CN102464804A - Sodium heparin biological decomposition agent - Google Patents
Sodium heparin biological decomposition agent Download PDFInfo
- Publication number
- CN102464804A CN102464804A CN2010105544367A CN201010554436A CN102464804A CN 102464804 A CN102464804 A CN 102464804A CN 2010105544367 A CN2010105544367 A CN 2010105544367A CN 201010554436 A CN201010554436 A CN 201010554436A CN 102464804 A CN102464804 A CN 102464804A
- Authority
- CN
- China
- Prior art keywords
- sodium heparin
- sodium
- heparin sodium
- decomposition agent
- biological decomposition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/141—Feedstock
- Y02P20/143—Feedstock the feedstock being recycled material, e.g. plastics
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02W—CLIMATE CHANGE MITIGATION TECHNOLOGIES RELATED TO WASTEWATER TREATMENT OR WASTE MANAGEMENT
- Y02W30/00—Technologies for solid waste management
- Y02W30/50—Reuse, recycling or recovery technologies
- Y02W30/62—Plastics recycling; Rubber recycling
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a sodium heparin biological decomposition agent, which is obtained by mixing industrial flake caustic soda, sodium metabisulfite, biological protease and water in a certain weight ratio. The sodium heparin biological decomposition agent has the advantages of capability of effectively extracting an active resin special for sodium heparin, increase in the activity of the resin special for the sodium heparin, increase in the extraction amount of the sodium heparin, reduction in the discharge of wastes, high efficiency, low cost and safety and reliability for using, and can be widely taken as a biological decomposition agent for treating the resin special for the sodium heparin.
Description
Technical field
The present invention relates to a kind of resin dedicated biolysis agent of heparin sodium and preparation method thereof of handling.
Background technology
Heparin sodium is the anticoagulation medicine that from the intestines mucosa of animal, particularly pig, extracts, in hospital's purposes very extensively.Extract heparin sodium crude and adopt resin enzymolysis process usually, soon scrape the mucous membrane liquid of getting and carry out enzymolysis, adsorb with the resin dedicated D254 of heparin sodium, D199 again, and then wash-out, precipitate, dry the acquisition heparin sodium at last from the animal small intestine.This shows the resin dedicated very key that in the process of extracting heparin sodium, plays a part of heparin sodium.Heparin sodium is resin dedicated to be the translucent spherical particle of oyster white, and it can be reused, but after using 1 year usually, wherein shrink in the hole on 10～30% the resin surface; Forfeiture elasticity tarnishes and vigor, becomes dead resin; The result causes the adsorptive power of all resins to reduce greatly, has reduced the extracted amount of heparin sodium, so the common practice is that these resins are buried as waste material; Both increase the resin dedicated consumption of heparin sodium, improved production cost, increased the weight of environmental pollution again.
Summary of the invention
The purpose of this invention is to provide a kind of heparin sodium biolysis agent that can effectively remove dead resin and preparation method thereof.
The object of the invention is achieved through following technical proposals.
The agent of a kind of heparin sodium biolysis, it is made up of the raw material of following weight part:
3.6～4.4 parts in industrial sheet alkali, 2.7～3.3 parts of Sodium Pyrosulfites, 2.7～3.3 parts of bio proteases, 80～90 parts in water.
The preparation method of heparin sodium biolysis agent, it comprises the following steps:
1. take by weighing each primary industry sheet alkali, Sodium Pyrosulfite, bio protease, water by above-mentioned weight proportion, subsequent use;
2. above-mentioned raw materials is mixed, stir, get final product.
Raw material of the present invention is selected its easy moisture absorption of sheet alkali for use, is strong corrosive material, and the activated molecule of heparin sodium in resin dedicated are effectively activated or survival; Select Sodium Pyrosulfite for use, it is water-soluble, makes the aqueous solution be acid, as sanitas, SYNTHETIC OPTICAL WHITNER and raising agent; Select bio protease for use, it can improve the speed of chemical reaction as catalyzer, makes reaction more be prone to carry out.During use with the resin dedicated ratio in 1: 2 of agent of heparin sodium biolysis and the heparin sodium that uses 1 year repeatedly; Mix, left standstill 12-36 hour, then reactive resin float over the agent of heparin sodium biolysis above; Dead resin then precipitates; So can collect reactive resin and can continue to use effectively with reactive resin and dead resin isolation, dead resin then abandons.
The present invention compared with prior art has following advantage:
1, reduces the resin dedicated consumption 70～90% of heparin sodium, reduced production cost.
2, improve the resin dedicated vigor of heparin sodium, increased the extracted amount of heparin sodium.
3, reduce the resin dedicated quantity discharged of discarded heparin sodium, protected environment.
Embodiment
Embodiment 1
1. take by weighing industrial sheet alkali 4kg, Sodium Pyrosulfite 3kg, bio protease 3kg, water 90kg;
2. above-mentioned raw materials is mixed, stir, promptly get the resin dedicated biochemical decomposition agent of 100kg heparin sodium.
Claims (2)
1. heparin sodium biolysis agent is characterized in that, it is made up of the raw material of following weight part:
3.6～4.4 parts in industrial sheet alkali, 2.7～3.3 parts of Sodium Pyrosulfites, 2.7～3.3 parts of bio proteases, 80～90 parts in water.
2. the preparation method of 1 described heparin sodium biolysis agent as requested, it comprises the following steps:
1. take by weighing each primary industry sheet alkali, Sodium Pyrosulfite, bio protease, water by above-mentioned weight proportion, subsequent use;
2. above-mentioned raw materials is mixed, stir, get final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010554436.7A CN102464804B (en) | 2010-11-14 | 2010-11-14 | Sodium heparin biological decomposition agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010554436.7A CN102464804B (en) | 2010-11-14 | 2010-11-14 | Sodium heparin biological decomposition agent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102464804A true CN102464804A (en) | 2012-05-23 |
| CN102464804B CN102464804B (en) | 2016-05-18 |
Family
ID=46068953
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201010554436.7A Expired - Fee Related CN102464804B (en) | 2010-11-14 | 2010-11-14 | Sodium heparin biological decomposition agent |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102464804B (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101649336A (en) * | 2008-08-25 | 2010-02-17 | 射洪县天贵畜产品加工厂 | Novel process for producing sodium heparin |
| CN101649008A (en) * | 2008-12-17 | 2010-02-17 | 四川天成生化科技有限公司 | Process for producing low molecular sodium heparin |
| CN101735340A (en) * | 2010-01-18 | 2010-06-16 | 叶青理 | Method for preparing heparin sodium by combining enzymolysis and salt decomposition |
-
2010
- 2010-11-14 CN CN201010554436.7A patent/CN102464804B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101649336A (en) * | 2008-08-25 | 2010-02-17 | 射洪县天贵畜产品加工厂 | Novel process for producing sodium heparin |
| CN101649008A (en) * | 2008-12-17 | 2010-02-17 | 四川天成生化科技有限公司 | Process for producing low molecular sodium heparin |
| CN101735340A (en) * | 2010-01-18 | 2010-06-16 | 叶青理 | Method for preparing heparin sodium by combining enzymolysis and salt decomposition |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102464804B (en) | 2016-05-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160518 Termination date: 20191114 |