CN102416134A - Medicine for treating children's hypophrenia and preparation method thereof - Google Patents

Abstract

The invention discloses a medicine for treating children's mental retardation, which is characterized by being prepared from the following raw material medicines in parts by weight: 20-50 parts of mulberry, 20-25 parts of arillus longan, 10-18 parts of wolfberry, 20-30 parts of polygala tenuifolia, 2-5 parts of ginseng, 6-15 parts of almond, 20-25 parts of Chinese yam, 50-80 parts of Chinese gooseberry, 5-8 parts of kudzu root, 10-15 parts of concha arcae, 5-15 parts of dried orange peel, 10-20 parts of codonopsis pilosula, 20-25 parts of deerhorn glue, 5-8 parts of donkey-hide gelatin, 20-30 parts of fructus alpiniae oxyphyllae and 5-10 parts of semen cuscutae. The preparation method of the medicine for treating children's mental retardation comprises the following steps: drying ginseng, pulverizing into fine powder, soaking mulberry, arillus longan, wolfberry fruit, polygala tenuifolia, almond, Chinese yam, Chinese gooseberry, radix puerariae, concha arcae, dried orange peel, codonopsis pilosula, fructus alpiniae oxyphyllae and semen cuscutae in water for 1-2 hours, decocting twice, adding 5 times of water for each time, decocting for 120 minutes, combining decoction, concentrating filtrate to obtain an extract with the relative density of 1.10-1.2 at 80 ℃; grinding colla Cornus Cervi and colla Corii Asini into fine powder, mixing with Ginseng radix and the above extract, stirring, drying, and making into granule. The raw materials are mixed and coordinated and matched with each other, so that the traditional Chinese medicine composition has the effects of tonifying liver and kidney, enriching blood and nourishing heart, strengthening brain and soothing nerves, promoting blood circulation and dredging orifices and the like, and also has the advantages of obvious curative effect and few side effects.

Description

A kind of medicine and method for preparing of treating mental retardation of children

Technical field

The present invention relates to a kind of medicine and method for preparing of treating mental retardation of children, belong to pharmaceutical sanitary field.

Background technology

Mental retardation of children is the able-bodied commonly encountered diseases of a kind of serious harm child, and the state of an illness is complicated and be difficult to cure.This disease has brought great misery not only for the child, and has caused burden to family and society.The traditional Chinese medical science thinks that " mental retardation " belongs to dull-witted category, and the cause of disease mainly comprises: natural endowment is not enough; Kidney storing essence comprises congenital essence and acquired essence.The heart controlling mental and emotional activities, liver chief instigator slightly, kidney master intelligence and store essential substances, the smart marrow of giving birth to fills on the marrow in brain, people's growth promoter comprises that brain grows the vital essence that all needs kidney and hidden.

Summary of the invention

One of the object of the invention has provided the medicine of the little treatment mental retardation of children of a kind of side effect.

Another purpose of the present invention has provided a kind of process for preparing medicine of above-mentioned treatment mental retardation of children.

The technical scheme that the present invention adopts is following:

A kind of medicine of treating mental retardation of children is characterized in that being processed by following bulk drugs:

Fructus Mori 20-50, Arillus Longan 20-25, Fructus Lycii 10-18, Radix Polygalae 20-30, Radix Ginseng 2-5, Semen Armeniacae Amarum 6-15; Rhizoma Dioscoreae 20-25, Isodon ternifolius 50-80, Radix Puerariae 5-8, Concha Arcae 10-15, Pericarpium Citri Reticulatae 5-15; Radix Codonopsis 10-20, Colla cornus cervi 20-25, Colla Corii Asini 5-8, Fructus Alpiniae Oxyphyllae 20-30, Semen Cuscutae 5-10.

A kind of method for preparing of said treatment mental retardation of children medicine may further comprise the steps:

A, take by weighing raw material according to proportioning;

B, with Radix Ginseng oven dry, powder becomes fine powder, and is subsequent use;

C, Fructus Mori, Arillus Longan, Fructus Lycii, Radix Polygalae, Semen Armeniacae Amarum, Rhizoma Dioscoreae, Isodon ternifolius, Radix Puerariae, Concha Arcae, Pericarpium Citri Reticulatae, Radix Codonopsis, Fructus Alpiniae Oxyphyllae, Semen Cuscutae add water retting 1-2 hour; Decoct twice; Add 5 times of water yields at every turn; Decocted 120 minutes, and merged decoction liquor, the extractum that it is 1.10-1.2 that filtrating is concentrated into 80 ℃ of following relative densities;

D, Colla cornus cervi and Colla Corii Asini are ground into fine powder, then add above-mentioned extractum simultaneously with Radix Ginseng again and mix, and stir, and drying is processed granule.

Pharmacology analysis:

Fructus Mori: have the YIN nourishing of enriching blood, promoting the production of body fluid to quench thirst, effect such as intestine moistening is dry, cure mainly deficiency of YIN-blood and cause have a dizzy spell tinnitus cardiopalmus, irritated insomnia, soreness of the waist and knees, early whitening of beard and hair, the xerostomia of quenching one's thirst, diseases such as constipation with dry stool.

Arillus Longan: have the reinforcing the heart spleen, replenishing QI and blood, the effect of tranquilizing mind cures mainly spleen deficiency, the palpitation with fear due to the insufficiency of vital energy and blood, palpitation with a distress feeling, insomnia, forgetful, blood deficiency and yellow complexion has through diseases such as uncomfortable, metrorrhagias.

Fructus Lycii: have the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, blood-enriching tranquillizing, promoting the production of body fluid to quench thirst, the effect of nourishing the lung to arrest cough cures mainly hepatic and renal YIN deficiency, soreness of the waist and knees, dizziness, dizzy, the many tears of blurred vision, cough due to consumptive disease is quenched one's thirst, diseases such as seminal emission.

Radix Polygalae: have the Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, the repercussive effect cures mainly the insomnia and dreamful sleep that disarmony between the heart and kidney causes, forgetful palpitation with fear, and staring spells, expectoration is not well, sore swollen toxin, breast swell and pain.

Radix Ginseng: strongly invigorating primordial QI, promote the production of body fluid admittedly take off, calm the nerves.

Semen Armeniacae Amarum: contain abundant flavonoid and Polyphenols composition, this composition not only can reduce the content of cholesterol in human body, can also significantly reduce the initiation potential of heart disease and a lot of chronic diseases.

Rhizoma Dioscoreae: ability tonifying the spleen and stomach, lung benefiting kidney, contain compositions such as choline, triterpenoid saponin, allantoin, starch, aminoacid, cure mainly weakness of the spleen and stomach, diet reduces, loose stool diarrhoea, women's lukorrhagia due to hypofunction of the spleen, chronic cough of deficiency lung dry pharynx, emission due to deficiency of the kidney, frequent micturition, the polydipsia of quenching one's thirst.

Isodon ternifolius: invigorating the spleen to clear away damp pathogen, invigorating the lung and the kidney, " Huainan book on Chinese herbal medicine " record " is controlled deficient qi and blood, trauma, seminal emission stranguria of cold type.Regulating menstruation is reposed, and clothes add smart marrow, the seed of prolonging life mended for a long time.”

Semen Cuscutae: acrid in the mouth, sweet, slightly warm in nature; Return the liver,kidney,spleen warp; Gas and property are slow, can float and can sink, and have the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity.

Radix Puerariae: contain rich in amino acid and the trace element that enriches such as ferrum, selenium, zinc, calcium etc., can promote child's physique, the growth of intelligence.

Concha Arcae: go into late at night, lung, spleen channel.Reduce phlegm softening the hard mass, dissipating blood stasis, removing food stagnancy." modern practical Chinese medicine ": be used for rickets of child, pulmonary tuberculosis, diseases such as lymphoid tuberculosis.

Radix Codonopsis: cure mainly weakness of the spleen and stomach, deficiency of both QI and blood, fatigue and lack of strength, lack of appetite, thirsty, chronic diarrhea, proctoptosis.

Colla cornus cervi: control deficiency of kidney-QI, asthenia weakness and emaciation, lumbago, carbuncle of yin nature, impotence in male, spermatorrhea, women's deficiency-cold of uterus, metrorrhagia, leukorrhagia.

Colla Corii Asini, " detailed outline " record: Colla Corii Asini, main point are just enriched blood and liquid, so can the lung heat clearing tonifying YIN and control all card.

Fructus Alpiniae Oxyphyllae: ancient Chinese medicine doctor and herbal treatise are all said Fructus Alpiniae Oxyphyllae ability kidney invigorating and YANG supporting, the controlling nocturnal emission with astringent drugs reducing urination, and the warming the spleen stopping leak, happy color is prolonged life, improving memory.

The present invention has the following advantages and effect:

The present invention mixes the above-mentioned raw materials medicine, coordinates each other, cooperates between each medicine, has liver and kidney tonifying, replenishing blood for nourishing heart, invigorating brain and relieving mental uneasiness, an effect such as sensible of invigorating blood circulation, advantage evident in efficacy, few side effects that product of the present invention also has.

The specific embodiment

Below in conjunction with specific embodiment the present invention is explained further details, following explanation only is exemplary, does not limit protection scope of the present invention.

Embodiment 1

1, prescription: Fructus Mori 20, Arillus Longan 25, Fructus Lycii 10, Radix Polygalae 30, Radix Ginseng 5, Semen Armeniacae Amarum 15, Rhizoma Dioscoreae 20, Isodon ternifolius 80, Radix Puerariae 5, Concha Arcae 10, Pericarpium Citri Reticulatae 5, Radix Codonopsis 10, Colla cornus cervi 20, Colla Corii Asini 5, Fructus Alpiniae Oxyphyllae 30, Semen Cuscutae 10.

2, preparation:

A, take by weighing raw material according to proportioning;

B, with Radix Ginseng oven dry, powder becomes fine powder, and is subsequent use;

C, Fructus Mori, Arillus Longan, Fructus Lycii, Radix Polygalae, Semen Armeniacae Amarum, Rhizoma Dioscoreae, Isodon ternifolius, Radix Puerariae, Concha Arcae, Pericarpium Citri Reticulatae, Radix Codonopsis, Fructus Alpiniae Oxyphyllae, Semen Cuscutae add water retting 1-2 hour; Decoct twice; Add 5 times of water yields at every turn; Decocted 120 minutes, and merged decoction liquor, the extractum that it is 1.10-1.2 that filtrating is concentrated into 80 ℃ of following relative densities;

D, Colla cornus cervi and Colla Corii Asini are ground into fine powder, then add above-mentioned extractum simultaneously with Radix Ginseng again and mix, and stir, and drying is processed granule, packing, every bag of 10g dress.

Usage and consumption: oral, three times on the one, a 20-40g.

Embodiment 2

Prescription: a kind of medicine of treating mental retardation of children is characterized in that being processed by following bulk drugs: Fructus Mori 50g, Arillus Longan 20 g, Fructus Lycii 18 g, Radix Polygalae 20 g; Radix Ginseng 2 g, Semen Armeniacae Amarum 6 g, Rhizoma Dioscoreae 25 g, Isodon ternifolius 50 g; Radix Puerariae 8 g, Concha Arcae 15 g, Pericarpium Citri Reticulatae 15 g, Radix Codonopsis 20 g; Colla cornus cervi 25 g, Colla Corii Asini 8 g, Fructus Alpiniae Oxyphyllae 20 g, Semen Cuscutae 5 g.

Method for preparing and usage and consumption are with embodiment 1.

Embodiment 3

Prescription: a kind of medicine of treating mental retardation of children is characterized in that being processed by following bulk drugs: Fructus Mori 30g, Arillus Longan 22 g, Fructus Lycii 16 g, Radix Polygalae 26g; Radix Ginseng 4g, Semen Armeniacae Amarum 10g, Rhizoma Dioscoreae 22g, Isodon ternifolius 60 g; Radix Puerariae 7g, Concha Arcae 12 g, Pericarpium Citri Reticulatae 10g, Radix Codonopsis 15 g; Colla cornus cervi 22g, Colla Corii Asini 6g, Fructus Alpiniae Oxyphyllae 25g, Semen Cuscutae 8g.

Method for preparing and usage and consumption are with embodiment 1.

One, clinical trial: through 158 gently routine-severe mental retardation two logical clinical observation on the therapeutic effect (are treated 100 examples; Matched group 58 examples); Proof the present invention has sick child's memory, reading ability, many moving, attention etc. and improves in various degree, has improved the level of intelligence of infant, has improved IQ.As follows with the clinical setting summary at present:

Two, study subject: meet mental retardation of children diagnostic criteria and Chinese medical discrimination standard, age 4-12 year, IQ 65-20 (weight degree mental retardation) infant.

Three, testing program: except that open bank, other two groups are all adopted random packet active drug double blind control method to carry out.

Four, the instructions about how to take medicine and the course of treatment: the treatment group, medicine of the present invention, oral, three times on the one, a 20g, boiled water is taken after mixing it with water.Matched group: eagle Pharmaceutical Technology Co., Ltd far away produces increases the intelligence capsule, oral, a 3-5 grain, 3 times on the one.

Five, curative effect judging standard and result

1, produce effects: IQ improves 5; Effectively: IQ improves 2; Invalid: the IQ no change.

2, result: after taking Drug therapy of the present invention, two groups are tried infant and in the clinical symptoms method improvement are arranged all.Through t check there were significant differences property, through X ²Check, P＜0.05, diversity is remarkable.Two groups of IQ integrations are carried out the t check, and P＜0.01 explains that the intelligence of infant is improved.Through each item integration before and after two groups of v factors, perceptual organization's factor and the memory fact treatment is carried out paired t-test; P all＜0.01; According to the mean of t check difference, can find out that the present invention is superior to the memory fact effect the effect of v factor, perceptual organization's factor.

Through analyzing treatment group obvious effective rate is 49.6%, and total effective rate is 78.4%; The obvious effective rate of matched group is 24.2%, and total effective rate is 67.6%, and through analyzing, two groups of curative effects are variant, explain that curative effect of the present invention is superior to the treatment of control group medicine.Detect through safety indexes, medicine of the present invention is to the not influence of Hb, WBC and the heart, liver, renal function.

Sum up: medicine of the present invention is used for treatment treatment mental retardation of children disease, through clinical to gently-clinical observation of severe infant, obvious effective rate is 49.6%, total effective rate is 78.4%, fine infant IQ level, the non-evident effect of improving.

Claims (2)

1. medicine of treating mental retardation of children is characterized in that being processed by following bulk drugs:

Fructus Mori 20-50, Arillus Longan 20-25, Fructus Lycii 10-18, Radix Polygalae 20-30, Radix Ginseng 2-5, Semen Armeniacae Amarum 6-15; Rhizoma Dioscoreae 20-25, Isodon ternifolius 50-80, Radix Puerariae 5-8, Concha Arcae 10-15, Pericarpium Citri Reticulatae 5-15; Radix Codonopsis 10-20, Colla cornus cervi 20-25, Colla Corii Asini 5-8, Fructus Alpiniae Oxyphyllae 20-30, Semen Cuscutae 5-10.

2. the method for preparing of the said treatment mental retardation of children of claim 1 medicine is characterized in that may further comprise the steps:

A, take by weighing raw material according to proportioning;

B, with Radix Ginseng oven dry, powder becomes fine powder, and is subsequent use;

C, Fructus Mori, Arillus Longan, Fructus Lycii, Radix Polygalae, Semen Armeniacae Amarum, Rhizoma Dioscoreae, Isodon ternifolius, Radix Puerariae, Concha Arcae, Pericarpium Citri Reticulatae, Radix Codonopsis, Fructus Alpiniae Oxyphyllae, Semen Cuscutae add water retting 1-2 hour; Decoct twice; Add 5 times of water yields at every turn; Decocted 120 minutes, and merged decoction liquor, the extractum that it is 1.10-1.2 that filtrating is concentrated into 80 ℃ of following relative densities;

D, Colla cornus cervi and Colla Corii Asini are ground into fine powder, then add above-mentioned extractum simultaneously with Radix Ginseng again and mix, and stir, and drying is processed granule.