of above embodiment just is used for helping to understand method of the present invention and core concept thereof.Should be pointed out that for those skilled in the art, under the prerequisite that does not break away from the principle of the invention, can also carry out some improvement and modification to the present invention, these improvement and modification also fall in the protection domain of claim of the present invention.
To the above-mentioned explanation of the disclosed embodiments, make this area professional and technical personnel can realize or use the present invention.Multiple modification to these embodiment will be conspicuous concerning those skilled in the art, and defined General Principle can realize under the situation that does not break away from the spirit or scope of the present invention in other embodiments among this paper.Therefore, the present invention will can not be restricted to these embodiment shown in this paper, but will meet and principle disclosed herein and features of novelty the wideest corresponding to scope.
Claims (8)
1. the method for preparing of a medical dressing is characterized in that, comprises the steps:
(a) base material is carried out pretreatment, said base material is selected from Corii Sus domestica biological dressing or amniotic membrane biological dressing or the medical cloth of carbon fiber, and said pretreatment comprises carries out exsiccant process to said base material;
(b) under vacuum environment, through physical gas-phase deposite method composite nano silver granule on base material;
The base material that (c) will be compounded with nano-Ag particles is placed in the medical iodine tincture and soaks, and obtains medical dressing.
2. the method for preparing of medical dressing according to claim 1, it is characterized in that: the pretreatment of said base material also comprises the process that base material is flattened.
3. the method for preparing of medical dressing according to claim 1, it is characterized in that: in the said step (b), the physical vacuum deposition process is a magnetron sputtering method.
4. the method for preparing of medical dressing according to claim 3, it is characterized in that: the power of magnetron sputtering is 30～300 watts, the time is 0～60 second.
5. the method for preparing of medical dressing according to claim 4 is characterized in that: said step (b) specifically describes and is:
(1) base material with silver-colored target and pretreatment completion is positioned in the vacuum chamber;
(2) vacuum chamber is carried out evacuation, the air pressure in the control vacuum chamber is at first pressure;
(3) open the radio-frequency power supply preheating, logical argon is controlled at 3～5Pa with gas pressure in vacuum, the beginning magnetron sputtering;
(4) after sputter is accomplished, close radio-frequency power supply, stop to supply argon, to carrying out evacuation in the vacuum chamber and control air pressure at second pressure, it is indoor to feed nitrogen to vacuum then, treats that air pressure reaches after 1 atmospheric pressure, takes out base material.
6. the method for preparing of medical dressing according to claim 5, it is characterized in that: said first pressure is less than 10
-2Pa, said second pressure is less than 10
-3Pa.
7. the method for preparing of medical dressing according to claim 1, it is characterized in that: the time that said base material soaks in medical iodine tincture is more than 24 hours.
8. medical dressing is characterized in that: said medical dressing obtains according to any described method for preparing of claim 1 to 7.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100060200A CN102512703A (en) | 2012-01-10 | 2012-01-10 | Medicinal dressing and preparation method thereof |
| CN 201320010684 CN203029680U (en) | 2012-01-10 | 2013-01-09 | Medical dressing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100060200A CN102512703A (en) | 2012-01-10 | 2012-01-10 | Medicinal dressing and preparation method thereof |
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| CN102512703A true CN102512703A (en) | 2012-06-27 |
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| CN 201320010684 Expired - Fee Related CN203029680U (en) | 2012-01-10 | 2013-01-09 | Medical dressing |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108926741A (en) * | 2018-06-20 | 2018-12-04 | 复旦大学附属华山医院 | A kind of preparation method of amnion biological sticking patch |
| CN111358807A (en) * | 2020-04-01 | 2020-07-03 | 赵莹 | Nano-silver modified complex iodine composite dry powder disinfection aerosol and preparation method thereof |
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2012
- 2012-01-10 CN CN2012100060200A patent/CN102512703A/en active Pending
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2013
- 2013-01-09 CN CN 201320010684 patent/CN203029680U/en not_active Expired - Fee Related
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| 《中国公共卫生》 20101130 景红霞，黄桂娟，鲁双云，夏栋林，顾海鹰 纳米银/猪皮基质医用敷料抑菌效果评价 1.2.1纳米银/猪皮基质敷料制备 1-7 第26卷, 第11期 * |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108926741A (en) * | 2018-06-20 | 2018-12-04 | 复旦大学附属华山医院 | A kind of preparation method of amnion biological sticking patch |
| CN108926741B (en) * | 2018-06-20 | 2021-05-25 | 复旦大学附属华山医院 | Preparation method of amnion biological patch |
| CN111358807A (en) * | 2020-04-01 | 2020-07-03 | 赵莹 | Nano-silver modified complex iodine composite dry powder disinfection aerosol and preparation method thereof |
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| CN203029680U (en) | 2013-07-03 |
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Application publication date: 20120627 |