CN102382231B - Polyacrylic resin I and preparation method thereof - Google Patents
Polyacrylic resin I and preparation method thereof Download PDFInfo
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- CN102382231B CN102382231B CN 201110263181 CN201110263181A CN102382231B CN 102382231 B CN102382231 B CN 102382231B CN 201110263181 CN201110263181 CN 201110263181 CN 201110263181 A CN201110263181 A CN 201110263181A CN 102382231 B CN102382231 B CN 102382231B
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Abstract
The invention discloses polyacrylic resin I. The polyacrylic resin I is characterized by comprising 100 parts by weight of methacrylic acid, 18 to 26 parts by weight of ethyl acrylate, 69 to 87 parts by weight of butyl acrylate, 0.336 to 0.660 parts by weight of potassium persulphate or ammonium persulfate, 100.019 to 0.064 parts by weight of nonoxynol, 0.729 to 1.512 parts by weight of sodium dodecyl sulfate, 802.917 to 4.963 parts by weight of tween and 438 to 526 parts by weight of purified water. The invention also relates to a preparation method of the polyacrylic resin I. The polyacrylic resin I can be utilized as an enteric coating material of a pharmaceutic solid preparation, also can be utilized as a sustained-release framework material of a solid preparation, is convenient for use, and has good release effects.
Description
Technical field
The present invention relates to a kind of pharmaceutical excipient, particularly a kind of polyacrylic resin I; The invention still further relates to the method for making of this polyacrylic resin I.
Background technology
Latax product of the prior art is because the polymeric constituent prescription is not too reasonable, and its film forming is poorly soluble, causes the stripping of encapsulate substances not enough; Simultaneously, latax is liquid product, and inconvenience is preserved, and easily goes mouldy, easily freezing makes product rotten, liquid product inconvenience transportation; In addition, the limitation that the latax product uses can not can be made water dispersion and make dressing of as the pressed powder product, also can fully mix with raw material and other auxiliary materials and do the use of framework material compressing tablet.
Summary of the invention
Technical problem to be solved by this invention is at the deficiencies in the prior art, provides a kind of new prescription more reasonable, easy to use, a kind of polyacrylic resin I that releasing effect is good.
Technical problem to be solved by this invention is to realize by following technical scheme.The present invention is a kind of polyacrylic resin I, is characterized in: it is to be made by following materials of weight proportions:
Methacrylic acid 100; Ethyl propenoate 18～26;
Butyl acrylate 69～87; Potassium Persulphate or ammonium persulphate 0.336～0.660;
Nonokynol-9 10 0.019～0.064; Sodium lauryl sulphate 0.729～1.512;
Tween 80 2.917～4.963; Purified water 438～526.
Above-described a kind of polyacrylic resin I is characterized in: the preferred weight proportioning of each raw material is:
Methacrylic acid 100; Ethyl propenoate 22;
Butyl acrylate 78; Potassium Persulphate or ammonium persulphate 0.496;
Nonokynol-9 10 0.041; Sodium lauryl sulphate 1.121;
Tween 80 3.940; Purified water 482.
Polyacrylic resin I of the present invention can adopt ordinary method of the prior art to be prepared.The following method preparation of preferred use: a kind of preparation method as the described polyacrylic resin I of above technical scheme is characterized in that its step is as follows:
(1) will add by purified water, Potassium Persulphate or ammonium persulphate, nonokynol-9 10, sodium lauryl sulphate and the tween 80 that described weight proportion takes by weighing in the reactor; Stirred autoclave is with reactor heat temperature raising to 60～90 ℃;
(2) will mix the adding high level tank by methacrylic acid, ethyl propenoate, the butyl acrylate that described weight proportion takes by weighing, be added drop-wise in the reactor then; Be added dropwise to complete back control temperature of reaction kettle at 95～105 ℃ and continue 30～60 minutes; Carry out spraying drying after the cooling, get polyacrylic resin I powder.
Polyacrylic resin I of the present invention is a kind of water dispersion enteric thin film coating material, it is the white powder of a kind of granularity about 200～250 microns, and it is to add the product that initiator potassium persulfate (ammonium) and emulsifying agent nonokynol-9 10, sodium lauryl sulphate, tween 80 and purified water copolymerization obtain by spraying drying by methacrylic acid, ethyl propenoate, butyl acrylate.Product of the present invention can be dispersed into latax again in water.
Compared with prior art, the present invention has the following advantages:
1, it is a kind of medicinal thin film coating material of water dispersion of solid powdery, and pressed powder can become latax through redispersion, and keeps the performance of latax.
2, pressed powder product and original latax product ratio are convenient to store, and liquid product was damaged by frost easily in winter, caused in the quality guaranteed period to lose efficacy; Be convenient to transportation.
3, product of the present invention can be used as the enteric-coating material of medical solid preparation, and the sustained-release matrix material that also can be used as solid preparation uses, and easy to use, releasing effect is good.
Embodiment
Below further describe concrete technical scheme of the present invention, so that those skilled in the art understands the present invention further, and do not constitute the restriction to its right.
Embodiment 1, a kind of polyacrylic resin I, and it is to be made by following materials of weight proportions:
Methacrylic acid 100; Ethyl propenoate 18;
Butyl acrylate 69; Potassium Persulphate or ammonium persulphate 0.336;
Nonokynol-9 10 0.019; Sodium lauryl sulphate 0.729;
Tween 80 2.917; Purified water 438;
Be prepared into into by the prior art ordinary method.
Embodiment 2, a kind of polyacrylic resin I, and it is to be made by following materials of weight proportions:
Methacrylic acid 100; Ethyl propenoate 26;
Butyl acrylate 87; Potassium Persulphate or ammonium persulphate 0.660;
Nonokynol-9 10 0.064; Sodium lauryl sulphate 1.512;
Tween 80 4.963; Purified water 526;
Preparation method's step of described polyacrylic resin I is as follows:
(1) will add by purified water, Potassium Persulphate or ammonium persulphate, nonokynol-9 10, sodium lauryl sulphate and the tween 80 that described weight proportion takes by weighing in the reactor; Stirred autoclave is with reactor heat temperature raising to 60 ℃;
(2) will mix the adding high level tank by methacrylic acid, ethyl propenoate, the butyl acrylate that described weight proportion takes by weighing, be added drop-wise in the reactor then; Be added dropwise to complete back control temperature of reaction kettle at 95 ℃ and continue 30 minutes; Carry out spraying drying after the cooling, get polyacrylic resin I powder.
Embodiment 3, a kind of polyacrylic resin I, and it is to be made by following materials of weight proportions:
Methacrylic acid 100; Ethyl propenoate 22;
Butyl acrylate 78; Potassium Persulphate 0.496;
Nonokynol-9 10 0.041; Sodium lauryl sulphate 1.121;
Tween 80 3.940; Purified water 482;
Preparation method's step of described polyacrylic resin I is as follows:
(1) will add by purified water, Potassium Persulphate, nonokynol-9 10, sodium lauryl sulphate and the tween 80 that described weight proportion takes by weighing in the reactor; Stirred autoclave is with reactor heat temperature raising to 90 ℃;
(2) will mix the adding high level tank by methacrylic acid, ethyl propenoate, the butyl acrylate that described weight proportion takes by weighing, be added drop-wise in the reactor then; Be added dropwise to complete back control temperature of reaction kettle at 105 ℃ and continue 60 minutes; Carry out spraying drying after the cooling, get polyacrylic resin I powder.
Carry out the dressing test with embodiment 3 prepared polyacrylic resin I, process and result are as follows:
1, test is formed with coating material:
(1) polyacrylic resin I water dispersion preparation:
Polyacrylic resin I 590g; Sodium hydroxide solution (1 mol/L) 197g;
Pure water 1180g;
The polyacrylic resin I of 590g is slowly poured in the water of 1180g while stirring, continue to be stirred 5 minutes, under agitation dropping sodium solution slowly continues to stir 30 minutes, filters through 80 mesh sieves, and it is stand-by to make 1967g polyacrylic resin I water dispersion.
(2) coating material is formed:
Polyacrylic resin I water dispersion 1967g;
Talcum powder 590g;
Triethyl citrate 59g;
Pure water 2384g.
2, experimental implementation process and result thereof:
(1) talcum powder, triethyl citrate are added in the 2384g water, homogenize 5 minutes is slowly poured this suspension in the 1967g water dispersion, stirs 30 minutes, filters through 80 mesh sieves, namely is made into coating liquid;
(2) with equipment such as high-efficiency coating pot, peristaltic pump, automatic spray guns, grasp processing parameters such as nozzle and sheet bed spacing 150mm, air output 7m3/min, 55 ℃ of inlet temperature, 37 ℃ of sheet bed tempertaures, coating pan rotating speed 12rpm, whiff pressure 0.15Mpa, hydrojet speed 49g/min, the sheet after coated places 6 hours dryings of 40 ℃ of baking ovens.Sheet behind the dressing is complete, smooth;
(3) slaking test: coating tablet is not disintegration in 2 hours in acid solution, disintegration in the fastest 6 minutes, the slowest 23 minutes in the pH6.8 damping fluid.Slaking test is qualified.
Claims (2)
1. polyacrylic resin I, it is characterized in that: it is to be made by following materials of weight proportions:
Methacrylic acid 100; Ethyl propenoate 18～26;
Butyl acrylate 69～87; Potassium Persulphate or ammonium persulphate 0.336～0.660;
Nonokynol-9 10 0.019～0.064; Sodium lauryl sulphate 0.729～1.512;
Tween 80 2.917～4.963; Purified water 438～526;
Its preparation methods steps is as follows:
(1) will add by purified water, Potassium Persulphate or ammonium persulphate, nonokynol-9 10, sodium lauryl sulphate and the tween 80 that described weight proportion takes by weighing in the reactor; Stirred autoclave is with reactor heat temperature raising to 60～90 ℃;
(2) will mix the adding high level tank by methacrylic acid, ethyl propenoate, the butyl acrylate that described weight proportion takes by weighing, be added drop-wise in the reactor then; Be added dropwise to complete back control temperature of reaction kettle at 95～105 ℃ and continue 30～60 minutes; Carry out spraying drying after the cooling, get polyacrylic resin I powder.
2. a kind of polyacrylic resin I according to claim 1, it is characterized in that: the weight proportion of each raw material is:
Methacrylic acid 100; Ethyl propenoate 22;
Butyl acrylate 78; Potassium Persulphate or ammonium persulphate 0.496;
Nonokynol-9 10 0.041; Sodium lauryl sulphate 1.121;
Tween 80 3.940; Purified water 482.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 201110263181 CN102382231B (en) | 2011-09-07 | 2011-09-07 | Polyacrylic resin I and preparation method thereof |
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| CN 201110263181 CN102382231B (en) | 2011-09-07 | 2011-09-07 | Polyacrylic resin I and preparation method thereof |
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| CN102382231A CN102382231A (en) | 2012-03-21 |
| CN102382231B true CN102382231B (en) | 2013-08-21 |
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| CN106008788B (en) * | 2016-05-18 | 2017-11-07 | 连云港万泰医药辅料技术有限公司 | A kind of hypotonicity Sustained release coating materials and preparation method thereof |
| CN105833281B (en) * | 2016-05-18 | 2018-02-02 | 连云港万泰医药辅料技术有限公司 | A kind of aqueous enteric film coating pre-mix dose and preparation method thereof |
| CN111961152A (en) * | 2020-08-26 | 2020-11-20 | 连云港恒阳药业有限公司 | Polyacrylic resin emulsion as enteric medicine coating material and its prepn |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102127184A (en) * | 2010-12-24 | 2011-07-20 | 张晓梅 | Enteric medicinal coating polyacrylic resin emulsion with internal plasticization function and preparation method thereof |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102127184A (en) * | 2010-12-24 | 2011-07-20 | 张晓梅 | Enteric medicinal coating polyacrylic resin emulsion with internal plasticization function and preparation method thereof |
Non-Patent Citations (4)
| Title |
|---|
| 杨燕等.高延展性聚合物水分散体的制备和特性研究.《中国药科大学学报》.2009,第40卷(第4期),第310-315页. |
| 王振国等.药用丙烯酸树脂的研究.《高分子材料科学与工程》.1995,第11卷(第1期),第1-6页. |
| 药用丙烯酸树脂的研究;王振国等;《高分子材料科学与工程》;19950131;第11卷(第1期);第1-6页 * |
| 高延展性聚合物水分散体的制备和特性研究;杨燕等;《中国药科大学学报》;20090430;第40卷(第4期);第310-315页 * |
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Application publication date: 20120321 Assignee: Lianyungang Wantai Pharmaceutical Material Co. Ltd. Assignor: Zhang Shaoguo Contract record no.: 2014320000080 Denomination of invention: Polyacrylic acid resin 1 and preparation method thereof Granted publication date: 20130821 License type: Exclusive License Record date: 20140228 |
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