CN102464804B - Sodium heparin biological decomposition agent - Google Patents

Sodium heparin biological decomposition agent Download PDF

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Publication number
CN102464804B
CN102464804B CN201010554436.7A CN201010554436A CN102464804B CN 102464804 B CN102464804 B CN 102464804B CN 201010554436 A CN201010554436 A CN 201010554436A CN 102464804 B CN102464804 B CN 102464804B
Authority
CN
China
Prior art keywords
liquaemin
decomposition agent
biological decomposition
sodium
resin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201010554436.7A
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Chinese (zh)
Other versions
CN102464804A (en
Inventor
蔡天贵
刘泰山
蔡静
蔡成良
胡小翠
蔡承儒
蔡成英
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SICHUAN TIANCHENG BIO-TECHNOLOGY Co Ltd
Original Assignee
SICHUAN TIANCHENG BIO-TECHNOLOGY Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SICHUAN TIANCHENG BIO-TECHNOLOGY Co Ltd filed Critical SICHUAN TIANCHENG BIO-TECHNOLOGY Co Ltd
Priority to CN201010554436.7A priority Critical patent/CN102464804B/en
Publication of CN102464804A publication Critical patent/CN102464804A/en
Application granted granted Critical
Publication of CN102464804B publication Critical patent/CN102464804B/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/141—Feedstock
    • Y02P20/143—Feedstock the feedstock being recycled material, e.g. plastics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02W—CLIMATE CHANGE MITIGATION TECHNOLOGIES RELATED TO WASTEWATER TREATMENT OR WASTE MANAGEMENT
    • Y02W30/00—Technologies for solid waste management
    • Y02W30/50—Reuse, recycling or recovery technologies
    • Y02W30/62—Plastics recycling; Rubber recycling

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention discloses a kind of sodium heparin biological decomposition agent, it is mixed according to a certain weight ratio by industrial sheet alkali, sodium pyrosulfite, bio protease and water. It is resin dedicated that the present invention can extract active liquaemin effectively, there is the resin dedicated vigor of the liquaemin of increasing, increase the extracted amount of liquaemin, reduce waste discharge amount, efficiency is high, cost is low, safe and reliable, can be widely used as and process liquaemin resin dedicated biological decomposition agent.

Description

Sodium heparin biological decomposition agent
Technical field
The present invention relates to a kind of resin dedicated biological decomposition agent of liquaemin and preparation method thereof of processing.
Background technology
Liquaemin is the anticoagulation medicine extracting from the intestinal mucosa of animal, particularly pig, in hospitalPurposes is very extensive. Extract heparin sodium crude and conventionally adopt resin enzymolysis process, be about to little from animalOn intestines, the mucous membrane liquid of scraping carries out enzymolysis, then adsorbs with the resin dedicated D254 of liquaemin, D199,And then wash-out, finally precipitate, dry obtain liquaemin. As can be seen here, liquaemin is resin dedicatedIn the process of extracting liquaemin, play a part very crucial. Liquaemin is resin dedicated is milkyTranslucent spherical particle, it can be reused, but conventionally use after 1 year, and wherein 10～30%Shrink in hole on resin surface, loses elasticity, tarnishes and vigor, becomes dead resin, resultCause the adsorption capacity of all resins greatly to reduce, reduced the extracted amount of liquaemin, so conventionallyThe practice be that these resins are buried as waste material, both increased the resin dedicated use of liquaeminAmount, has improved production cost, has increased the weight of again environmental pollution.
Summary of the invention
The object of this invention is to provide a kind of sodium heparin biological decomposition agent that can effectively remove dead resinAnd preparation method thereof.
Object of the present invention is achieved by following technical proposals.
A kind of sodium heparin biological decomposition agent, it is made up of the raw material of following weight portion:
3.6～4.4 parts, industrial sheet alkali, 2.7～3.3 parts of sodium pyrosulfites, bio protease 2.7～80～90 parts of 3.3 parts, water.
The preparation method of sodium heparin biological decomposition agent, it comprises the following steps:
1. by above-mentioned weight proportion take each primary industry sheet alkali, sodium pyrosulfite, bio protease,Water, for subsequent use;
2. above-mentioned raw materials is mixed, stirs evenly.
Its easy moisture absorption of raw material choose sheet alkali of the present invention, is strong corrosive material, makes liquaemin specialAnakmetomeres in resin are effectively activated or are survived; Select sodium pyrosulfite, it is water-soluble, makesIt is acid that the aqueous solution is, as anticorrisive agent, bleaching agent and raising agent; Select bio protease, its workFor catalyst, can improve the speed of chemical reaction, reaction is more easily carried out. When use by liquaeminThe resin dedicated ratio in 1: 2 of biological decomposition agent and the Reusability liquaemin of 1 year, mixes,Leave standstill 12-36 hour, reactive resin float over sodium heparin biological decomposition agent above, dead resin isPrecipitation, so can, effectively by reactive resin and dead resin isolation, collect reactive resin and can continueContinuous use, dead resin abandons.
The present invention compared with prior art has the following advantages:
1, reduce the resin dedicated consumption 70～90% of liquaemin, reduced production cost.
2, improve the resin dedicated vigor of liquaemin, increased the extracted amount of liquaemin.
3, reduce the resin dedicated discharge capacity of discarded liquaemin, protected environment.
Detailed description of the invention
Embodiment 1
1. take industrial sheet alkali 4kg, sodium pyrosulfite 3kg, bio protease 3kg, water 90kg;
2. above-mentioned raw materials is mixed, stir, obtain 100kg liquaemin resin dedicatedBiochemical distintegrant.

Claims (2)

1. a sodium heparin biological decomposition agent, is characterized in that, it is by the raw material of following weight portionForm:
3.6～4.4 parts, industrial sheet alkali, 2.7～3.3 parts of sodium pyrosulfites, bio protease 2.7～80～90 parts of 3.3 parts, water.
2. the preparation method of the sodium heparin biological decomposition agent described in 1 as requested, it comprises followingStep:
1. by above-mentioned weight proportion take each primary industry sheet alkali, sodium pyrosulfite, bio protease,Water, for subsequent use;
2. above-mentioned raw materials is mixed, stirs evenly.
CN201010554436.7A 2010-11-14 2010-11-14 Sodium heparin biological decomposition agent Expired - Fee Related CN102464804B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201010554436.7A CN102464804B (en) 2010-11-14 2010-11-14 Sodium heparin biological decomposition agent

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201010554436.7A CN102464804B (en) 2010-11-14 2010-11-14 Sodium heparin biological decomposition agent

Publications (2)

Publication Number Publication Date
CN102464804A CN102464804A (en) 2012-05-23
CN102464804B true CN102464804B (en) 2016-05-18

Family

ID=46068953

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201010554436.7A Expired - Fee Related CN102464804B (en) 2010-11-14 2010-11-14 Sodium heparin biological decomposition agent

Country Status (1)

Country Link
CN (1) CN102464804B (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101649336A (en) * 2008-08-25 2010-02-17 射洪县天贵畜产品加工厂 Novel process for producing sodium heparin
CN101649008A (en) * 2008-12-17 2010-02-17 四川天成生化科技有限公司 Process for producing low molecular sodium heparin
CN101735340A (en) * 2010-01-18 2010-06-16 叶青理 Method for preparing heparin sodium by combining enzymolysis and salt decomposition

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101649336A (en) * 2008-08-25 2010-02-17 射洪县天贵畜产品加工厂 Novel process for producing sodium heparin
CN101649008A (en) * 2008-12-17 2010-02-17 四川天成生化科技有限公司 Process for producing low molecular sodium heparin
CN101735340A (en) * 2010-01-18 2010-06-16 叶青理 Method for preparing heparin sodium by combining enzymolysis and salt decomposition

Also Published As

Publication number Publication date
CN102464804A (en) 2012-05-23

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Granted publication date: 20160518

Termination date: 20191114

CF01 Termination of patent right due to non-payment of annual fee