CN102406728B - Medicinal composition for treating lymphaden inflammations - Google Patents
Medicinal composition for treating lymphaden inflammations Download PDFInfo
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- CN102406728B CN102406728B CN2011103543453A CN201110354345A CN102406728B CN 102406728 B CN102406728 B CN 102406728B CN 2011103543453 A CN2011103543453 A CN 2011103543453A CN 201110354345 A CN201110354345 A CN 201110354345A CN 102406728 B CN102406728 B CN 102406728B
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Abstract
The invention discloses a medicinal composition for treating the lymphaden inflammations. The medicinal composition is prepared from the following raw materials: bitter apricot seed, lumbricus, calculus bovis and plantago asiatica, wherein the mass part ratio of the bitter apricot seed to the lumbricus to the calculus bovis to the plantago asiatica is (1.8 to 2.2):(2.7 to 3.3):(0.9 to 1.1):(3.6 to 4.4); and preferably, the mass part ratio is 2:3:1:4. The medicinal composition provided by the invention has exact prescription, is safe and reasonable and has a simple and easy process. A clinical result shows that the medicinal composition has good curative effects on various inflammations, such as lymphnoditis, thyroid cyst, pustule sore, parotitis, amygdalitis, herpes, otitis media and the like, and particularly, the recovery rate of the medicinal composition on the lymphnoditis can reach 100 percent. Moreover, a patient has no untoward effect in the process of taking the medicinal composition and no abnormity in three routine tests and liver and kidney function check.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition for the treatment of the lymph node inflammation.
Background technology
Inflammation is common clinically various histoorgan common diseases, and formation is many because of the vehement sense of pyretic toxicity, intestinal abdomen intrinsic heat, and pyretic toxicity caves in; Or because of internal organs QI and blood stasis, pyretic toxicity Yong Sheng and causing.Various inflammation as lymphadenitis, parotitis, thyroid cyst, pustule ulcer, tonsillitis, herpes and otitis media etc., belong to commonly encountered diseases, frequently-occurring disease.Medicine has a lot, but mostly has certain deficiency.
Think at present, to be antibacterial invade due to lymph node along lymphatic vessel lymphadenitis.The normal companion of primary disease sees the disease that primary infection is arranged, when as throat, oral cavity, face head etc., infection being arranged, and can be with under volume or cervical lymph node enlargement, pain.Pathogenic bacterium mostly are staphylococcus aureus and streptococcus.Easily send out the position and be the lymph node at cervical region, axillary fossa and groin position.From traditional Chinese medical science angle, primary disease is how to be altered in meridians by the heresy of fire-toxin, and coagulation of QI-blood forms.Mostly first suffer from the insidious diseases such as carbuncle furuncle, poison is walked to alter, the multiple abscess meridians; Or because of skin wound, infect pathogenic heat poison; Or because of depressed emotion, contain in heart-fire, vim and vigour are driven in the wrong direction and are given birth to.Though card is at table, and the source is originally in inner.In brief, the cause of disease is by fire-toxin, and pathogenesis is coagulation of QI-blood, and sick position is between meridians.Western medical treatment often adopts antibiotic, but the human body long-term taking can produce certain dependency, and after the western medicine rehabilitation, the probability of recurrence is very high.Therefore the advantages such as the Chinese traditional treatment disease is generally the principle in line with treatment must aim at the pathogenesis of disease, has curative effect clear and definite, and side effect is little develop a kind of instant effect, the effective medicine for the treatment of inflammation (especially lymphadenitis), are significant.
Summary of the invention
The purpose of this invention is to provide a kind of pharmaceutical composition that inflammation is especially treated the lymph node inflammation for the treatment of.
Pharmaceutical composition provided by the present invention is made by following raw material: Semen Armeniacae Amarum, Pheretima, Calculus Bovis and Semen Plantaginis; Wherein, the ratio of quality and the number of copies of described Semen Armeniacae Amarum, Pheretima, Calculus Bovis and Semen Plantaginis is (1.8-2.2): (2.7-3.3): (0.9-1.1): (3.6-4.4), the preferred mass portion rate is 2: 3: 1: 4.
Above-mentioned Semen Armeniacae Amarum, Pheretima, Calculus Bovis and Semen Plantaginis all meet the pertinent regulations under each medical material item of text of Chinese Pharmacopoeia version in 2010.
The preparation method of pharmaceutical composition of the present invention is as follows: above-mentioned four Chinese medicine Semen Armeniacae Amarum, Pheretima, Calculus Bovis and Semen Plantaginis are drawn materials in proportion, pulverize, mix homogeneously and get final product.
A further object of the present invention is to provide the application of aforementioned pharmaceutical compositions.
Pharmaceutical composition provided by the present invention can be used for being prepared into the medicine for the treatment of inflammation, especially is prepared into the medicine for the treatment of lymphadenitis.Also can be prepared into simultaneously the medicine of the common inflammation such as treatment thyroid cyst, pustule ulcer, parotitis, tonsillitis, herpes or otitis.
The medicine of the treatment inflammation of making take pharmaceutical composition provided by the present invention as active component is especially treated the lymphadenitis medicine, also belongs to protection scope of the present invention.
Described medicine can import by the method for oral, external, injection, infiltration, absorption, physics or chemistry mediation body such as muscle, Intradermal, subcutaneous, vein, mucosal tissue; Or mixed by other materials or wrap up after import body.
When needing, can also add one or more pharmaceutically acceptable carriers in said medicine.Described carrier comprises diluent, excipient, filler, binding agent, wetting agent, disintegrating agent, absorption enhancer, surfactant, absorption carrier, lubricant of pharmaceutical field routine etc.
Can make oral formulations take pharmaceutical composition of the present invention as active medicine, described oral formulations comprises: all acceptable dosage forms on tablet, dispersible tablet, hard capsule, soft capsule, granule, pill, micropill, powder, drop pill, slow releasing preparation, controlled release preparation, syrup, oral liquid, soft extract and extractum pharmaceutics.The medicine of above-mentioned various dosage forms all can be according to the conventional method preparation of pharmaceutical field.
The usage and dosage of said medicine is generally: every day 1 time, each 5-10g takes diaphoresis with yellow wine.Be 3 to 5 days the course for the treatment of.
Pharmaceutical composition prescription provided by the present invention is clear and definite, and safe and reasonable is simple for process.Clinical effectiveness shows, pharmaceutical composition provided by the present invention all has therapeutic effect preferably to various common inflammation, especially lymphadenitis is had significant curative effect.Lymphadenitis, thyroid cyst, pustule ulcer, parotitis or tonsillitic patient can take effect after taking medicine one day, basic recovery from illness in three days; Cure rate to lymphadenitis can reach 100%, the painful and heavy financial burden of having avoided simultaneously Western medicine to have an injection, infuse and perform the operation bringing.And without any untoward reaction, three large routine tests and hepatic and renal function check no abnormality seen to patient in drug administration process.
The specific embodiment
The invention will be further described below by specific embodiment, but the present invention is not limited thereto.
Experimental technique described in following embodiment if no special instructions, is conventional method; Described reagent and material if no special instructions, all can obtain by commercial sources.
The present invention crude drug Semen Armeniacae Amarum, Pheretima, Calculus Bovis and Semen Plantaginis used all meets the pertinent regulations under each medical material item of text of Chinese Pharmacopoeia version in 2010.Before feeding intake, be tested and appraised, ingredients is in kind to conform to title, the quality conformance with standard.
The Chinese medicine composition of embodiment 1, preparation treatment lymph node inflammation
Be 2: 3: 1 with Semen Armeniacae Amarum, Pheretima, Calculus Bovis and Semen Plantaginis according to ratio of quality and the number of copies: 4 ratio is drawn materials, and every medicated powder is broken into 30 purpose powder, mixing, and get final product.
Embodiment 2, clinical trial
Adopt embodiment 1 sample to carry out clinical trial.By to being in hospital and patient's 150 examples such as the lymphadenitis of outpatient service, thyroid cyst, pustule ulcer, parotitis, tonsillitis, herpes, otitis media are carried out clinical observation.Be 3-5 days the course for the treatment of, during treatment, takes medicine every day 1 time, and each 10g takes diaphoresis with yellow wine.
Result shows: this medicine all has therapeutic effect preferably to common various inflammation, especially lymphadenitis is had significant curative effect; And this is safe and reliable, have no side effect.Concrete outcome sees Table 1.
Table 1, therapeutic outcome statistics
Annotate: 1. produce effects: the inflammatory symptoms such as lymphadenectasis, pain, heating, abscess disappear, and whole body can be looked into without positive sign.
2. effective: symptom and sign disappears substantially, and the lymph node of local enlargement obviously dwindles, without symptoms such as pain, heatings.
3. invalid: symptom and sign have no improvement.
Without any untoward reaction, three large routine tests and hepatic and renal function check no abnormality seen to patient in drug administration process.
Model case is summarized as follows:
1, Zhang Wanru man 22 years old patient on February 9th, 2011 conscious neck swelling, body temperature rise to 39 ℃, second day begins that pain is arranged, and confirms as acute lymphadenitis at county hospital through routine blood test and B ultrasonic to the hospital outpatient inspection, following the doctor's advice take medicine the transfusion after have no curative effect.Patient begins to take the medicine of the present invention (embodiment 1) morning February 14, once a day, 10g/ time, take with 50 gram yellow wine, the second day pain alleviates, temperature decline, took continuously three days, malaise symptoms disappeared in the 4th day, went hospital's further consultation, lymph node has recovered normally, and it is normal that the routine blood test indices has recovered.
2,43 years old patient of your continuous female of history feels oxter and the sense of groin mild pain at the beginning of 2010 10 months, and pain grows with each passing day in subsequently five months, and with the higher sign of body temperature.On March 16th, 2011 was diagnosed as the inboard lymphadenectasis of the two abdomen thighs in two oxters in the ultrasound diagnosis of Suning hospital, and it is higher that routine blood test detects leukocyte.On March 28th, 2011 Suning hospital again B ultrasonic be diagnosed as lymphadenitis between oxter abdomen, butt crack.Lose curative effect by the doctor's advice transfusion of taking medicine after 3 days.The patient changed the medicine that takes the present invention (embodiment 1) for the first time since April 1, once-a-day, 10g/ time, take with 50 gram yellow wine, next day, feels pain alleviated, and took continuously three days (once-a-day), and pain disappeared substantially in the 4th day; Take the 6th day pain and thoroughly disappear, in hospital's check, routine blood test is normal, and groin place and axillary lymph knot have recovered normal, and inflammation disappears.
3, the refined fragrant female of Cao, 69 years old patient December in 2010 burst hyperpyrexia on the 8th, cervical pain, lose curative effect after eating febrifuge, December in 2010 11 days is in the B ultrasonic diagnosis of Renhe, Suning County hospital: first visit is thyroid cyst, and routine blood test shows leucocytosis, follows the doctor's advice to take medicine and does not still bring down a fever after transfusion.
December in 2010 21 days is in the first visit of the People's Hospital, Suning County, thyroid lobus lateralis dexter cross section: 3.7X3.6cm, lobus lateralis sinister cross section 1.3X1.3cm, the bilateral fibrous capsule of thyroid gland is smooth, the essence Echo heterogenicity is even, lobus lateralis dexter shows 3.3X2.5cm, the cystoid thing that swells, and the border is clear, interior entrant sound is poor, companion's band shape is cut apart and is dispersed in strong echo luminous point, and rear companion " comet tail " levies CDFI: do not visit and obvious blood flow signal in swollen thing.A plurality of low echo nodules of another demonstration, the maximum size is 0.8cmX0.7cm approximately, and lobus lateralis sinister separately shows a plurality of low echo nodules, and the maximum size is 1.1X0.7cm approximately, all as seen is dispersed in strong echo luminous point in tuberosity, CDFI: do not visit and obvious blood flow signal in tuberosity.Tentative diagnosis is: multiple thyroid nodules, the thyroid lobus lateralis dexter class capsule thing that swells, thyroiditis.Patient follow the doctor's advice take medicine and infuse after all have no curative effect.
The patient began to eat the medicine of taking the present invention (embodiment 1) on the 26th in December, once-a-day, 10g/ time, take with 50 gram yellow wine, next day, fever symptoms alleviated; After taking medicine the 3rd day, temperature recovery is normal, and the cervical pain sense disappears; After taking medicine the 5th day, sign recovers normal.Show after the check of Suning County hospital: thyroid returns to the normal appearance size, and inflammation disappears, and temperature recovery is normal.
4, Lv Ji peace man 66 years old patient December in 2010 burst body temperature on the 2nd increases, oxter pain, be diagnosed as slight axillary lymph knot the Suning County people scorching, in the same year December 6 morning began to take for the first time the medicine of the present invention (embodiment 1), once-a-day, 5g/ time, take with 50 gram yellow wine, the second day of taking medicine begins, and body temperature begins to descend, and takes medicine once by same dose every other day, after three auxiliary medicines, temperature recovery is normal, oxter pain disappears, and in the check of Suning County hospital, the axillary lymph knot is replied normal.
5, accepted the Xinjiang patient of several years open-endeds of suppurating after a lymphadenitis in 1988 for medical treatment, the patient introduces through the fellow villager and begins to take this medicine, proportioning at that time is Semen Armeniacae Amarum, Pheretima, Calculus Bovis and Semen Plantaginis, proportioning is 3: 2: 2: 3, pulverize, 15g/ time, take with 50 gram yellow wine, the secretions of the second day open sore part of taking medicine obviously reduces, take the second pair by same dose every other day, itch around the open sore part of (taking medicine the 4th day) after taking the second auxiliary medicine and begin healing, (after 12 days) open sore part all healed after taking continuously 6 auxiliary medicines, begin by Semen Armeniacae Amarum after one week, Pheretima, Calculus Bovis and Semen Plantaginis, proportioning is 2: 3: 1: 4, pulverize, yellow wine takes, 10g/ time, once in a week, took continuously for 3 weeks, after 3 weeks, lymph node recovers normal.Front and back have been taken 9 auxiliary medicines altogether.
Claims (5)
1. a pharmaceutical composition for the treatment of inflammation, made by following raw material: Semen Armeniacae Amarum, Pheretima, Calculus Bovis and Semen Plantaginis; Wherein, the ratio of quality and the number of copies of described Semen Armeniacae Amarum, Pheretima, Calculus Bovis and Semen Plantaginis is (1.8-2.2): (2.7-3.3): (0.9-1.1): (3.6-4.4);
Described inflammation is selected from following at least a: lymphadenitis, thyroid cyst, pustule ulcer, parotitis, tonsillitis, herpes and otitis media.
2. pharmaceutical composition according to claim 1, it is characterized in that: in described pharmaceutical composition, the ratio of quality and the number of copies of Semen Armeniacae Amarum, Pheretima, Calculus Bovis and Semen Plantaginis is 2:3:1:4.
3. pharmaceutical composition according to claim 1 and 2, is characterized in that: take with yellow wine when described pharmaceutical composition is taken.
4. the application of the described pharmaceutical composition of any one in the medicine of preparation treatment inflammation in claim 1-3; Described inflammation is selected from following at least a: lymphadenitis, thyroid cyst, pustule ulcer, parotitis, tonsillitis, herpes and otitis media.
5. application according to claim 4 is characterized in that: described inflammation is lymphadenitis.
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Non-Patent Citations (3)
| Title |
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| 《地龙药理作用研究进展概况》;马艳春 等;《中国临床保健杂志》;20090830;第12卷(第4期);第436-438页 * |
| 卢宏民.《牛黄、杏仁》.《中药大辞典》.1983,第81、158页. * |
| 马艳春 等.《地龙药理作用研究进展概况》.《中国临床保健杂志》.2009,第12卷(第4期),第436-438页. |
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