CN102449727B - 具有微分离子迁移率谱仪和质谱仪的离子分析装置及使用方法 - Google Patents

具有微分离子迁移率谱仪和质谱仪的离子分析装置及使用方法 Download PDF

Info

Publication number
CN102449727B
CN102449727B CN201080019355.5A CN201080019355A CN102449727B CN 102449727 B CN102449727 B CN 102449727B CN 201080019355 A CN201080019355 A CN 201080019355A CN 102449727 B CN102449727 B CN 102449727B
Authority
CN
China
Prior art keywords
ion
waveform
ions
differential
vacuum
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201080019355.5A
Other languages
English (en)
Chinese (zh)
Other versions
CN102449727A (zh
Inventor
R·贾尔斯
D·帕帕纳斯塔休
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shimadzu Corp
Original Assignee
Shimadzu Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shimadzu Corp filed Critical Shimadzu Corp
Priority to CN201510495958.7A priority Critical patent/CN105181781B/zh
Publication of CN102449727A publication Critical patent/CN102449727A/zh
Application granted granted Critical
Publication of CN102449727B publication Critical patent/CN102449727B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • G01N27/622Ion mobility spectrometry
    • G01N27/624Differential mobility spectrometry [DMS]; Field asymmetric-waveform ion mobility spectrometry [FAIMS]

Landscapes

  • Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
CN201080019355.5A 2009-05-01 2010-04-30 具有微分离子迁移率谱仪和质谱仪的离子分析装置及使用方法 Active CN102449727B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201510495958.7A CN105181781B (zh) 2009-05-01 2010-04-30 具有微分离子迁移率谱仪和质谱仪的离子分析装置及使用方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0907619.1 2009-05-01
GBGB0907619.1A GB0907619D0 (en) 2009-05-01 2009-05-01 Ion analysis apparatus and method of use
PCT/GB2010/000873 WO2010125357A2 (en) 2009-05-01 2010-04-30 Ion analysis apparatus and method of use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201510495958.7A Division CN105181781B (zh) 2009-05-01 2010-04-30 具有微分离子迁移率谱仪和质谱仪的离子分析装置及使用方法

Publications (2)

Publication Number Publication Date
CN102449727A CN102449727A (zh) 2012-05-09
CN102449727B true CN102449727B (zh) 2015-09-09

Family

ID=40792192

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201080019355.5A Active CN102449727B (zh) 2009-05-01 2010-04-30 具有微分离子迁移率谱仪和质谱仪的离子分析装置及使用方法
CN201510495958.7A Active CN105181781B (zh) 2009-05-01 2010-04-30 具有微分离子迁移率谱仪和质谱仪的离子分析装置及使用方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201510495958.7A Active CN105181781B (zh) 2009-05-01 2010-04-30 具有微分离子迁移率谱仪和质谱仪的离子分析装置及使用方法

Country Status (6)

Country Link
US (1) US8610054B2 (https=)
EP (1) EP2425446B1 (https=)
JP (1) JP5652473B2 (https=)
CN (2) CN102449727B (https=)
GB (1) GB0907619D0 (https=)
WO (1) WO2010125357A2 (https=)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5237734B2 (ja) * 2008-09-24 2013-07-17 日本電子株式会社 収差補正装置および該収差補正装置を備える荷電粒子線装置
GB201205009D0 (en) * 2012-03-22 2012-05-09 Micromass Ltd Multi-dimensional survey scans for improved data dependent acquisitions (DDA)
WO2013171569A1 (en) * 2012-05-18 2013-11-21 Dh Technologies Development Pte. Ltd. Reducing interferences in isobaric tag-based quantification
GB2502155B (en) 2012-05-18 2020-05-27 Fasmatech Science And Tech Sa Apparatus and method for controlling ions
GB2508574B (en) * 2012-06-24 2014-12-17 Fasmatech Science And Technology Sa Improvements in and relating to the control of ions
EP2965075B2 (en) * 2013-03-06 2022-09-21 Micromass UK Limited Optimised ion mobility separation timescales for targeted ions
GB2512640A (en) * 2013-04-04 2014-10-08 Fasmatech Science And Technology Sa Improvements in and relating to the production and control of ions
GB201309282D0 (en) * 2013-05-23 2013-07-10 Shimadzu Corp Circuit for generating a voltage waveform
US9564302B2 (en) * 2013-06-21 2017-02-07 Dh Technologies Development Pte. Ltd. Contamination filter for mass spectrometer
RU2673792C2 (ru) 2013-06-27 2018-11-30 Имплант Сайенсиз Корпорэйшн Двухполярный искровой источник ионов
CN104282525A (zh) * 2013-07-01 2015-01-14 中国科学院大连化学物理研究所 一种大气压下的离子聚焦传输透镜
US20160187296A1 (en) 2013-08-14 2016-06-30 Dh Technologies Development Pte. Ltd. Ion Mobility Method and Apparatus
JP6202103B2 (ja) * 2013-12-17 2017-09-27 株式会社島津製作所 質量分析装置及び質量分析方法
CN103745906B (zh) * 2013-12-23 2016-04-27 聚光科技(杭州)股份有限公司 一种离子测量装置
EP3092484A4 (en) * 2013-12-31 2017-08-23 DH Technologies Development PTE. Ltd. Vacuum dms with high efficiency ion guides
JP6549130B2 (ja) * 2013-12-31 2019-07-24 ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド 微分移動度分光計のための噴射注入器入口
JP6090201B2 (ja) * 2014-02-19 2017-03-08 株式会社島津製作所 マススペクトルデータ処理装置及びマススペクトルデータ処理方法
GB2525194B (en) * 2014-04-14 2017-03-29 Thermo Fisher Scient (Bremen) Gmbh Method of assessing vacuum conditions in a mass spectrometer
CN104051220B (zh) * 2014-06-03 2017-01-18 清华大学深圳研究生院 一种离子分离装置
US9941106B2 (en) * 2014-06-11 2018-04-10 Micromass Uk Limited Quadrupole robustness
GB201410369D0 (en) * 2014-06-11 2014-07-23 Micromass Ltd Monitoring IMS environment for improved CCS accuracy and precision
EP3155414B8 (en) * 2014-06-11 2021-12-01 Micromass UK Limited Monitoring ion mobility spectrometry environment for improved collision cross section accuracy and precision
CN104237058A (zh) * 2014-09-23 2014-12-24 中国科学技术大学 一种热重分子束质谱联用装置
GB2531292B (en) * 2014-10-14 2019-06-12 Smiths Detection Watford Ltd Method and apparatus
EP3270148B1 (en) * 2015-03-09 2019-11-20 Shimadzu Corporation Parallel plate-type non-uniform electric field ion mobility spectrometry device
CN106340437B (zh) 2015-07-09 2019-03-22 株式会社岛津制作所 质谱仪及其应用的减少离子损失和后级真空负载的方法
EP3338298B1 (en) 2015-08-21 2025-07-09 Pharmacadence Analytical Services, LLC Novel methods of evaluating performance of an atmospheric pressure ionization system
JP2017090393A (ja) * 2015-11-17 2017-05-25 株式会社島津製作所 イオン移動度分離装置
US10770279B2 (en) * 2015-11-27 2020-09-08 Shimadzu Corporation Ion transfer apparatus
EP4300540A3 (en) * 2016-04-02 2024-03-27 DH Technologies Development Pte. Ltd. System and method for filtering high mobility ions
CN107271575B (zh) * 2016-04-08 2020-01-14 株式会社岛津制作所 离子迁移谱和质谱并行分析的方法及装置
CN109075014A (zh) * 2016-04-19 2018-12-21 英国质谱公司 传输管校准
US10458944B2 (en) * 2016-06-03 2019-10-29 Bruker Daltonik Gmbh Trapped ion mobility spectrometer with high ion storage capacity
WO2018069982A1 (ja) * 2016-10-11 2018-04-19 株式会社島津製作所 イオンガイド及び質量分析装置
CN108091544B (zh) * 2016-11-21 2019-09-06 中国科学院大连化学物理研究所 一种基于微分迁移谱离子筛选的质谱化学电离源
CN109390206A (zh) * 2017-08-04 2019-02-26 中国科学技术大学 小型化便携式质谱仪及用于产生水团簇离子的离子源装置
CN111758146A (zh) * 2018-01-17 2020-10-09 Dh科技发展私人贸易有限公司 用于提高msms置信度的dm-swath获取
CN108404592B (zh) * 2018-05-10 2021-03-19 苏州大学附属第二医院 一种可有效提高集气效果的手术室用麻醉废气净化装置
JP2020020746A (ja) * 2018-08-03 2020-02-06 株式会社リコー 検出装置
EP3889997A4 (en) * 2018-11-29 2022-04-20 Shimadzu Corporation Mass spectrometer
GB2591069A (en) * 2019-08-30 2021-07-21 Shimadzu Corp Device for performing field asymmetric waveform ion mobility spectrometry
GB2586786A (en) * 2019-08-30 2021-03-10 Shimadzu Corp Device for performing field asymmetric waveform ion mobility spectrometry
GB2586787A (en) 2019-08-30 2021-03-10 Shimadzu Corp Device for performing field asymmetric waveform ion mobility spectrometry
US11293898B2 (en) 2020-02-06 2022-04-05 Thermo Finnigan Llc Duty cycle improvement for a mass spectrometer using ion mobility separation
CN113871284B (zh) * 2020-06-30 2025-04-25 株式会社岛津制作所 质谱仪
US11092569B1 (en) * 2020-07-05 2021-08-17 Cannabix Technologies Inc. Apparatus and methods for detection of molecules
US11273465B1 (en) * 2020-09-17 2022-03-15 Desaraju Subrahmanyam Tunable electrostatic ion and fluid flow generator and electroacoustic transducer
CN112595562B (zh) * 2020-12-11 2022-12-06 中国科学院工程热物理研究所 可灵活布置的质谱同温原位采样接口和质谱同温原位采样方法
GB202102365D0 (en) * 2021-02-19 2021-04-07 Thermo Electron Mfg Limited High pressure ion optical devices
CN115705992A (zh) * 2021-08-11 2023-02-17 株式会社岛津制作所 离子迁移谱-质谱联用分析装置
CN117012610A (zh) * 2022-04-28 2023-11-07 株式会社岛津制作所 质谱仪及其真空系统的形成方法
WO2024061468A1 (en) * 2022-09-23 2024-03-28 Shimadzu Corporation Differential ion mobility analysis
WO2024061469A1 (en) 2022-09-23 2024-03-28 Shimadzu Corporation Differential ion mobility spectrometry
CN116110772B (zh) * 2023-01-29 2024-11-15 山东省分析测试中心 一种差分离子迁移谱-质谱联用离子传输系统及设备
EP4621402A1 (en) 2024-03-19 2025-09-24 Bruker Switzerland AG Differential mobility spectrometer

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2432255A (en) * 2005-11-10 2007-05-16 Micromass Ltd A mass spectrometer comprising an ion mobility separator
CN101067616A (zh) * 2007-06-06 2007-11-07 中国科学院合肥物质科学研究院 纵向高场不对称波形离子迁移谱装置
CN101416271A (zh) * 2006-05-22 2009-04-22 株式会社岛津制作所 平行板电极布置设备和方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000063949A1 (en) 1999-04-16 2000-10-26 Mds Inc. Mass spectrometer, including coupling of an atmospheric pressure ion source to a low pressure mass analyzer
EP1273029B8 (en) 2000-03-14 2006-01-11 National Research Council Canada Faims apparatus and method with laser-based ionization source
GB0031342D0 (en) 2000-12-21 2001-02-07 Shimadzu Res Lab Europe Ltd Method and apparatus for ejecting ions from a quadrupole ion trap
CA2391060C (en) 2001-06-21 2011-08-09 Micromass Limited Mass spectrometer
US7091481B2 (en) * 2001-08-08 2006-08-15 Sionex Corporation Method and apparatus for plasma generation
JP2006521006A (ja) * 2003-03-03 2006-09-14 ブリガム・ヤング・ユニバーシティ 直交加速飛行時間型質量分析のための新規な電子イオン化源
ATE512458T1 (de) * 2004-12-07 2011-06-15 Micromass Ltd Massenspektrometer
US7351960B2 (en) 2005-05-16 2008-04-01 Thermo Finnigan Llc Enhanced ion desolvation for an ion mobility spectrometry device
EP1963835A1 (en) * 2005-11-07 2008-09-03 Sionex Corporation Method and apparatus for ion mobility based sample analysis
US7528365B2 (en) * 2006-02-07 2009-05-05 Applera Corporation Chemical noise reduction for mass spectrometry
US20090283674A1 (en) 2006-11-07 2009-11-19 Reinhold Pesch Efficient Atmospheric Pressure Interface for Mass Spectrometers and Method
GB0622780D0 (en) 2006-11-15 2006-12-27 Micromass Ltd Mass spectrometer
US7550717B1 (en) 2006-11-30 2009-06-23 Thermo Finnigan Llc Quadrupole FAIMS apparatus
GB0703578D0 (en) 2007-02-23 2007-04-04 Micromass Ltd Mass spectrometer

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2432255A (en) * 2005-11-10 2007-05-16 Micromass Ltd A mass spectrometer comprising an ion mobility separator
CN101416271A (zh) * 2006-05-22 2009-04-22 株式会社岛津制作所 平行板电极布置设备和方法
CN101067616A (zh) * 2007-06-06 2007-11-07 中国科学院合肥物质科学研究院 纵向高场不对称波形离子迁移谱装置

Also Published As

Publication number Publication date
EP2425446B1 (en) 2015-07-01
EP2425446A2 (en) 2012-03-07
JP2012525672A (ja) 2012-10-22
US20120056085A1 (en) 2012-03-08
CN105181781B (zh) 2018-08-21
CN105181781A (zh) 2015-12-23
WO2010125357A3 (en) 2011-01-06
CN102449727A (zh) 2012-05-09
GB0907619D0 (en) 2009-06-10
US8610054B2 (en) 2013-12-17
JP5652473B2 (ja) 2015-01-14
WO2010125357A2 (en) 2010-11-04

Similar Documents

Publication Publication Date Title
CN102449727B (zh) 具有微分离子迁移率谱仪和质谱仪的离子分析装置及使用方法
AU2002257177B2 (en) Methods and apparatus for electrospray-augmented high field asymmetric ion mobility spectrometry
EP1102986B1 (en) Apparatus and method for atmospheric pressure 3-dimensional ion trapping
US9618488B2 (en) Interfacing capillary electrophoresis to a mass spectrometer via an impactor spray ionization source
US8941058B2 (en) Utilizing gas flows in mass spectrometers
JP5497615B2 (ja) 質量分析装置
US8822915B2 (en) Atmospheric pressure ionization mass spectrometer
CN102971826B (zh) 大气压电离质谱仪
CA2770819A1 (en) Coupling ion differential mobility based ambient pressure ion pre-filtering and ion focusing for a portable mass spectrometer
CN102265377B (zh) 耦合至堆积环离子导向器的电动或静电透镜
US8890058B2 (en) Mass spectrometer
US20200381241A1 (en) Hybrid mass spectrometric system
JP2014514574A (ja) Faimsセルを組み込んだイオン移動度分光分析装置
US20090026366A1 (en) Mass spectrometer
JP5759036B2 (ja) 質量分析装置
JP2001101992A (ja) 大気圧イオン化質量分析装置
US8207495B2 (en) Quadrupole mass spectrometer
EP1391912A2 (en) Apparatus and method for atmospheric pressure 3-dimensional ion trapping
HK40114920A (zh) 差分捕获离子迁移率过滤器
HK40114921A (zh) 差分捕集离子淌度分离器
Wang Development and Implementation of High Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS) on FTICR MS for Analysis of Biomolecules

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant