CN102512635B - Chinese medicine mixture and application thereof and preparing method of Chinese medicine composition and Chinese medicine mixture - Google Patents
Chinese medicine mixture and application thereof and preparing method of Chinese medicine composition and Chinese medicine mixture Download PDFInfo
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Abstract
The invention provides a Chinese medicine composition, a preparing method of a Chinese medicine mixture, the Chinese medicine mixture prepared and obtained by the preparing method and application of the Chinese mixture. In the Chinese composition, by means of reasonable proportion of content and coordinate effects of medicinal materials, the Chinese medicine mixture prepared and obtained by the preparing method has good curative effects in treatment of rheumatism and rheumatoid arthritis.
Description
Technical field
The invention belongs to the Chinese medicine compound technical field, be specifically related to the preparation method of a kind of Chinese medicine composition, herb mixture and herb mixture and the application thereof that is obtained by this preparation method.
Background technology
Rheumatism, rheumatoid arthritis are a kind of chronic systemic autoimmune diseases.Main infringement whole body is the joint everywhere, is multiple and symmetry chronic hyperplastic synovitis, and the destruction that causes thus articular cartilage and joint capsule causes the ankylosis deformity at last.Except the joint, health other organ or tissues also can get involved, and comprise that subcutaneous tissue, the heart, blood vessel, lung, spleen, lymph node, eye and serous coat etc. locate.The primary disease age of onset is many between 25-55 year, also sees the child.Women's sickness rate than the high 2-3 of male doubly.Primary disease is chronic process, and pathological changes exacerbates and alleviates repeatedly and hockets.China is populous nation, is also rheumatism state occurred frequently simultaneously, particularly in southern city.At present the patient of significant proportion not have to respond to existing Drug therapy and maybe can not reach lasting response, clinical new, more effective antirheumatic is still existed objective demand thereby point out.
Chinese medicine has a long history in China, the effectiveness such as many medical materials have removing dampness, subside a swelling, invigorate blood circulation, pain relieving, invigorating the liver and kidney, bone and muscle strengthening, but do not find yet a kind of Chinese medicine preparation that can have good treatment rheumatism, rheumatoid arthritis at present.
Summary of the invention
The invention solves and do not find a kind of technical problem that can have the Chinese medicine preparation of good treatment rheumatism, rheumatoid arthritis in prior art.
the invention provides a kind of Chinese medicine composition, described Chinese medicine composition contains following component: Radix Clematidis 10-15 weight portion, Radix Gentianae Macrophyllae 10-15 weight portion, Pheretima 5-8 weight portion, Fructus Chaenomelis 10-15 weight portion, Rhizoma Chuanxiong 10-15 weight portion, Ramulus Uncariae Cum Uncis 3-6 weight portion, Radix Angelicae Pubescentis 10-15 weight portion, Rhizoma Corydalis 5-8 weight portion, Periostracum Cicadae 5-8 weight portion, Rhizoma Homalomenae 8-12 weight portion, Cortex Eucommiae 8-12 weight portion, Rhizoma Curcumae 10-15 weight portion, Cortex Acanthopancis 10-15 weight portion, Herba Lycopodii 5-8 weight portion, Caulis Clematidis Armandii 10-15 weight portion, Radix Polygoni Multiflori 10-15 weight portion, Flos Carthami 5-8 weight portion, Flos Lonicerae 10-15 weight portion, Pericarpium Citri Reticulatae 5-8 weight portion, Radix Notoginseng 1-4 weight portion, Cornu Cervi Pantotrichum 0.1-0.5 weight portion, Radix Glycyrrhizae 10-15 weight portion.
The present invention also provides a kind of preparation method of herb mixture, described preparation method comprises: Chinese medicine composition provided by the invention is mixed in proportion, add alcohol reflux after 1 hour soaking at room temperature 2-5 days, cross 100 order screens, add aqueous sucrose solution in filtrate, obtain described herb mixture.
The present invention also provides a kind of herb mixture, and described herb mixture is prepared by preparation method provided by the invention.
At last, the invention provides the application of described herb mixture in treatment rheumatism, rheumatoid arthritis.
In Chinese medicine composition provided by the invention, the inventor makes and adopts the herb mixture that Chinese medicine composition provided by the invention prepares having good curative effect aspect treatment rheumatism, rheumatoid arthritis by rational proportion, the synergism of each medical material of research.Simultaneously, in the preparation method of herb mixture provided by the invention, by adopting the soak with ethanol Chinese medicine composition, and choose reasonable soak time, make the leaching rate of active component in Chinese medicine composition of the present invention higher, in herb mixture provided by the invention, the active drug component has higher content thereby make, thereby treatment rheumatism, rheumatoid arthritis aspect is had better curative effect.
The specific embodiment
the invention provides a kind of Chinese medicine composition, described Chinese medicine composition contains following component: Radix Clematidis 10-15 weight portion, Radix Gentianae Macrophyllae 10-15 weight portion, Pheretima 5-8 weight portion, Fructus Chaenomelis 10-15 weight portion, Rhizoma Chuanxiong 10-15 weight portion, Ramulus Uncariae Cum Uncis 3-6 weight portion, Radix Angelicae Pubescentis 10-15 weight portion, Rhizoma Corydalis 5-8 weight portion, Periostracum Cicadae 5-8 weight portion, Rhizoma Homalomenae 8-12 weight portion, Cortex Eucommiae 8-12 weight portion, Rhizoma Curcumae 10-15 weight portion, Cortex Acanthopancis 10-15 weight portion, Herba Lycopodii 5-8 weight portion, Caulis Clematidis Armandii 10-15 weight portion, Radix Polygoni Multiflori 10-15 weight portion, Flos Carthami 5-8 weight portion, Flos Lonicerae 10-15 weight portion, Pericarpium Citri Reticulatae 5-8 weight portion, Radix Notoginseng 1-4 weight portion, Cornu Cervi Pantotrichum 0.1-0.5 weight portion, Radix Glycyrrhizae 10-15 weight portion.
In Chinese medicine composition provided by the invention, the inventor makes and adopts the herb mixture that Chinese medicine composition provided by the invention prepares having good curative effect aspect treatment rheumatism, rheumatoid arthritis by rational proportion, the synergism of each medical material component of research.
Particularly, in Chinese medicine composition provided by the invention, the mechanism of action of each medical material component is:
Radix Clematidis: acrid in the mouth, salty, warm; Return urinary bladder channel.Radix Clematidis has the function of expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, is used for rheumatic arthralgia, lumbocrural pain, beriberi cold type of pain, injury from falling down.
Radix Gentianae Macrophyllae: acrid in the mouth, hardship, property is flat; Enter stomach, liver, gallbladder meridian.Radix Gentianae Macrophyllae has the function of wind-damp dispelling, clearing away damp-heat, stopping numbness pain, is used for rheumatic arthralgia, the contracture of muscle arteries and veins, the tired pain of joint, day dried meat hectic fever, infantile malnutrition heating.
Pheretima: salty in the mouth, cold; Return liver, spleen, urinary bladder channel.Pheretima has fixed horrified, the collateral dredging of heat clearing away, relievings asthma, the function of diuresis, is used for the diseases such as unconsciousness due to high fever, infantile convulsion tic, arthralgia, hemiplegia, dyspnea and cough due to lung-heat, oliguria edema.
Fructus Chaenomelis: acid, temperature.Fructus Chaenomelis energy suppressing the hyperactive liver Shujin, stomach function regulating blood stasis dispelling are used for arthralgia chiefly caused by damp pathogen contracture, the heavy pain of waist knee joint acid, rush down convulsion, beriberi edema.
Rhizoma Chuanxiong: acrid in the mouth, little hardship, warm in nature; Enter liver, gallbladder, heart born of the same parents warp.Rhizoma Chuanxiong has the function of blood-activating and qi-promoting, wind-expelling pain-stopping, is used for menoxenia, amenorrhea, dysmenorrhea, mass in the abdomen stomachache, headache, rheumatic arthralgia.
Ramulus Uncariae Cum Uncis: sweet, cool; Return liver, pericardium channel.Ramulus Uncariae Cum Uncis can heat clearing away suppressing the hyperactive liver, dispelling wind and relieving convulsion, dizzy, the dysphoric cold of being used for having a headache, infantile convulsion tic, pre-eclampsia, vascular hypertension.
Radix Angelicae Pubescentis: acrid in the mouth, hardship, slightly warm in nature; Enter kidney, urinary bladder channel.Radix Angelicae Pubescentis has the function of expelling wind and removing dampness, numbness relieving and pain relieving, is used for anemofrigid-damp arthralgia, lumbocrural pain, few cloudy volt wind headache.
Rhizoma Corydalis: acrid, bitter, warm; Return liver, spleen channel.Rhizoma Corydalis has the function of promoting blood circulation to remove blood stasis, promoting the circulation of QI pain relieving, is used for the breast side of body, chamber abdomen pain, amenorrhea dysmenorrhea, postpartum stagnation.
Periostracum Cicadae: sweet, cold.Periostracum Cicadae can fall apart wind dehumidifying, sore-throat relieving, rash, nebula removing, spasmolytic are used for rheumatism flu, pharyngalgia, silent, measles without adequate eruption, rubella pruritus, conjunctival congestion cataracta, convulsion with spasms, tetanus.
Rhizoma Homalomenae: bitter, hot, temperature; Return liver, kidney channel.Rhizoma Homalomenae has the function of wind dispelling collateral dredging, strengthening bone and muscle, alleviating pain and detumescence, is used for anemofrigid-damp arthralgia, bones and muscles pain, contracture numbness.
The Cortex Eucommiae: sweet, warm; Return liver, kidney channel.The Cortex Eucommiae has invigorating the liver and kidney, bone and muscle strengthening, antiabortive function, is used for that lumbago due to renal deficiency, muscles and bones are unable, blood leaking in gestation, frequent fetal movement.
Rhizoma Curcumae: acrid, bitter, warm; Return liver, spleen channel.Rhizoma Curcumae has the function of circulation of qi promoting removing blood stasis, removing food stagnancy pain relieving, the diseases such as Yong Yu mass in the abdomen mass in the abdomen, congestion amenorrhea, food stagnation distending pain, early cervical carcinoma.
Cortex Acanthopancis: warm in nature, acrid in the mouth, hardship.Cortex Acanthopancis can wind-damp dispelling, invigorating the liver and kidney, bone and muscle strengthening, is used for that rheumatic arthralgia, muscles and bones flaccidity are soft, children's's walking retardation in children, body void are weak, edema, beriberi.
Herba Lycopodii: hardship, suffering, temperature; Return liver, spleen, kidney channel.Herba Lycopodii has the function of expelling wind and cold, dehumidifying detumescence, relaxing muscles and tendons to promote blood circulation, is used for anemofrigid-damp arthralgia, joint aches, skin numbness, tetraparesis, edema, traumatic injury.
Caulis Clematidis Armandii: bitter in the mouth, cold in nature; Enter the heart, small intestinal, urinary bladder channel.Caulis Clematidis Armandii has clearing away heart-fire, diuresis, stimulates the menstrual flow, the function of stimulating milk secretion, be used for aphtha of the mouth and tongue, vexed dark coloured urine, edema, the puckery pain of pyretic stranguria, leucorrhea, amenorrhea, breast less, the disease such as damp and hot arthralgia pain.
Radix Polygoni Multiflori: bitter, sweet, puckery, warm.The detoxifcation of Radix Polygoni Multiflori energy, eliminating carbuncle, loosening bowel to relieve constipation are used for scrofula carbuncle sore, rubella pruritus, dryness of the intestine constipation, hyperlipidemia.
Flos Carthami: hot, warm; GUIXIN, Liver Channel.Flos Carthami has the function of promoting blood circulation to remove blood stasis, relieving pain of dysmenorrhea, be used for amenorrhea, dysmenorrhea, lochia not Yin, mass in the abdomen mass in the abdomen, skin infection swell and ache, injury from falling down.
Flos Lonicerae: cold in nature, sweet in the mouth.Flos Lonicerae energy heat-clearing and toxic substances removing, wind-heat dissipating are used for carbuncle furuncle, sore throat, erysipelas, warm blood fulminant dysentery, anemopyretic cold, epidemic febrile disease heating.
Pericarpium Citri Reticulatae: bitter, hot, warm; Return lung, spleen channel.Pericarpium Citri Reticulatae has the function of regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm, is used for the diseases such as distension and fullness of the chest and abdomen, lack of appetite and vomiting, cough disease be many.
Radix Notoginseng: sweet, little hardship, temperature; Return liver, stomach warp.Radix Notoginseng has the function of dissipating blood stasis hemostasis, subduing swelling and relieving pain, is used for haematemesis, hemoptysis, has blood in stool, epistaxis, metrorrhagia, traumatic hemorrhage, breast ventral spine pain, falls and flutter congestion, carbuncle pain.
Cornu Cervi Pantotrichum: sweet, salty, warm; Return liver, kidney channel.Cornu Cervi Pantotrichum has invigorating kidney-YANG, benefiting essence-blood, bone and muscle strengthening, is transferred to punching, the function of holder sore, is used for that impotence and seminal emission, cold womb are infertile, weakness and emaciation, Mental fatigue, fear of cold, dizzy, Hiccough and deaf, spinal column cold type of pain, muscles and bones flaccidity are soft, bleeding not during menses, carbuncle of yin nature are not held back.
Radix Glycyrrhizae: sweet in the mouth, property is flat; GUIXIN, lung, taste warp.Radix Glycyrrhizae has the function of invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, all medicines of adjusting, is used for that weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough disease are many, extremity contraction urgency pain, carbuncle sore tumefacting virus, cushion toxicity, pessimum.
as a kind of preferred implementation of the present invention, the content of described each component of Chinese medicine composition is: Radix Clematidis 12 weight portions, Radix Gentianae Macrophyllae 12 weight portions, Pheretima 6 weight portions, Fructus Chaenomelis 12 weight portions, Rhizoma Chuanxiong 12 weight portions, Ramulus Uncariae Cum Uncis 4 weight portions, Radix Angelicae Pubescentis 12 weight portions, Rhizoma Corydalis 6 weight portions, Periostracum Cicadae 6 weight portions, Rhizoma Homalomenae 10 weight portions, the Cortex Eucommiae 10 weight portions, Rhizoma Curcumae 12 weight portions, Cortex Acanthopancis 12 weight portions, Herba Lycopodii 6 weight portions, Caulis Clematidis Armandii 12 weight portions, Radix Polygoni Multiflori 12 weight portions, Flos Carthami 6 weight portions, Flos Lonicerae 12 weight portions, Pericarpium Citri Reticulatae 6 weight portions, Radix Notoginseng 2 weight portions, Cornu Cervi Pantotrichum 0.4 weight portion, Radix Glycyrrhizae 12 weight portions.
The present invention also provides a kind of preparation method of herb mixture, described preparation method comprises: Chinese medicine composition provided by the invention is mixed in proportion, add alcohol reflux after 1 hour soaking at room temperature 2-5 days, cross 100 order screens, add aqueous sucrose solution in filtrate, obtain described herb mixture.
In the preparation method of herb mixture provided by the invention, by adopting alcohol reflux and soaking Chinese medicine composition, and choose reasonable soak time, make the active component in Chinese medicine composition of the present invention have higher leaching rate, in herb mixture provided by the invention, the active drug component has higher content thereby make, thereby treatment rheumatism, rheumatoid arthritis aspect is had better curative effect.
Under preferable case, the consumption of described ethanol is 6-12 times of Chinese medicine composition weight.More preferably in situation, the consumption of described ethanol is 8 times of Chinese medicine composition weight.
In the present invention, the volumetric concentration of described ethanol is 30-50%.Under preferable case, the volumetric concentration of described ethanol is 38%.
The present inventor's discovery, when adopting ethanol that Chinese medicine composition provided by the invention is soaked, its soak time can not be too short, otherwise the active component in Chinese medicine composition can not fully leach.Soak time can not be long, otherwise the active component that leaches can dissolve in Chinese medicine composition again.The present inventor finds by great many of experiments, and during at 2-5 days, in Chinese medicine composition, active component has higher leaching rate when time of soak with ethanol.Under preferable case, the time of soak with ethanol is 4 days, and this moment, the leaching rate of active component reached 19.8%.
In the present invention, described aqueous sucrose solution is various aqueous sucrose solutions commonly used in prior art.For example, the mass concentration of described aqueous sucrose solution is 70-80%.Under preferable case, the consumption of described aqueous sucrose solution is 0.8-1.1 times of Chinese medicine composition weight.
The invention provides a kind of herb mixture, described herb mixture is prepared by preparation method provided by the invention.
At last, the invention provides the application of described herb mixture in treatment rheumatism, rheumatoid arthritis.
The present inventor confirms by experiment, and herb mixture provided by the invention has good curative effect to treatment rheumatism, rheumatoid arthritis.
In order to make technical problem solved by the invention, technical scheme and beneficial effect clearer, below in conjunction with embodiment, the present invention is further elaborated.Should be appreciated that specific embodiment described herein only in order to explain the present invention, is not intended to limit the present invention.
Embodiment 1
(1) preparation Chinese medicine composition S1: Radix Clematidis 12 weight portions, Radix Gentianae Macrophyllae 12 weight portions, Pheretima 6 weight portions, Fructus Chaenomelis 12 weight portions, Rhizoma Chuanxiong 12 weight portions, Ramulus Uncariae Cum Uncis 4 weight portions, Radix Angelicae Pubescentis 12 weight portions, Rhizoma Corydalis 6 weight portions, Periostracum Cicadae 6 weight portions, Rhizoma Homalomenae 10 weight portions, the Cortex Eucommiae 10 weight portions, Rhizoma Curcumae 12 weight portions, Cortex Acanthopancis 12 weight portions, Herba Lycopodii 6 weight portions, Caulis Clematidis Armandii 12 weight portions, Radix Polygoni Multiflori 12 weight portions, Flos Carthami 6 weight portions, Flos Lonicerae 12 weight portions, Pericarpium Citri Reticulatae 6 weight portions, Radix Notoginseng 2 weight portions, Cornu Cervi Pantotrichum 0.4 weight portion, Radix Glycyrrhizae 12 weight portions.
(2) Chinese medicine composition S1 first being adopted volumetric concentration is 38% alcohol reflux 1 hour, then continued soaking at room temperature 2 days, the ethanol consumption is 8 times of Chinese medicine composition weight, then cross 100 order screens, add aqueous sucrose solution in filtrate, the aqueous sucrose solution consumption is 1 times of Chinese medicine composition weight, obtains the herb mixture of 50L, is designated as S10.
Embodiment 2-4
Adopt the herb mixture S20-S40 of the Chinese medicine composition S1 Preparation Example 2-4 of embodiment 1, difference is: the time of immersion is as shown in table 1.
Embodiment 5-8
Preparation Chinese medicine composition A1: Radix Clematidis 10 weight portions, Radix Gentianae Macrophyllae 10 weight portions, Pheretima 5 weight portions, Fructus Chaenomelis 10 weight portions, Rhizoma Chuanxiong 10 weight portions, Ramulus Uncariae Cum Uncis 3 weight portions, Radix Angelicae Pubescentis 10 weight portions, Rhizoma Corydalis 5 weight portions, Periostracum Cicadae 5 weight portions, Rhizoma Homalomenae 8 weight portions, the Cortex Eucommiae 8 weight portions, Rhizoma Curcumae 10 weight portions, Cortex Acanthopancis 10 weight portions, Herba Lycopodii 5 weight portions, Caulis Clematidis Armandii 10 weight portions, Radix Polygoni Multiflori 10 weight portions, Flos Carthami 5 weight portions, Flos Lonicerae 10 weight portions, Pericarpium Citri Reticulatae 5 weight portions, Radix Notoginseng 1 weight portion, Cornu Cervi Pantotrichum 0.1 weight portion, Radix Glycyrrhizae 10 weight portions.
It is 38% alcohol reflux 1 hour that Chinese medicine composition A1 is first adopted volumetric concentration, then continue soaking at room temperature, the ethanol consumption is 6 times of Chinese medicine composition weight, soak time is as shown in table 1, then cross 100 order screens, add aqueous sucrose solution in filtrate, the aqueous sucrose solution consumption is 0.8 times of Chinese medicine composition weight, obtain the herb mixture of 50L, be designated as A10-A40.
Embodiment 9-12
Preparation Chinese medicine composition B1: Radix Clematidis 15 weight portions, Radix Gentianae Macrophyllae 15 weight portions, Pheretima 8 weight portions, Fructus Chaenomelis 15 weight portions, Rhizoma Chuanxiong 15 weight portions, Ramulus Uncariae Cum Uncis 6 weight portions, Radix Angelicae Pubescentis 15 weight portions, Rhizoma Corydalis 8 weight portions, Periostracum Cicadae 8 weight portions, Rhizoma Homalomenae 12 weight portions, the Cortex Eucommiae 12 weight portions, Rhizoma Curcumae 15 weight portions, Cortex Acanthopancis 15 weight portions, Herba Lycopodii 8 weight portions, Caulis Clematidis Armandii 15 weight portions, Radix Polygoni Multiflori 15 weight portions, Flos Carthami 8 weight portions, Flos Lonicerae 15 weight portions, Pericarpium Citri Reticulatae 8 weight portions, Radix Notoginseng 4 weight portions, Cornu Cervi Pantotrichum 0.5 weight portion, Radix Glycyrrhizae 15 weight portions.
It is 38% alcohol reflux 1 hour that Chinese medicine composition B1 is first adopted volumetric concentration, then continue soaking at room temperature, the ethanol consumption is 12 times of Chinese medicine composition weight, soak time is as shown in table 1, then cross 100 order screens, add aqueous sucrose solution in filtrate, the aqueous sucrose solution consumption is 1.1 times of Chinese medicine composition weight, obtain the herb mixture of 50L, be designated as B10-B40.
Can find out from the test result of table 1, when adopting Chinese medicine composition provided by the invention to prepare herb mixture, add that the time of soaking at room temperature is all to have higher leaching rate in 2-5 days after alcohol reflux; When wherein, the soaking at room temperature time is 4 days, leaching rate is the highest.It can also be seen that from upper table 1, adopt the leaching effect of the Chinese medicine composition S30 that optimization formula of the present invention obtains better, 4 days its leaching rates of soaking at room temperature are up to 19.8%.
Get that in the embodiment of above different formulations, best S30, A30, the B30 of leaching rate is respectively used to rheumatism, rheumatoid arthritis people, secondary for each person every day, each 20ml takes 30 days cycles.Efficacy result is as shown in table 2 below.
Relatively can find out from the result of the test of table 2, to rheumatism, the equal tool of rheumatoid arthritis efficacy and saferry preferably, effective percentage is up to more than 89.2%, wherein significantly effectively up to more than 27% in preferable range of the present invention for Chinese medicine composition.In addition, it can also be seen that from upper table 2, adopt Chinese medicine composition S30 that optimization formula of the present invention obtains to the better efficacy and saferry of having of rheumatism, rheumatoid arthritis.
Above embodiment is only the preferred embodiment of the present invention, should be pointed out that to those skilled in the art, and under the prerequisite that does not break away from the principle of the invention, some improvement of having done also should be considered as protection scope of the present invention.
Claims (9)
1. one kind is used for the treatment of rheumatism, the Chinese medicine composition of rheumatoid arthritis, it is characterized in that, described Chinese medicine composition is made by following raw material: Radix Clematidis 10-15 weight portion, Radix Gentianae Macrophyllae 10-15 weight portion, Pheretima 5-8 weight portion, Fructus Chaenomelis 10-15 weight portion, Rhizoma Chuanxiong 10-15 weight portion, Ramulus Uncariae Cum Uncis 3-6 weight portion, Radix Angelicae Pubescentis 10-15 weight portion, Rhizoma Corydalis 5-8 weight portion, Periostracum Cicadae 5-8 weight portion, Rhizoma Homalomenae 8-12 weight portion, Cortex Eucommiae 8-12 weight portion, Rhizoma Curcumae 10-15 weight portion, Cortex Acanthopancis 10-15 weight portion, Herba Lycopodii 5-8 weight portion, Caulis Clematidis Armandii 10-15 weight portion, Radix Polygoni Multiflori 10-15 weight portion, Flos Carthami 5-8 weight portion, Flos Lonicerae 10-15 weight portion, Pericarpium Citri Reticulatae 5-8 weight portion, Radix Notoginseng 1-4 weight portion, Cornu Cervi Pantotrichum 0.1-0.5 weight portion, Radix Glycyrrhizae 10-15 weight portion.
2. Chinese medicine composition according to claim 1, it is characterized in that, described Chinese medicine composition is made by following raw material: Radix Clematidis 12 weight portions, Radix Gentianae Macrophyllae 12 weight portions, Pheretima 6 weight portions, Fructus Chaenomelis 12 weight portions, Rhizoma Chuanxiong 12 weight portions, Ramulus Uncariae Cum Uncis 4 weight portions, Radix Angelicae Pubescentis 12 weight portions, Rhizoma Corydalis 6 weight portions, Periostracum Cicadae 6 weight portions, Rhizoma Homalomenae 10 weight portions, the Cortex Eucommiae 10 weight portions, Rhizoma Curcumae 12 weight portions, Cortex Acanthopancis 12 weight portions, Herba Lycopodii 6 weight portions, Caulis Clematidis Armandii 12 weight portions, Radix Polygoni Multiflori 12 weight portions, Flos Carthami 6 weight portions, Flos Lonicerae 12 weight portions, Pericarpium Citri Reticulatae 6 weight portions, Radix Notoginseng 2 weight portions, Cornu Cervi Pantotrichum 0.4 weight portion, Radix Glycyrrhizae 12 weight portions.
3. preparation method that is used for the treatment of the herb mixture of rheumatism, rheumatoid arthritis, it is characterized in that, described preparation method comprises: the described raw material of Chinese medicine of claim 1 or 2 is mixed in proportion, add alcohol reflux after 1 hour soaking at room temperature 2-5 days, cross 100 order screens, add aqueous sucrose solution in filtrate, obtain described herb mixture.
4. preparation method according to claim 3, is characterized in that, the consumption of described ethanol is 6-12 times of described raw material of Chinese medicine weight.
5. preparation method according to claim 4, is characterized in that, the consumption of described ethanol is 8 times of described raw material of Chinese medicine weight.
6. according to claim 3-5 described preparation methoies of any one, is characterized in that, the volumetric concentration of described ethanol is 30-50%.
7. according to claim 3-5 described preparation methoies of any one, is characterized in that, the time of soaking at room temperature is 4 days.
8. according to claim 3-5 described preparation methoies of any one, is characterized in that, the mass concentration of described aqueous sucrose solution is 70-80%; The consumption of aqueous sucrose solution is 0.8-1.1 times of described raw material of Chinese medicine weight.
9. a herb mixture that is used for the treatment of rheumatism, rheumatoid arthritis, is characterized in that, described herb mixture is prepared by the described preparation method of claim 3-8 any one.
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