CN102397370A - Submicron powder Jinfang Baidu San normal temperature preparation method and special two-way airflow screen grader - Google Patents
Submicron powder Jinfang Baidu San normal temperature preparation method and special two-way airflow screen grader Download PDFInfo
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Abstract
The invention discloses a submicron powder Jinfang Baidu San normal temperature preparation method, which comprises the following steps that: herba schizonepetae, divaricate saposhnikovia root, notopterygium root, heracleum hemsleyanum michaux, radix bupleuri, peucedanum root, bitter orange, tuckahoe, balloon flower, rhizoma ligustici wallichii, liquorice and field mint are selected, dried and pulverized into coarse powder, the coarse powder is uniformly blended according to a proportion and is placed into a rod mill to be pulverized, the pulverized powder is blown into a special two-way airflow screen grader to pass through a 500-mesh sieve, the powder passing the sieve and having the granularity being less than or equal to 25 micrometers is conveyed into a cyclone collector to collect by airflow produced by a draught fan to obtain the submicron powder Jinfang Baidu San finished product; and powders which cannot pass through the 500-mesh sieve are collected by a funnel and are conveyed into the rod mill through a pipeline to be circularly pulverized. The submicron powder Jinfang Baidu San has advantages that: the entire preparation process is carried out under the normal temperature, no low temperature or other special additional conditions are required; the granularity of the prepared finished product medicine is less than or equal to 25 micrometers, so the cell wall breaking rate and the bioavailability are greatly improved; and the two-way airflow screen grader utilized in the method can simplify the preparation process of the submicron powder Jinfang Baidu San.
Description
Technical field
The present invention relates to the veterinary drug preparation field, especially relate to superfine powder Antiphlogistic Powder of Schizonepetae and Ledebouriellae normal temperature preparation method; The invention still further relates to the special-purpose two-way airflow screening machine that is used for this method.
Background technology
Chinese herbal medicine is carrying out having the incomparable superiority of other chemical synthetic drugs aspect the prevention and treatment of diseases: safe, toxic and side effects is little, effective ingredient is many, hazard residue is few, action target spot is many; Can bring into play combined effect; Be difficult for producing drug resistance, scalable immunity of organisms, enhancing body resistance against diseases in anti-bacteria and anti-virus.More and more stress food safety in the our times various countries, call under green, the ecological overall background, apply prevention and the control that herbal medicine carries out Animal diseases and be of great practical significance.
The present invention adopts the prescription of " People's Republic of China's veterinary drug allusion quotation " in 2010 two Antiphlogistic Powder of Schizonepetae and Ledebouriellae that record of version, this side's effect: relieving the exterior syndrome by diaphoresis, the wind damp eliminating of loosing.Mostly the Antiphlogistic Powder of Schizonepetae and Ledebouriellae that is applied to birds at present is the powder of coarse pulverization; Have deficiencies such as dosage is big, dosage form thick, appearance poor, effective ingredient can not fully discharge, and bioavailability is low; Have a strong impact on Chinese medicine quality and clinical therapeutic efficacy, and can not directly add the drinking-water use.
The broken technology of Chinese medicine ultra-fine powder is renewal and the development to traditional crushing technology; It had both kept the advantage of Chinese medicine technology of preparing; Injected new vitality for the modern production of Chinese medicine again; Have a extensive future, but in actual production, remain in some problems and a difficult problem: (1) production efficiency is low, the power consumption height is the principal element of restriction Chinese medicine ultra-fine powder large-scale production for animals.Rod mill is in traditional closed circuit method crushing process; When most of material has reached fineness requirement, always there is few part coarse powder to be mixed in wherein, make this part coarse powder further be crushed to the granularity that requires need prolong the pulverizing time significantly; Make crush efficiency reduce, power consumption significantly increases; (2) it is poor that there are the material particular diameter uniformity after the classification in selecting crude drugs with winnower classification and grading wheel classification; Influenced the quality of production of herbal medicine compound recipe superfine powder greatly; Especially when being applied to the use of animal drinking-water, because a small amount of not existence of breaking cellular wall cell is difficult to reach instructions for use.(3) traditional one-way gas flow is sieved, because Chinese medicine is when carrying out micronizing, along with reducing of particle diameter; Material particles surface area and surface energy increase; Adsorptivity increases, and mobile variation is prone to be gathered into bulky grain etc. and causes the sieve classification of crossing that surpasses 200 order fineness medicated powder to be difficult to carry out.The existence of above-mentioned factor has had a strong impact on standardization, the large-scale production of herbal medicine superfine powder, and popularization on veterinary clinic and use.
Summary of the invention
The object of the invention is to provide a kind of rapid-action, good effect, bioavailability is high, the clinical application amount is few superfine powder Antiphlogistic Powder of Schizonepetae and Ledebouriellae normal temperature preparation method.
Another purpose of the present invention is to provide a kind of special-purpose two-way airflow screening machine that is applied to superfine powder Antiphlogistic Powder of Schizonepetae and Ledebouriellae normal temperature preparation method.
Superfine powder Antiphlogistic Powder of Schizonepetae and Ledebouriellae normal temperature preparation method of the present invention comprises the steps:
The first step, choose crude drug Herba Schizonepetae, windproof, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Radix Bupleuri, Radix Peucedani, Fructus Aurantii, Poria, Radix Platycodonis, Rhizoma Chuanxiong, Radix Glycyrrhizae, Herba Menthae, clean, dry naturally, cut into long section of 3-5cm, through natural drying or dry to moisture≤10%;
Second the step, under 20 ℃～25 ℃ temperature with above-mentioned raw materials medicine pulverize separately, obtain granularity 60～80 purpose Chinese medicine coarse powder;
The 3rd step, with above-mentioned raw materials medicine coarse powder according to Herba Schizonepetae: windproof: Rhizoma Et Radix Notopterygii: Radix Angelicae Pubescentis: Radix Bupleuri: Radix Peucedani: Fructus Aurantii: Poria: Radix Platycodonis: Rhizoma Chuanxiong: Radix Glycyrrhizae: the weight portion ratio mix homogeneously of Herba Menthae=9:6:5:5:6:5:6:9:6:5:3:3;
The 4th step, with the 3rd step gained coarse powder place pulverize in the rod mill after; Be fed into special-purpose two-way airflow screening machine through wind and cross 500 mesh sieves, the air-flow that the powder that obtains particle diameter≤25 micron of sieving is produced by air-introduced machine is transported to collect in the tornado feeder set and promptly gets superfine powder Antiphlogistic Powder of Schizonepetae and Ledebouriellae finished product; The powder of not crossing 500 mesh sieves arrives circulation pulverizing once more in the said rod mill through the funnel collection and through line transportation.Finished product superfine powder Antiphlogistic Powder of Schizonepetae and Ledebouriellae is sub-packed in the aluminium foil bag, and every bag weighs 100g, 200g, 500g, 1000g, 2000g etc.
Special-purpose two-way airflow screening machine of the present invention comprises JIKE and sets within it the downward screen drum of chamber intermediate openings, the order number of said screen drum >=500 orders; The nozzle of screen drum is connected with the funnel upper shed that is arranged on the JIKE bottom mutually; Chassis cavity is connected with air-introduced machine through the negative pressure chamber on top; Be provided with the door font rotating spraying trachea that constitutes by transverse tube and standpipe in the zone between screen drum and JIKE; The puff prot of said door font rotating spraying trachea is for axially being opened in the groove on its tube wall along said transverse tube and standpipe respectively; Said groove is offered towards the screen drum direction respectively; The groove width 0.5-2 millimeter of groove, the middle part of transverse tube and drive motors driving coupling; Be provided with blast pipe in the screen drum centre position, the air outlet of said blast pipe passes screen drum and is connected with the transverse tube middle part of door font rotating spraying trachea and is connected through the rolling bearing rolling; The air inlet of blast pipe extends outside the said hopper side walls and is connected with the blast orifice of aerator; In screen drum, be provided with feed pipe, above the discharging opening of said feed pipe, be provided with the buffering umbrella, the charging aperture of feed pipe extends outside the hopper side walls and is communicated with powder conveying fan air outlet through wind stopping device.
The air inducing of said air-introduced machine is pressed and is 1000pa, and the air inducing amount is 3000m
3/ h; The rotating speed of said drive motors is 155 rev/mins; The blast pressure of said aerator is 33kpa, and the blow rate required is 320m
3/ h; The wind pressure that goes out of said powder conveying fan is 24kpa, and air output is 150m
3/ h; The sidewall of said screen drum and roof respectively with corresponding standpipe and transverse tube between distance be 25 millimeters.
The invention has the advantages that whole process of preparation all carries out at normal temperatures, do not need low temperature or special additional conditions; Final drug particle diameter≤25 micron of preparation; Improve cell wall breaking rate (sporoderm-broken rate reaches more than 95%) and bioavailability greatly, strengthened pharmacological action, thereby reduced treatment disease dosage; Practiced thrift medical material; Also improve simultaneously the abnormal smells from the patient and the mouthfeel of medicine, make and directly adopt the water way administration to be achieved, changed the deficiency that Chinese powder medicine can only spice can not be drunk water and take; The Antiphlogistic Powder of Schizonepetae and Ledebouriellae of ultra micro powder can evenly stick on the animal pellet feed simultaneously, has solved particulate material and can not mix the problem of using with Chinese medicine; The two-way airflow screening machine that uses in the inventive method has been simplified the preparation technology of superfine powder Antiphlogistic Powder of Schizonepetae and Ledebouriellae greatly, has realized the purpose that the Chinese powder medicine quality standard is controlled, be suitable for large-scale industrial production.
The clinical therapeutic efficacy of preparation of the present invention obtains checking through following test:
Test examples 1, the test of Jingfang toxicity-removing powder ultramicro powder preparation treatment infectious bronchitis of chicken
1. experiment material
1.1 virus:
Avian infectious bronchitis virus chick embryo allantoic liquid (M
41, 2 * 10
5.4ED
50), the standard strain that experiment uses antibacterial to provide as Microbiological Lab of Agricultural University Of He'nan.
1.2 laboratory animal: the healthy extra large blue laying hen of 25 ages in days is public young
1.3 medicine:
Jingfang toxicity-removing powder ultramicro powder: adopt the present invention's preparation.
Antiphlogistic Powder of Schizonepetae and Ledebouriellae: according to second one of " Chinese veterinary drug allusion quotation " version in 2010, in prepared in laboratory.
2. experimental technique
2.1 test is divided into groups:
Be divided into and be Jingfang toxicity-removing powder ultramicro powder, Antiphlogistic Powder of Schizonepetae and Ledebouriellae, positive controls and four groups of blank, 50/group.A positive controls counteracting toxic substances, not medication treatment; Blank is counteracting toxic substances not, a medication.Application method is a spice, dose 15g/kg.
2.2 seed culture of viruses inocalation method:
Test chicken is intramuscular injection inoculation avian infectious bronchitis virus allantoic fluid 1ml respectively.
2.3 clinical observation on the therapeutic effect:
The artificial challenge begins dispensing after 3 days, free choice feeding, and logotype 5 days, the drug withdrawal continued was observed 5 days, and experimental period is 10 days.Note observing chicken crowd clinical event every day, log cuts open and examines the chicken that dies of illness, and observes pathological changes, confirms the cause of the death.
3. treatment experimental result
Jingfang toxicity-removing powder ultramicro powder, Antiphlogistic Powder of Schizonepetae and Ledebouriellae and chloromycetin treatment infectious bronchitis of chicken outcome record are seen table 1.Can be found out by table 1: Jingfang toxicity-removing powder ultramicro powder group is compared with the blank group, and the therapeutical effect significant difference explains that the Jingfang toxicity-removing powder ultramicro powder has the effect of treatment infectious bronchitis of chicken; Jingfang toxicity-removing powder ultramicro powder group and Antiphlogistic Powder of Schizonepetae and Ledebouriellae group have significant difference to above-mentioned therapeutical effect, and are superior to the Antiphlogistic Powder of Schizonepetae and Ledebouriellae group.
Table 1 Jingfang toxicity-removing powder ultramicro powder, Antiphlogistic Powder of Schizonepetae and Ledebouriellae treatment infectious bronchitis of chicken
Test examples 2, the test of Jingfang toxicity-removing powder ultramicro powder treatment avian influenza virus
1. experiment material
1.1 virus:
Chicken fowl H5N1 influenza virus chick embryo allantoic liquid (is called for short GD, 2 * 10
5.4ED
50), the standard strain that experiment uses antibacterial to provide as Microbiological Lab of Agricultural University Of He'nan.
1.2 laboratory animal: the healthy extra large blue laying hen of 42 ages in days is public young
1.3 medicine:
Jingfang toxicity-removing powder ultramicro powder: adopt the present invention's preparation.
Antiphlogistic Powder of Schizonepetae and Ledebouriellae: according to second one of " Chinese veterinary drug allusion quotation " version in 2010, in prepared in laboratory.
2. experimental technique
2.1 test is divided into groups:
Be divided into and be Jingfang toxicity-removing powder ultramicro powder, Antiphlogistic Powder of Schizonepetae and Ledebouriellae, positive controls and four groups of blank, 50/group.A positive controls counteracting toxic substances, not medication treatment; Blank is counteracting toxic substances not, a medication.Application method is a spice, dose 15g/kg.
2.2 seed culture of viruses inocalation method: test chicken is intramuscular injection inoculation avian infectious bronchitis virus allantoic fluid 1ml respectively.
2.3 clinical observation on the therapeutic effect:
The artificial challenge begins dispensing after 3 days, free choice feeding, and logotype 5 days, the drug withdrawal continued was observed 5 days, and experimental period is 7 days.Note observing chicken crowd clinical event every day, log cuts open and examines the chicken that dies of illness, and observes pathological changes, confirms the cause of the death.
3. treatment experimental result
Jingfang toxicity-removing powder ultramicro powder and Antiphlogistic Powder of Schizonepetae and Ledebouriellae treatment avian influenza virus outcome record are seen table 2.Can be found out by table 2: Jingfang toxicity-removing powder ultramicro powder group is compared with the blank group, and the therapeutical effect significant difference explains that the Jingfang toxicity-removing powder ultramicro powder has treatment avian influenza virus function; Jingfang toxicity-removing powder ultramicro powder group and Antiphlogistic Powder of Schizonepetae and Ledebouriellae group have significant difference to above-mentioned therapeutical effect, and are superior to the Antiphlogistic Powder of Schizonepetae and Ledebouriellae group.
Table 2 Jingfang toxicity-removing powder ultramicro powder, Antiphlogistic Powder of Schizonepetae and Ledebouriellae treatment avian influenza virus
| Group | The Jingfang toxicity-removing powder ultramicro powder | Antiphlogistic Powder of Schizonepetae and Ledebouriellae | Positive control | Blank |
| Laboratory animal number (only) | 50 | 50 | 50 | 50 |
| Death toll (only) on the 3rd | 4 | 5 | 4 | 0 |
| Death toll (only) on the 4th | 10 | 12 | 14 | 0 |
| Death toll (only) on the 5th | 6 | 8 | 12 | 0 |
| Death toll (only) on the 6th | 2 | 8 | 10 | 0 |
| Death toll (only) on the 7th | 1 | 4 | 7 | 0 |
| Total death toll (only) | 23 | 37 | 47 | 0 |
| Mortality rate (%) | 46 | 74 | 94 | 0 |
| Cure rate (%) | 54 | 26 | —— | —— |
Description of drawings
Fig. 1 is the production equipment system figure of the method for the invention.
Fig. 2 is the structural representation of special-purpose two-way airflow screening machine according to the invention.
The specific embodiment
Like Fig. 1, shown in 2, superfine powder Antiphlogistic Powder of Schizonepetae and Ledebouriellae normal temperature preparation method of the present invention comprises the steps:
The first step, choose crude drug Herba Schizonepetae, windproof, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Radix Bupleuri, Radix Peucedani, Fructus Aurantii, Poria, Radix Platycodonis, Rhizoma Chuanxiong, Radix Glycyrrhizae, Herba Menthae, clean, dry naturally, cut into long section of 3-5cm, through natural drying or dry to moisture≤10%;
Second the step, under 20 ℃～25 ℃ temperature with above-mentioned raw materials medicine pulverize separately, obtain granularity 60～80 purpose Chinese medicine coarse powder;
The 3rd step, with above-mentioned raw materials medicine coarse powder according to Herba Schizonepetae: windproof: Rhizoma Et Radix Notopterygii: Radix Angelicae Pubescentis: Radix Bupleuri: Radix Peucedani: Fructus Aurantii: Poria: Radix Platycodonis: Rhizoma Chuanxiong: Radix Glycyrrhizae: the weight portion ratio mix homogeneously of Herba Menthae=9:6:5:5:6:5:6:9:6:5:3:3;
The 4th goes on foot, at first opens powder conveying fan 15, air-introduced machine 5, aerator 11, drive motors 8.The blow pressure of powder conveying fan 15 is 24kpa, and the blowing amount is 150m
3/ h; The air inducing of air-introduced machine 5 is pressed and is 1000pa, and the air inducing amount is 3000m
3/ h; The blast pressure of aerator 11 is 33kpa, blow rate required 320m
3/ h; The rotating speed of drive motors 8 is 155 rev/mins;
1, with the 3rd step gained coarse powder place pulverize in the rod mill 16 after; Powder body to be fractionated is arranged in the downward screen drum 2 of JIKE 1 inner chamber intermediate openings being brought into by high velocity air through wind stopping device 14, feed pipe 12 under the power of the blowing effect of powder conveying fan 15 in the rod mill 16; And, powder body to be fractionated is disperseed in screen drum 2 through the impulsive force of buffering umbrella 13 reduction powder body to be fractionated in screen drum 2; The order number of screen drum 2 is 500 orders;
2, dispersive powder body to be fractionated carries out classification through screen drum 2 in the screen drum 2 under air-introduced machine 5 effects, and fine powder negative pressure chamber 4 through JIKE 1 top under the negative-pressure air-flow effect that air-introduced machine 5 produces of passing screen drum 2 is transported to collect in the tornado feeder set 17 and promptly gets superfine powder Antiphlogistic Powder of Schizonepetae and Ledebouriellae finished product.The powder body sinking warp through screen drum 2 is collected with the funnel 3 that screen drum 2 under sheds are connected mutually and is transported in the said rod mill 16 circulation once more through pipeline 18 and pulverizes;
3, door font rotating spraying trachea rotates through rolling bearing 10 under drive motors 8 drives; The wind that aerator 11 is seen off is in blast pipe 9 gets into said transverse tube 6 and standpipe 7; And through be opened in the puff prot ejection that has the groove structure on transverse tube 6 and standpipe 7 tube walls respectively vertically towards screen drum 2 directions; Form the evenly blowback air-flow in screen drum 2 at screen drum 2 end faces and side; Powder body in the screen drum 2 is further atomized, stop powder body on screen drum 2, to lump simultaneously and stop up sieve screen apertures, make the powder body that does not pass through screen drum 2 along with the air-flow whirlpool that forms sinks to getting in the funnel 3.The groove width that is opened in groove on transverse tube 6 and standpipe 7 tube walls is respectively vertically selected between 0.5 millimeter-2 millimeters as required, between the roof of transverse tube 6 and standpipe 7 and corresponding screen drum 2 and the sidewall apart from being respectively 25 millimeters.
The superfine powder Antiphlogistic Powder of Schizonepetae and Ledebouriellae finished product of preparation is sub-packed in the aluminium foil bag and stores, every bag heavy 500g or 1000g.
Claims (3)
1. a superfine powder Antiphlogistic Powder of Schizonepetae and Ledebouriellae normal temperature preparation method is characterized in that: comprise the steps:
The first step, choose crude drug Herba Schizonepetae, windproof, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Radix Bupleuri, Radix Peucedani, Fructus Aurantii, Poria, Radix Platycodonis, Rhizoma Chuanxiong, Radix Glycyrrhizae, Herba Menthae, clean, dry naturally, cut into long section of 3-5cm, through natural drying or dry to moisture≤10%;
Second the step, under 20 ℃～25 ℃ temperature with above-mentioned raw materials medicine pulverize separately, obtain granularity 60～80 purpose Chinese medicine coarse powder;
The 3rd step, with above-mentioned raw materials medicine coarse powder according to Herba Schizonepetae: windproof: Rhizoma Et Radix Notopterygii: Radix Angelicae Pubescentis: Radix Bupleuri: Radix Peucedani: Fructus Aurantii: Poria: Radix Platycodonis: Rhizoma Chuanxiong: Radix Glycyrrhizae: the weight portion ratio mix homogeneously of Herba Menthae=9:6:5:5:6:5:6:9:6:5:3:3;
The 4th step, with the 3rd step gained coarse powder place pulverize in the rod mill (16) after; Be fed into special-purpose two-way airflow screening machine through wind and cross 500 mesh sieves, the air-flow that the powder that obtains particle diameter≤25 micron of sieving is produced by air-introduced machine (5) is transported to collect in the tornado feeder set (17) and promptly gets superfine powder Antiphlogistic Powder of Schizonepetae and Ledebouriellae finished product; The powder of not crossing 500 mesh sieves is transported to circulation pulverizing once more in the said rod mill (16) through funnel (3) collection and through pipeline (18).
2. according to the special-purpose two-way airflow screening machine of the said superfine powder Antiphlogistic Powder of Schizonepetae and Ledebouriellae of claim 1 normal temperature preparation method, it is characterized in that: comprise JIKE (1) and the downward screen drum of chamber intermediate openings (2) that sets within it, the order number of said screen drum (2) >=500 orders; The nozzle of screen drum (2) is connected with funnel (3) upper shed that is arranged on JIKE (1) bottom mutually; JIKE (1) inner chamber is connected with air-introduced machine (5) through the negative pressure chamber (4) on top; Zone being positioned between screen drum (2) and the JIKE (1) is provided with the door font rotating spraying trachea that is made up of transverse tube (6) and standpipe (7); The puff prot of said door font rotating spraying trachea is for axially being opened in the groove on its tube wall along said transverse tube (6) and standpipe (7) respectively; Said groove is offered towards screen drum (2) direction respectively; The groove width 0.5-2 millimeter of groove, the middle part of transverse tube (6) and drive motors (8) driving coupling; Be provided with blast pipe (9) in screen drum (2) centre position, the air outlet of said blast pipe (9) passes screen drum (2) and is connected with transverse tube (6) middle part of door font rotating spraying trachea and is connected through rolling bearing (10) rolling; The air inlet of blast pipe (9) extends outside said funnel (3) sidewall and is connected with the blast orifice of aerator (11); In screen drum (2), be provided with feed pipe (12); Be provided with buffering umbrella (13) in the discharging opening of said feed pipe (12) top, the charging aperture of feed pipe (12) extends outside funnel (3) sidewall and is communicated with powder conveying fan (15) air outlet through wind stopping device (14).
3. special-purpose two-way airflow screening machine according to claim 2 is characterized in that: the air inducing of said air-introduced machine (5) is pressed and is 1000pa, and the air inducing amount is 3000m
3/ h; The rotating speed of said drive motors (8) is 155 rev/mins; The blast pressure of said aerator (11) is 33kpa, and the blow rate required is 320m
3/ h; The wind pressure that goes out of said powder conveying fan (15) is 24kpa, and air output is 150m
3/ h; The sidewall of said screen drum (2) and roof respectively with corresponding standpipe (7) and transverse tube (6) between distance be 25 millimeters.
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| CN104825872A (en) * | 2015-05-07 | 2015-08-12 | 河南省康星药业股份有限公司 | Normal-temperature preparation and thin-layer identification method of ultrafine powder capable of clearing heat and removing toxicity |
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