CN102491300A - 一种双亲性单分散羟基磷灰石单晶纳米棒的制备方法 - Google Patents
一种双亲性单分散羟基磷灰石单晶纳米棒的制备方法 Download PDFInfo
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- CN102491300A CN102491300A CN2011103631238A CN201110363123A CN102491300A CN 102491300 A CN102491300 A CN 102491300A CN 2011103631238 A CN2011103631238 A CN 2011103631238A CN 201110363123 A CN201110363123 A CN 201110363123A CN 102491300 A CN102491300 A CN 102491300A
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- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 title claims abstract description 41
- 239000002073 nanorod Substances 0.000 title claims abstract description 34
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 229910052588 hydroxylapatite Inorganic materials 0.000 title abstract description 10
- 238000000034 method Methods 0.000 claims abstract description 34
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 28
- 238000006243 chemical reaction Methods 0.000 claims abstract description 18
- ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 claims abstract description 11
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims abstract description 9
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims abstract description 9
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims abstract description 9
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000005642 Oleic acid Substances 0.000 claims abstract description 9
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims abstract description 9
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims abstract description 9
- 239000000126 substance Substances 0.000 claims abstract description 6
- 229910019142 PO4 Inorganic materials 0.000 claims abstract description 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims abstract description 5
- 239000010452 phosphate Substances 0.000 claims abstract description 5
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims abstract description 3
- 239000012752 auxiliary agent Substances 0.000 claims abstract description 3
- ZCCIPPOKBCJFDN-UHFFFAOYSA-N calcium nitrate Chemical compound [Ca+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ZCCIPPOKBCJFDN-UHFFFAOYSA-N 0.000 claims description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
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- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 10
- 239000011575 calcium Substances 0.000 claims description 8
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- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims description 5
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- 235000011008 sodium phosphates Nutrition 0.000 claims description 4
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims description 4
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims description 3
- 229910000397 disodium phosphate Inorganic materials 0.000 claims description 3
- 235000019800 disodium phosphate Nutrition 0.000 claims description 3
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- 229910052698 phosphorus Inorganic materials 0.000 claims description 2
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims description 2
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- ODINCKMPIJJUCX-UHFFFAOYSA-N Calcium oxide Chemical compound [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 description 2
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- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 description 2
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- 206010031252 Osteomyelitis Diseases 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-L Phosphate ion(2-) Chemical compound OP([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-L 0.000 description 1
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- 125000000217 alkyl group Chemical group 0.000 description 1
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- 229910052586 apatite Inorganic materials 0.000 description 1
- 235000011175 beta-cyclodextrine Nutrition 0.000 description 1
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- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
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- 239000011734 sodium Substances 0.000 description 1
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104640623A (zh) * | 2012-09-18 | 2015-05-20 | 株式会社小糸制作所 | 吸附方法、吸附分离方法和用于药物传递的载体 |
CN105129756A (zh) * | 2015-09-22 | 2015-12-09 | 西北大学 | 一种低温矿化制备亚纳米级羟基磷灰石超细针的方法 |
CN106063947A (zh) * | 2016-05-25 | 2016-11-02 | 西北大学 | 一种硒掺杂纳米羟基磷灰石的制备方法 |
CN108046227A (zh) * | 2017-12-21 | 2018-05-18 | 衢州学院 | 一种低温制备微米级针状羟基钙磷灰石的方法 |
CN109502565A (zh) * | 2018-12-21 | 2019-03-22 | 湖北工业大学 | 一步法制备油溶性羟基磷灰石纳米棒的方法 |
CN113398326A (zh) * | 2021-05-21 | 2021-09-17 | 华南理工大学 | 一种表面接枝egcg的羟基磷灰石纳米棒及其制备方法和应用 |
CN116374973A (zh) * | 2023-02-08 | 2023-07-04 | 浙江大学 | 一种双层油酸法制备水相均匀分散的羟基磷灰石的方法 |
Citations (1)
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CN101297978A (zh) * | 2008-06-17 | 2008-11-05 | 东南大学 | 一种羟基磷灰石纳米杆的制备方法 |
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Patent Citations (1)
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CN101297978A (zh) * | 2008-06-17 | 2008-11-05 | 东南大学 | 一种羟基磷灰石纳米杆的制备方法 |
Non-Patent Citations (1)
Title |
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朱丹琛等: "以环糊精为模板水热合成羟基磷灰石", 《人工晶体学报》 * |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104640623A (zh) * | 2012-09-18 | 2015-05-20 | 株式会社小糸制作所 | 吸附方法、吸附分离方法和用于药物传递的载体 |
US9795896B2 (en) | 2012-09-18 | 2017-10-24 | Koito Manufacturing Co., Ltd. | Adsorption method, adsorption separation method, and drug delivery carrier |
CN105129756A (zh) * | 2015-09-22 | 2015-12-09 | 西北大学 | 一种低温矿化制备亚纳米级羟基磷灰石超细针的方法 |
CN106063947A (zh) * | 2016-05-25 | 2016-11-02 | 西北大学 | 一种硒掺杂纳米羟基磷灰石的制备方法 |
CN108046227A (zh) * | 2017-12-21 | 2018-05-18 | 衢州学院 | 一种低温制备微米级针状羟基钙磷灰石的方法 |
CN109502565A (zh) * | 2018-12-21 | 2019-03-22 | 湖北工业大学 | 一步法制备油溶性羟基磷灰石纳米棒的方法 |
CN113398326A (zh) * | 2021-05-21 | 2021-09-17 | 华南理工大学 | 一种表面接枝egcg的羟基磷灰石纳米棒及其制备方法和应用 |
CN113398326B (zh) * | 2021-05-21 | 2022-07-26 | 华南理工大学 | 一种表面接枝egcg的羟基磷灰石纳米棒及其制备方法和应用 |
CN116374973A (zh) * | 2023-02-08 | 2023-07-04 | 浙江大学 | 一种双层油酸法制备水相均匀分散的羟基磷灰石的方法 |
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