CN102440775A - Biological tissue dielectric property measuring electrode - Google Patents
Biological tissue dielectric property measuring electrode Download PDFInfo
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- CN102440775A CN102440775A CN2011102866950A CN201110286695A CN102440775A CN 102440775 A CN102440775 A CN 102440775A CN 2011102866950 A CN2011102866950 A CN 2011102866950A CN 201110286695 A CN201110286695 A CN 201110286695A CN 102440775 A CN102440775 A CN 102440775A
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Abstract
A biological tissue dielectric property measuring electrode consists of four coaxial metal electrode layers and insulating layers arranged among the metal electrode layers. The front end of the measuring electrode is conical. The four metal electrode layers form four electrodes, electrical impedance of measured biological tissues is measured by a four-electrode method, the metal electrode layer on the innermost side and the metal electrode layer on the outermost side are used as stimulating electrodes, and the metal electrode layers between the metal electrode layer on the innermost side and the metal electrode layer on the outermost side are used as measuring electrodes. After the electrical impedance is measured, cell constants of the biological tissue dielectric property measuring electrode can be used for calculating dielectric property of the measured biological tissues.
Description
Technical field
The invention belongs to the electrical measurement field, be specifically related to a kind of measurement electrode that is used to measure biological tissue's dielectric property.
Background technology
At present; When measuring biological tissue's dielectric property; Need at first measure the electrical impedance of tested biological tissue under different frequency; Re-use the electrode constant of measurement electrode, calculate the electrical conductivity of tested biological tissue under different frequency and relative dielectric coefficient, thereby obtain the dielectric property of biological tissue.When carrying out biological tissue's impedance bioelectrical measurement, owing to there is bigger contact impedance between the electrode skin,, generally use four electrode method to measure in order to reduce the influence of this contact impedance, pair of electrodes is used to apply excitation, and another counter electrode is measured.
At present; General rectangle or the columniform measuring box of adopting is cut into cuboid or cylinder with tested biological tissue earlier, and the tested biological tissue after will cutting out again puts into corresponding measuring box; On the cross section at measuring box two ends, apply excitation then; In tissue, set up the electric field of a rule, re-use the pair of electrodes of placing in the middle of the measuring box and carry out voltage measurement, thereby calculate the electrical impedance characteristics of tested biological tissue; Based on the electrode constant (obtaining) of impedance bioelectrical measurement result and measuring box, calculate the electrical conductivity and relative dielectric coefficient of tested biological tissue again by the sectional area of measuring box and the distance calculation between the measurement electrode.
Owing to need before measuring, tested biological tissue be cut into cuboid or cylinder; Operating process is comparatively complicated; Just there is the problem of following several respects in this: at first, biological tissue is generally softer, and is not easy to be cut into the cuboid or the cylinder of rule; Cuboid after can not guaranteeing to prune or cylinder are at the sectional area strict conformance at diverse location place; Influenced by this, the electric field of in tested biological tissue, setting up in the measuring process just can not guarantee strict uniformity, thereby introduces error; Secondly, the biological tissue's volume that can be used in measurement sometimes is big inadequately, can't be cut into the shape that needs; At last; This metering system is cut out after need biological tissue being exsomatized again; It is longer to operate the needed time; Make tissue lose biological activity, and the dielectric property that loses bioactive biological tissue have than big difference, can't accurately obtain the dielectric property in body biological tissue with this metering system with dielectric property in body biological tissue.
So the measuring device of current biological tissue's dielectric property is convenient, not accurate enough inadequately, need a kind of measuring device that can carry out the dielectric property measurement accurately, easily.
Summary of the invention
The object of the present invention is to provide a kind of when measuring biological tissue's dielectric property; Need not prune tested biological tissue; But directly measurement electrode is inserted tested biological tissue, directly measure biological tissue's dielectric property measurement electrode of the electrical impedance of tested biological tissue.
For achieving the above object, the technical scheme that the present invention adopts is: this measurement electrode is made up of co-axial four layers of metal electrode layer and the insulating barrier that is arranged between each metal electrode layer, and the front end of this measurement electrode is coniform.
The inboard of described four layers of metal electrode layer is a solid metal cylinder, in this solid metal cylinder outside coaxial package successively three diameters metallic cylinder is from small to large arranged, and between solid metal cylinder and each metallic cylinder, is provided with dielectric isolation layer.
The diameter of described solid metal cylinder is 200um, and the internal diameter of first metallic cylinder is that 400um, external diameter are 600um, and the internal diameter of second metallic cylinder is that 900um, external diameter are 1200um, and the internal diameter of the 3rd metallic cylinder is that 1500um, external diameter are 1800um.
The cone shape cone angle of described measurement electrode front end is 30 degree.
Described solid metal cylinder is the positive energize electrode, and outermost the 3rd metallic cylinder is the negative energize electrode, and intermediary first metallic cylinder is positive measurement electrode, and second metallic cylinder is negative measurement electrode.
Described metal electrode layer adopts rustless steel to process.
Compared with prior art; The invention has the advantages that: can directly measurement electrode be inserted in the tested biological tissue during use; Need not prune biological tissue, can not be owing to the inhomogeneous error of introducing of pruning; Particularly it can directly measure the dielectric property in body biological tissue, thereby not only can the simplified measurement step, and can provide more accurately, real biological tissue dielectric property measurement result.
Description of drawings
Fig. 1 is the 3-D view of measurement electrode of the present invention.
Fig. 2 is the profile of measurement electrode of the present invention.
Fig. 3 is the vertical view of measurement electrode of the present invention.
The specific embodiment
Below in conjunction with accompanying drawing the present invention is done further explain.
Referring to Fig. 1,2,3, the present invention includes the insulating barrier between co-axial four layers of metal electrode layer and the metal electrode layer; In described four layers of metal electrode layer, the most inboard metal electrode layer is a solid metal cylinder 1, and its outside is the metallic cylinder 2,3,4 that three layers of diameter increase successively; Described four layers of metal electrode layer are according to the size of diameter, coaxial successively being nested together; It is separated between four layers of metal electrode layer, to be provided with dielectric isolation layer 5,6,7 districts; The front end of measurement electrode is designed to coniform, helps measurement electrode on the one hand and inserts biological tissue, can increase the contact impedance of electrode and biological tissue on the other hand.
Metal electrode layer of the present invention adopts rustless steel to process, and is convenient to processing on the one hand, can make electrode keep enough intensity to be beneficial to insert biological tissue on the other hand.
The diameter of described measurement electrode can not be too big, if diameter is too big, can makes the structure of biological tissue that bigger change takes place when then inserting biological tissue, thereby influence measurement result; The diameter of measurement electrode can not be too little, if diameter is too little, is unfavorable on the one hand processing, makes also that on the other hand the contact impedance between electrode tissue increases, thereby be unfavorable for the enforcement of measuring.Through simulation analysis and practice examining; Select the diameter of each metal level of measurement electrode to be: the diameter of the most inboard solid metal cylinder 1 is 200um; The internal diameter of first metallic cylinder 2 is that 400um, external diameter are 600um; The internal diameter of second metallic cylinder 3 is that 900um, external diameter are 1200um, and the internal diameter of outermost layer the 3rd metallic cylinder 4 is that 1500um, external diameter are 1800um.
When carrying out the dielectric property measurement; Can be with the most inboard solid metal cylinder 1 and outermost the 3rd metallic cylinder 4 as exciting electrode; Apply excitation through this two courses biological tissue; With middle two metal layers be first, second metallic cylinder 2,3 as measurement electrode, measure the response voltage signal of biological tissue.
Good with contacting of each metal level to guarantee biological tissue with the contact area of biological tissue in order to increase each metal level of measurement electrode, simultaneously also for the ease of measurement electrode is inserted biological tissue, the front end of described measurement electrode is designed to coniform.The cone angle of this circular cone can not be too big, otherwise can not guarantee that contact surface between electrode and the biological tissue is enough big, can not guarantee contact well, nor be convenient to insert biological tissue; The cone angle of this circular cone can not be too little, if coning angle is too big, then when tested biological tissue is thin, vertebral body will penetrate tested biological tissue and can't implement to measure.Through preferred, think that the cone angle of circular cone of measurement electrode front end is that 30 degree are comparatively suitable.
More than explanation just is used to help to understand the structure and the core concept thereof of measurement electrode of the present invention; And should not be construed as limitation of the present invention; Any structure based on measurement electrode of the present invention; Any change part of on the size of measurement electrode and implementation method, being carried out is all in protection scope of the present invention.
Claims (6)
1. biological tissue's dielectric property measurement electrode is characterized in that: this measurement electrode is made up of co-axial four layers of metal electrode layer and the insulating barrier that is arranged between each metal electrode layer, and the front end of this measurement electrode is coniform.
2. biological tissue according to claim 1 dielectric property measurement electrode; It is characterized in that: the inboard of described four layers of metal electrode layer is a solid metal cylinder (1); In this solid metal cylinder outside coaxial package successively three diameters metallic cylinder (2,3,4) is from small to large arranged, between solid metal cylinder (1) and each metallic cylinder (2,3,4), be provided with dielectric isolation layer (5,6,7).
3. biological tissue according to claim 1 dielectric property measurement electrode; It is characterized in that: the diameter of described solid metal cylinder (1) is 200um; The internal diameter of first metallic cylinder (2) is that 400um, external diameter are 600um; The internal diameter of second metallic cylinder (3) is that 900um, external diameter are 1200um, and the internal diameter of the 3rd metallic cylinder (4) is that 1500um, external diameter are 1800um.
4. biological tissue according to claim 1 dielectric property measurement electrode is characterized in that: the cone shape cone angle of described measurement electrode front end is 30 degree.
5. biological tissue according to claim 1 dielectric property measurement electrode; It is characterized in that: described solid metal cylinder (1) is the positive energize electrode; Outermost the 3rd metallic cylinder (4) is the negative energize electrode; Intermediary first metallic cylinder (2) is positive measurement electrode, and second metallic cylinder (3) is negative measurement electrode.
6. biological tissue according to claim 1 dielectric property measurement electrode is characterized in that: described metal electrode layer adopts rustless steel to process.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011102866950A CN102440775A (en) | 2011-09-23 | 2011-09-23 | Biological tissue dielectric property measuring electrode |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011102866950A CN102440775A (en) | 2011-09-23 | 2011-09-23 | Biological tissue dielectric property measuring electrode |
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| CN102440775A true CN102440775A (en) | 2012-05-09 |
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| CN2011102866950A Pending CN102440775A (en) | 2011-09-23 | 2011-09-23 | Biological tissue dielectric property measuring electrode |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103989475A (en) * | 2014-05-09 | 2014-08-20 | 思澜科技（成都）有限公司 | Electrode fixing device for electrical impedance tomography |
| CN105769191A (en) * | 2014-12-25 | 2016-07-20 | 中国科学院深圳先进技术研究院 | Human body health detection device and method |
| CN107635503A (en) * | 2015-05-12 | 2018-01-26 | 纳维斯国际有限公司 | Analyzed by dielectric property and carry out damage assessment |
| CN107374628B (en) * | 2017-07-13 | 2020-05-29 | 中国医学科学院生物医学工程研究所 | Minimally invasive biological tissue conductivity/dielectric constant measuring electrode and measuring method |
| US11622713B2 (en) | 2016-11-16 | 2023-04-11 | Navix International Limited | Estimators for ablation effectiveness |
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| US4227151A (en) * | 1977-08-27 | 1980-10-07 | Malcom-Ellis (Liverpool) Limited | Measurement and monitoring of the electrical conductivity of liquor samples |
| JPH01227907A (en) * | 1988-03-09 | 1989-09-12 | Japan Radio Co Ltd | Thin film resistance value detector |
| JPH09138249A (en) * | 1995-10-26 | 1997-05-27 | Schlumberger Overseas Sa | Method and device for measuring resistivity of mud in well hole |
| JP2000266711A (en) * | 1999-03-19 | 2000-09-29 | Ryusho Sangyo Kk | Conductivity sensor |
| US20110125050A1 (en) * | 2004-09-21 | 2011-05-26 | The Trustees Of The University Of Pennsylvania | Multiple-Electrode and Metal-Coated Probes |
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2011
- 2011-09-23 CN CN2011102866950A patent/CN102440775A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4227151A (en) * | 1977-08-27 | 1980-10-07 | Malcom-Ellis (Liverpool) Limited | Measurement and monitoring of the electrical conductivity of liquor samples |
| JPH01227907A (en) * | 1988-03-09 | 1989-09-12 | Japan Radio Co Ltd | Thin film resistance value detector |
| JPH09138249A (en) * | 1995-10-26 | 1997-05-27 | Schlumberger Overseas Sa | Method and device for measuring resistivity of mud in well hole |
| JP2000266711A (en) * | 1999-03-19 | 2000-09-29 | Ryusho Sangyo Kk | Conductivity sensor |
| US20110125050A1 (en) * | 2004-09-21 | 2011-05-26 | The Trustees Of The University Of Pennsylvania | Multiple-Electrode and Metal-Coated Probes |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103989475A (en) * | 2014-05-09 | 2014-08-20 | 思澜科技（成都）有限公司 | Electrode fixing device for electrical impedance tomography |
| CN103989475B (en) * | 2014-05-09 | 2019-01-22 | 思澜科技（成都）有限公司 | Electrode fixing device for electrical impedance tomography |
| CN105769191A (en) * | 2014-12-25 | 2016-07-20 | 中国科学院深圳先进技术研究院 | Human body health detection device and method |
| CN105769191B (en) * | 2014-12-25 | 2018-11-06 | 中国科学院深圳先进技术研究院 | A kind of health detection device and method |
| CN107635503A (en) * | 2015-05-12 | 2018-01-26 | 纳维斯国际有限公司 | Analyzed by dielectric property and carry out damage assessment |
| US11622713B2 (en) | 2016-11-16 | 2023-04-11 | Navix International Limited | Estimators for ablation effectiveness |
| US11744515B2 (en) | 2016-11-16 | 2023-09-05 | Navix International Limited | Estimation of effectiveness of ablation adjacency |
| CN107374628B (en) * | 2017-07-13 | 2020-05-29 | 中国医学科学院生物医学工程研究所 | Minimally invasive biological tissue conductivity/dielectric constant measuring electrode and measuring method |
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Application publication date: 20120509 |