CN102415405A - Dinotefuran micron-emulsion and preparation method thereof - Google Patents
Dinotefuran micron-emulsion and preparation method thereof Download PDFInfo
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- CN102415405A CN102415405A CN2011103390655A CN201110339065A CN102415405A CN 102415405 A CN102415405 A CN 102415405A CN 2011103390655 A CN2011103390655 A CN 2011103390655A CN 201110339065 A CN201110339065 A CN 201110339065A CN 102415405 A CN102415405 A CN 102415405A
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- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- YKBZOVFACRVRJN-UHFFFAOYSA-N dinotefuran Chemical compound [O-][N+](=O)\N=C(/NC)NCC1CCOC1 YKBZOVFACRVRJN-UHFFFAOYSA-N 0.000 title abstract description 9
- 239000000839 emulsion Substances 0.000 title abstract description 7
- 238000004945 emulsification Methods 0.000 title 1
- 239000004094 surface-active agent Substances 0.000 claims abstract description 22
- 239000006184 cosolvent Substances 0.000 claims abstract description 17
- 239000002904 solvent Substances 0.000 claims abstract description 15
- 239000003960 organic solvent Substances 0.000 claims abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000004530 micro-emulsion Substances 0.000 claims description 49
- 239000000203 mixture Substances 0.000 claims description 14
- 239000003795 chemical substances by application Substances 0.000 claims description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 9
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 9
- 238000003756 stirring Methods 0.000 claims description 9
- 239000004615 ingredient Substances 0.000 claims description 7
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 6
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 6
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 6
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 claims description 6
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 6
- 230000000740 bleeding effect Effects 0.000 claims description 6
- 239000003381 stabilizer Substances 0.000 claims description 6
- -1 styryl phenol formaldehyde resin Chemical compound 0.000 claims description 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 4
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 4
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 4
- 150000001450 anions Chemical class 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 4
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims description 4
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexyloxide Natural products O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 claims description 3
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical group CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 claims description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 2
- 241001272567 Hominoidea Species 0.000 claims description 2
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- 229930006000 Sucrose Natural products 0.000 claims description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 2
- OOCMUZJPDXYRFD-UHFFFAOYSA-L calcium;2-dodecylbenzenesulfonate Chemical compound [Ca+2].CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O.CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O OOCMUZJPDXYRFD-UHFFFAOYSA-L 0.000 claims description 2
- 239000004202 carbamide Substances 0.000 claims description 2
- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2r)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 claims description 2
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 claims description 2
- 239000008103 glucose Substances 0.000 claims description 2
- 235000011187 glycerol Nutrition 0.000 claims description 2
- 229920001568 phenolic resin Polymers 0.000 claims description 2
- 229920000570 polyether Polymers 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 claims description 2
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 claims description 2
- 229910052938 sodium sulfate Inorganic materials 0.000 claims description 2
- 235000011152 sodium sulphate Nutrition 0.000 claims description 2
- 239000005720 sucrose Substances 0.000 claims description 2
- 125000002243 cyclohexanonyl group Chemical group *C1(*)C(=O)C(*)(*)C(*)(*)C(*)(*)C1(*)* 0.000 claims 1
- 239000000575 pesticide Substances 0.000 abstract description 5
- 230000001276 controlling effect Effects 0.000 abstract 1
- 238000004806 packaging method and process Methods 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 18
- 238000009472 formulation Methods 0.000 description 8
- 239000000126 substance Substances 0.000 description 8
- 239000008187 granular material Substances 0.000 description 7
- 230000003449 preventive effect Effects 0.000 description 7
- 239000003814 drug Substances 0.000 description 6
- 241000238631 Hexapoda Species 0.000 description 5
- 230000000361 pesticidal effect Effects 0.000 description 5
- 210000000481 breast Anatomy 0.000 description 4
- 231100000053 low toxicity Toxicity 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 230000000857 drug effect Effects 0.000 description 3
- 238000009313 farming Methods 0.000 description 3
- 238000000593 microemulsion method Methods 0.000 description 3
- 241000254173 Coleoptera Species 0.000 description 2
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 description 2
- 241000176086 Sogatella furcifera Species 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 description 2
- 241000607479 Yersinia pestis Species 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 238000003912 environmental pollution Methods 0.000 description 2
- 239000002917 insecticide Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 1
- FNRMMDCDHWCQTH-UHFFFAOYSA-N 2-chloropyridine;3-chloropyridine;4-chloropyridine Chemical compound ClC1=CC=NC=C1.ClC1=CC=CN=C1.ClC1=CC=CC=N1 FNRMMDCDHWCQTH-UHFFFAOYSA-N 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 241001124076 Aphididae Species 0.000 description 1
- 241000256844 Apis mellifera Species 0.000 description 1
- 241001674044 Blattodea Species 0.000 description 1
- 241001414720 Cicadellidae Species 0.000 description 1
- 241001498622 Cixius wagneri Species 0.000 description 1
- 241000238571 Cladocera Species 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 241000255925 Diptera Species 0.000 description 1
- 241000256602 Isoptera Species 0.000 description 1
- 241000255777 Lepidoptera Species 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241000257159 Musca domestica Species 0.000 description 1
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 description 1
- 244000061176 Nicotiana tabacum Species 0.000 description 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 1
- 241000209094 Oryza Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 208000031320 Teratogenesis Diseases 0.000 description 1
- 241001414989 Thysanoptera Species 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 239000003905 agrochemical Substances 0.000 description 1
- 230000000711 cancerogenic effect Effects 0.000 description 1
- 231100000315 carcinogenic Toxicity 0.000 description 1
- 239000013066 combination product Substances 0.000 description 1
- 229940127555 combination product Drugs 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 238000005338 heat storage Methods 0.000 description 1
- 238000002703 mutagenesis Methods 0.000 description 1
- 231100000350 mutagenesis Toxicity 0.000 description 1
- 229960002715 nicotine Drugs 0.000 description 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 229930192474 thiophene Natural products 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to the field of pesticide preparations, and provides a dinotefuran micron-emulsion and a preparation method thereof. The dinotefuran micron-emulsion comprises components of, by weight: 1-40% of dinotefuran, 10-30% of a solvent, 10-25% of a surfactant, 5-15% of a co-solvent, and balance of water. The dinotefuran micron-emulsion provided by the invention is advantaged in low cost, simple preparation process, low packaging requirement, reduced organic solvent dosage, low residue, and small pollution on the environment. The controlling effect provided by the dinotefuran micron-emulsion is higher than that of dinotefuran particle preparations. Therefore, the dinotefuran micron-emulsion is suitable to be broadly popularized.
Description
Technical field
The present invention relates to the pesticidal preparations field, relate to a kind of MTI-446 microemulsion and preparation method thereof specifically.
Background technology
MTI-446 (dinotefuran); Chemical name is (RS)-1-methyl-2-nitro-3-[(3-oxolane)-methyl] guanidine; It is the third generation nicotinic insecticide of Mitsui chemical company exploitation; The chemical constitution of itself and existing nicotinic insecticide is far from each other, and chloro-pyridine base, chloro thiazolyl before its tetrahydrofuran base has replaced do not contain the halogen family element.Simultaneously, also different at aspect of performance with nicotine.Be mainly used in aphid, leafhopper, plant hopper, thrips, aleyrodid and resistant strain thereof on the various crop such as control wheat, paddy rice, cotton, vegetables, fruit tree, tobacco leaf; Simultaneously coleoptera, diptera, Semiptera, Lepidoptera, beetle order and total wing order insect are had efficiently, and sanitary insect pests such as blattaria, termite, housefly are had efficiently.Fool proof to mammal, rat acute is low toxicity through skin and per os toxicity; To fish and water flea low toxicity; To honeybee safety; No teratogenesis, carcinogenic and mutagenesis.
The formulation of the MTI-446 pesticide product of using on the agricultural chemicals market at present is main with granule mainly, yet if the level that the preventive effect of MTI-446 granule is wanted to reach higher just needs to increase formulation rate, this can cause very big pollution to environment.
Simultaneously; The raising of Along with people's environmental consciousness; To the restriction increasingly stringent of the organic solvent that uses in the pesticidal preparations, thereby impel pesticidal preparations along efficient, low toxicity, develop with the good direction of Environmental compatibility, exploitation uses no or little the novel form of organic solvent; To replace pesticidal preparations, wherein be the direction that the pesticides new formulation of matrix has become world's formulations of pesticide research and development with water.
Microemulsion (microemulsion, ME) being is matrix with water, utilize physicochemical liquid-in-liquid dispersions system theoretical with method prepare efficient, store and transport safety, novel green pesticidal preparations that environmental pollution is low.Microemulsion has reduced consumption of organic solvent, has alleviated the pressure to environment greatly, and is significant for protection Agro-ecology balance, more helps the sustainable development of agricultural.Therefore research and develop a kind of efficient, low toxicity, environment amenable MTI-446 pest killing micro emulsion is of great significance.
Summary of the invention
In view of this, the object of the invention is to provide a kind of efficient, little, environment amenable MTI-446 microemulsion of formulation rate.
For realizing the object of the invention, the present invention adopts following technical scheme:
A kind of MTI-446 microemulsion; Comprise MTI-446, solvent, surfactant, cosolvent and water; Wherein, the percentage by weight of the said microemulsion gross weight of each ingredients constitute is MTI-446 1-40%, organic solvent 10-30%, surfactant 10-25%, cosolvent 5-15%, and surplus is a water;
MTI-446 microemulsion according to the invention is active component with the MTI-446, and as preferably, the percentage by weight that said MTI-446 accounts for said microemulsion gross weight is 5-20%.
Solvent according to the invention is selected from cyclohexanone, toluene, xylol, DMSO, dimethyl formamide.
As preferably, the percentage by weight that said solvent accounts for said microemulsion gross weight is 15-20%.
Surfactant according to the invention is selected from one or more in the OPEO of NPE or nonionic of compound, calcium dodecyl benzene sulfonate, styryl phenol formaldehyde resin polyoxyethylene-polyoxypropylene block type polyethers, nonionic of compound, anion and non-ionic surface active agent and the solvent of anion and non-ionic surface active agent.
In certain embodiments; Said surfactant is agricultural newborn 0201B, agricultural newborn 0203B, agricultural newborn 0204C, farming breast 2201, OP series farming breast or farming breast 500; The agricultural breast of said OP series is preferably agricultural newborn OP-10 or agricultural newborn OP-21, and said surfactant is preferably agricultural newborn 0204C, agricultural newborn OP-10 or agricultural newborn OP-21
Cosolvent according to the invention is ethanol, propyl alcohol, isopropyl alcohol or the tert-butyl alcohol, is preferably ethanol or isopropyl alcohol.As preferably, the percentage by weight that said cosolvent accounts for said microemulsion gross weight is 10-15%.
MTI-446 microemulsion according to the invention can also comprise stabilizing agent, antifreezing agent and short bleeding agent, and wherein, the percentage by weight of the said microemulsion gross weight of each ingredients constitute is: stabilizing agent 1-5% antifreezing agent, 1-5% and short bleeding agent 1-10%.
Antifreezing agent according to the invention is selected from one or more in ethylene glycol, propane diols, glycerine, polyethylene glycol, sorbierite, urea, sucrose, the glucose.Said short bleeding agent is azone, lauryl alcohol sodium sulphate, sodium lignin sulfonate or APES.That said stabilizing agent can be selected from is well known in the art, stabilizing agent commonly used.
The present invention also provides the preparation method of said MTI-446 microemulsion, according to said percentage by weight, MTI-446 is fully mixed with surfactant, cosolvent, adds other compositions again, mixes, and adds entry at last, can be made into microemulsion after fully stirring.
Physicochemical property and field control effectiveness test result show; MTI-446 microemulsion according to the invention stable performance, transparent wide ranges, resolution ratio are low; Rice fulgorid had significant drug effect; And compare with the MTI-446 granule of same dose (in active component), preventive effect is apparently higher than the preventive effect of granule.Show that MTI-446 microemulsion according to the invention need not increase formulation rate and can reach higher preventive effect, alleviated farm chemical ingredients and increased the pressure that brings to environment.
Can be known that by above technical scheme thiophene worm piperazine microemulsion cost according to the invention is low, the preparation process is simple; Packing instructions are low, reduced the usage amount of organic solvent simultaneously, and are residual few; Environmental pollution is little, and preventive effect is higher than the MTI-446 granule, suits large area to popularize.
Embodiment
The embodiment of the invention discloses a kind of MTI-446 microemulsion and preparation method thereof.Those skilled in the art can use for reference this paper content, suitably improve technological parameter and realize.Special needs to be pointed out is that all similarly replace and change apparent to those skilled in the art, they all are regarded as and are included in the present invention.Product of the present invention is described through preferred embodiment, and the related personnel obviously can change or suitably change and combination product as herein described in not breaking away from content of the present invention, spirit and scope, realizes and use technology of the present invention.
In order further to understand the present invention, the present invention is elaborated below in conjunction with embodiment.
Embodiment 1:5% MTI-446 microemulsion
MTI-446 is fully mixed with solvent, surfactant, cosolvent, add entry again, can be made into microemulsion after fully stirring.
Embodiment 2: physicochemical property is measured
The MTI-446 microemulsion of getting embodiment 1 preparation carries out the physicochemical property test, and the result is following:
Outward appearance: as clear as crystal single-phase liquid;
Transparency temperature zone: bear 5 ℃ to more than 60 ℃;
Low-temperature stability: following 2 weeks layering, crystallization do not occur at-5 ℃;
Heat storage stability: (54 ± 2) ℃ down 2 all active ingredient resolution ratios less than 3%;
Stability of emulsion: with the water-reducible emulsion-stabilizing of any ratio;
Ageing stability: normal temperature is stable down.
Embodiment 3: field control effectiveness test
MTI-446 microemulsion and commercially available certain MTI-446 granule of getting embodiment 1 preparation carry out field control effectiveness test.5 processing are established in test, and each formulation rate is seen table 1, and every processing repeats for 4 times, with reference to the Ministry of Agriculture " pesticide field efficacy medicine test criterion ", respectively investigate borer population one time in 1-3 days, 7 days after the dispenser, and statistics is also calculated the preventive effect result and seen table 1.Go down rate and control efficiency of insect population calculated by following formula.
Wherein, PT
0Borer population alive before the expression chemicals treatment district medicine; PT
1Borer population alive behind the expression chemicals treatment district medicine; CK
0Borer population alive before the expression blank district medicine; CK
1Borer population alive behind the expression blank district medicine; PT representes the chemicals treatment district insect population rate that goes down; CK representes the blank district insect population rate that goes down.
Table 1 5% MTI-446 microemulsion to rice fulgorid control efficiency (7d)
Visible by table 1 result; The drug effect of 5% MTI-446 microemulsion 20g/ mu is 71.5%; With the drug effect significant difference of 1% MTI-446 granule 100g/ mu, both effective ingredient consumption are 1g/ mu, show the good drug efficacy of MTI-446 microemulsion according to the invention; Need not increase formulation rate and can reach higher preventive effect, alleviate farm chemical ingredients and increased the pressure that brings to environment.
Embodiment 4:10% MTI-446 microemulsion
MTI-446 is fully mixed with solvent, surfactant, cosolvent, and then add other composition mixings, add entry again, can be made into microemulsion after fully stirring.Physicochemical property test each item index and field control effectiveness test result are similar with embodiment 1.
Embodiment 5:15% MTI-446 microemulsion
MTI-446 is fully mixed with solvent, surfactant, cosolvent, and then add other composition mixings, add entry again, can be made into microemulsion after fully stirring.Physicochemical property test each item index and field control effectiveness test result are similar with embodiment 1.
Embodiment 6:20% MTI-446 microemulsion
MTI-446 is fully mixed with solvent, surfactant, cosolvent, and then add other composition mixings, add entry again, can be made into microemulsion after fully stirring.Physicochemical property test each item index and field control effectiveness test result are similar with embodiment 1.
Embodiment 7:25% MTI-446 microemulsion
MTI-446 is fully mixed with solvent, surfactant, cosolvent, add entry again, can be made into microemulsion after fully stirring.Physicochemical property test each item index and field control effectiveness test result are similar with embodiment 1.
Embodiment 8:30% MTI-446 microemulsion
MTI-446 is fully mixed with solvent, surfactant, cosolvent, add entry again, can be made into microemulsion after fully stirring.Physicochemical property test each item index and field control effectiveness test result are similar with embodiment 1.
Embodiment 9:40% MTI-446 microemulsion
MTI-446 is fully mixed with solvent, surfactant, cosolvent, and then add other composition mixings, add entry again, can be made into microemulsion after fully stirring.Physicochemical property test each item index and field control effectiveness test result are similar with embodiment 1.
The explanation of above embodiment just is used for helping to understand method of the present invention and core concept thereof.Should be pointed out that for those skilled in the art, under the prerequisite that does not break away from the principle of the invention, can also carry out some improvement and modification to the present invention, these improvement and modification also fall in the protection domain of claim of the present invention.
Claims (6)
1. MTI-446 microemulsion; It is characterized in that; Comprise MTI-446, solvent, surfactant, cosolvent and water; Wherein, the percentage by weight of the said microemulsion gross weight of each ingredients constitute is MTI-446 1-40%, organic solvent 10-30%, surfactant 10-25%, cosolvent 5-15%, and surplus is a water; Said solvent is cyclohexanone, toluene, xylol, DMSO or dimethyl formamide; Said surfactant is selected from one or more in the OPEO of NPE or nonionic of compound, calcium dodecyl benzene sulfonate, styryl phenol formaldehyde resin polyoxyethylene-polyoxypropylene block type polyethers, nonionic of compound, anion and non-ionic surface active agent and the solvent of anion and non-ionic surface active agent; Said cosolvent is selected from ethanol, propyl alcohol, isopropyl alcohol or the tert-butyl alcohol.
2. according to the said MTI-446 microemulsion of claim 1, it is characterized in that said MTI-446 percentage by weight is 5-20%.
3. according to the said MTI-446 microemulsion of claim 1, it is characterized in that, also comprise stabilizing agent, antifreezing agent and short bleeding agent, the percentage by weight of the said microemulsion gross weight of each ingredients constitute is stabilizing agent 1-5%, antifreezing agent 1-5% and short bleeding agent 1-10%.
4. according to the said MTI-446 microemulsion of claim 3, it is characterized in that said antifreezing agent is selected from one or more in ethylene glycol, propane diols, glycerine, polyethylene glycol, sorbierite, urea, sucrose, the glucose.
5. according to the said MTI-446 microemulsion of claim 3, it is characterized in that said short bleeding agent is azone, lauryl alcohol sodium sulphate, sodium lignin sulfonate or APES.
6. the preparation method of any said MTI-446 microemulsion of claim 1-5 is characterized in that, MTI-446 is fully mixed with surfactant, cosolvent, adds other compositions again, evenly mixes, and adds entry at last, can be made into microemulsion after fully stirring.
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| CN201110339065.5A CN102415405B (en) | 2011-10-31 | 2011-10-31 | Dinotefuran micron-emulsion and preparation method thereof |
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| CN201110339065.5A CN102415405B (en) | 2011-10-31 | 2011-10-31 | Dinotefuran micron-emulsion and preparation method thereof |
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| CN102415405B CN102415405B (en) | 2014-06-11 |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105145617A (en) * | 2015-10-19 | 2015-12-16 | 中国农业科学院棉花研究所 | Compound synergistic pesticide |
| CN105532656A (en) * | 2016-01-28 | 2016-05-04 | 南京善思生物科技有限公司 | Environment-friendly dinotefuran microemulsion and preparation method thereof |
| CN105638650A (en) * | 2016-01-28 | 2016-06-08 | 南京善思生物科技有限公司 | Environment-friendly dinotefuran microemulsion free of organic solvent and preparation method thereof |
| CN105746566A (en) * | 2016-03-29 | 2016-07-13 | 西北农林科技大学 | Dinotefuran-containing liquid agent for being infused into tree trunks |
| CN106359474A (en) * | 2016-08-31 | 2017-02-01 | 江苏星源生物科技有限公司 | Fungicidal composition for preventing and treating rice planthopper and application thereof |
| CN109511671A (en) * | 2018-10-19 | 2019-03-26 | 江西博邦生物药业有限公司 | Pesticide dinotefuran aqua and its preparation method |
| CN109984141A (en) * | 2017-12-31 | 2019-07-09 | 海南正业中农高科股份有限公司 | A kind of microemulsion containing dinotefuran |
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| CN100450360C (en) * | 2006-11-14 | 2009-01-14 | 华南理工大学 | Rotenone and dinotefuran mixed microemulsion and preparation method thereof |
| CN102204563A (en) * | 2011-04-08 | 2011-10-05 | 湖南大方农化有限公司 | Pesticide composition containing dinotefuran |
| CN102217639A (en) * | 2011-04-21 | 2011-10-19 | 青岛海利尔药业有限公司 | Insecticidal composition containing dinotefuran and chlorantraniliprole |
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| CN100450360C (en) * | 2006-11-14 | 2009-01-14 | 华南理工大学 | Rotenone and dinotefuran mixed microemulsion and preparation method thereof |
| CN102204563A (en) * | 2011-04-08 | 2011-10-05 | 湖南大方农化有限公司 | Pesticide composition containing dinotefuran |
| CN102217639A (en) * | 2011-04-21 | 2011-10-19 | 青岛海利尔药业有限公司 | Insecticidal composition containing dinotefuran and chlorantraniliprole |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105145617A (en) * | 2015-10-19 | 2015-12-16 | 中国农业科学院棉花研究所 | Compound synergistic pesticide |
| CN105532656A (en) * | 2016-01-28 | 2016-05-04 | 南京善思生物科技有限公司 | Environment-friendly dinotefuran microemulsion and preparation method thereof |
| CN105638650A (en) * | 2016-01-28 | 2016-06-08 | 南京善思生物科技有限公司 | Environment-friendly dinotefuran microemulsion free of organic solvent and preparation method thereof |
| CN105532656B (en) * | 2016-01-28 | 2018-05-22 | 南京善思生物科技有限公司 | A kind of environmental-friendly dinotefuran micron-emulsion and preparation method thereof |
| CN105638650B (en) * | 2016-01-28 | 2018-06-01 | 南京善思生物科技有限公司 | A kind of environmental-friendly dinotefuran micron-emulsion of organic solvent-free and preparation method thereof |
| CN105746566A (en) * | 2016-03-29 | 2016-07-13 | 西北农林科技大学 | Dinotefuran-containing liquid agent for being infused into tree trunks |
| CN105746566B (en) * | 2016-03-29 | 2018-09-25 | 西北农林科技大学 | A kind of trunk injection liquor containing dinotefuran |
| CN106359474A (en) * | 2016-08-31 | 2017-02-01 | 江苏星源生物科技有限公司 | Fungicidal composition for preventing and treating rice planthopper and application thereof |
| CN109984141A (en) * | 2017-12-31 | 2019-07-09 | 海南正业中农高科股份有限公司 | A kind of microemulsion containing dinotefuran |
| CN109511671A (en) * | 2018-10-19 | 2019-03-26 | 江西博邦生物药业有限公司 | Pesticide dinotefuran aqua and its preparation method |
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