CN102512444A - Preparation method for mongolian medicine vermilion nanometer powder - Google Patents
Preparation method for mongolian medicine vermilion nanometer powder Download PDFInfo
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- CN102512444A CN102512444A CN2011104107432A CN201110410743A CN102512444A CN 102512444 A CN102512444 A CN 102512444A CN 2011104107432 A CN2011104107432 A CN 2011104107432A CN 201110410743 A CN201110410743 A CN 201110410743A CN 102512444 A CN102512444 A CN 102512444A
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Abstract
The invention discloses a preparation method for mongolian medicine vermilion nanometer powder. The method is as follows: mercury nitrate and thioacetamide are used as raw materials for preparation of nanometer mercuric sulfide by using a wet process; a solution with a certain concentration is prepared from the raw materials; the raw materials are rapidly mixed under magnetic stirring, and the solution is uniformly heated until the solution boils so as to prepare nanometer mercuric sulfide powder. According to the invention, environmental pollution in traditional preparation processes for mongolian medicine vermilion is reduced, the process of preparation is more controllable, components are more specific, and quality of different batches of the nanometer powder is stable.
Description
Technical field
Invention relates to mongolian medicine Vermilion powder preparation field, especially, relates to a kind of Vermilion nano-powder preparation process.
Background technology
Vermilion, i.e. Vermilion is that sulfur rises refining with hydrargyrum and forms, and its property is dry strong, also can rot gum contraction muscle, and its merits and demerits and Calomelas are same also.Claim clever sand again, Yin-yang ascending-descending, the extreme misery that both helped is saved the refreshing red of urgency for holding up danger, but can not be obeyed ear for a long time.Soviet Union and Eastern Europe's slope speech, this medicine is controlled trouble regurgitation of a specified duration, and all tell contraryly, and so vomiting inducing convulsion in children has to cooperate the wonderful of negative and positive also.Rumble of rolling stones Zhu opacity precious red inorganic pigments are known for bright color, eventually becoming faded and pest moth known to the world, caught in the ancient books of Dan moth paper and Chinese calligraphy with the finest inks is to use this rumble of rolling stones Zhu made .Vermilion in, application all arranged in the mongolian medicine.Its clear efficacy, the external disinfection and deinsectization promotes wound healing, the interior tranquillizing and allaying excitement of using is evident in efficacy in clinical practice.There is 44% compatibility to use in the mongolian medicine watered pill.
Vermilion is artificial processed product, and traditional concocting method is that hydrargyrum and the sofril of getting equivalent put into and wiped good iron pan with tallow oil and heat, and ceaselessly stirs with ironware; Note the duration and degree of heating; When retrogradation, take off pot immediately and stir, treat to be placed on again after thinning fire and go up heating; Cool after the repeated multiple times like this, the back section that condenses is that sky blue (no hydrargyrum granule) is as the criterion.A large amount of mercuryvapours evaporate into and cause great environmental pollution in the air in this method concocting process, simultaneously the staff are caused actual bodily harm.We are devoted for years in the application of nanotechnology in traditional medicine.The present invention concocts the controlled Vermilion nano powder that prepared that combines with nanotechnology and traditional mongolian medicine Vermilion, solved the Vermilion tradition concoct seriously polluted, uneven components, quality problem of unstable.
Summary of the invention
An object of the present invention is to provide a kind of mongolian medicine Vermilion nano-powder preparation process; It specifically comprises: Mercury pernitrate. is made into the solution (pH＜6.0) of the dilute acidic solution of 0.01-0.1mol/L, under magnetic agitation, add the thioacetyl amine aqueous solution (concentration be Mercury pernitrate. 5-10 doubly), more than the revolution 1000rad/min; Stir 1-10 after second; Speed with 5-15 ℃/min is warming up to boiling, continue back flow reaction 10-50 minute red powder, after the cooling with the red powder centrifugalize; And with ethanol and deionized water respectively clean 3-5 all over after, normal temperature drying makes exsiccant mongolian medicine Vermilion nano powder in baking oven.
The nanometer Vermilion powder footpath scope that the present invention concocts is between the 35-200 nanometer.
The test of pesticide effectiveness: we adopt pentobarbital sodium and the short sleep experiments of chloral hydrate, and Vermilion and traditional method acquisition Vermilion drug effect that the present invention is obtained contrast.The concrete experiment as follows:
Pentobarbital sodium: get the mice of the about 24g of body weight, 56, be divided into 4 groups at random, gastric infusion nanometer Vermilion 0.1g/kg (small dose group); (0.3g/kg heavy dose of group); Tradition Vermilion 0.3g/kg, solvent C MC-Na 0.3g/kg, successive administration 7 days, and behind last administration 30min, ip pentobarbital sodium 75mg/kg, with disappearance to time of recovering of righting reflex be index determining length of one's sleep, sleep incubation period, sleep percentage rate.Experimental result is seen table 1.
The chloral hydrate hypnosis: it is the same with administration to divide into groups, and behind last administration 30min ip chloral hydrate 0.4g/kg, the record righting reflex begins to disappear the time to recovering.Experimental result is seen table 2.
Table 1, Vermilion nano powder and traditional method are concocted Vermilion to the short sleep experiments of pentobarbital sodium relatively
| Group | Dosage | Sleep % | Average hide (min) that sleep | The P value |
| 1 group of nanometer Vermilion | 0.1g/kg | 75％ | 5±1.80 | ＜0.05 |
| 2 groups of nanometer Vermilion | 0.3g/kg | 100％ | 4±0.76 | ＜0.01 |
| Tradition Vermilion group | 0.3g/kg | 75％ | 5±2.27 | ＜0.05 |
| Matched group | 0.3g/kg | 50％ | 14±6.34 |
Table 2, Vermilion nano powder and traditional method are concocted Vermilion to the short sleep experiments of pentobarbital sodium relatively
| Group | Dosage | Sleep % | The average sleep incubation period | The P value |
| 1 group of nanometer Vermilion | 0.1g/kg | 86％ | 10±0.69 | ＜0.05 |
| 2 groups of nanometer Vermilion | 0.3g/kg | 100％ | 6±1.70 | ＜0.01 |
| Tradition Vermilion group | 0.3g/kg | 80％ | 6±1.40 | ＜0.01 |
| Matched group | 0.3g/kg | 60％ | 14±2.98 |
The nanometer Vermilion of the present invention preparation has the short sleep effect of tangible assistance pentobarbital sodium, also has to promote the effect of chloral hydrate hypnotic preferably, and when reaching identical drug effect with mongolian medicine Vermilion tradition article, the dosage of nanometer Vermilion reduces greatly.
The accompanying drawing summary description
Accompanying drawing 1 is the scanning electron microscope picture of nanometer Vermilion powder
Accompanying drawing 2 is the X-ray energy spectrum analysis result of nanometer Vermilion powder
The specific embodiment
Further describe the present invention through following instance; And do not limit the present invention in any way; Under the prerequisite that does not deviate from technical solution of the present invention, any change or change that this area professional and technical personnel that the present invention made is realized easily all will fall within the claim scope of the present invention.
Embodiment 1:
Mercury pernitrate. is made into the solution (pH＜6.0) of 0.01mol/L dilute acidic solution; Under magnetic agitation, add thioacetyl amine aqueous solution (concentration is 5 times of Mercury pernitrate .); More than the revolution 1000rad/min; Stir after 1 second, be warming up to boiling with the speed of 5 ℃/min, continue back flow reaction 50 minutes red powder.With the red powder centrifugalize, and after respectively cleaning 5 times with ethanol and deionized water (each washing all needs ultra-sonic dispersion), drying makes exsiccant mongolian medicine Vermilion nano powder in baking oven after the cooling.
Mercury pernitrate. is made into the solution (pH＜6.0) of 0.05mol/L dilute acidic solution; Under magnetic agitation, add thioacetyl amine aqueous solution (concentration is 8 times of Mercury pernitrate .); More than the revolution 1000rad/min; Stir after 5 seconds, be warming up to boiling with the speed of 10 ℃/min, continue back flow reaction 30 minutes red powder.With the red powder centrifugalize, and after respectively cleaning 4 times with ethanol and deionized water (each washing all needs ultra-sonic dispersion), drying makes exsiccant mongolian medicine Vermilion nano powder in baking oven after the cooling.
Embodiment 3
Mercury pernitrate. is made into the solution (pH＜6.0) of 0.1mol/L dilute acidic solution; Under magnetic agitation, add thioacetyl amine aqueous solution (concentration is 10 times of Mercury pernitrate .); More than the revolution 1000rad/min; Stir after 10 seconds, be warming up to boiling with the speed of 15 ℃/min, continue back flow reaction 10 minutes red powder.With the red powder centrifugalize, and after respectively cleaning 3 times with ethanol and deionized water (each washing all needs ultra-sonic dispersion), drying makes exsiccant mongolian medicine Vermilion nano powder in baking oven after the cooling.
Claims (2)
1. the method for preparing of a mongolian medicine Vermilion nano powder; It is characterized in that this method comprises the solution (pH＜6.0) that Mercury pernitrate. is made into the dilute acidic solution of 0.01-0.1mol/L, under magnetic agitation, add thioacetyl amine aqueous solution (concentration is 5-10 times of Mercury pernitrate .), more than the revolution 1000rad/min; Stir 1-10 after second; Speed with 5-15 ℃/min is warming up to boiling, continue back flow reaction 10-50 minute red powder, after the cooling with the red powder centrifugalize; And with ethanol and deionized water respectively clean 3-5 all over after, normal temperature drying makes exsiccant mongolian medicine Vermilion nano powder in baking oven.
2. Vermilion nano powder that makes according to the method for preparing of claim 1.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104591262A (en) * | 2015-01-26 | 2015-05-06 | 河南科技大学 | Method for preparing mercury sulfide nanoparticles through dripping reflux |
| CN111973627A (en) * | 2020-09-29 | 2020-11-24 | 内蒙古医科大学 | Mongolian medicine mercury processing device and method |
| CN113304171A (en) * | 2021-05-26 | 2021-08-27 | 内蒙古医科大学 | Preparation method and application of targeted mercury sulfide nanoparticle medicine |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1362100A (en) * | 2001-01-05 | 2002-08-07 | 杨孟君 | Nano Jiuhua medicine and its preparation |
| CN101028454A (en) * | 2007-03-26 | 2007-09-05 | 刘高地 | Externally-applied bone-set plaster and its production |
| CN101181338A (en) * | 2007-11-26 | 2008-05-21 | 李章平 | Chinese medicine prescription for curing empyrosis and preparation method thereof |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1362100A (en) * | 2001-01-05 | 2002-08-07 | 杨孟君 | Nano Jiuhua medicine and its preparation |
| CN101028454A (en) * | 2007-03-26 | 2007-09-05 | 刘高地 | Externally-applied bone-set plaster and its production |
| CN101181338A (en) * | 2007-11-26 | 2008-05-21 | 李章平 | Chinese medicine prescription for curing empyrosis and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104591262A (en) * | 2015-01-26 | 2015-05-06 | 河南科技大学 | Method for preparing mercury sulfide nanoparticles through dripping reflux |
| CN111973627A (en) * | 2020-09-29 | 2020-11-24 | 内蒙古医科大学 | Mongolian medicine mercury processing device and method |
| CN113304171A (en) * | 2021-05-26 | 2021-08-27 | 内蒙古医科大学 | Preparation method and application of targeted mercury sulfide nanoparticle medicine |
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