CN102399686B - After-extraction production line for fermentation liquid of enzymic preparation - Google Patents
After-extraction production line for fermentation liquid of enzymic preparation Download PDFInfo
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- CN102399686B CN102399686B CN 201110278163 CN201110278163A CN102399686B CN 102399686 B CN102399686 B CN 102399686B CN 201110278163 CN201110278163 CN 201110278163 CN 201110278163 A CN201110278163 A CN 201110278163A CN 102399686 B CN102399686 B CN 102399686B
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M21/00—Bioreactors or fermenters specially adapted for specific uses
- C12M21/14—Bioreactors or fermenters specially adapted for specific uses for producing enzymes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M45/00—Means for pre-treatment of biological substances
- C12M45/04—Phase separators; Separation of non fermentable material; Fractionation
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/12—Purification
Abstract
The invention discloses an after-extraction production line for fermentation liquid of an enzymic preparation, and provides a complete set of after-extraction solution for the fermentation liquid of the enzymic preparation, which can be used for increasing purity of the enzymic preparation, controlling activity of enzyme liquid, and reducing discharge of waste impurities and waste water. The after-extraction production line for the fermentation liquid of the enzymic preparation is mainly characterized in that: all advantages of filter pressing of a plate frame, microfiltration of a tubular membrane and ultrafiltration of a roll type membrane in solid-liquid separation and liquid-liquid separation are utilized sufficiently; detailed structures and designs of all operation units are combined perfectly; and an obvious effect is achieved in removing bacteria and slag, purifying effective components, reducing labor intensity, saving energy, reducing emission and the like.
Description
Technical field:
The present invention relates to a kind of extraction production line, relate to or rather a kind of novel post-extraction production line for enzyme preparation fermentation.
Background technology:
The rear extraction production line of enzyme preparation fermented liquid, the limpid degree of zymin the finished product, the purity of effective constituent, the stability of remove the gred bacteria-eliminating efficacy, quality product have been determined, whether also finally affect product has high quality, whether meets more extensive use necessary requirement, whether energy-saving and emission-reduction of production process, environmental protection whether more, therefore, strengthen the research and development of after zymin, extracting production line and technique, the development of zymin industry is had to important industrial value.
China's tradition zymin extraction process simple coarse, the general filter press that adopts adds ultrafiltration and concentration, product is impure many, and degerming is except solid weak effect, and product clarity is poor, product is difficult to reach the food grade requirement, simultaneously, waste liquid, waste sludge discharge are more, are difficult to meet the requirement of environmental protection, energy consumption is large, labour intensity is high, is not suitable for industry development requirement.
Summary of the invention:
The object of the invention is to overcome the deficiency of extractive technique after existing enzyme preparation fermented liquid, a kind of novel post-extraction production line for enzyme preparation fermentation is provided; This production line bacteria-eliminating efficacy is good, and product clarity is high, and energy consumption is low.
The present invention includes plate-and-frame filter press etc., it is characterized in that the outlet of fermented liquid storage tank is connected with the import of plate-and-frame filter press by valve, pump, the outlet of plate-and-frame filter press is connected to press filtration clear liquid storage tank by valve, forms the sheet frame press filteration system; The outlet of press filtration clear liquid storage tank is connected with the import of micro-filtrate membrane filtration machine by valve, pump, the pump outlet connected in the outlet of press filtration clear liquid storage tank, connect into a minor loop by pump, valve and the outlet of micro-filtrate membrane filtration machine trapped fluid, form the tubular type micro-filtration recycle system; The outlet of micro-filtrate membrane filtration machine connects concentrated solution storage tank after the micro-filtration ultrafiltration by valve, after the micro-filtration ultrafiltration, the outlet of concentrated solution storage tank is connected with the import of ultrafiltration membrance filter machine by valve, pump, at spiral wound Membrane filtering machine trapped fluid, export, valve and concentrated solution storage tank by two series connection connect into a loop, form the spiral wound membrane filtration system.
After described press filtration clear liquid storage tank, micro-filtration ultrafiltration, the concentrated solution storage tank also connects respiratory organ, with the regulating tank internal pressure, stop external dust to fall into the filter pipe system.
The pump outlet connected in fermented liquid storage tank outlet, connect a valve and form a branch road and be connected with the fermented liquid storage tank, and a valve of plate-and-frame filter press outlet connection forms a branch road and is connected with the fermented liquid storage tank.
In the trapped fluid outlet of micro-filtrate membrane filtration machine, the valve and the press filtration clear liquid storage tank that connect two series connection connect into a middle loop; The valve and the fermented liquid storage tank that connect two series connection form a large loop.
In the trapped fluid outlet of spiral wound Membrane filtering machine, the valve that connects two series connection connects into a finished fluid outlet; At spiral wound Membrane filtering machine purified liquor outlet, connect a valve and connect into waste liquid outlet.
At the abhiseca place of press filtration clear liquid storage tank, connect a valve and connect pure water (water-dialyzing) branch road by this valve.
At press filtration clear liquid storage tank abhiseca, connect into press filtration clear liquid storage tank by respiratory organ and breathe outlet; Concentrated solution storage tank abhiseca after the micro-filtration ultrafiltration, connect into concentrated solution storage tank after the micro-filtration ultrafiltration by respiratory organ and breathe outlet.
As shown from the above technical solution, the present invention has comprehensively adopted the sealed filtration novel process of filter press, tubular membrane micro-filtration, rolled film ultrafiltration, in conjunction with press filtration, micro-filtration, ultrafiltration apparatus characteristics, take full advantage of the advantage of each equipment, at aspects such as degerming slagging-off, purifying effective constituent, minimizing labour intensity, energy-saving and emission-reduction, obtained significant effect.
1, good solid-liquid separation effect is arranged after utilizing plate-and-frame filter press to form filtering layer, solid phase part liquid content is few, and loss of effective components is little, and the solid water content is few, and the solid phase drying cost is low; Filter press can separate fermented liquid overwhelming majority solid phase, has improved the microfiltration membrane operating mode.
2, microfiltration membrane can be held back residual thalline impurity and polymer soluble material after the press filtration of fermented liquid mesoplate effectively, guarantees that product clarity is high, impure few; Micro-filtration is held back part and is returned to press filtration function maximum possible recovery solid, separates liquid phase, reclaims effective constituent, simultaneously, alleviates the environmental protection pressure of discharge.
3, ultra-filtration membrane can filter small-molecule substance, holds back effective constituent, improves finished product purity; Can, according to the requirement of finished product vigor, adjust cycles of concentration; Ultrafiltration and concentration belongs to physical sepn, and cost is low, less energy consumption.
The accompanying drawing explanation:
Accompanying drawing is structural representation of the present invention.
In figure, 1. fermented liquid storage tank, 2. plate-and-frame filter press, 3,7. respiratory organ, 4. press filtration clear liquid storage tank, 5. micro-filtrate membrane filtration machine, 6. concentrated solution storage tank after the micro-filtration ultrafiltration, 8. ultrafiltration membrance filter machine;
F means valve, F1, F2 ... F14, F15; B means pump: B1, B2, B3, B4.
Embodiment:
Below in conjunction with accompanying drawing, the present invention is further illustrated.
As shown in drawings, the present invention includes main structure of system, and the system branch structure.
About main structure of system:
The outlet of fermented liquid storage tank 1 is connected with the import of plate-and-frame filter press 2 by valve F1, pump B1, and the outlet of plate-and-frame filter press 2 is connected to press filtration clear liquid storage tank 4 by valve F2, forms the sheet frame press filteration system; The outlet of press filtration clear liquid storage tank 4 is connected with the import of micro-filtrate membrane filtration machine 5 by valve F3, pump B2, in pump B2 outlet, by pump B4, valve F9 and the 5 trapped fluid outlets of micro-filtrate membrane filtration machine, connects into a minor loop, forms the tubular type micro-filtration recycle system; The outlet of micro-filtrate membrane filtration machine 5 connects concentrated solution storage tank 6 after the micro-filtration ultrafiltration by valve F4, after the micro-filtration ultrafiltration, the outlet of concentrated solution storage tank 6 is connected with the import of ultrafiltration membrance filter machine 8 by valve F10, pump B3, in the 8 trapped fluid outlets of spiral wound Membrane filtering machine, connect into a loop by F14, F15 and concentrated solution storage tank 6, form the spiral wound membrane filtration system.
About the system branch structure:
(1) in pump B1 outlet, connect a branch road by F5 and be connected with fermented liquid storage tank 1, plate-and-frame filter press 2 outlets connect a branch road by valve F6 and are connected with fermented liquid storage tank 1.
(2) in the 5 trapped fluid outlets of micro-filtrate membrane filtration machine, by F9, F7 and press filtration clear liquid storage tank 4, connect into a middle loop; Form a large loop by F9, F8 and fermented liquid storage tank 1.
(3) in the 8 trapped fluid outlets of spiral wound Membrane filtering machine, by F14, F11, connect into a finished fluid outlet; In spiral wound Membrane filtering machine 8 clear liquids (waste liquid) outlet, by F12, connect into waste liquid outlet.
(4), at press filtration clear liquid storage tank 4 abhiseca places, by F13, connect pure water (water-dialyzing) branch road.
(5), at press filtration clear liquid storage tank 4 abhisecas, connect into storage tank 4 by respiratory organ 3 and breathe outlet; Concentrated solution storage tank 6 abhisecas after the micro-filtration ultrafiltration, connect into concentrated solution storage tank 6 after the micro-filtration ultrafiltration by respiratory organ 7 and breathe outlet.
Operating process of the present invention:
(1), filter press operating process
Described as lower component: fermented liquid storage tank 1, valve F1, pump B1, plate-and-frame filter press 2, valve F2, valve F6, valve F5 form the filter press system; Wherein, valve F2 is plate press filtration purified liquor outlet valve, and F6 is the turbid solution reverse flow valve, and F5 is the fermented liquid variable valve.
Fermented liquid, under the driving of pump B1, through valve F1, pump B1, enters plate-and-frame filter press, and clear liquor enters plate press filtration clear liquid storage tank 4 through F2, completes the filter press process.Wherein:
1, exporting fermented liquid variable valve valve F5 in parallel with pump B1 functions as follows: 1, adjust the uninterrupted that plate-and-frame filter press 2 work initial stage pump B1 pump into fermented liquid, the filtering layer that accelerates plate-and-frame filter press 2 forms; Later stage is along with the filtering layer of plate-and-frame filter press 2 is more and more thicker, the machine internal pressure rises rapidly, filtration velocity slows down, open F5, release the fermented liquid that part pump B1 pumps into, allow plate-and-frame filter press 2 diaphragm cavity internal pressure risings, until the full solid filter residue of diaphragm cavity content, turn off again F5 and B1 pump, start pneumatics, press dry filter residue.
2, the turbid solution reverse flow valve F6 in parallel with plate-and-frame filter press 2 outlets functions as follows: at the 2 work initial stages of plate-and-frame filter press, filtering layer not yet forms or is not formed into enough thick, and a large amount of solid phases see through barrier film and enter filtrate, now, open F6, allow filtrate be back to storage tank, until plate-and-frame filter press 2 form enough thick filtering layer, filtrate enough limpid after, close F6, open valve F2, plate-and-frame filter press 2 works on, and filtrate flows to clear liquid storage tank 4 through valve F2, until this batch of filter press completes.
(ii), tubular membrane micro-filtration operating process
Described as lower component: press filtration clear liquid storage tank 4, valve F3, pump B2 and export pump B4 in parallel, valve F9, F7, F8, and outlet connect valve F4 etc. and form the tubular membrane microfiltration systems, wherein, pump B4, valve F9, micro-filtrate membrane filtration machine 5, outlet connect the formation tubular membrane filter recycle systems such as valve F4.
Open F3, ejector priming B2, the filter press clear liquid in press filtration clear liquid storage tank 4 pumps into the tubular membrane filter recycle system under pump B2 drives, and opens F9, start recycle pump B4, open F4, the filter press clear liquid, under the driving of B4, enters micro-filtrate membrane filtration machine 5 and obtains other clear liquid of micro-filtration level, clear liquid enters storage tank 6 by F4, raffinate continues continuous circulating filtration under the effect of B4, and simultaneously, B2 constantly supplements feed liquid in the micro-filtration recycle system; In the micro-filtration recycle system along with sludge concentration progressively improves, micro-filtration recycle system internal pressure can progressively raise, when reaching certain pressure, open valve F7, by raffinate release in storage tank 4 with tank in the clear liquid mixed diluting, close again F7 and continue aforesaid operations, until, after multi-pass operations, micro-filtration filtering system internal pressure is fluctuation no longer, while being stabilized in set(ting)value, illustrate that press filtration clear liquid storage tank 4 interior sludge concentrations are consistent with concentration in the micro-filtration filtering system, now micro-filtration filters and has approached the limit; Then, open F13, to the interior supplementary a certain amount of pure water of tank 4, residue in thinning tank, close F13, repeats above-mentioned micro-filtration operation, until the above results occurs; Then close F7, open F8, residue is pressed into to storage tank 1, residue is carried out to filter press, now complete the operation of tubular membrane micro-filtration.
(iii), rolled film ultrafiltration and concentration operating process
Described as lower component: concentrated solution storage tank 6 after the micro-filtration ultrafiltration, F10, B3, ultrafiltration membrance filter machine 8, F14, F15, F12, F11, and respiratory organ 7 form rolled film ultrafiltration and concentration systems.
Micro-filtration clear liquid after the micro-filtration ultrafiltration in concentrated solution storage tank 6 under the driving of pump B3, through valve F10, pump B3, enter ultra-filtration membrane thickner 8, the waste liquid such as small molecules and water is discharged through waste liquid outlet valve F12 through rolled film, concentrated solution is concentrated solution storage tank 6 after F14, the ultrafiltration of F15 backflow micro-filtration, aforesaid operations moves in circles, until the concentrated solution enzyme activity reaches necessary requirement, then turn off F15, open finished product outlet valve F11, concentrated solution is discharged to finished product storage tank through product outlet.
Respiratory organ F7 plays the concentrated solution storage tank 6 tank internal pressure effects after the micro-filtration ultrafiltration of regulating.
Claims (3)
1. a post-extraction production line for enzyme preparation fermentation, comprise plate-and-frame filter press, it is characterized in that:
The outlet of fermented liquid storage tank (1) is connected with the import of plate-and-frame filter press (2) by valve F1, pump B1, and the outlet of plate-and-frame filter press (2) is connected to press filtration clear liquid storage tank (4) by valve F2, forms the sheet frame press filteration system; The outlet of press filtration clear liquid storage tank (4) is connected with the import of micro-filtrate membrane filtration machine (5) by valve F3, pump B2, at pump B2, export, connect into a minor loop by pump B4, valve F9 and the outlet of micro-filtrate membrane filtration machine (5) trapped fluid, form the tubular type micro-filtration recycle system; The outlet of micro-filtrate membrane filtration machine (5) connects concentrated solution storage tank (6) after the micro-filtration ultrafiltration by valve F4, after the micro-filtration ultrafiltration, the outlet of concentrated solution storage tank (6) is connected with the import of spiral wound Membrane filtering machine (8) by valve F10, pump B3, at spiral wound Membrane filtering machine (8) trapped fluid, export, after F14, F15 by two series connection and micro-filtration ultrafiltration, concentrated solution storage tank (6) connects into a loop, forms the spiral wound membrane filtration system;
At press filtration clear liquid storage tank (4) abhiseca, connect into press filtration clear liquid storage tank (4) by respiratory organ (3) and breathe outlet; Concentrated solution storage tank (6) abhiseca after the micro-filtration ultrafiltration, connect into concentrated solution storage tank (6) after the micro-filtration ultrafiltration by respiratory organ (7) and breathe outlet;
In pump B1 outlet, connection valve F5 forms a branch road and is connected with fermented liquid storage tank (1), and plate-and-frame filter press (2) outlet connection valve F6 forms another branch road and is connected with fermented liquid storage tank (1);
In the outlet of micro-filtrate membrane filtration machine (5) trapped fluid, connect valve F9, F7 and press filtration clear liquid storage tank (4) and connect into a middle loop, connect F9, F8 and fermented liquid storage tank (1) and form a large loop.
2. post-extraction production line for enzyme preparation fermentation as claimed in claim 1, is characterized in that: in the outlet of spiral wound Membrane filtering machine (8) trapped fluid, connect F14, F11 and connect into a finished fluid outlet; At spiral wound Membrane filtering machine (8) purified liquor outlet, connect F12 and connect into waste liquid outlet.
3. post-extraction production line for enzyme preparation fermentation as claimed in claim 1, it is characterized in that: at press filtration clear liquid storage tank (4), the abhiseca place arranges F13, and connects the pure water branch road by F13.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110278163 CN102399686B (en) | 2011-09-18 | 2011-09-18 | After-extraction production line for fermentation liquid of enzymic preparation |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 201110278163 CN102399686B (en) | 2011-09-18 | 2011-09-18 | After-extraction production line for fermentation liquid of enzymic preparation |
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| CN102399686A CN102399686A (en) | 2012-04-04 |
| CN102399686B true CN102399686B (en) | 2013-02-27 |
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| CN 201110278163 Expired - Fee Related CN102399686B (en) | 2011-09-18 | 2011-09-18 | After-extraction production line for fermentation liquid of enzymic preparation |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104817452B (en) * | 2014-12-19 | 2016-09-28 | 三达膜科技（厦门）有限公司 | A kind of method extracting abscisic acid from abscisic acid fermentation liquid |
| CN106834086B (en) * | 2017-02-23 | 2019-03-08 | 浙江兰博生物科技股份有限公司 | A kind of separation of fermentative broth device |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101857857A (en) * | 2010-05-18 | 2010-10-13 | 青岛康地恩生物科技有限公司 | Method for preparing food-grade acid pectase preparation |
| CN102154408A (en) * | 2011-01-13 | 2011-08-17 | 天津市工业微生物研究所 | Sclerotium rolfssii scleroglucan online fermentation extraction method and system |
| CN102399687A (en) * | 2011-09-18 | 2012-04-04 | 淮北市三和诺生物工程有限责任公司 | Multifunctional post-extraction production line for enzyme preparation fermentation liquid |
| CN202201899U (en) * | 2011-09-18 | 2012-04-25 | 淮北市三和诺生物工程有限责任公司 | Post extraction product line for fermentation liquor of enzymic preparations |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101857857A (en) * | 2010-05-18 | 2010-10-13 | 青岛康地恩生物科技有限公司 | Method for preparing food-grade acid pectase preparation |
| CN102154408A (en) * | 2011-01-13 | 2011-08-17 | 天津市工业微生物研究所 | Sclerotium rolfssii scleroglucan online fermentation extraction method and system |
| CN102399687A (en) * | 2011-09-18 | 2012-04-04 | 淮北市三和诺生物工程有限责任公司 | Multifunctional post-extraction production line for enzyme preparation fermentation liquid |
| CN202201899U (en) * | 2011-09-18 | 2012-04-25 | 淮北市三和诺生物工程有限责任公司 | Post extraction product line for fermentation liquor of enzymic preparations |
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