CN102459599A - 糖蛋白vi的核酸调节剂 - Google Patents

糖蛋白vi的核酸调节剂 Download PDF

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Publication number
CN102459599A
CN102459599A CN2010800352956A CN201080035295A CN102459599A CN 102459599 A CN102459599 A CN 102459599A CN 2010800352956 A CN2010800352956 A CN 2010800352956A CN 201080035295 A CN201080035295 A CN 201080035295A CN 102459599 A CN102459599 A CN 102459599A
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gpvi
ligand
nucleic acid
ligands
platelet
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CN2010800352956A
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Chinese (zh)
Inventor
J·M·莱泽
C·P·鲁斯科尼
D·布鲁克斯
S·L·泽伦科夫斯克
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Regado Biosciences Inc
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Regado Biosciences Inc
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N2310/00—Structure or type of the nucleic acid
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    • G01N2800/00—Detection or diagnosis of diseases
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    • G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism
    • G—PHYSICS
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    • G01N2800/00—Detection or diagnosis of diseases
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CN2010800352956A 2009-06-03 2010-06-03 糖蛋白vi的核酸调节剂 Pending CN102459599A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US18384709P 2009-06-03 2009-06-03
US61/183847 2009-06-03
US30095110P 2010-02-03 2010-02-03
US61/300951 2010-02-03
PCT/US2010/037319 WO2010141771A1 (en) 2009-06-03 2010-06-03 Nucleic acid modulators of glycoprotein vi

Publications (1)

Publication Number Publication Date
CN102459599A true CN102459599A (zh) 2012-05-16

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US (1) US8318923B2 (https=)
EP (1) EP2438169B1 (https=)
JP (1) JP2012528597A (https=)
KR (1) KR20120055529A (https=)
CN (1) CN102459599A (https=)
AU (1) AU2010256511B2 (https=)
CA (1) CA2764449A1 (https=)
IL (1) IL216725A0 (https=)
RU (1) RU2571660C2 (https=)
SG (1) SG176644A1 (https=)
WO (1) WO2010141771A1 (https=)

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CN107849108A (zh) * 2015-03-03 2018-03-27 阿瓦隆生物制品有限公司 聚乙二醇化的il‑11的组合物和方法

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WO2012050611A2 (en) * 2010-10-13 2012-04-19 Duke University Aptamers to glycoprotein vi
US9687529B2 (en) 2011-05-05 2017-06-27 Duke University Method of controlling coagulation
US8735367B2 (en) * 2011-06-27 2014-05-27 University Of Utah Research Foundation Small molecule-dependent split aptamer ligation
CA2894174A1 (en) * 2012-12-06 2014-06-12 Regado Biosciences Inc. Oligonucleotide formulation
WO2014193800A2 (en) 2013-05-28 2014-12-04 The Johns Hopkins University Aptamers for the treatment of sickle cell disease
WO2016176426A1 (en) 2015-04-28 2016-11-03 Duke University Thrombus imaging aptamers and methods of using same
EP3512526A4 (en) 2016-09-16 2020-05-27 Duke University VON WILLEBRAND FACTOR (VWF) TARGETING AGENTS AND METHODS OF USE
CN108823247A (zh) * 2018-06-05 2018-11-16 山东省医学科学院附属医院 一种人源化cd-19嵌合抗原受体t淋巴细胞载体及其应用
CN110951866A (zh) * 2019-12-27 2020-04-03 河南中医药大学 一种检测gpvi基因启动子区甲基化水平的引物及其检测方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107849108A (zh) * 2015-03-03 2018-03-27 阿瓦隆生物制品有限公司 聚乙二醇化的il‑11的组合物和方法

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WO2010141771A1 (en) 2010-12-09
IL216725A0 (en) 2012-02-29
RU2571660C2 (ru) 2015-12-20
SG176644A1 (en) 2012-01-30
CA2764449A1 (en) 2010-12-09
EP2438169B1 (en) 2017-08-09
US8318923B2 (en) 2012-11-27
EP2438169A1 (en) 2012-04-11
US20100311820A1 (en) 2010-12-09
JP2012528597A (ja) 2012-11-15
RU2011154087A (ru) 2013-07-27
AU2010256511A1 (en) 2012-01-12
KR20120055529A (ko) 2012-05-31
AU2010256511B2 (en) 2016-01-14

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