CN102450282A - Green long-acting zoonosis vector prevention and control medicament - Google Patents
Green long-acting zoonosis vector prevention and control medicament Download PDFInfo
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- CN102450282A CN102450282A CN2010105127797A CN201010512779A CN102450282A CN 102450282 A CN102450282 A CN 102450282A CN 2010105127797 A CN2010105127797 A CN 2010105127797A CN 201010512779 A CN201010512779 A CN 201010512779A CN 102450282 A CN102450282 A CN 102450282A
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Abstract
A green long-acting zoonosis vector control medicament provided by the invention is prepared from an insect growth regulator (IGR), a plant essential oil and/or a low-toxicity high-efficiency pesticide, a bactericide, an insect attractant and/or a repellant, a sustained release agent and the like. According to different use conditions and environments, by the adoption of microemulsification and sol technologies, a spraying agent, a sol coating, a film-forming inhibitor and a sol-forming inhibitor are prepared to form different release mechanisms so as to satisfy control demands in different places. The medicament provided by the invention has low toxicity and high efficiency, has effects of killing ovum, inhibiting insect growth and resisting bacteria and mildew, has a long persistent period, is not easy to generate resistance, has low residual, can be used to minimize the spread of diseases and eliminate the pollution caused by unbalance of drug application, is beneficial to the ecological environment, and is used to control zoonosis vectors (such as flea, louse, mite, tick, mosquito, fly, ant, cockroach and the like) in the fields of public place, garden, urban landscaping, means of transportation, neighborhood, hotel, school, restaurant, household, pet, animal husbandry, culturing farm and the like.
Description
Technical field
The present invention relates to a kind of green, the long-acting people beast disease communication media series prevention and control series medicament that takes a disease altogether.Relate in particular and a kind ofly contain water baseization microemulsion, colloidal sol slowly-releasing plastics, film forming sustained release agent, the colloidal sol moulding sustained release preparation that insect growth regulator, IGR (IGR), many components plants essential oil and/or low toxic pesticide, bactericidal agent etc. are formed, and in the above-mentioned preparation and/or contain the preparation of insect attractant and/or repellant.The invention still further relates to said preparation in public places, place such as gardens, urban afforestation, transport facility (automobile, train, steamer, aircraft etc.), hotel, school, dining room, family, pet, animal farm, plant, prevention and control people beast take a disease altogether disease communication media (flea, lice, mite, tick, mosquito, fly, cockroach, ant etc.) and antibacterial mildew-resistant.Belong to sanitary insect pest prevention and control field.
Background technology
In the period of nearly 30, the whole world has been found new infectious disease of kind more than 30 and a collection of rampant once again old infectious disease successively, and wherein considerable part is zoonosis (Zoonosis).About five, 60,000,000 people of the annual death toll in the current whole world, wherein about 1st/3rd, die from infectious disease.The infecting both domestic animals and human disease that exists in the world at present has kind more than 200 approximately, the nearly kind more than 130 of China (plague, tuberculosis, dengue fever, toxoplasma, AIDS, tuberculosis, legionaires' disease, rabies, helicobacter pylori disease, encephalitis B, influenza, bird flu, SARS and current first flow or the like).Therefore, pay close attention to the popular present situation and the development trend of infecting both domestic animals and human disease, inquire into how to pay attention to and take precautions against the infecting both domestic animals and human disease, concerning the important topic of national security and Development of Economy.
Most of infecting both domestic animals and human diseases are infected to the people by the arthropod-borne of animal body surface usually.Arthropods (ant, fly, cockroach, mite, horsefly, lice, flea, tick etc.) plays an important role in the propagation of zoonosis, and its mechanical transmission mode is when biting humans and animals, brings pathogene in the skin into.Biological transmission is after pathogene gets in the segmental appendage kinetoplast, through the growth breeding of certain hour, infects the human or animal again.
The sick kind of infecting both domestic animals and human disease gets more and more, and epidemic factor is on the increase.Come into fashion like pet feeding in the family of city, the infecting both domestic animals and human disease also from the rural area, the pastoral area gets into the city.People have also increased the risk of trouble " pet is sick " when enjoying happy that pet brings.
Plague the infected's death is in necessarily, and it is not rarely seen in historical data that disease causes the incident that whole country or provincialism thoroughly destroy.Be engaged in the insect-borne infectious disease result of study for a long time according to Guiyang Medical College lacquer one ring professor and show that the main communication media of the plague is the mouse flea, the risk that some areas of China still exist " plague " to propagate, and the propagation of the plague is mainly the mouse flea.
The risk of livestock and poultry industry and product increases; This type of epidemic situation mainly contains: aftosa, bird flu, swine fever, newcastle disease, pig breeding and respiratory syndrome, rabies, infectious bronchitis of chicken, Marek's disease etc.; Its morbidity is wide, belong to infecting both domestic animals and human more; To livestock and poultry breeding industry, great to people ' s health harm.
Plant, the main communication media of animal farm have: hematophaguses such as mosquito, fly, cockroach, sand fly, midge, horsefly, buffalo gnat, and lice, wriggle, mite, flea and other insects etc.Plant, the main harmful microorganism of animal farm have: coliform bacteria, parasite, reproductive and respiratory syndrome, pestivirus, bacillus anthracis, tubercle bacillus, bomb fly and heel fly, multiceps, necrobacillus, capripox virus, pasteurella multocida,, marek's disease virus, aviadenovirus, fowl cerebrospinal tract virus, Pseudomonas aeruginosa etc.
Flea extensively distributes in the whole world, is a kind of insect that quantitatively is only second to ant, has importance on the economics.Show that according to the recent investigation result of the U.S. pet supplies AEM U.S. had family more than half (59%) to have pets such as dog, cat in 1996.Amount to support family's number that pet is arranged and surpassed 5,800 ten thousand families, the expense that only is used to every year prevent and treat the pet flea in the U.S. is just above 1,000,000,000 dollars.It is reported that China Shenzhen pet economy has reached 5.7 hundred million yuan.
As long as clear and definite animal reservoir, communication media, control its source, cut off it and propagate chain, disease popularity just will be controlled.Therefore, must accelerate research and development prevention and control infecting both domestic animals and human transmission media medicament.
The Amphixenosis is the very important one type of infectious disease of natural world and human society, and occurrence scope is all over the world, once takes place in history repeatedly to be very popular, and receives the extensive concern of international community and news media at present.
Control to the infecting both domestic animals and human disease relates to people, animal, environment; The great infecting both domestic animals and human disease of a series of harmfulness is carried out control; Need government and multidisciplinary, multidisciplinary coordinated; There is the expert of every aspects such as public hygienics, clinical medicine, etiology, epidemiology, molecular biology, ecology, microbiology, entomology, zoology, social science, the humanities to participate in, many-sided coordination such as health, agricultural, forest department, scientific research institution, medical colleges and schools and cooperation arranged, fully reallocate resources; Synergistic operation could effectively be controlled the attack from the Amphixenosis with all strength.
According to the principle of putting prevention first, as long as clear and definite animal reservoir, communication media, control its source, cut off it and propagate chain, disease popularity just will be controlled.Therefore, research and development prevention and control media medicament helps the infection of infecting both domestic animals and human disease.
Over nearly 50 years, whole world new discovery and cause all infectious diseases of the mankind that society is panic, portion passes to the people by animal, animal is that the medium of human cause of disease and the viewpoint of storage vault obtain generally } the same and attention of people.Along with whole world Developing of Animal Industry and social progress, the Amphixenosis to prevent and treat situation severe more, new Amphixenosis constantly occurs; Once ill localized epidemics was serious altogether for old people, and the Amphixenosis is the dead the biggest factor of human infectious disease, also was to need human important fort of capturing; Look forward to the future, along with the extensive distribution and the variation of animal pathogenic, the Amphixenosis still can not eliminate the potential threat of the mankind; The Amphixenosis, necessary " people and animals prevent and treat altogether ".
Summary of the invention
Another object of the present invention is to provide a kind of green, the long-acting people beast disease communication media series prevention and control medicament that takes a disease altogether; Be used for public place, gardens, urban afforestation, sub-district, the vehicles (automobile, train, steamer, aircraft), hotel, school, dining room, family, pet, herding and plant etc., people beast take a disease altogether prevention and control, the antibacterial mildew-resistant of disease communication media (flea, lice, mite, tick, mosquito, fly, cockroach, ant etc.).
Another object of the present invention is to provide a kind of can directly be used for animal body surface sprayings such as pet, pig, ox, sheep, chicken, duck; Be used for public place etc., directly spraying, do not need airtight, directly to prevention and control place spraying or with sol preparation, plastics on object, the room inner wall film-coating, or employing moulding sustained release preparation is placed on indoor getting final product.Satisfy the demand of different places.
Main purpose of the present invention is to provide a kind of green, the long-acting people beast disease communication media series prevention and control medicament that takes a disease altogether; This protectant have insecticidal spectrum wide, efficient, kill ovum, suppress insect growth, consumption is little, dispenser is convenient, insect is difficult for developing immunity to drugs; Antibacterial mildew-resistant; Residual low, can reduce transmission of disease, can eliminate the pollution that unbalance dispenser causes, the improvement of favourable ecotope.
Another object of the present invention is to provide a kind of water baseization microemulsion; Be transparent homogeneous liquid, particle diameter 5～50nm is stable under-10～50 ℃ condition; For use in indoor and outdoors such as family, dining room, the vehicles, meeting rooms; Be sprayed on the object and leave no trace, do not pollute object, water is prone to the spray of wash-out.
For realizing above-mentioned purpose; The present invention is auxiliary composition by insect growth regulator, IGR (IGR), multicomponent plants essential oil, low toxicity highly effective pesticide, bactericide, synergist, bleeding agent, water-soluble solvent, stabilizing agent, insect attractant and/or repellant, film forming sustained release agent and moulding sustained release agent etc., and its preparation method is following:
A. adopt microemulsion technology to prepare the method that high infiltration rate is imitated water baseization microemulsion;
B. adopt the colloidal sol technology to prepare the method that water is prone to the long-acting slow-release plastics of wash-out and/or contains the sol solutions of insect attractant;
C. adopt release membranes to prepare the method that water is difficult for the long-acting slow-release plastics of wash-out and/or contains the release membranes of insect attractant;
D. adopt the technological method for preparing the moulding sustained release preparation and/or contain the colloidal sol body preparation of insect attractant of colloidal sol;
E. adopt from sol material and prepare the method that water is prone to long-acting slow-release plastics, the moulding sustained release agent of wash-out and/or contains the sol preparation of other insect attractants as insect attractant;
For realizing above-mentioned purpose; The inventor is through long-term discovering in this field; Select insect growth regulator, IGR (suppress insect growth, be difficult for developing immunity to drugs, reduce dosage and number of times), plants essential oil, plant extracts, containing benezene water-soluble solvent, water baseization microemulsion reinforcement infiltration for use, reduce dosage.To different targets, select the effective ingredient of different insecticidal mechanisms for use, taken into full account the activity stack synergistic effect that is mixed, make insect be difficult to develop immunity to drugs.
The present invention has made full use of the multi-functional character of each component, and on the basis of the compatibility of considering each component, the plants essential oil of selecting for use was both antibacterial as mildew-resistant, insecticide, the solvent of double as part insecticide again; Propane diols phenylate and ethanol is both as outside the solvent, also the double as bactericide; Propane diols is both as stabilizing agent, again the bleeding agent of double as fortification of plants essential oil; Agar, pectin, sodium alginate had both been made colloidal sol, and self also makes insect attractant.Thereby realize the purpose efficient, that consumption is little.
The inventor is through long-term discovering in this field; In existing insect growth regulator, IGR; Fenoxycarb can suppress insect population, suppress the growth that insect gives birth to (larva → each length of time → pupa → butterfly → lay eggs → ovum hatching → larva) process entirely, has the function that ovum, inhibition are extremely casted off a skin, suppressed pupa, inhibitionization butterfly, suppress to lay eggs, suppress the ovum hatching.The most important communication media of zoonosis is a type arthropods such as flea, mosquito, tick; According to reporting both at home and abroad; And the result of study of our more than ten years shows: fenoxycarb has good performance the control arthropods; The unique effect that the ovum worm kills together can overall process be killed the insect of generation overlap, suppresses the generation again of insect pest comprehensively.
Fenoxycarb toxicity is hanged down rat oral LD50＞10000 (reporting 16800 abroad) mg/kg; Insecticidal activity with wide spectrum is effective to diptera, coleoptera, Homoptera, Hymenoptera, Lepidoptera, different inferior wing order, thrips, psocopteran 50 various pests and some acarians, nematode.Fenoxycarb is compared with other insect growth regulator, IGR; Dosage is little, and (0.1～10ppm), other insect growth regulator, IGR comparative trials such as employing fenoxycarb and methoprene show, under condition; The consumption of fenoxycarb is 0.2～0.5 times of other insect growth regulator, IGR consumptions, and residual low.
Fenoxycarb can be prevented and treated the insect that existing insecticide is had resistance, is 100% to the corrected mortality of the sanitary insect pest worm first generation (F1) and the second generation (F2).To sanitary insect pest almost, second generation adult inhibitory rate of reproduction reaches 100%.Therefore, when being used for the prevention and control sanitary insect pest, its lasting period reached more than 2 years.Though fenoxycarb has used one, vicennial history, the rarely seen so far report that resistance is arranged.
Fenoxycarb has long but double grading that environment is not polluted of lasting period.Many agricultural chemicals, this two specific character are difficult to occur simultaneously, often the lasting period long, chemical stability is all right, though favourable to desinsection, be lost in soil and the river after, often form environmental pollution.And fenoxycarb makes this two specific character be able to combine preferably; This performance can obtain explaining from the half life period of fenoxycarb under varying environment, when in water, because of it is insoluble in water, and be prone to absorbed by the organic matter in the water, and after illumination, the half life period is 5 hours.After getting into soil, can be dissipated fast, use and can not in earth, observe fenoxycarb after three days.
Fenoxycarb is used to prevent and treat the object insect and has following characteristics: 1. have stomach toxicity and action of contace poison concurrently, insecticidal spectrum is wide; 2. to pest efficient, and to the mammal low toxicity; 3. the lasting period long, but double grading free from environmental pollution; 4. can prevent and treat the resistant strain insect.5. can suppress the full growing stage of insect.Select that thereby fenoxycarb can realize that insecticidal spectrum is wide for use, long, residual low, the purpose that is difficult for producing resistance of environmental protection, lasting period.
The inventor is through long-term discovering in this field; Fenoxycarb all has certain synergistic effect to existing insecticide; Particularly pyrethroid, carbamate insecticide are had good synergistic effect, this specific character is relevant with the molecular structure of fenoxycarb.
Fenoxycarb is used to prevent and treat the object insect and has following characteristics: 1. have stomach toxicity and action of contace poison concurrently, insecticidal spectrum is wide; 2. to pest efficient, and to the mammal low toxicity; 3. the lasting period can reach 2 years, but the double grading that environment is not polluted; 4. can prevent and treat the resistant strain insect.5. can suppress the full growing stage of insect.Thereby can realize that insecticidal spectrum is wide, long, residual low, the purpose that is difficult for producing resistance of environmental protection, lasting period.
Pyrrole propyl ether (having another name called pyriproxyfen) is a kind of insect growth regulator, IGR, belongs to phenyl ether compound.Can suppress the growth of larva, be used to prevent and treat sanitary insect pests such as mosquito, fly, blattaria, blattaria is had special efficacy, Homoptera, tassel wing day, diptera, lepidoptera pest are all had efficiently.Have efficiently, dosage is few, and the lasting period is long, to the characteristics of crop safety to the fish low toxicity, to characteristics such as eco-environmental impact are little.
The present invention adopts bactericide (ethylene glycol phenyl ether, ethanol, the dimethyl fumarate that many components plants essential oil is antibacterial as mildew-resistant, the insecticide combination is existing; The diphenyl ether bactericide: 3,4-dichloro-diphenyl ether, 3,4-dibromodiphenyl ether, 2; 2; 4 '-three chloro-, 2 ' dihydroxy diphenyl ether, halo nitrotrimethylolmethane phenylate, halo ADP ether compound etc., compound prescription has increased antibiotic sterilization effect.The inventor is through long-term discovering in this field; The plants essential oil that contains many components is compared with the plants essential oil of high-purity single component; Because material aldehydes, terpenes in its many components have antibacterial mildew-resistant, insecticidal action, therefore many components have the pesticide resistance of better resisting insect.Select for use among the present invention Main Ingredients and Appearance content be many components essential oil of 60～80% as fungus-proof pesticide, synergist, can be used as the solvent of the former medicine of part simultaneously.For this reason, the present invention selects for use and contains main component citral 65～75% litsea cubeba oils, and all the other components are citrene, methyl heptenone, australene, nopinene, linalool etc.; Select the eucalyptus oil that contains main component cineole 60～80% for use, all the other components are alpha-terpineol, australene, terpinyl acetate, aromadendrene, terpinene, linalool etc.; Select for use to contain main component firpene 60～75% turpentine oil, all the other components are the essential oil of laurene, terpinene, α phellandrene; These components can play synergy, synergy, compare with high-purity citral, help preventing that insect from developing immunity to drugs.The plant essence of selecting for use can be used as flavorant, for this to the person poultry harmless.
Litsea cubeba oil is the flavorant that China GB2760-86 regulation allows use, and the oral LD50 of rat is 4960mg/kg, has the activity and the antitoxic action that suppress fungi, has Pesticidal and sterilizing, can eliminate aflatoxin in the paddy.The main component citral has stronger bacteriostasis to staphylococcus aureus, Escherichia coli, typhoid bacillus and shigella dysenteriae in the litsea cubeba oil, and Candida albicans, Candida tropicalis, candida parakrusei, Cryptococcus neoformans, fonsecaea dermatitidis, hormodendrum verrucosa, sporothrix, gypsum appearance microspore silk bacterium and trichophyton gypseum etc. are all had tangible bacteriostasis.Citral gas is smoked to stop fungi (aspergillus flavus, aspergillus niger, aspergillus ustus and penicillium chrysogenum) going mouldy to rice and traditional Chinese medicine etc.Litsea cubeba oil is to human non-toxic, and is free from environmental pollution.
Eucalyptus oil can be used as flavorant, and LD50＞5000mg/kg has mildew-resistant and sterilization and anticorrosion effect.FEMA regulation: senior staff officer considers and is soft drink 1.7mg/kg in the food; The eucalyptus oil compound prescription is all stronger to the inhibitory action of gram positive bacteria and negative bacterium.Turpentine oil, cinnamon oil have higher contact toxicity to corn weevil, lesser grain borer and red flour beetle adult.Litsea cubeba oil, eucalyptus oil, turpentine oil also have the smoked kill effect to sanitary insect pest.
Add propane diols in the conventional microemulsion as antifreeze, the inventor discovers that propane diols has the effect that strengthens permeability and availability to plants essential oil, and the optimization proportioning that plants essential oil cooperates with propane diols is 0.8: 1.65.
The inventor finds, because diversity of organism, the bactericide of one-component is compared with the bactericide of many components; Therefore selected for use to have multi-functional ethylene glycol phenyl ether, ethanol, in as solvent, the double as bactericide; To different occasions, can add dimethyl fumarate where necessary.
Diethanol phenylate low toxicity, rat oral: LD50=1260mg/kg is a broad-spectrum antiseptic; Can effectively kill Gram-positive and negative bacterium, mould, and saccharomycete: effective especially to the unicellular bacterium of vacation and other gram-negative bacterias; Be used with other bactericidal activity compositions; Strengthen the activity of other antibacterial agents, in addition, the diethanol phenylate also is good solvent.Therefore, have sterilization and double as solvent dual-use function among the present invention.
Dimethyl fumarate is a kind of efficient, wide spectrum newly developed, low toxicity, stable novel antibacterial mould inhibitor, and has insecticidal action concurrently.It can suppress more than 30 kind of mould, saccharomycete and bacterium, and the inhibition of multiple moulds such as aflatoxins common in the food and AN is had better effect.It can distil and have contact and stifling sterilization double action.Food and drug administration classifies these article as food additives and is used widely.China also approved is used as antimildew agent for food and food additives with it.
Plant be for a long time with insect coevolution process in; Produced the secondary metabolites of defence insect's food-taking; In the Secondary Metabolism of Plant product owing to contain the material of some biologically actives; Known have kind more than 2000 (Chiu, et al.1993 report 30,000 kinds) plant to have active insecticidal components, can be divided into following several big type by its chemical constitution: 1. glucoside; 2. phenol and quinones; 3. alkaloids; 4. terpenes; 5. steroid class; 6. Coumarins; 7. xylan class; 8. polyyne class;
The present invention selects for use low toxicity efficiently to be prone to degrading pesticide, is the plant resource extract, and the pyrethroid of American-European registered registration and organophosphorus insecticides are main.Wherein: the plant resource extract adopts plant insecticide pyrethrins, rotenone, nicotine, matrine, stemonine, seal chinaberry, Celastrus angulatus, Tea Saponin, tea withered etc.; Because having in mammal (the comprising human body) body can be with the enzyme of its decomposition; Above-mentioned plant resource extract is decomposed into water and carbonic acid gas easily rapidly, noresidue, not contaminated food products and environment.
Pyrethrin (mainly be present in spend in) is a kind of typical never poison, and wherein main component is pyrethrin I and II, have tag, stomach toxicity and repellent action, can work simultaneously to peripheral nervous system, central nervous system and other organ-tissues; It is strong that insect is knocked down power, and insecticidal spectrum is wide, and working concentration is low, can very fast metabolism in mammalian body, and to the people, animal low toxicity, to plant and Environmental security.Pyrethrins has following characteristics: 1. desinsection wide spectrum; 2. desinsection speed is fast; 3. the lasting period is long; 4. nontoxic to people and animals, in people's carcass, decompose rapidly; 5. there is not pesticide resistance; 6. in natural environment, be prone to degraded, noresidue.
Celastrus angulatus is to have anesthesia, food refusal and stomach toxicity, action of contace poison from the active insecticidal components that Celastrus angulatus extracts; And characteristics such as do not develop immunity to drugs, killed natural enemies, physicochemical property be not stable; Celastrus angulatus I has the food refusal effect to insect; Celastrus angulatus II, III have the stomach toxicity toxic action to insects such as black cutworn, tomato moth, anomis flavas, and Celastrus angulatus IV has the selection anesthetic effect to insect.
Select for use the low toxicity efficient pesticides to select for use The World Health Organization (WHO) to recommend, satisfy LD50 >=500mg/kg and pyrethroid insecticides (Permethrin, tetramethrin, d-phenothrin, ether chrysanthemum ester,, cyphenothrin, dtetramethrin, transfluthrin, bioresmethrin, resmethrin etc.) and organophosphorus insecticide (malathion, fenifrothion, pirimiphos-methyl, Entex, phoxim, bromophos, Swebate, Nankor, azamethiphos, chlorpyrifos-methyl) simultaneously with multiclass sanitary insect pests such as can killing mosquito, flea, lice, fly, cockroach
Adopt benzene class (toluene, xylol etc.) solvent different with other most of insecticides tested, the present invention selects water-soluble solvent for use, propane diols phenylate, ethanol, N, innoxious solvents such as dinethylformamide, oxolane, N-N-methyl 2-pyrrolidone N-, therefore more environmental protection, safety.Plants essential oil solubilized part insecticide in the prescription, but double as solvent.Because this microemulsion is containing benezene solvent and solvent naphtha not.Because the inventor screened above-mentioned solvent combinations, realized that microemulsion is sprayed at not stay trace on the object, do not pollute and damage the object outward appearance.
The present invention is green, long-acting people beast takes a disease the altogether described water baseization microemulsion of disease communication media series prevention and control medicament, colloidal sol technology are prepared into the preparation method of spray, film forming sustained release agent and moulding sustained release agent:
A. adopt microemulsion technology to prepare the method that high infiltration rate is imitated water baseization microemulsion: to select 4～15% water-soluble solvent for use; At room temperature with the emulsifier thin up, all the other components are dissolved in the water baseization solvent, then two solution are mixed; Be prepared into transparent homogeneous liquid; Particle diameter 5～50nm, stable under-10～50 ℃ condition, consumption is 0.1～10ppm.Water baseization microemulsion is compared with missible oil, not containing benezene solvent and solvent naphtha, and being sprayed at does not have trace on the object; Do not pollute object; When keeping same control efficiency, reduce the consumption of effective ingredient, significantly reduced the consumption of organic solvent, made preparation more meet environmental protection requirement.
B. adopt the colloidal sol technology to prepare the method that water is prone to the long-acting slow-release plastics of wash-out and/or contains the sol solutions of insect attractant: after the colloidal sol dilute with water described in the claim 8 is stirred; Normal temperature is regulated PH=6.0～8.0 down; The powerful stirring adds described water baseization microemulsion of a and/or insect attractant down fast; Leave standstill after stirring and form green, long-acting object mildew-resistant desinsection vitreosol liquid; Sol solutions after the dilution and water baseization emulsifier proportion are 0.05～1.5, and that this colloidal sol can directly be applied to is indoor, bin inwall, carpet, dining table cloth, the tables and chairs back side, ground or body of wall are first-class, and consumption is 20～50mg/m
2
C. adopt release membranes to prepare the method that water is difficult for the long-acting polymer slowly-releasing plastics of wash-out and/or contains the release membranes of insect attractant: with the film forming sustained release agent described in the claim 8 (other macromolecule aqueous solution or emulsions such as polyvinyl alcohol, degradable acrylic acid and polyacrylic); After dilute with water stirs; Normal temperature is regulated pH value down; The powerful stirring adds described water baseization microemulsion of a and/or insect attractant down fast; Leave standstill after stirring and form green, long-acting object mildew-resistant desinsection sustained release preparation; Filming emulsion after the dilution and water baseization emulsifier proportion are 0.1～1.5, and that this plastics can directly be applied to is indoor, bin inwall, carpet, dining table cloth, the tables and chairs back side, ground or body of wall are first-class, and consumption is 20～50mg/m
2
D. adopt colloidal sol technology preparation moulding sustained release preparation and/or contain the method for the colloidal sol body preparation of insect attractant: after the colloidal sol class moulding sustained release agent water described in the claim 8 is adjusted to suitable concentration and stirs; Normal temperature is regulated PH=6.0～8.0 down; The powerful stirring adds described water baseization microemulsion of a and/or insect attractant down fast, after stirring, pours in the container of definite shape; Leave standstill to form and have the green of definite shape, long-acting object mildew-resistant desinsection sustained release preparation; Moulding glue and water baseization emulsifier proportion are 0.6～2.5, and this colloidal sol body is used to have certain profile, press certain way and arrange; Place in object casing or the storehouse object periphery and/or sized-multiple;
E. adopt from sol material and prepare the method that water is prone to long-acting slow-release plastics, the moulding sustained release agent of wash-out and/or contains the sol preparation of other insect attractants: claim 8 is described from as the agar of insect attractant or pectin, sodium alginate, gelatin, cyclodextrin as insect attractant; After water is adjusted to suitable concentration and stirs; Normal temperature is regulated pH value down; The powerful stirring adds described water baseization microemulsion of a and/or insect attractant down fast; After stirring, pour in the container of definite shape, leave standstill formation and have the green of definite shape, long-acting object mildew-resistant desinsection sustained release preparation; During preparation long-acting slow-release plastics; Glue and water baseization emulsifier proportion from as insect attractant are 0.05～1.5, when preparing long-acting moulding sustained release preparation, are 0.6～2.5 from glue and water baseization emulsifier proportion as insect attractant.
Preparation of the present invention have low toxicity efficient, kill ovum, suppress insect growth, the lasting period is long, be difficult for producing resistance, antibacterial mildew-resistant, residual low, can reduce transmission of disease, can eliminate the pollution that unbalance dispenser causes, favourable ecotope.
Embodiment
The present invention comes explanation objects and advantages of the present invention further through embodiment, and described only is exemplary with illustrative, rather than the qualification of claim of the present invention.
Embodiment 1
With litsea cubeba oil 2.5g, fenoxycarb 1.2g, pyrethrins 0.3g, Butacide 1%, Butacide 1.6g, 2; 2; 4 '-three chloro-, 2 ' dihydroxy diphenyl ether 2g, ethylene glycol phenyl ether 1.0g, propane diols 2.5g and be dissolved in the 5g ethanol are stirred to the liquid that forms transparent and homogeneous; With 16gAEO-9,5g OP-10, the 5g Tween 80 is dissolved in the 50g water, is stirred to the liquid that forms transparent and homogeneous; Then that the two is mixed, and add insect attractant 3g in the claim, stir the solution that forms transparent and homogeneous, mend then and add water to 100g.
Characteristic: make the liquid that water baseization micro emulsion is a transparent and homogeneous, particle diameter 5～25nm, stable performance under-15～+ 55 ℃ of conditions.Not containing benezene solvent and solvent naphtha are sprayed at the cotton article and go up and do not have trace basically, do not pollute spray.
Purposes: be used for public place, gardens, urban afforestation, transport facility (automobile, train, steamer, aircraft etc.), sub-district, hotel, school, dining room, family, pet, herding and plant etc., take a disease the altogether prevention and control of disease communication media (flea, lice, mite, tick, mosquito, fly, cockroach, ant etc.) of people beast; (staphylococcus aureus, Escherichia coli, typhoid bacillus and shigella dysenteriae have stronger bacteriostasis, and Candida albicans, Candida tropicalis, candida parakrusei, Cryptococcus neoformans, fonsecaea dermatitidis, hormodendrum verrucosa, sporothrix, gypsum appearance microspore silk bacterium and trichophyton gypseum etc. are all had tangible bacteriostasis for inhibition and kill bacteria; Can stop going mouldy that fungi (aspergillus flavus, aspergillus niger, aspergillus ustus and penicillium chrysogenum) causes.
Method for using: with 500～1000 times of microemulsion thin ups, directly on the plant of green belt, spray by stoste 25～30mg/m2, also can directly directly spraying on object.Spraying is three times continuously, and 3～7 days at interval, 1～3 month lasting period (zone >=50000～100000m2, the zone is little, corresponding weak point of lasting period), fenoxycarb (IGR) stoped insect can not become adult.
Embodiment 2
With litsea cubeba oil 2.5g, fenoxycarb 1.2g, ether chrysanthemum ester 0.5g, pirimiphos-methyl 0.3g, Butacide 1%, Butacide 1.6g, 2; 2; 4 '-three chloro-, 2 ' dihydroxy diphenyl ether 2g, ethylene glycol phenyl ether 1.0g, propane diols 2.5g and be dissolved in the 5g ethanol are stirred to the liquid that forms transparent and homogeneous; With 18gAEO-9,6g OP-10, the 6g Tween 80 is dissolved in the 50g water, is stirred to the liquid that forms transparent and homogeneous; Then that the two is mixed, and add insect attractant 3g in the claim, stir the solution that forms transparent and homogeneous, mend then and add water to 100g, subsequent use
Take by weighing 0.3g pectin join the 89.7g temperature be in 75～85 ℃ the hot water agitation and dilution to all dissolvings; Be cooled to≤45 ℃ after; Stir, regulate PH to 7～8, stir then down; Add above-mentioned microemulsion and WHYY-2 type insect attractant 10g, leave standstill after stirring and just form transparent thick liquid.
Characteristic: the colloidal sol that makes is the transparent and homogeneous thick liquid, and stable under normal temperature condition, being sprayed at does not have spot on the object, and water is prone to wash-out.
Purposes: gardens, urban afforestation, animal farm, plant, take a disease the altogether prevention and control of disease communication media (flea, lice, mite, tick, mosquito, fly, cockroach, ant etc.) of people beast suppress and kill bacteria (with embodiment 1) and going mouldy.
Method for using: the preparation agent is directly filmed by 25～30mg/m2, and continuous three times, 3～7 days at interval, the lasting period: indoor 1～3 month, outdoor: 0.5～1 month, fenoxycarb (IGR) stoped insect can not become adult.
Embodiment 3
With litsea cubeba oil 3g, fenoxycarb 1.0g, tetramethrin 0.1g, permethrin 0.9g, Butacide 1.0g, 2,2,4 '-three chloro-, 2 ' dihydroxy diphenyl ether 3g, ethylene glycol phenyl ether 1.0g, propane diols 3g are dissolved in the 5.0g ethanol, are stirred to the liquid that forms transparent and homogeneous; With 16g AEO-9,7g OP-10, the 5g Tween 80 is dissolved in the 45g water, is stirred to the liquid that forms transparent and homogeneous; Then with the two the mixed solution that forms transparent and homogeneous that stirs, mend then and add water to 100g (when this prescription is used for screen window during increase by 2～5g repellant) with wall outside window.
Characteristic: make the liquid that water baseization micro emulsion is a transparent and homogeneous, particle diameter 5～25nm, stable performance under-15～+ 55 ℃ of conditions.Not containing benezene solvent and solvent naphtha are sprayed at the cotton article and go up and do not have trace basically, do not pollute spray.
Purposes: be used for the pet body surface, take a disease the altogether prevention and control of disease communication media (flea, lice, mite, tick, mosquito, fly, cockroach, ant etc.) of people beast suppress and kill bacteria (with embodiment 1) and going mouldy.
Method for using: preparation is directly sprayed by 25～30mg/m2, spray continuously three times, 3～7 days at interval, 3～6 months lasting periods (in automobile, train, steamer, the aircraft storehouse), fenoxycarb (IGR) stoped insect can not become adult.
Embodiment 4
With litsea cubeba oil 2.5g, fenoxycarb 1.0g, d-phenothrin 0.50g, permethrin 0.5g, Butacide 1.0g, 3,4-dibromodiphenyl ether, ethylene glycol phenyl ether 1.0g, propane diols 3g are dissolved in the 5.0g ethanol, are stirred to the liquid that forms transparent and homogeneous; With 16g AEO-9,7g OP-10, the 5g Tween 80 is dissolved in the 40g water, is stirred to the liquid that forms transparent and homogeneous; With the two the mixed solution that forms transparent and homogeneous that stirs, mend then and add water to 100g then, subsequent use.
Take by weighing the 1.2g carboxymethyl cellulose join the 88.8g temperature be in 90～95 ℃ the hot water agitation and dilution to all dissolvings; Be cooled to≤45 ℃ after; Stir, regulate PH to 7～8, stir then down; Add above-mentioned microemulsion and WHQB-2 type insect repellent 10g, leave standstill after stirring and just form transparent thickness sol solutions.
Characteristic: the colloidal sol that makes is the transparent and homogeneous thick liquid, and stable under normal temperature condition, being sprayed at does not have spot on the object, and water is prone to wash-out.
Purposes: be used for take a disease the altogether prevention and control of disease communication media (flea, lice, mite, tick, mosquito, fly, cockroach, ant etc.) of people beast in the vehicles (automobile, train, steamer, the aircraft) storehouse, suppress and kill bacteria (with embodiment 1) and going mouldy.
Method for using: preparation is directly filmed by 25～30mg/m2, and continuous three times, 3～7 days at interval, 3～6 months lasting periods (in automobile, train, steamer, the aircraft storehouse), fenoxycarb (IGR) stoped insect can not become adult.
Embodiment 5
With litsea cubeba oil 3g, fenoxycarb 1.2g, pyrethrins 0.50g, Butacide 1.0g, 2,2,4 '-three chloro-, 2 ' dihydroxy diphenyl ether 2g, ethylene glycol phenyl ether 1.0g, propane diols 3g are dissolved in the 5.0g ethanol, are stirred to the liquid that forms transparent and homogeneous; With 16gAEO-9,7g OP-10, the 5g Tween 80 is dissolved in the 40g water, is stirred to the liquid that forms transparent and homogeneous; With the two the mixed solution that forms transparent and homogeneous that stirs, mend then and add water to 100g then, subsequent use.
Take by weighing 0.25g agar join the 94.75g temperature be in 75～85 ℃ the hot water agitation and dilution to all dissolvings; Be cooled to≤45 ℃ after; Stir, regulate PH to 7～8, stir then down; Add above-mentioned microemulsion and WHQB-3 type insect repellent 5g, leave standstill after stirring and just form transparent thick liquid.
Characteristic: the colloidal sol that makes is the transparent and homogeneous thick liquid, and stable under normal temperature condition, being sprayed at does not have spot on the object, and water is prone to wash-out.
Purposes: be used for the pet body surface, take a disease the altogether prevention and control of disease communication media (flea, lice, mite, tick, mosquito, fly, cockroach, ant etc.) of people beast suppress and kill bacteria (with embodiment 1).
Method for using: after pet cleaned, with microemulsion by 25～30mg/m2 to directly spraying spraying of pet (avoiding eye), continuous three times, 3～7 days at interval, 3～6 months lasting periods, fenoxycarb (IGR) stops bred.
Embodiment 6
Litsea cubeba oil 3g, fenoxycarb 1.2g, permethrin 1.0g, tetramethrin 0.6, Butacide 1.0g, ethylene glycol phenyl ether 1.0g, propane diols 3g are dissolved in the 5.0g ethanol, are stirred to the liquid that forms transparent and homogeneous; With 16gAEO-9,7g OP-10, the 5g Tween 80 is dissolved in the 40g water, is stirred to the liquid that forms transparent and homogeneous; With the two the mixed solution that forms transparent and homogeneous that stirs, mend then and add water to 100g then.
Characteristic: make the liquid that water baseization micro emulsion is a transparent and homogeneous, particle diameter 5～25nm, stable performance under-15～+ 55 ℃ of conditions.Not containing benezene solvent and solvent naphtha are sprayed at the cotton article and go up and do not have trace basically, do not pollute spray.
Purposes: be used for the animal farm animal body surface, raise in the circle, take a disease the altogether prevention and control of disease communication media (flea, lice, mite, tick, mosquito, fly, cockroach, ant etc.) of people beast suppress and kill bacteria (with embodiment 1) and going mouldy.
Method for using: after will raising the interior cleaning and sterilizing of circle, directly spray with (avoiding eye) to body surfaces such as pig, ox, sheep by 25～30mg/m2 with microemulsion.1～3 month lasting period, fenoxycarb (IGR) stops breeding.
Embodiment 7
Insect attractant is made up of following composition:
WHYY-1 type: maltose 25%, lactic acid 5%, indoles 13%, benzyl acetate 10%, lauric acid 5%, methyl eugenol 3%, mixing essence 2%, distiller's yeast 2%, water-soluble solvent 7%, surfactant 28%;
WHYY-2 type: sucrose 30%, lactic acid 8%, benzyl acetate 8%, methyl eugenol 8%, mixing essence 8%, distiller's yeast 2%, water-soluble solvent 5%, surfactant 30%;
WHYY-3 type: sucrose 30%, lactic acid 8%, indoles 10%, benzyl acetate 7%, methyl eugenol 5%, mixing essence 3%, distiller's yeast 2%, water-soluble solvent 8%, surfactant 27%;
Embodiment 8
Insect repellent is made up of following composition:
WHQB-1 type (indoor): 10% Flos Chrysanthemi Indici extract 40%, litsea cubeba oil 5%, eucalyptus oil 10%, turpentine oil 10%, salicylic acid 3%, water-soluble solvent 5%, surfactant 25%;
WHQB-2 type (indoor and outdoor is used): N, N-diethyl-benzamide 35%, litsea cubeba oil 5%, eucalyptus oil 10%, turpentine oil 8%, salicylic acid 5%, water-soluble solvent 7%, surfactant 28%);
WHQB-3 type (indoor and outdoor is used): N, N-diethyl-benzamide 30%, litsea cubeba oil 5%, eucalyptus oil 10%, turpentine oil 8%, camphor 5%, salicylic acid 5%, water-soluble solvent 8%, surfactant 27%).
Claims (10)
1. green, the long-acting people beast disease communication media series prevention and control medicament that takes a disease altogether; According to insect rule of life and different environments for use; Adopt technology such as micro emulsion, colloidal sol, slowly-releasing; Be prepared into different preparations such as water baseization micro emulsion spray, colloidal sol and/or gel slow-released agent, polymer film forming sustained release agent, colloidal sol and/or gel forming sustained release agent, form different releasing mechanisms, satisfy different places prevention and control demand; Can eliminate the pollution that unbalance dispenser causes; The improvement of favourable ecotope, the present invention by insect growth regulator, IGR (IGR), contain multi-component plants essential oil and/or low toxicity efficient pesticides, bactericide, synergist, bleeding agent, water-soluble solvent, stabilizing agent, insect attractant and/or repellant, film forming sustained release agent and moulding sustained release agent etc. are formed, its preparation method is following:
A. adopt microemulsion technology to prepare the method that high infiltration rate is imitated Amphixenosis's communication media prevention and control medicament of water baseization microemulsion;
B. adopt colloidal sol technology preparation water to be prone to the long-acting colloidal sol and/or the gel rubber sustained-release plastics of wash-out and/or to contain insect attractant or the method for repellant Amphixenosis prevention and control medicament;
C. adopting slow release method to prepare water is difficult for the long-acting polymer film forming sustained release agent of wash-out and/or contains insect attractant or the method for Amphixenosis's communication media prevention and control medicament of repellant;
D. adopt colloidal sol technology preparation colloidal sol and/or gel forming sustained release preparation and/or contain insect attractant or the method for Amphixenosis's communication media prevention and control medicament of insect repellent;
E. adopt from sol material and prepare the method that water is prone to the long-acting sol preparation of wash-out as insect attractant.
2. green according to claim 1, the long-acting people beast disease communication media series prevention and control medicament that takes a disease altogether; It is characterized in that described insect growth regulator, IGR is fenoxycarb and/or methoprene, hydroprene, pyrrole propyl ether; Diflubenzuron, bollworm killing urea; More than one or theys' composition, its consumption is 0.05～5%;
3. green according to claim 1, the long-acting people beast disease communication media series prevention and control medicament that takes a disease altogether; It is characterized in that described to contain multi-component plants essential oil be that litsea cubeba oil, eucalyptus oil, turpentine oil, schizonepeta essential oil etc. contain aldehyde and many components of terpenes plants essential oil; More than one or theys' composition; Its content is 1.5～15%; And select for use plants essential oil to cooperate with propane diols, to increase the permeability and the availability of effective ingredient, it is 0.8: 1.65 that its plants essential oil and propane diols are optimized proportioning; Many components plants essential oil is meant the non-high-purity major constituent essential oil that from a plant species, extracts; The essential oil of multicomponent ability is compared with the essential oil of high-purity single component; Have synergy, synergy, help preventing pest resistance to insecticide, for this reason; It is 65～75% essential oil that litsea cubeba oil is selected main component citral content for use, and all the other components are citrene, methyl heptenone, australene, nopinene, linalool etc.; Eucalyptus oil is selected the eucalyptus oil that contains cineole 60～80% for use, and all the other compositions are alpha-terpineol, australene, terpinyl acetate, aromadendrene, terpinene, linalool etc.; Turpentine oil is selected firpene 60～75% for use, and all the other components are the essential oil of laurene, terpinene, α phellandrene.The schizonepeta essential oil is selected main component terpene, terpene alcohols, aldehydes 75% bullion for use.
4. green according to claim 1, the long-acting people beast disease communication media series prevention and control medicament that takes a disease altogether; It is characterized in that described low toxicity efficient pesticides is: plant source and plant source modification pesticide (pyrethrins, Celastrus angulatus, rotenone, seal chinaberry, nicotine, matrine, stemonine, Tea Saponin, tea are withered etc.), microbial insecticide (Dipel, AVM), The World Health Organization (WHO) are recommended; Satisfy LD50 >=500mg/kg simultaneously and have pyrethroid insecticides (Permethrin, tetramethrin, d-phenothrin, ether chrysanthemum ester, cyphenothrin, dtetramethrin, transfluthrin, bioresmethrin, resmethrin etc.) and the organophosphorus insecticide (malathion, fenifrothion, pirimiphos-methyl, Entex, phoxim, bromophos, Swebate, Nankor, azamethiphos, chlorpyrifos-methyl) that to kill sanitary insect pest; More than one or theys' composition, its content is 0.05～5%; Adopt above-mentioned pesticide simultaneously, add synergist (Butacide, Octacide 264), more than one or theys' composition, its content is 0.5～3%, with the ratio of insect growth regulator, IGR be 0.6～1.5.
5. according to claim 1 and 3 described greens, the long-acting people beast disease communication media series prevention and control medicament that takes a disease altogether; It is characterized in that described bactericide is plants essential oil, ethylene glycol phenyl ether, ethanol, the diphenyl ether bactericide (3 in the claim 3; 4-dichloro-diphenyl ether, 3; 4-dibromodiphenyl ether, 2,2,4 '-three chloro-, 2 ' dihydroxy diphenyl ether, halo nitrotrimethylolmethane phenylate, halo ADP ether compound and dimethyl fumarate; More than one or theys' composition, its content is 2.5～15%.
6. according to claim 1 and 5 described greens, the long-acting people beast disease communication media series prevention and control medicament that takes a disease altogether; It is characterized in that described solvent for the low toxicity water-soluble solvent of containing benezene not like ethylene glycol phenyl ether, ethanol, N; Dinethylformamide, oxolane, N-N-methyl 2-pyrrolidone N-etc.; Two or more, its content is 3～15%, the plants essential oil double as oil-dissolving solvent described in the claim 3.
7. green according to claim 1, the long-acting people beast disease communication media series prevention and control medicament that takes a disease altogether; It is characterized in that described insect attractant and repellant are water baseization micro emulsion or fluid composition; Wherein said insect attractant is made up of following material: carbohydrate (sucrose, glucose, maltose etc.) 10～30%, lactic acid 5～10%, indoles 10～20%, benzyl acetate 5～15%, lauric acid 5～15%, methyl eugenol 5～15%, palmitic acid 5～15%, mixing essence 2～5%, distiller's yeast 2～8%, valeric acid 2～8%; Water-soluble solvent 2～8%; Surfactant 5～35%, consumption are 1.5～25% of preparation; Described insect repellent is made up of following composition: wherein indoor repellant is 10% Flos Chrysanthemi Indici extract 20～60%, litsea cubeba oil 3～10%, eucalyptus oil 5～15%; Turpentine oil 5～15%; Salicylic acid 2～5%, water-soluble solvent 2～8%, surfactant 5～35%; Indoor and outdoor is used: N, N-diethyl-benzamide 20～45%, litsea cubeba oil 5～15%, eucalyptus oil 5～20%, turpentine oil 5～10%, acetic acid 2～10%, water-soluble solvent 2～8%, surfactant 5～35%), consumption is 1.5～25% of a preparation.
8. green according to claim 1, the long-acting people beast disease communication media series prevention and control medicament that takes a disease altogether; It is characterized in that described 1. colloidal sol and/or gel slow-released agent are the colloidal sol of low silicon colloidal sol, agar, pectin, carboxymethyl cellulose (salt), hydroxyethylcellulose, sodium alginate, gelatin, modified starch, xanthans, cyclodextrin composition; Its consumption is 0.1～1.2%; Outward appearance is a transparent body thick liquid, films in the place that is used for the easy wash-out of water; 2. described polymer film forming sustained release agent is other macromolecule aqueous solution or emulsions such as acrylic acid and polyacrylic, polyvinyl alcohol, polyethylene kind; And do not produce the polymer of chemical reaction, degradable and vitrification point≤80 ℃ with above-mentioned active ingredient; Its consumption is 0.05～2.5%; Outward appearance is a thick liquid, and curable film-forming is used for water and is difficult for wash-out, more long-acting filming; 3. described colloidal sol moulding sustained release agent is Ludox, agar, pectin, carboxymethyl cellulose (salt), hydroxyethylcellulose, sodium alginate isosol, and its consumption is 0.8～8%; 4. described is the colloidal sol that agar, pectin, sodium alginate, gelatin, cyclodextrin etc. contain carbohydrate and/or protein and/or starch from the colloidal sol as insect attractant.
9. green according to claim 1, the long-acting people beast disease communication media series prevention and control medicament that takes a disease altogether; It is characterized in that described surfactant is nonionic and/or anion surfactant and/or cationic surfactant: wherein, nonionic: nonionics such as NPE (TX series), polyoxyethylene 20 sorbitan monolaurate (Tween-80), AEO (AEO), polyoxyethylene nonylphenyl ether, Emulsifier EL-60; Anion: neopelex/calcium (LAS), 6501, lauryl sodium sulfate (calcium) etc., cationic surfactant is a quaternary ammonium salt; Two or more, their composition, its consumption are 15～35%.
10. according to the described green of claim 1～9, the long-acting people beast disease communication media series prevention and control medicament that takes a disease altogether, it is characterized in that described water baseization microemulsion, colloidal sol and/or gel rubber sustained-release is filmed, the preparation method of polymer film forming sustained release agent and colloidal sol and/or gel forming sustained release preparation, prepare the method that water is prone to the colloidal sol sustained release agent of wash-out from the colloidal sol as insect attractant:
A. the method for water baseization microemulsion: adopt 4～15% water-soluble solvent, at room temperature with the emulsifier thin up, all the other components are dissolved in the water baseization solvent, then two solution are mixed; Be prepared into transparent homogeneous liquid, particle diameter 5～50nm is stable under-10～50 ℃ condition; Being sprayed at object does not have spot, does not pollute object, and consumption is 0.1～10ppm; When being used for pet, livestock body surface, its consumption is 5～50ppm, 90～180 days lasting periods;
B. the preparation method of colloidal sol and/or gel rubber sustained-release plastics: after the colloidal sol dilute with water described in the claim 8 stirred; Normal temperature is regulated PH=6.0～8.0 down; The powerful stirring adds the described water baseization microemulsion of a and/or insect attractant or repellant down fast, leaves standstill after stirring and forms the transparent sol preparation that contains, and sol solutions after the dilution and water baseization emulsifier proportion are 0.5～1.5; Sol content is 0.05～1.5%; Said preparation can directly be applied to pet, livestock body surface (can not add attractant with repellant), and indoor, bin inwall, carpet, dining table cloth, the tables and chairs back side, ground or body of wall are first-class, and consumption is 20～50mg/m
2
C. the preparation method of polymer film forming sustained release agent: with aqueous solutions of polymers described in the claim 8 or emulsion (other macromolecule aqueous solution or emulsions such as polyvinyl alcohol, degradable acrylic acid and polyacrylic); After dilute with water stirs; Normal temperature is regulated pH value down; The powerful stirring adds described water baseization microemulsion of a and/or insect attractant down fast, leaves standstill after stirring and forms the film forming sustained release agent, and polymer emulsion after the dilution and water baseization emulsifier proportion are 0.2～1.5; That this plastics can directly be applied to is indoor, bin inwall, carpet, dining table cloth, the tables and chairs back side, ground or body of wall are first-class, and consumption is 20～50mg/m
2
D. the preparation method of colloidal sol and/or gel forming sustained release preparation: after the colloidal sol water described in the claim 8 was adjusted to suitable concentration and stirs, normal temperature was regulated PH=6.0～8.0 down, and powerful the stirring adds described water baseization microemulsion of a and/or insect attractant down fast; After stirring; Pour in the container of definite shape, leave standstill and form the vitreosol body with definite shape, sol content is 0.2～3.5%; This colloidal sol body is used to have certain profile; Press certain way and arrange, place in object casing or the storehouse, (object periphery) and/or sized-multiple;
E. be prone to the colloidal sol sustained release agent of wash-out and/or contain insect attractant or the method for repellant from prepare water as the colloidal sol of insect attractant: will be from as the agar of insect attractant or pectin, sodium alginate, gelatin, xanthans, cyclodextrin; After water is adjusted to suitable concentration and stirs; Normal temperature is regulated PH=6.0～8.0 down, and powerful the stirring adds the described water baseization microemulsion of a and/or insect attractant or repellant down fast, after stirring; Pour in the container of definite shape; Leaving standstill and form the colloidal sol body preparation with definite shape, when preparing long-acting colloidal sol slowly-releasing plastics, is 0.05～1.5% from the sol content as insect attractant; When preparing long-acting moulding sustained release preparation, be 0.2～3.5% from sol content as insect attractant.
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