CN102512434A - Combination drug used for killing genitals microorganisms of female Tibetan mastiffs and assisting reproduction - Google Patents
Combination drug used for killing genitals microorganisms of female Tibetan mastiffs and assisting reproduction Download PDFInfo
- Publication number
- CN102512434A CN102512434A CN2011104474287A CN201110447428A CN102512434A CN 102512434 A CN102512434 A CN 102512434A CN 2011104474287 A CN2011104474287 A CN 2011104474287A CN 201110447428 A CN201110447428 A CN 201110447428A CN 102512434 A CN102512434 A CN 102512434A
- Authority
- CN
- China
- Prior art keywords
- genitals
- canis lupus
- lupus familiaris
- female
- medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to a combination drug used for killing genitals microorganisms of female Tibetan mastiffs and assisting reproduction. The combination drug contains matrine, podophyllotoxin, berberine, vitamin C, etoposide and antifungal drugs in western medicine.
Description
Technical field
The present invention relates to field of veterinary, be specifically related to a kind of composition of medicine that is used to kill the composition of medicine of the microorganism of female Canis lupus familiaris genitals, assisted reproduction.
Background technology
Female Canis lupus familiaris is infertile comprise congenital infertile infertile with the day after tomorrow.
Female Canis lupus familiaris is congenital infertile, is meant that mainly the genitals of female Canis lupus familiaris is unusual, exists birth defect, female Canis lupus familiaris that physiological decease etc. is arranged.Female Canis lupus familiaris congenital infertile mainly contains following three kinds of situation, should not breed kind of large fierce dog and use.
1, genitals's defective has discrete female Canis lupus familiaris, genital malformation, and such as lacking vaginal orifice and vagina, or atresia of vagina, or the urethra lobe excessively grows, and female Canis lupus familiaris can't be fertilized smoothly.2, the bisexuality deformity has few Canis lupus familiaris the bisexuality characteristic to occur, and this mainly is because some people in the Canis lupus familiaris growth course, has used exogenous androgen, causes the Canis lupus familiaris bisexuality.Existing ovary has testis again, perhaps has only testis and anovarism, and female Canis lupus familiaris vaginal orifice is narrow and small, and perineum is longer, can't become pregnant smoothly.3, congenital inmature aplasia, refer to that mainly female Canis lupus familiaris reaches the sexually matured age after, but find genitals still developmental immaturity or aplasia, labia and cervix uteri hypoplasia, vagina is short and narrow, sub-official and ovary are all very little, do not possess reproductive performance.
The posteriority of female Canis lupus familiaris is infertile to have a major reason, is its reproductive system of infected by microbes, still, does not still treat the composition of medicine of female Canis lupus familiaris reproductive system infected by microbes, assisted reproduction now, therefore, develops this type medicine and has vast market.
Technical scheme
The invention provides a kind of composition of medicine that is used to kill the microorganism of female Canis lupus familiaris genitals, assisted reproduction.Especially relate to the composition of medicine of killing the phallic fungus of female Canis lupus familiaris.
The present invention relates to a kind of composition of medicine that is used to kill the microorganism of female Canis lupus familiaris genitals, assisted reproduction,
Contain matrine, podophyllotoxin, berberine, vitamin C, etoposide.
The present invention relates to a kind of composition of medicine that is used to kill the microorganism of female Canis lupus familiaris genitals, assisted reproduction:
Contain the Western medicine antifungal drug.
The present invention relates to a kind of composition of medicine that is used to kill the microorganism of female Canis lupus familiaris genitals, assisted reproduction: contain
Posaconazole 1-3, terbinafine HCl 1-3, laurocapram 20-40, ethanol 40-200.
The present invention relates to a kind of composition of medicine that is used to kill the microorganism of female Canis lupus familiaris genitals, assisted reproduction: contain matrine 1-3, podophyllotoxin 1-3, berberine 1-3; Vitamin C 1-3; Etoposide 1-3, posaconazole 1-3, terbinafine HCl 1-3; Laurocapram 20-40, ethanol 40-200.
Specific embodiment 1
A kind of composition of medicine that is used to kill the microorganism of female Canis lupus familiaris genitals, assisted reproduction: its concrete dosage form is a liquid dosage form; Its method for making is first general: posaconazole 1g, terbinafine HCl 1g add 20 g laurocapram filtration sterilizations with 75% ethanol, 20 g dissolving, add 75% ethanol 100g mix homogeneously then, obtain liquid preparation, in the bottle of packing into.
Specific embodiment 2
A kind of composition of medicine that is used to kill the microorganism of female Canis lupus familiaris genitals, assisted reproduction: its concrete dosage form is a liquid dosage form,
Its method for making is first general: matrine 3 g, podophyllotoxin 3 g, berberine 3 g; Vitamin C 3 g; Etoposide 3 g posaconazole 3g, terbinafine HCl 3g add 40 g laurocapram filtration sterilizations with 75% ethanol, 60 g dissolving, add 75% ethanol 140g mix homogeneously then; Obtain liquid preparation, in the bottle of packing into.
Specific embodiment 3
A kind of composition of medicine that is used to kill the microorganism of female Canis lupus familiaris genitals, assisted reproduction: its concrete dosage form is a liquid dosage form; Its method for making is first general: matrine 1 g, podophyllotoxin 1 g, berberine 1 g; Vitamin C 1 g; Etoposide 1 g posaconazole 1g, terbinafine HCl 1g add 20 g laurocapram filtration sterilizations with 75% ethanol, 30 g dissolving, add 75% ethanol 100g mix homogeneously then; Obtain liquid preparation, in the bottle of packing into.
Specific embodiment 4
The 1st group, in 1 week before breeding, around the external genitalia of 6 female Canis lupus familiaris, dosage is with the spray liquid of specific embodiment 1: 5g/ time, and 3 times/1 day;
The 2nd group, in 1 week before breeding, around the external genitalia of 6 female Canis lupus familiaris, dosage is with the spray liquid of specific embodiment 3: 5g/ time, and 3 times/1 day;
Matched group, 1 week before breeding, adopt Da Keling Emulsion to be coated with around other 6 female Canis lupus familiaris external genitalia outward, dosage is: 5g/ time, 3 times/1 day;
The result finds: the effect of killing fungus has tangible difference, and the situation of assisted reproduction also has tangible difference.
The 1st group, the 2nd group has good extensive antifungic action.Check the fungus in the amniotic fluid of 3 groups of female Canis lupus familiaris, and observe the childbirth situation, write down following situation:
| Average content | The 1st group | The 2nd group | Matched group |
| Candida albicans (mg/L) | 5.2 | 3.7 | 25.5 |
| Cryptococcus histolyticus (mg/L) | 9.8 | 4.6 | 96.4 |
| Dermatophytes (mg/L) | 17.4 | 5.6 | 108.9 |
| Intrapartum hemorrhage situation (mL) | 50 | 30 | 290 |
| Divide recovery time in puerperium (my god) | 4.2 | 2.7 | 8.9 |
| Little Canis lupus familiaris number (only/nest) | 7.4 | 9.7 | 4.1 |
Therefore, medicine of the present invention has the good fungus of killing, and can promote the effect of the fertility of Canis lupus familiaris, is worth developing in veterinary applications.
Claims (3)
1. a composition of medicine that is used to kill the microorganism of female Canis lupus familiaris genitals, assisted reproduction is characterized in that: contain matrine, podophyllotoxin, berberine, vitamin C, etoposide.
2. a composition of medicine that is used to kill the microorganism of female Canis lupus familiaris genitals, assisted reproduction is characterized in that: contain the Western medicine antifungal drug.
3. a kind of composition of medicine that is used to kill the microorganism of female Canis lupus familiaris genitals, assisted reproduction according to claim 1 is characterized in that containing: matrine 1-3, podophyllotoxin 1-3; Berberine 1-3, vitamin C 1-3, etoposide 1-3; Posaconazole 1-3; Terbinafine HCl 1-3, laurocapram 20-40, ethanol 40-200.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011104474287A CN102512434A (en) | 2011-12-28 | 2011-12-28 | Combination drug used for killing genitals microorganisms of female Tibetan mastiffs and assisting reproduction |
| CN 201210233459 CN102743404B (en) | 2011-12-28 | 2012-07-06 | Composite medicine used for killing genital microbes of female Tibetan Mastiff and assisting reproduction |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011104474287A CN102512434A (en) | 2011-12-28 | 2011-12-28 | Combination drug used for killing genitals microorganisms of female Tibetan mastiffs and assisting reproduction |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102512434A true CN102512434A (en) | 2012-06-27 |
Family
ID=46283688
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011104474287A Withdrawn CN102512434A (en) | 2011-12-28 | 2011-12-28 | Combination drug used for killing genitals microorganisms of female Tibetan mastiffs and assisting reproduction |
| CN 201210233459 Expired - Fee Related CN102743404B (en) | 2011-12-28 | 2012-07-06 | Composite medicine used for killing genital microbes of female Tibetan Mastiff and assisting reproduction |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201210233459 Expired - Fee Related CN102743404B (en) | 2011-12-28 | 2012-07-06 | Composite medicine used for killing genital microbes of female Tibetan Mastiff and assisting reproduction |
Country Status (1)
| Country | Link |
|---|---|
| CN (2) | CN102512434A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109453172A (en) * | 2018-12-26 | 2019-03-12 | 湖北中博绿亚生物技术有限公司 | Pharmaceutical composition, preparation method and its application |
| CN111067897A (en) * | 2020-01-20 | 2020-04-28 | 中山大学 | Antifungal composition and application thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1185934C (en) * | 2002-10-10 | 2005-01-26 | 余京儒 | Disinfectant lotion for body's vulva and vagina |
| CN1518976A (en) * | 2003-09-02 | 2004-08-11 | 李跃亨 | Externally used pharmaceutics for treating colpitis mycotica |
-
2011
- 2011-12-28 CN CN2011104474287A patent/CN102512434A/en not_active Withdrawn
-
2012
- 2012-07-06 CN CN 201210233459 patent/CN102743404B/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109453172A (en) * | 2018-12-26 | 2019-03-12 | 湖北中博绿亚生物技术有限公司 | Pharmaceutical composition, preparation method and its application |
| CN111067897A (en) * | 2020-01-20 | 2020-04-28 | 中山大学 | Antifungal composition and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102743404A (en) | 2012-10-24 |
| CN102743404B (en) | 2013-06-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Chen et al. | A systematic review and network meta‐analysis comparing the use of Foley catheters, misoprostol, and dinoprostone for cervical ripening in the induction of labour | |
| Sharma et al. | Management of infertility in low resource countries | |
| Hawkins et al. | Current pharmacotherapy options for labor induction | |
| CN102743404B (en) | Composite medicine used for killing genital microbes of female Tibetan Mastiff and assisting reproduction | |
| Kale et al. | Vaginal mucosa–A promising site for drug therapy | |
| Cristobal et al. | The new LNG-releasing IUS: a new opportunity to reduce the burden of unintended pregnancy | |
| Stout | Fungal endometritis in the mare | |
| Liechty et al. | Animal models of contraception: utility and limitations | |
| CN101606945A (en) | Compound sodium sulfadimidine injection liquid for pig and preparation method thereof | |
| CN101612158A (en) | Compound ofloxacin injection of animals for treating postnatal infection and preparation method thereof | |
| Swerts et al. | Effects of fluoxetine and imipramine in rat fetuses treated during a critical gestational period: a macro and microscopic study | |
| US11219655B2 (en) | Abortion medications and administration method thereof | |
| CN204049793U (en) | Intrauterine adhesion control device | |
| CN106266037B (en) | Liquid gel and preparation method thereof | |
| CN102652752A (en) | Drug composition for treating senile vaginitis and preparation method thereof | |
| CN104546885A (en) | Medicine composition for treating skin diseases as well as preparation method and application thereof | |
| CN103127490A (en) | Medicinal composition for treating vulvovaginal candidiasis | |
| Wenjiea et al. | Effectiveness evaluation of alginate oligosaccharides antibacterial gel for bacterial vaginosis | |
| Cohain | Case series: symptomatic group B streptococcus vaginitis treated with fresh garlic | |
| CN104288162B (en) | A kind of milch cow doxycycline hydrochloride uterus injectant and preparation method thereof | |
| Metelkina et al. | Experience of use of the combined medication Vagiferon® for topical application in the treatment of bacterial vaginosis | |
| CN104188987A (en) | Formula and preparation method of veterinary injectant for preventing and treating endometritis | |
| Chen et al. | Tideglusib, a prospective alternative to nonoxynol-9 contraceptive | |
| CN103479958B (en) | A kind of suppository for the treatment of gynaecopathia and preparation method thereof | |
| Singh et al. | Management of infertility in ayurveda perspective: a single case report |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| DD01 | Delivery of document by public notice |
Addressee: Wang Shuang Document name: Notification of Approving Refund |
|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C04 | Withdrawal of patent application after publication (patent law 2001) | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20120627 |