CN102512524B - Medicine for treating secretory otitis media and acute suppurative otitis media - Google Patents
Medicine for treating secretory otitis media and acute suppurative otitis media Download PDFInfo
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- CN102512524B CN102512524B CN2011104582101A CN201110458210A CN102512524B CN 102512524 B CN102512524 B CN 102512524B CN 2011104582101 A CN2011104582101 A CN 2011104582101A CN 201110458210 A CN201110458210 A CN 201110458210A CN 102512524 B CN102512524 B CN 102512524B
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Abstract
A medicine for treating secretory otitis media and acute suppurative otitis media is prepared by uniformly blending borneol, mint, Rhizoma Coptidis, indigo naturalis, alum, gallnut, forsythia, aired fresh pig gallbladder and gardenia in a form of power and in a volume ratio of 2: 1: 1: 0.5: 2: 0.5: 0.5: 2: 0.5.
Description
Technical field
The present invention relates to treat the Chinese herbal medicine formula of secreted, acute suppurative otitis media.
Background technology
Although the Chinese medicine formula of having applied at present about the treatment otitis media is more, but remain in certain problem, the one, certain of filling a prescription required or multiple Chinese herbal medicine are expensive, should not promote, as " ear medicine and the production method thereof for the treatment of chronic otitis media " (China, publication number CN1094962, open day 1994.11.16), these rare Chinese medicines such as related Radix Ginseng, Radix Codonopsis, Cornu Cervi Pantotrichum of filling a prescription are rareer, so that production cost is higher and product promotion is restricted.The 2nd, the Chinese herbal medicine that a lot of prescriptions relate to is of a great variety, as " Chinese medicine for the treatment of acute suppurative otitis media " (China, publication number CN101152385, open day 2008.04.02), and, it is of a great variety that this prescription relates to Chinese herbal medicine, certainly will influence the manufacturing efficient of this medicine.The 3rd, the [kind for the treatment of otitis media is also many, but is to use drop must make use complicated.The 4th, some prescription also has a certain amount of hormone, as " the ear bactericidal composition of nonirritant, the irritated reaction of nothing, no ototoxicity " (China, publication number CN1160999, open day 1997.10.01), this prescription also has hydrocortisone, and the application of hormone must be restricted.
High speed development along with society, the fast pace of life and the high pressure of work make that the otitis media sickness rate was on the rise in recent years, and along with economic development, crowd's quantity of participating in physical trainings such as swimming increases year by year, this also makes the otitis media sickness rate rise, and the method for present clinical treatment otitis media is still based on antibiotic, and because the specific position of middle ear, and the blood flow feature, make effects of antibiotics not good, especially for suppurative otitis media, make the patient suffer huge misery and economic loss, but still do not have satisfied therapeutic effect, in the time for the treatment of, caused the waste of antibiotic abuse and national precious medical resource virtually yet.In order to reduce the treatment cost, reduce patient's slight illness, alleviate country's medical treatment reimbursement burden, develop the Chinese medicine advantage, I create a kind of new medicine wp formula in conjunction with oneself prescription handed down from one's ancestors.
Summary of the invention
The Therapeutic Method that the present invention adopts is Chinese herbal medicine external medication method.Technical scheme of the present invention is achieved in that a kind of external used medicine (middle ear are peaceful) for the treatment of secreted, acute suppurative otitis media, be made up of Borneolum Syntheticum, Herba Menthae, Rhizoma Coptidis, Indigo Naturalis, Alumen, Galla Chinensis, Fructus Forsythiae, fresh Fel Sus domestica, the Fructus Gardeniae of drying in the shade, be 2: 1: 1 with above-mentioned Chinese medicine by volume with powdery: 0.5: 2: 0.5: 0.5: 2: 0.5 ratio stirred and gets final product.
Borneolum Syntheticum: " Newly Revised Canon of Materia Medica ": " main trusted subordinate's pathogen, rheumatism is gathered, and deafness makes eye bright, and goes conjunctival congestion skin nebula." Compendium of Material Medica: " treat that sore throat, headache, nose are flat, toothache, typhoid fever protrusion of the tongue, children's's pox fall into.Logical all keys, the stagnated fire of loosing." " medical center bun want ": " and the Borneolum Syntheticum master stagnated fire of loosing, the deep heat of energy is controlled infantile convulsion, expectorant fan, sore throat, and swelling of the tongue, toothache, deafness, breath, conjunctival congestion cataract, pox poison cave in, parasite killing, hemorrhoid, expedite the emergence of, and property is walked and is not kept, also can the granulation promoting pain relieving.Right loose and easily exhaust, is that YIN-cold is also after all.”
Herba Menthae: hot cold sweating and heat resolving medicine.But external training the mind dysmenorrhoea, skin pruritus, erythra and eczema etc.
Rhizoma Coptidis: heat clearing and damp drying, eliminating fire and detoxication.Be used for damp and hot feeling of fullness, the vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood is told nosebleed, conjunctival congestion, the carbuncle furuncle is quenched one's thirst in toothache; External treatment eczema, eczema, auditory meatus is suppurated.
Indigo Naturalis: cold in nature, salty in the mouth, the function clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body cures mainly pyretic toxicity and sends out diseases such as speckle, haematemesis; Skin infection is controlled in external application, mumps.
Alumen:. " detailed outline ": the usefulness of Alumen has four: the sputum of vomiting and diarrhea wind heat, get its sour and bitter flavors can cause of vomiting and diarrhea also; Control all blood pain, proctoptosis, the prolapse of the uterus, skin infection gets that it is sour and astringent and receive also; Control phlegm retention, let out dysentery, collapse, be with, wind-eye, get its receipts and dampness also; Control sore throat carbuncle, the snakeworm wound is stung, and gets its detoxifcation also.Therefore Alumen is removed the rotten and let fresh grow, and makes effect such as tympanum drying.
Galla Chinensis: sour in the mouth is puckery, cold in nature.Have effects such as convergence, antibiotic, detoxifcation.
Fructus Forsythiae: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, dispelling wind and heat pathogens has the title of " persons particularly liable to develop skin infection's panacea ".Control warm, erysipelas, macule, the carbuncle and ulcer toxic swelling, scrofula, urine stranguria with urinary obstruction, clearing away heart-fire.
Fel Sus domestica: bitter, cold, salty.Control and quench one's thirst, constipation, jaundice, pertussis, asthma, have loose bowels, dysentery, conjunctival congestion, sore throat, stare at ear, carbuncle.
Fructus Gardeniae: heat removing and blood cooling medicine.Effect: pathogenic fire purging relieving restlessness; Clearing away heat-damp and promoting diuresis; Removing pathogenic heat from blood and toxic substance from the body.Cure mainly: calentura is vexed; The liver-fire conjunctival congestion; Headache; Damp and hot yellow infantile malnutrition; Stranguria; The dysentery hematuria; Aphtha of the mouth and tongue; Sore swollen toxin; Sprain and swell and ache.
External used medicine of the present invention has granulation promoting, logical all keys, loose stagnated fire, reducing swelling and alleviating pain, heat clearing away, moisturize, effect such as detoxifcation.Said herbal medicine is through organic assembling, dialectical compatibility and assist a ruler in governing a country mutually, and directly contacts with affected part by medicine, has strengthened this medicine heat-clearing and toxic substances removing, reducing swelling and alleviating pain, has moisturized the effect of granulation promoting, thereby reached the purpose of curing suppurative otitis media.
Concrete compound method and using method: this prescription is made up of Borneolum Syntheticum, Herba Menthae, Rhizoma Coptidis, Indigo Naturalis, Alumen, Galla Chinensis, YINQIAO, fresh Fel Sus domestica, the Fructus Gardeniae of drying in the shade, and be 2: 1: 1 with above-mentioned Chinese medicine by volume with powdery: 0.5: 2: 0.5: 0.5: 2: 0.5 ratio stirred and gets final product.Wherein the preparation process of fresh pig gallbladder powder is: fresh Fel Sus domestica degrease is dried in the shade, pulverize.The medicine that is made into is packed in the dry air-tight bottle, can preserve 1 to 2 year.
Using method: during treatment, have only when transudate occurring in patient's ear, be about to powdered drug and pushed in the ear by cotton rod, fill up and get final product, needn't compacting, get a cotton-wool then and clog the external ear mouth.Taking-up dough overnight, the powder combined incrustation shape that becomes of transudate can drop out from middle ear automatically, needn't take out voluntarily, at this moment, pathological changes is fully recovered, simple administrated method, and process can not make the patient do not feel like oneself, and makes that patient's compliance is preferable, especially infant patient and outstanding.
Clinical effectiveness: on the nearly 200 routine secreted of curing before 2006 and suppurative otitis media patient's basis, I carry out trickle adjustment to prescription handed down from one's ancestors, and take prospective cohort study, selected patient's standard is " suffering from secretory otitis media or acute-chronic purulent otitis media ", and the otitis media of other types is got rid of.By November 30 this year, this research has continued the time in 5 years half, during treat above-mentioned two kinds of otitis media patient 232 examples (secreting type 139 examples wherein altogether, suppurative 93 examples), criterion of cure be secretions stop secretion or suppurative liquid clear, pain is removed, with ill before audition identical; The recurrence judge is symptom and reappears; Invalid standard is that relevant clinical symptom alleviation degree in 1 week is less than 50%.Among the 139 routine secretory otitis media patients 127 example is cured and is occurred recurring (following up a case by regular visits to 2 months to 64 months time period in follow-up period, average 37.6 months), (time period 4 was to 23 months in a period of time appearance recurrence behind the 6 routine patient treatments, average 15.3 months, relapse rate is 4.3%), 5 people among the recurrence patient select medication again, and the result still obtains to cure, 3 people are invalid in 136 examples of following up a case by regular visits to, and lose after the 3 people medication first and follow up a case by regular visits to.Among 138 examples of curing (the first medications of 133 examples+5 example recurrence patients) the secretory otitis media patient through a drug namely healing person account for 112 examples (81.2%), 15 examples are cured (10.9%) through twice medication, 11 routine patients cure (7.9%) through 3 medications, just controlling total cure rate is 97.8% (rejecting 3 example mistakes follows up a case by regular visits to), and the back confirms, has 2 examples to suffer from Cholesteatomatous Tympanitis in the 3 invalid examples.Among the 93 routine suppurative otitis media patients 83 example is cured and is occurred recurring (following up a case by regular visits to 3 months to 63 months time period in follow-up period, average 39.2 months), (time period 6 was to 37 months in a period of time appearance recurrence behind the 4 routine patient treatments, average 22.3 months, relapse rate is 4.3%), 4 people among the recurrence patient all select medication again, and the result still obtains to cure, 2 people are invalid in 93 examples, lose after the 4 people medication first and follow up a case by regular visits to.Among 87 examples of curing (the first medications of 83 examples+4 example recurrence patients) the suppurative otitis media patient through a drug namely healing person account for 72 examples (82.8%), 10 examples are cured (11.5%) through twice medication, 5 routine patients cure (5.7%) through 3 medications, and just controlling total cure rate is 97.8% (rejecting 4 example mistakes follows up a case by regular visits to).This medicine is for above-mentioned two types of otitis media therapeutic effect and relapse rate no difference of science of statistics (P>0.05), and all shows better curative effect, illustrates that the two does not have significant difference to two types of otitis media effects and relapse rate; This statistical data is compared with clinical antibiotic therapy otitis media data of the same period, and statistics shows difference (P<0.01), and this drug effect fruit will be much better than effects of antibiotics.More meaningfully, this medicine is in curative effect---social economy than aspect shown huge advantage, saved national medical resource greatly.Simultaneously, in the perspective experimentation of this formation, do not find complication or the toxic and side effects relevant with medication as yet, from the safety of this external Chinese medicine powder is described to a great extent.
This prescription process for preparation is simple, match well system by the powdery volume and also saved technological process, and the process of drying in the shade of Fel Sus domestica need not other auxiliary processes, and production cost is lower, is easy to clinical expansion.
Claims (2)
1. external used medicine for the treatment of secreted, acute suppurative otitis media, be made up of Borneolum Syntheticum, Herba Menthae, Rhizoma Coptidis, Indigo Naturalis, Alumen, Galla Chinensis, Fructus Forsythiae, fresh Fel Sus domestica, the Fructus Gardeniae of drying in the shade, it is characterized in that: be 2: 1: 1 with above-mentioned Chinese medicine by volume with powdery: 0.5: 2: 0.5: 0.5: 2: 0.5 ratio stirred and gets final product.
2. the purposes of the described medicine of claim 1 in the external used medicine of preparation treatment secreted, acute suppurative otitis media.
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CN105395633A (en) * | 2015-12-13 | 2016-03-16 | 王金国 | Liniment for external application for suppurative otitis media and preparing method thereof |
CN106821726A (en) * | 2017-01-23 | 2017-06-13 | 安徽绿莹彩龙艾绒制药有限公司 | A kind of medicine moxa-moxibustion of moxibustion otitis media suppurative |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1038760A (en) * | 1988-06-21 | 1990-01-17 | 苏兆波 | Process for festered-car curing powders |
US6524627B1 (en) * | 2002-03-20 | 2003-02-25 | Daehan Biolink Co., Ltd. | Pharmaceutical composition for preventing and treating allergic diseases and a method for preparation thereof |
CN101461862A (en) * | 2008-12-26 | 2009-06-24 | 王海燕 | Traditional Chinese Medicine Formula for Treating Otitis Media |
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Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1038760A (en) * | 1988-06-21 | 1990-01-17 | 苏兆波 | Process for festered-car curing powders |
US6524627B1 (en) * | 2002-03-20 | 2003-02-25 | Daehan Biolink Co., Ltd. | Pharmaceutical composition for preventing and treating allergic diseases and a method for preparation thereof |
CN101461862A (en) * | 2008-12-26 | 2009-06-24 | 王海燕 | Traditional Chinese Medicine Formula for Treating Otitis Media |
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