CN102408511A - Synthesis method for linear PMMA-MA (Polymethyl Methacrylate-Methyl Acrylate) bead powder - Google Patents
Synthesis method for linear PMMA-MA (Polymethyl Methacrylate-Methyl Acrylate) bead powder Download PDFInfo
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- CN102408511A CN102408511A CN2011103076988A CN201110307698A CN102408511A CN 102408511 A CN102408511 A CN 102408511A CN 2011103076988 A CN2011103076988 A CN 2011103076988A CN 201110307698 A CN201110307698 A CN 201110307698A CN 102408511 A CN102408511 A CN 102408511A
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Abstract
The invention discloses a synthesis method for linear PMMA-MA (Polymethyl Methacrylate-Methyl Acrylate) bead powder which comprises the steps as follows: firstly, 800ml pure water is added into a 2,000ml threeneck flask; then polyving alcohol, hydroxypropyl-cellulose and lauryl sodium sulfate are added into the flask and are stirred and dispersed uniformly; secondarily, the temperature is slowly raised to 50 DEG C and then the mixed liquid of methyl methacrylate, methyl acrylate, benzoyl peroxide and divinylbenzene are poured into the flask at once; thirdly, the temperature is raised according to a specific curve and the reaction is stopped after the temperature is completely raised, and fourthly, the mixture is washed by distilled water and dried in vacuum. The grain size of the PMMA-MA (Polymethyl Methacrylate-Methyl Acrylate) bead powder can be better controlled through the method, and is uniform; the uniform sizes of the grains are beneficial for the uniformity of products and stationarity of coagulation time during later mixing process; therefore, the use safety and reliability of PMMA bone cement are greatly improved.
Description
Technical field:
The present invention relates to technical field of polymer materials, relate to a kind of compound method of linear PMMA-MA pearl powder in particular.
Background technology:
The PMMA bone cement is an immobilization material commonly used in a kind of surgery joint replacement, in the surgical procedure for PMMA require increasingly high.PMMA bone cement powder globule size has very big influence to its performance; The powder granularity size influences the homogeneity of product in the later stage mixing process and the stationarity of setting time, provides a kind of powder of globule size homogeneous could improve the safe reliability that bone cement uses greatly.
Summary of the invention:
The compound method that the purpose of this invention is to provide a kind of linear PMMA-MA pearl powder.Adopt present method synthetic pearl powder to can be good at controlling the globule size of powder, help the homogeneity of product in the later stage mixing process and the stationarity of setting time, improve the safe reliability that bone cement uses greatly.
The technological solution that adopts for realization the object of the invention is following:
A kind of compound method of linear PMMA-MA pearl powder may further comprise the steps:
1. at first the 800ml pure water is added in the there-necked flask of 2000ml, adds hydroxylated cellulose, sodium lauryl sulphate, Z 150PH then, dispersed with stirring is even;
2. slowly be warming up to 50 ℃, again the mixed solution of TEB 3K, methyl acrylate, Lucidol, Vinylstyrene once poured into to there-necked flask;
3. heat up stopped reaction after accomplishing by specific curves;
4. distilled water wash, vacuum-drying.
In the technique scheme, the additional proportion of described hydroxylated cellulose, sodium lauryl sulphate, Z 150PH is respectively 1～5%, 3～7%, 1～6%.
In the technique scheme, it is to be warming up to 70～75 ℃ with 10～20 ℃/minute that described specific curves heats up, and is incubated after 7～10 hours and is warming up to 80～90 ℃ with 2～5 ℃/minute, is incubated 2～3 hours, stops heating.
Beneficial effect of the present invention is:
1. synthetic PMMA-MA pearl powder degree size homogeneous of the present invention.
The granularity of synthetic PMMA-MA pearl powder 2. of the present invention is between the 10-100 micron.
3. pearl powder of the present invention helps the homogeneity of product in the later stage mixing process and the stationarity of setting time, improves the safe reliability that bone cement uses greatly.
Embodiment:
Below in conjunction with embodiment the present invention is described further, but the present invention's scope required for protection is not limited to the described scope of embodiment.
Embodiment 1
The 800ml pure water is added in the there-necked flask of 2000ml, adds Z 150PH, hydroxylated cellulose, sodium lauryl sulphate, dispersed with stirring is even.Slowly be warming up to 50 ℃ then, again the mixed solution of TEB 3K, methyl acrylate, Lucidol, Vinylstyrene once poured into to there-necked flask.Be warming up to 70 ℃ with 12 ℃/minute again, be incubated after 7 hours and be warming up to 80 ℃, be incubated 2 hours, stop heating with 3 ℃/minute.Distilled water wash, vacuum-drying.
In the present embodiment, the additional proportion of described hydroxylated cellulose, sodium lauryl sulphate, Z 150PH is respectively 2.6%, 4.3%, 1.4%; The powder granularity MV that finally obtains is 26 microns.
Embodiment 2
The 800ml pure water is added in the there-necked flask of 2000ml, adds Z 150PH, hydroxylated cellulose, sodium lauryl sulphate, dispersed with stirring is even.Slowly be warming up to 50 ℃ then, again the mixed solution of TEB 3K, methyl acrylate, Lucidol, Vinylstyrene once poured into to there-necked flask.Be warming up to 75 ℃ with 15 ℃/minute again, be incubated after 9 hours and be warming up to 85 ℃, be incubated 3 hours, stop heating with 2 ℃/minute.Distilled water wash, vacuum-drying.
In the present embodiment, the additional proportion of described hydroxylated cellulose, sodium lauryl sulphate, Z 150PH is respectively 3.5%, 4.7%, 2.4%; The powder granularity MV that finally obtains is 58 microns.
Embodiment 3
The 800ml pure water is added in the there-necked flask of 2000ml, adds Z 150PH, hydroxylated cellulose, sodium lauryl sulphate then, dispersed with stirring is even.Slowly be warming up to 50 ℃, again the mixed solution of TEB 3K, methyl acrylate, Lucidol, Vinylstyrene once poured into to there-necked flask.Be warming up to 75 ℃ with 18 ℃/minute, be incubated after 10 hours and be warming up to 90 ℃, be incubated 2 hours, stop heating with 5 ℃/minute.Distilled water wash, vacuum-drying.
In the present embodiment, the additional proportion of described hydroxylated cellulose, sodium lauryl sulphate, Z 150PH is respectively 4.2%, 5.4%, 2.7%; The powder granularity MV that finally obtains is 34 microns.
Claims (3)
1. the compound method of a linear PMMA-MA pearl powder may further comprise the steps:
1. at first the 800ml pure water is added in the there-necked flask of 2000ml, adds hydroxylated cellulose, sodium lauryl sulphate, Z 150PH then, dispersed with stirring is even;
2. slowly be warming up to 50 ℃, again the mixed solution of TEB 3K, methyl acrylate, Lucidol, Vinylstyrene once poured into to there-necked flask;
3. heat up stopped reaction after accomplishing by specific curves;
4. distilled water wash, vacuum-drying.
2. the compound method of a kind of linear PMMA-MA pearl powder according to claim 1 is characterized in that: the additional proportion of described hydroxylated cellulose, sodium lauryl sulphate, Z 150PH is respectively 1～5%, 3～7%, 1～6%.。
3. the compound method of a kind of linear PMMA-MA pearl powder according to claim 1; It is characterized in that: it is to be warming up to 70～75 ℃ with 10～20 ℃/minute that described specific curves heats up; Be incubated and be warming up to 80～90 ℃ with 2～5 ℃/minute after 7～10 hours; Be incubated 2～3 hours, stop heating.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201110307698.8A CN102408511B (en) | 2011-10-12 | 2011-10-12 | Synthesis method for linear PMMA-MA (Polymethyl Methacrylate-Methyl Acrylate) bead powder |
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| CN201110307698.8A CN102408511B (en) | 2011-10-12 | 2011-10-12 | Synthesis method for linear PMMA-MA (Polymethyl Methacrylate-Methyl Acrylate) bead powder |
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| CN102408511A true CN102408511A (en) | 2012-04-11 |
| CN102408511B CN102408511B (en) | 2014-03-12 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103113506A (en) * | 2012-12-17 | 2013-05-22 | 青岛博益特生物材料有限公司 | Ester-adsorbed ternary macroporous adsorption resin |
| CN115400269A (en) * | 2022-08-16 | 2022-11-29 | 武汉理工大学 | Injectable bone cement and preparation method and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102068386A (en) * | 2010-12-02 | 2011-05-25 | 天津大学 | Butyl methacrylate and methyl methacrylate copolymer-based denture base material and preparation method and use thereof |
| CN102068387A (en) * | 2010-12-02 | 2011-05-25 | 天津大学 | Methyl acrylate (MA)-methyl methacrylate (MMA) copolymer-base denture base material as well as preparation method and application thereof |
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2011
- 2011-10-12 CN CN201110307698.8A patent/CN102408511B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102068386A (en) * | 2010-12-02 | 2011-05-25 | 天津大学 | Butyl methacrylate and methyl methacrylate copolymer-based denture base material and preparation method and use thereof |
| CN102068387A (en) * | 2010-12-02 | 2011-05-25 | 天津大学 | Methyl acrylate (MA)-methyl methacrylate (MMA) copolymer-base denture base material as well as preparation method and application thereof |
Non-Patent Citations (1)
| Title |
|---|
| 石花蕾等: "悬浮共聚合法制备聚丙烯酸乙酯/甲基丙烯酸甲酯软微球及动力学研究", 《华南农业大学学报》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103113506A (en) * | 2012-12-17 | 2013-05-22 | 青岛博益特生物材料有限公司 | Ester-adsorbed ternary macroporous adsorption resin |
| CN115400269A (en) * | 2022-08-16 | 2022-11-29 | 武汉理工大学 | Injectable bone cement and preparation method and application thereof |
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| CN102408511B (en) | 2014-03-12 |
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Address after: 430065, Tsing Ling Town Industrial Zone, Hongshan District, Hubei, Wuhan Province, No. 18 Patentee after: Wuhan Mindray Technology Co., Ltd Address before: 430070 Hubei Province, Wuhan city Hongshan District Road No. 28 North Industrial Park Bookstore Patentee before: WUHAN DRAGONBIO ORTHOPEDIC PRODUCTS Co.,Ltd. |