CN102511660A - Coenzyme Q10 premix, preparation method thereof, and application thereof - Google Patents
Coenzyme Q10 premix, preparation method thereof, and application thereof Download PDFInfo
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- CN102511660A CN102511660A CN201110410869XA CN201110410869A CN102511660A CN 102511660 A CN102511660 A CN 102511660A CN 201110410869X A CN201110410869X A CN 201110410869XA CN 201110410869 A CN201110410869 A CN 201110410869A CN 102511660 A CN102511660 A CN 102511660A
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Abstract
The invention discloses a coenzyme Q10 premix which belongs to feed additive. The coenzyme Q10 premix is composed of components of, by weight: 2-5% of coenzyme Q10, and 95-98% of a carrier. The invention also discloses a preparation method thereof. The method comprises a step that: coenzyme Q10 and the carrier are gradually well mixed in a mixer with an equal-quantity progressive increasing method. The invention also discloses the application of coenzyme Q10 and the coenzyme Q10 premix in preparing medicines used for controlling poultry gout, relieving poultry kidney pathological lesions caused by layer poultry gout, and enhancing poultry body immunities. The premix provides a substantial controlling effect against poultry gout. With the premix, poultry kidney pathological lesions caused by layer poultry gout can be substantially relieved, such that the death rate of ill poultry is reduced. Also, the premix does not contain organic component. The premix causes no toxic or side effect upon poultry, and no toxicity to the environment. Further, the preparation method provided by the invention is advantaged in simple method and convenient application. The method is labor-saving and material-saving.
Description
Technical field
The invention belongs to feed additive field, be specifically related to a kind of Co-Q10 pre-mixing agent and preparation method thereof.
Background technology
The fowl gout is mainly in poultry.The fowl gout is in enormous quantities usually to be taken place, and foreign statistic shows that the incidence of disease of gout is about 16～50%, and the death rate is higher.The fowl gout mainly is to cause kidney injury.At present; The morbidity of fowl gout has the trend that increases; Reason is that there are many factors of bringing out gout in the chicken crowd of intensive farm in Feed Manufacturing, the feeding and management level, particularly because feed resource is unstable, causes in the feed that calcic and albumen are too high to cause young laying hen generation gout easily.The fowl gout is that China's aviculture is cultured one of serious problems that face.There is not the effectively preventing method for the fowl gout at present; The medicine of treatment fowl gout mainly contains purine alcohol, probenecid, methenamine, dexamethasone, also have that kidney swollenly disappears, the swollen antidote of kidney; And some Chinese medicine etc., but effect is all undesirable or have a side effect.
Co-Q10 (CoQ10) is the fat-soluble quinones that extensively exists in the organism, and the number of its side chain iso-amylene unit of the ubiquinone of separate sources is different, and the ubiquinone in the mankind and the mammalian body is 10 iso-amylene units, so claim Co-Q10.Co-Q10 is that activator and immunopotentiator are breathed in cellular metabolism, have anti-oxidant, cardiac stimulant, anti-stress with the radicals scavenging function.Co-Q10 is used for the supplemental treatment in diseases such as angiocardiopathy, cancer, hepatitis, Parkinson's; And the application at aspects such as sports medical science and antifatigue effects, in cosmetics, oral hygiene goods, health product and food additives, use also relatively extensively.
The existing formulation of Co-Q10 comprises: Co-Q10 sheet, Co-Q10 soft capsule, coenzyme Q 10 injection, coenzyme Q10 capsule etc.
The patent application of existing Co-Q10 formulation mainly contains: Co-Q10 dry powder (publication number CN1633245A), the dry powder composite (publication number CN1969833A) that contains Co-Q10, compound coenzyme Q 10 medicine prepn (publication number CN101019854A), coenzyme Q 10 injection (publication number CN101278907A), topical co-enzyme Q 10 formulations (publication number CN102018693A), coenzyme Q 10 mini-pill (publication number CN101703477A).The subject matter that above-mentioned co-enzyme Q 10 formulations exists is: the solubility of Co-Q10 in water is extremely low, and water dispersible dry powder will reach the medical function of expection need take in the amount more much bigger than reality.Parenteral solution stress be big to animal, and workload is big, is not suitable for the administration of veterinary clinic colony.Solution is all the organic solvent hydrotropy at present, and toxicity is big, residual height, and the rising of carrier cost, and medicine was separated out easily when this formulation was used for livestock and fowl drinking water simultaneously.Preparation cost such as micropill and micro emulsion is higher, veterinary clinic is promoted and had certain limitation.
Geng Ailian etc. reported Co-Q10 to the effect of ascites symptoms broiler growth performance and oxidation resistance aspect (Geng Ailian etc. journal of animal science and veterinary medicine .36 (1), 16～20 (2005); Geng Ailian etc. Animal nutrition journal .18 (2), 86～92 (2006)) effect, but do not see the report of any relevant ubiquinone 10 aspect control fowl gout as yet.
Summary of the invention
The object of the invention is to provide a kind of Co-Q10 pre-mixing agent.This Co-Q10 pre-mixing agent can be used to prevent and treat the fowl gout, significantly relaxes the kidney pathology damage that laying hen fowl gout causes, and can significantly improve the fowl immunity of organisms.
Another purpose of the present invention is to provide the preparation method of above-mentioned Co-Q10 pre-mixing agent.
The present invention goes back the purposes that a purpose is to provide above-mentioned Co-Q10 pre-mixing agent.
The present invention realizes through following technical proposal:
A kind of Co-Q10 pre-mixing agent, its constituent and percentage by weight thereof are: Co-Q10 2～5%, carrier 95～98%.
Carrier described in the above-mentioned Co-Q10 pre-mixing agent is meant a kind of of zeolite powder, corn flour or starch etc.
The preparation method of above-mentioned Co-Q10 pre-mixing agent comprises the Co-Q10 drying, crosses 65 mesh sieves; With carrier drying, cross 50 mesh sieves; According to the equivalent incremental method, Co-Q10 and equivalent carrier are placed in the mixer, stirring and evenly mixing (5 minutes) gets the Co-Q10 pre-composition; In mixer, add the carrier with Co-Q10 pre-composition equivalent then, stirring and evenly mixing (5 minutes); So increase progressively the interpolation carrier, stir; In mixer, add remaining carrier at last, stirring and evenly mixing (15 minutes) promptly gets the Co-Q10 pre-mixing agent.
The method for using of Co-Q10 pre-mixing agent of the present invention as feed addictive, mixes the Co-Q10 pre-mixing agent and gets final product with basal diet.The additive capacity of Co-Q10 in feed is the 40mg/kg feed.
The purposes of Co-Q10 aspect preparation enhancing fowl immunity of organisms medicine.
The purposes of Co-Q10 aspect preparation control fowl gout medicine.
Co-Q10 relaxes the purposes aspect the kidney pathology damage medicine that laying hen fowl gout causes in preparation.
The purposes of above-mentioned Co-Q10 pre-mixing agent aspect preparation enhancing fowl immunity of organisms medicine.
The purposes of above-mentioned Co-Q10 pre-mixing agent aspect preparation control fowl gout medicine.
Above-mentioned Co-Q10 pre-mixing agent relaxes the purposes aspect the kidney pathology damage medicine that laying hen fowl gout causes in preparation.
Described fowl is meant chicken, duck, chicken, turkey, aquatic bird, dove or quail etc.
Advantage that the present invention has and beneficial effect: (1) Co-Q10 pre-mixing agent of the present invention has good prevention effect to the fowl gout, to significantly relaxing the kidney pathology damage that laying hen fowl gout causes, reduces the ill fowl death rate; (2) Co-Q10 pre-mixing agent of the present invention can significantly improve the fowl immunity of organisms, strengthens the fowl body resistance against diseases; (3) Co-Q10 pre-mixing agent of the present invention does not contain organic composition, and is nontoxic to the fowl poultry, do not have toxic and side effect, environmental sound; (4) Co-Q10 pre-mixing agent of the present invention is easy to use, can save a large amount of human and material resources; (5) Co-Q10 pre-mixing agent preparation method of the present invention is simple, and cost is low.
The specific embodiment
Below in conjunction with specific embodiment, further set forth the present invention.These embodiment only are used to the present invention is described and are not used in the scope of restriction requirement of the present invention protection.
The preparation of embodiment 1 Co-Q10 pre-mixing agent
Carry out according to following method:
(1) Co-Q10 (Agricultural University Of Nanjing pharmacological evaluation chamber provides) is dried to water content and is no more than 3%, cross 65 mesh sieves; Zeolite powder (Ninghai County is good to be provided with chemical industry Co., Ltd) is dried to water content and is no more than 5%, crosses 50 mesh sieves.
(2) get Co-Q10 40g, zeolite powder 1960g.According to the equivalent incremental method, earlier zeolite powder 40g and Co-Q10 40g are placed in the mixer of cleaning, mixed 5 minutes, form the Co-Q10 pre-composition; In mixer, add zeolite powder 80g then, mixed 5 minutes; Constantly mix according to the equivalent incremental method then; Adding mixes 15 minutes to mixing with remaining zeolite powder in mixer at last, promptly gets Co-Q10 pre-mixing agent 2000g, is encapsulated as the 1kg/ bag with clean bag.
The preparation of embodiment 2 Co-Q10 pre-mixing agents
Carry out according to following method:
(1) Co-Q10 is dried to water content and is no more than 3%, cross 65 mesh sieves, corn flour is dried to water content and is no more than 5%, crosses 50 mesh sieves.
(2) get Co-Q10 60g, zeolite powder 1940g.According to the equivalent incremental method, earlier corn flour 60g and Co-Q10 60g are placed in the mixer of cleaning, mixed 5 minutes, form the Co-Q10 pre-composition; In mixer, add corn flour 120g then, mixed 5 minutes; Constantly mix according to the equivalent incremental method; Add remaining corn flour at last in mixer and mix 15 minutes, promptly obtain Co-Q10 pre-mixing agent 2000g to mixing.Be encapsulated as the 1kg/ bag with clean bag.
The preparation of embodiment 3 Co-Q10 pre-mixing agents
Carry out according to following method:
(1) Co-Q10 is dried to water content and is no more than 3%, cross 65 mesh sieves, carrier starch is dried to water content and is no more than 5%, crosses 50 mesh sieves.
(2) get Co-Q10 100g, zeolite powder 1900g.According to the equivalent incremental method, earlier starch 100g and Co-Q10 100g are placed in the mixer of cleaning, mixed 5 minutes, form the Co-Q10 pre-composition; In mixer, add starch 200g then, mixed 5 minutes; Constantly mix according to the equivalent incremental method; In mixer, add remaining starch at last and mix 15 minutes, promptly obtain Co-Q10 pre-mixing agent 2000g to mixing.Be encapsulated as the 1kg/ bag with clean bag.
Embodiment 4 Co-Q10 pre-mixing agents are to the protective effect research of laying hen fowl gout kidney
Carry out according to following method:
(1) experiment medicine: the Co-Q10 pre-mixing agent of the embodiment of the invention 1,2,3 preparations;
(2) test method: the test place is in Agricultural University Of Nanjing's pharmacology group experimental animal room.120 1 age in days Yi Sha laying hens are divided into 4 groups at random, i.e. the drug test group (being numbered the 1st, 2,3 group respectively) and the control group of embodiment 1,2,3 preparation carry out 60 days feeding experiment.Preceding 30 days, control group fed basal diet (with reference to the preparation of NRC standard) added the Co-Q10 pre-mixing agent in the basal diet that test group is fed, and addition is 40mg (Co-Q10)/kg feed.The 30 days control group fed high-calcium, high-protein daily rations (calcium 3.85%, protein 28.73%) in back, test group is added the Co-Q10 pre-mixing agent in the high-calcium, high-protein feed, and addition still is 40mg (Co-Q10)/kg feed.In blood sampling in 0,8,16,24 day of the high-calcium, high-protein daily ration of feeding, separation of serum, dynamic measurement is observed the variation of uric acid, creatinine, urea nitrogen in the serum.During off-test, each group is cutd open 6 chickens of inspection, does the microscopic examination of kidney.
(3) result of the test:
1, clinical observation and cut open the inspection result
Control group typical fowl gout symptom occurs the 8th day of the high-calcium, high-protein daily ration of feeding, shows as body and becomes thin, and ight soil is water sample, and spirit is depressed, and serious dehydration appears in sick chicken, occurs deadly, and the death rate is 36.7% (11/30).Cut open the visible kidney enlargement of inspection, be piebald shape, deposit whiteness in the kidney essence, ureter is cut off the adularescent electrodeposition substance.Test group minority chicken fowl gout symptom occurs the 15th talent of the high-calcium, high-protein daily ration of feeding, and fragmentary dead, the 1st group of death rate is 6.7% (2/30), and the 2nd group of death rate is (1/30), and the 3rd group is not had death.Death rate chicken is cutd open inspection, and visible kidney enlargement is piebald shape, deposits whiteness in the kidney essence, and ureter is cut off the adularescent electrodeposition substance.
2, clinical blood biochemical indicator dynamic measurement result
Serum creatinine, uric acid, urea nitrogen are the indexs of clinical reflection renal function quality.Obvious when impaired when renal function, three's concentration can raise.
2.1 the detection of dynamic result of serum creatinine (seeing table 1)
Table 1 serum creatinine level detects (n=6) (μ mol/L) result of the test
Can know that by data in the table remove 0d beyond the highest heavens, the 1st, 2,3 group of creatinine levels all is starkly lower than control group.This result shows in the feed and to add the rising that Co-Q10 can effectively prevent creatinine levels in the fowl goat chicken.
2.2 the detection of dynamic result of serum uric acid (seeing table 2)
Table 2 serum uric acid level detects (n=6) (μ mol/L) result of the test
Can know that by data in the table remove 0d beyond the highest heavens, the 1st, 2,3 group of uric acid level all is starkly lower than control group.This result shows in the feed and to add the rising that Co-Q10 can effectively prevent uric acid level in the fowl goat chicken.
2.3 the detection of dynamic result of serum urea nitrogen (seeing table 3)
Table 3 serum urea nitrogen horizontal detection (n=6) is result of the test (mmol/L)
Can know that by data in the table remove 0d beyond the highest heavens, the 1st, 2,3 group of urea nitrogen levels all is starkly lower than control group.Be illustrated in and add the rising that Co-Q10 can effectively prevent UAN level in the fowl goat chicken in the feed.
3 pathological study results
Histopathology result shows that control group renal lesions degree is the most serious, shows as the necrosis of renal cells segment-like, ballooning degeneration, renal cells swelling, luminal stenosis even locking, massive inflammatory cells infiltrated.1st, 2,3 groups of renal lesions degree obviously are lighter than control group, and the renal cells oedema alleviates, inflammatory cell reduces, renal tubule, and it is clear that the glomerulus structure becomes.
The above results explanation Co-Q10 can effectively reduce the death that the fowl gout causes, can relax the kidney pathology damage that the fowl gout causes effectively simultaneously.
Embodiment 5 Co-Q10 pre-mixing agents are to the contrast test of the influence of fowl gout body's immunity
Carry out according to following method:
(1) trial drug: the Co-Q10 pre-mixing agent of the embodiment of the invention 1,2,3 preparations;
(2) test method: the test place is in Agricultural University Of Nanjing's pharmacology group experimental animal room.1 age in days Yi Sha egg chick, 120 plumages carry out routine immunization by the laying hen immune programme for children.Be divided into embodiment 1,2,3 drug prepared test group (being numbered the 1st, 2,3 group respectively) and blank group after weighing at random.Preceding 30 days, control group fed basal diet (with reference to the preparation of NRC standard) added the Co-Q10 pre-mixing agent in the basal diet that test group is fed, and addition is 40mg (Co-Q10)/kg feed.The 30 days control group fed high-calcium, high-protein daily rations (calcium 3.85%, protein 28.73%) in back, test group is added the Co-Q10 pre-mixing agent in the high-calcium, high-protein feed, and addition still is 40mg (Co-Q10)/kg feed.Test chicken is raised in cages, free choice feeding drinking-water.When the 8th day (chicken 39 ages in days) of the high-calcium, high-protein feed of feeding, randomly draw 6 for every group, heart blood sampling 2mL/ only, anticoagulant heparin is measured lymphopoiesis.During respectively at test 46,60 ages in days, get 6 chickens at random, carry out the immune organ assessment of indices for every group.Heavy (the g)/body weight (kg) of immune organ index=immune organ.
Adopting mtt assay to carry out the lymphocyte increment measures.The anti-freezing blood sample is used 1 times of Hanks ' liquid dilution, carefully be added in the lymphocyte separation medium upper strata, the centrifugal 20min of 2000rpm/min, cloud leukocytic cream in the middle of drawing is washed 2 times the centrifugal 10min of 1500rpm/min with serum-free RPMI1640 nutrient solution.Behind the viable count, using RPMI1640 nutrient solution adjustment cell concentration is 5 * 106/mL, joins in the 96 porocyte culture plates; 80 μ L/ holes, every hole add 20 μ L PHA (final concentration is 20 μ g/mL) again, place then under 37 ℃, 5%CO2 condition and cultivate 44h; Take out every hole and add MTT 20 μ L, after continuing to cultivate 4h, inhale and go supernatant; Every hole adds DMSO 100 μ L; Place on the micro-oscillator concussion 5min that deposition is dissolved fully cell plates, with on the enzyme linked immunological appearance at the 570nm place detection its absorbance (A570 value), as the lymphopoietic index of T.
(3) result of the test:
1, to the result of the test (seeing table 4) of the lymphopoietic influence of peripheral blood T
Table 4 couple peripheral blood T lymphopoiesis (A
570Value) result of the test of influence
| Group | 39 ages in days |
| Control group | 0.061±0.012 |
| The 1st group | 0.107±0.005 |
| The 2nd group | 0.144±0.021 |
| The 3rd group | 0.193±0.013 |
Can know that by data in the table the 1st, 2,3 group of T lymphocyte appreciation rate explains that apparently higher than control group adding Co-Q10 in the feed can obviously promote the lymphocytic propagation of T.
2, to the result of the test (seeing table 5) of the influence of immune organ index
The result of the test of table 5 pair different days laying hen immune organ index influence
Can know that by data in the table the 1st, 2,3 group of different days thymus index, index and spleen index and bursa of farbricius index are all apparently higher than control group.
The above results shows, adds Co-Q10 in the feed and can significantly strengthen fowl gout laying hen lymphopoiesis, can promote growing of immune organs such as thymus gland, spleen, the bursa of farbricius, thereby strengthens the laying hen immunologic function.
Claims (10)
1. a Co-Q10 pre-mixing agent is characterized in that its constituent and percentage by weight thereof are: Co-Q10 2～5%, carrier 95～98%.
2. according in the described Co-Q10 pre-mixing agent of claim 1, it is characterized in that described carrier is meant zeolite powder, corn flour or starch.
3. the preparation method of the described Co-Q10 pre-mixing agent of claim 1 is characterized in that comprising with the Co-Q10 drying, crosses 65 mesh sieves; With carrier drying, cross 50 mesh sieves; According to the equivalent incremental method, Co-Q10 and equivalent carrier are placed in the mixer, stirring and evenly mixing gets the Co-Q10 pre-composition; In mixer, add the carrier with Co-Q10 pre-composition equivalent then, stirring and evenly mixing; So increase progressively the interpolation carrier, stir; In mixer, add remaining carrier at last, stirring and evenly mixing promptly gets the Co-Q10 pre-mixing agent.
4. Co-Q10 strengthens the purposes aspect the fowl immunity of organisms medicine in preparation.
5. the purposes of Co-Q10 aspect preparation control fowl gout medicine.
6. Co-Q10 relaxes the purposes aspect the kidney pathology damage medicine that laying hen fowl gout causes in preparation.
7. the described Co-Q10 pre-mixing agent of claim 1 strengthens the purposes aspect the fowl immunity of organisms medicine in preparation.
8. the purposes of the described Co-Q10 pre-mixing agent of claim 1 aspect preparation control fowl gout medicine.
9. the described Co-Q10 pre-mixing agent of claim 1 relaxes the purposes aspect the kidney pathology damage medicine that laying hen fowl gout causes in preparation.
10. according to claim 7,8 or 9 described purposes, it is characterized in that described fowl is meant chicken, duck, chicken, turkey, aquatic bird, dove or quail.
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Cited By (1)
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Application publication date: 20120627 |