CN102379972B - Medicament for treating leukotrichia and calvities and preparation method thereof - Google Patents

Medicament for treating leukotrichia and calvities and preparation method thereof Download PDF

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CN102379972B
CN102379972B CN 201110374635 CN201110374635A CN102379972B CN 102379972 B CN102379972 B CN 102379972B CN 201110374635 CN201110374635 CN 201110374635 CN 201110374635 A CN201110374635 A CN 201110374635A CN 102379972 B CN102379972 B CN 102379972B
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CN102379972A (en
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刘东海
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Abstract

The invention relates to the field of traditional Chinese medicine and specifically relates to a medicament for treating leukotrichia and calvities and a preparation method thereof. The invention aims at providing the medicament which has no toxicity or side effects, can radically treat the leukotrichia and the calvities and further has the hair-growing effect, and the medicament comprises the following components in parts by weight: 500-600 parts of fleece-flower root (prepared with black bean), 400-500 parts of radix rehmanniae preparata, 400-500 parts of glossy privet fruit, 100-200 parts of Chinese angelica, 100-200 parts of membranous milkvetch root, 100-150 parts of ginseng and 100-150 parts of Szechuan lovage rhizome. The invention further provides medicinal liquor of the medicament and the preparation method thereof, and the preparation method comprises the following steps: weighing medicinal materials according to the formula, adding liquor for soaking, filtering, squeezing medicine residue, clarifying, performing fine filtration, adjusting the taste and adjusting the alcoholic strength. The invention further provides tablets or capsules of the medicament and the preparation method thereof, and the preparation method comprises the following steps: weighing the medicinal materials according to the formula, smashing, performing decoction, filtering, concentrating, drying and preparing into the tablets or the capsules. The medicament has obvious efficacy for the leukotrichia and the calvities and also has the treatment effect for prostatis, heart disease, kidney disease and muscular rigidity caused by qi and blood deficiency.

Description

Medicine for the treatment of hoariness and alopecia and preparation method thereof
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of medicine for the treatment of hoariness and alopecia and preparation method thereof.
Background technology
Nowadays, poliosis, alopecia have become the day by day serious problem of puzzlement people life.For solving the poliosis problem, the hair colouring methods that adopt are dyed black with hair dye with poliosis more at present.But this method just changes the outward appearance of hair, there is no therapeutical effect, and contains harmful chemical substance in the hair dye more, and life-time service can cause to a certain extent injury to human body.For the alopecia problem, basically male pattern baldness problem namely, how to treat with hormone medicine at present, namely by estrogen class medicament adjusting patient endocrine, reduce in a short period of time androgen secretion, effectively improve the greasy phenomenon of scalp, thereby effectively suppress alopecia and poliosis.It is careful that but the use of hormone needs, if the dosage improper use is easy to cause steroid-dependent dermatitis, allows user suffer from more disease; Muliebrity etc. perhaps occurs, it is physically and mentally healthy to affect the patient.
Summary of the invention
The purpose of this invention is to provide a kind of nontoxic, side effect, can fundamentally treat poliosis, alopecia and have the medicine of hair regrowth; And provide the preparation method of this medicine.
For achieving the above object, the invention provides a kind of medicine for the treatment of hoariness and alopecia, comprise the component of following weight portion: the Radix Polygoni Multiflori (Semen sojae atricolor system) 500-600, Radix Rehmanniae Preparata 400-500, Fructus Ligustri Lucidi 400-500, Radix Angelicae Sinensis 100-200, Radix Astragali 100-200, Radix Ginseng 100-150, Rhizoma Chuanxiong 100-150.
Preferably, the medicine for the treatment of hoariness and alopecia also comprises the component of following weight portion: Rhizoma Polygonati 100-200, Fructus Lycii 100-200.
Preferably, the medicine for the treatment of hoariness and alopecia also comprises the component of following weight portion: Rhizoma Polygonati 100-200, Fructus Lycii 100-200, Rhizoma Polygonati Odorati 100-200, Herba Ecliptae 200-300.
The most preferably prescription of the medicine for the treatment of hoariness and alopecia is (weight portion): the Radix Polygoni Multiflori (Semen sojae atricolor system) 530-550, Radix Rehmanniae Preparata 450-470, Fructus Ligustri Lucidi 450-470, Radix Angelicae Sinensis 120-150, Radix Astragali 120-150, Radix Ginseng 110-130, Rhizoma Chuanxiong 120-140, Rhizoma Polygonati 150-170, Fructus Lycii 140-160, Rhizoma Polygonati Odorati 150-180, Herba Ecliptae 250-270.
The present invention also provide a kind of usefulness medicated wine that above-mentioned processing of medical material forms with and preparation method thereof, described medicated wine adopts the described processing of medical material of aforesaid any one to form.
Concocting method can be: component takes by weighing corresponding medical material by weight, in medical material, add soaking in Chinese liquor, soak after filtration, namely get medicated wine after squeezing medicinal residues, clarification, fine straining, seasoning and the rectification precision, the disposable adding of described Chinese liquor soaked 1 month or at twice equivalent add and respectively soak two weeks.
Specifically namely: component takes by weighing corresponding medical material by weight, add 50 °~60 ° weight ratios with medical material in the medical material and be 100: 15 soaking in Chinese liquor, stir 1 the first every day in week, second week stirred 1 time in per 2 days, third and fourth per 3 days of week stirs 1 time, after 1 month soak, soak is after filtration, namely get medicated wine after squeezing medicinal residues, clarification, fine straining, seasoning and the rectification precision.
Perhaps component takes by weighing corresponding medical material by weight, in medical material, add 50 °~60 ° soaking in Chinese liquor, stir every day 1 time, get soak after 15 days, described soak gets filtrate after filtering, add in the above-mentioned medical material after filtering and 50 °~60 ° soaking in Chinese liquor of equivalent for the first time, stirred 1 time in per 2 days, and got soak after 15 days, described soak gets filtrate after filtering, then squeeze medicinal residues, reduce drug loss; Filtrate is merged, after clarification, fine straining, seasoning and rectification precision, namely get medicated wine.The above-mentioned total amount that adds Chinese liquor for twice is and the weight ratio of medical material 100: 15.
Adjust alcoholic strength and namely with the Chinese liquor of the higher or lower number of degrees alcoholic strength of medicated wine is adjusted to 40 °~50 °, to meet the alcohol drinking patterns of ordinary consumer.Namely taste, alcoholic strength are according to the alcohol drinking patterns adjustment of drinking person.
The usage and dosage of above-mentioned medicated wine: drink every day 1 to 2 time, each 50 to 100 milliliters, drink altogether 100 milliliters every day for good; This medicated wine can singly be drunk, can be with regard to food and drink, and the front drink of also can after meal or sleeping.
Taboo: this medicated wine can not be drunk with Other Drinks are mixed, and minor, anemia of pregnant woman, ethanol allergy sufferers are avoided drink; Must not drive motor vehicles after drinking or be engaged in high-risk operations.
The present invention also provides a kind of tablet that is prepared from said medicine or the preparation method of capsule and this tablet or capsule, comprise that component takes by weighing corresponding medical material by weight, the part of whole Radix Ginseng fleece-flower roots is ground into 100 order powder, except powder, all the other medical materials get concentrated solution after decocting, filter, concentrating, above-mentioned concentrated solution mixes with Radix Ginseng, radix polygoni multiflori powder, behind the spray-dried or vacuum drying 80~100 order medicated powder, above-mentioned medicated powder is equipped with suitable pharmaceutic adjuvant, makes pharmaceutically acceptable tablet or capsule.Medicinal residues after the decoction also compressible are processed, and reduce the loss of medicine active substance.
It is for the ease of convenient and dry and tabletting or packing after mixing with concentrated solution that the part medical material will be made powder.Why select Radix Ginseng then to be because it is comparatively famous and precious, all pulverize to have avoided decocting and thoroughly do not cause waste, because of the Radix Ginseng component less, so the Radix Polygoni Multiflori that will more easily pulverize also part pulverize.Concentrated solution will reduce moisture as far as possible is convenient to drying, but avoids being charred, and usually is controlled at moisture content 15-20%.So that concentrated solution is all absorbed by medicated powder, be convenient to the medicine oven dry, active ingredient is retained in the medicated powder.Namely Radix Ginseng, Radix Polygoni Multiflori powder and be moistening after concentrated solution mixes but still loose shape is easy to the processing such as follow-up drying most, the crushing quantity of the Radix Polygoni Multiflori is also as the benchmark flexible choice.
The usage and dosage of above-mentioned tablet or capsule: oral, day take 1 to 3 time, take 12 grams that total amount counts crude drug weight day to 18 grams, ante cibum or taking medicine after meal are taken before also can sleeping.
The pharmacological action of medicine of the present invention:
The traditional Chinese medical science is thought: " the kidney generating marrow and dominating bone, its Hua Zaifa ", " blood stored in the liver " and " hair is the sign of blood condition ", caused by liver and kidney deficiency, deficiency of YIN-blood, the deficiency of YIN is the excess of YANG then, and excess of YANG bringing about heat syndrome is had a surplus and body fluid cloth not, the not then exhausted and not hair care of hair follicle of cloth of body fluid, heat in blood blood stasis, QI and blood deficiency and not flourish.Work as deficiency of the liver and kindey, during blood and essence asthenia, crown hair follicle begins atrophy, and blood capillary attenuates, reduces around the hair follicle of the crown, and to the blood supply insufficiency of hair, then hair loses the nourishing of inherence and becomes greyish white or come off.
Based on above reason, core concept of the present invention is passage, nourishing blood, strengthens self hemopoietic function, blood vessel dilating, and blood circulation promoting strengthens autoimmunity, focuses on nourishing YIN in the time of the coordinating YIN and YANG balance.
The Radix Polygoni Multiflori (Semen sojae atricolor system) in the medicine of the present invention, Radix Rehmanniae Preparata have invigorating the liver and kidney, benefiting essence-blood, sharp liver, promote the effect of erythrocyte growth; Fructus Ligustri Lucidi has hemopoietic function, has that the cloudy blood of liver and kidney tonifying, clearind deficient heat, sharp liver, hair color make eye bright, the effect of strengthening the tendons and bones; Radix Angelicae Sinensis has the effect of the blood circulation and removing stasis blood tissue regeneration promoting blood of enriching blood; The Radix Astragali can be expanded whole body blood capillary, blood circulation promoting; The effect that Radix Ginseng has strongly invigorating primordial QI, promoting the production of body fluid to quench thirst, accent nutrition to defend; Rhizoma Chuanxiong has the effect of blood-activating and qi-promoting, wind-expelling pain-stopping, and it in head, promotes the head blood circulation with Radix Astragali combined effect; Rhizoma Polygonati, Rhizoma Polygonati Odorati have the effect of nourishing YIN; Fructus Lycii has the effect of tonifying kidney for improving eyesight; The effect of the favourable liver of Herba Ecliptae.
The specific selection of the accessory drugss such as compatibility, the especially Rhizoma Chuanxiong of the present invention by specific Chinese medicine, the Radix Astragali, Rhizoma Polygonati Odorati, Herba Ecliptae, it is remarkable to have made effect, the medicine of the treatment hoariness and alopecia of no side effects.
Medicine of the present invention confirms to have following beneficial effect by clinical trial:
1, take medicine of the present invention after 1 month, can reach the effect of hair anti-avulsion, it is blue or green that poliosis begins to turn, and without the dandruff, former hair color is more black.
2, take medicine of the present invention after 3 months, alopecia place begins to grow new, and it is blue or green that poliosis continues to turn, and youngster and patients with alopecia areata take effect can be faster.
3, young alopecia person (in the alopecia 5 years) takes medicine of the present invention successful after a year, the alopecia district all grow new and with old outward appearance zero difference, the most of blackening of poliosis.
4, middle aged alopecia person (three, 40 years old, 10 years alopecia histories are arranged approximately) takes medicine of the present invention successful after 2 years, and alopecia can all grow, and the large activation of hair returns to quantity before the alopecia, thickness, hardness, and poliosis disappears substantially.
5, alopecia in late period and poliosis person (four, five everyone 10 and older persons) take medicine of the present invention and took effect in 1 year, 2 years produce effects, 3 years basic original appearances of recovering.
6, medicine of the present invention also has therapeutical effect to prostatitis, heart disease, nephropathy, the muscular rigidity that causes of not living because of QI and blood.
The specific embodiment
The present invention is described in further detail below in conjunction with specific embodiment, and following examples are that the present invention is not limited to following examples to the explanation of invention.
Embodiment 1
Take by weighing corresponding medical material by following prescription: the Radix Polygoni Multiflori (Semen sojae atricolor system) 500g, Radix Rehmanniae Preparata 400g, Fructus Ligustri Lucidi 400g, Radix Angelicae Sinensis 100g, Radix Astragali 100g, Radix Ginseng 100g, Rhizoma Chuanxiong 100g.
In above-mentioned medical material, add 52 ° of Chinese liquor 11333g immersions, stir 1 the first every day in week, second week stirred 1 time in per 2 days, third and fourth per 3 days of week stirs 1 time, after 1 month soak, soak after filtration, squeezing medicinal residues, clarification, fine straining, namely get medicated wine after being 50 ° with crystal sugar seasoning and rectification precision.
Only need consider when wherein adjusting alcoholic strength that the number of degrees of raw material Chinese liquor and consumption get final product, need not calculate medicine and ooze the weight of medicated wine and the impact of the number of degrees, lower same.
Embodiment 2
Take by weighing corresponding medical material by following prescription: the Radix Polygoni Multiflori (Semen sojae atricolor system) 600g, Radix Rehmanniae Preparata 500g, Fructus Ligustri Lucidi 500g, Radix Angelicae Sinensis 200g, Radix Astragali 200g, Radix Ginseng 150g, Rhizoma Chuanxiong 150g, Rhizoma Polygonati 100g, Fructus Lycii 100g.
Add 60 ° of Chinese liquor 8333g immersions in above-mentioned medical material, stir every day 1 time, get soak after 15 days, described soak gets filtrate after filtering; The Chinese liquor 8333g that adds 50 ° in the above-mentioned medical material after filtering soaks, stirred 1 time in per 2 days, after 15 days soak, described soak after filtering filtrate, the squeezing medicinal residues get filtrate; Filtrate is merged, namely get medicated wine after being 45 ° through clarification, fine straining, with crystal sugar seasoning and rectification precision.
Embodiment 3
Take by weighing corresponding medical material by following prescription: the Radix Polygoni Multiflori (Semen sojae atricolor system) 530g, Radix Rehmanniae Preparata 450g, Fructus Ligustri Lucidi 450g, Radix Angelicae Sinensis 120g, Radix Astragali 150g, Radix Ginseng 110g, Rhizoma Chuanxiong 120g, Rhizoma Polygonati 200g, Fructus Lycii 200g, Rhizoma Polygonati Odorati 100g, Herba Ecliptae 200g.
5 one-tenth of the Radix Ginseng that will take by weighing by above-mentioned prescription, the Radix Polygoni Multiflori are ground into 100 order powder, except Radix Ginseng, Radix Polygoni Multiflori powder, all the other medical materials decoct and got concentrated solution in 5 hours after filtering, concentrating, above-mentioned concentrated solution mixes with Radix Ginseng, radix polygoni multiflori powder, get 80 order medicated powder after spray-dried, above-mentioned medicated powder is equipped with suitable pharmaceutic adjuvant, makes pharmaceutically acceptable tablet.
Embodiment 4
Take by weighing corresponding medical material by following prescription: the Radix Polygoni Multiflori (Semen sojae atricolor system) 550g, Radix Rehmanniae Preparata 470g, Fructus Ligustri Lucidi 470g, Radix Angelicae Sinensis 150g, Radix Astragali 150g, Radix Ginseng 130g, Rhizoma Chuanxiong 140g, Rhizoma Polygonati 150g, Fructus Lycii 140g, Rhizoma Polygonati Odorati 200g, Herba Ecliptae 300g.
5 one-tenth of the Radix Ginseng that will take by weighing by above-mentioned prescription, the Radix Polygoni Multiflori are ground into 100 order powder, except Radix Ginseng, Radix Polygoni Multiflori powder, all the other medical materials decoct and got concentrated solution in 6 hours after filtering, concentrating, above-mentioned concentrated solution mixes with Radix Ginseng, radix polygoni multiflori powder, behind vacuum drying, get 100 order medicated powder, above-mentioned medicated powder is equipped with suitable pharmaceutic adjuvant, makes pharmaceutically acceptable capsule.
Embodiment 5
Take by weighing corresponding medical material by following prescription: the Radix Polygoni Multiflori (Semen sojae atricolor system) 540g, Radix Rehmanniae Preparata 460g, Fructus Ligustri Lucidi 460g, Radix Angelicae Sinensis 135g, Radix Astragali 135g, Radix Ginseng 120g, Rhizoma Chuanxiong 130g, Rhizoma Polygonati 160g, Fructus Lycii 150g, Rhizoma Polygonati Odorati 165g, Herba Ecliptae 260g.
In above-mentioned medical material, add 50 ° of Chinese liquor 18100g immersions, stir 1 the first every day in week, second week stirred 1 time in per 2 days, third and fourth per 3 days of week stirs 1 time, after 1 month soak, soak after filtration, squeezing medicinal residues, clarification, fine straining, namely get medicated wine after being 40 ° with crystal sugar seasoning and rectification precision.
Following examples are in order to illustrate the beneficial effect of medicine of the present invention:
Embodiment 6
Liu, man, 65 years old, poliosis is bald, and poliosis accounts for 80%, 12 centimetres of the alopecia heads of district, wide 8 centimetres, the medicated wine of drinking the embodiment of the invention 1 after 1 month poliosis begin to turn blue or green, the alopecia district begins hair growth promoting after half a year, bald basic disappearance after 2 years, new hair growth promoting is hair color, and is by thin chap, normal gradually, except temples were greyish white, remainder is blackening all after 3 years.
Embodiment 7
Xiong, the man, 58 years old, poliosis was bald, drink the medicated wine of the embodiment of the invention 2 after, it is blue or green that poliosis turns gradually, begins hair growth promoting after 3 months, it is remarkable to drink after 1 year effect: former hair is almost complete white, existing most of blackening baldly disappears.
Embodiment 8
Tang, the man, 45 years old, suffered from alopecia areata 3 months in November, 2010, takes the tablet of the embodiment of the invention 3 after 2 months, and new growing now is normal hair.
Embodiment 9
Week certain, the man, 25 years old, suffer from the bald several years, work the capsule of taking the embodiment of the invention 4 in February, 2011 and namely begin hair generating after one week, now bald disappearance, the range estimation hair is normal, new only hardness is slightly less than old, still takes medicine adhering to.
The below illustrates the therapeutical effect of the disease that medicine of the present invention causes not living because of QI and blood with the clinical test results of the medicated wine of the embodiment of the invention 5:
Embodiment 10 (to prostatitic therapeutical effect)
Poplar, the man, 55 years old, certain company manager, the urine number of times is frequent, drinks this medicated wine after half a year, and the urine number of times reduces, and by per hour being kept to for 1 time 4 hours 1 time, it is normal that prostatic examination recovers.
Embodiment 11 (to prostatitic therapeutical effect)
Pan, the man, 65 years old, the retired professor, frequent micturition, urgent micturition can't be drunk this medicated wine after 3 months away from going into the street in the family, and the urine frequency is kept to nearly 2 hours 1 time.
Embodiment 12 (to prostatitic therapeutical effect)
Chen, the man, 46 years old, the long-distance driver, frequent micturition was drunk this medicated wine after 2 months, and the urine frequency is kept to 2~3 hours 1 time, and other symptom of prostatitis takes a turn for the better.
Embodiment 13 (to cardiopathic therapeutical effect)
Zhang, the man, 54 years old, desire for love disease of ZANG-organs in 2010 burst was in hospital, hospital diagnosis is myocardial infarction, leaves hospital after being ill, and is listless, pale complexion, general weakness, 2011 during the spring the mountain sweep a grave, tens meters ladder needs two people holding up.Begin in by the end of March, 2011 to drink this medicated wine, first day is drunk about 50 milliliters, and coughed night on the same day greatly, can not fall asleep, and after second day was drunk, cough was not drunk 50 milliliters before adhering to sleeping every night, and after 1 month, mental attitude improves a lot, and has rosy cheeks, and action is strong.Now taken this medicated wine 3 wheat harvesting periods, health is normal, and myocardial infarction never recurs.
Embodiment 14 (to the therapeutical effect of nephropathy)
Di, the woman, 56 years old, suffer from various diseases, can only walk more than 20 meter by apparatus for ride instead of walk, disappear when swollen during bipod in recent years, the urine color is red.In May in this year, both feet are swollen, can not wear footwear, and by it, recess is just loose for a long time.On May 10th, 2011 began to drink this medicated wine, and after 1 month, the bipod edema disappears entirely, can wear footwear and walk.
Embodiment 15 (to the therapeutical effect of muscular rigidity)
Fourth, the woman, 50 years old, bend over one's desk working for a long time, right arm was stiff in 2010, and is crooked, lift limitedly, in many ways seeks medical advice and has no result half a year, and the state of an illness is heavier.Drink this medicated wine after 1 month, the state of an illness has very large alleviation, can free bend and on lift.

Claims (10)

1. a medicine for the treatment of hoariness and alopecia is characterized in that: the component that comprises following weight portion: Semen sojae atricolor Radix Polygoni Multiflori Preparata 500-600, Radix Rehmanniae Preparata 400-500, Fructus Ligustri Lucidi 400-500, Radix Angelicae Sinensis 100-200, Radix Astragali 100-200, Radix Ginseng 100-150, Rhizoma Chuanxiong 100-150.
2. the medicine for the treatment of hoariness and alopecia according to claim 1 is characterized in that: the component that also comprises following weight portion: Rhizoma Polygonati 100-200, Fructus Lycii 100-200.
3. the medicine for the treatment of hoariness and alopecia according to claim 1, it is characterized in that: described medicine consisting of by weight: Semen sojae atricolor Radix Polygoni Multiflori Preparata 500-600, Radix Rehmanniae Preparata 400-500, Fructus Ligustri Lucidi 400-500, Radix Angelicae Sinensis 100-200, Radix Astragali 100-200, Radix Ginseng 100-150, Rhizoma Chuanxiong 100-150, Rhizoma Polygonati 100-200, Fructus Lycii 100-200, Rhizoma Polygonati Odorati 100-200, Herba Ecliptae 200-300.
4. the medicine for the treatment of hoariness and alopecia according to claim 1, it is characterized in that: described medicine consisting of by weight: Semen sojae atricolor Radix Polygoni Multiflori Preparata 530-550, Radix Rehmanniae Preparata 450-470, Fructus Ligustri Lucidi 450-470, Radix Angelicae Sinensis 120-150, Radix Astragali 120-150, Radix Ginseng 110-130, Rhizoma Chuanxiong 120-140, Rhizoma Polygonati 150-170, Fructus Lycii 140-160, Rhizoma Polygonati Odorati 150-180, Herba Ecliptae 250-270.
5. medicated wine for the treatment of hoariness and alopecia is characterized in that: described medicated wine adopts that the described processing of medical material of any one forms in the claim 1 to 4.
6. method of concocting medicated wine claimed in claim 5, it is characterized in that: comprise that component takes by weighing corresponding medical material by weight, in medical material, add soaking in Chinese liquor, soak after filtration, namely get medicated wine after squeezing medicinal residues, clarification, fine straining, seasoning and the rectification precision, the disposable adding of described Chinese liquor soaked 1 month or at twice equivalent add and respectively soak two weeks.
7. the method for process of preparing Chinese medicine medicated wine according to claim 6, it is characterized in that: total consumption of described Chinese liquor and the weight ratio of medical material are 100: 15.
8. the method for process of preparing Chinese medicine medicated wine according to claim 6, it is characterized in that: the alcoholic strength of described Chinese liquor is 50 °~60 °.
9. tablet or capsule for the treatment of hoariness and alopecia is characterized in that: described tablet or capsule adopt that the described medicine of any one is prepared from the claim 1 to 4.
10. method for preparing tablet claimed in claim 9 or capsule, it is characterized in that: comprise that component takes by weighing corresponding medical material by weight, the part of whole Radix Ginseng fleece-flower roots is ground into 100 order powder, except powder, all the other medical materials get concentrated solution after decocting, filter, concentrating, described concentrated solution mixes with Radix Ginseng, radix polygoni multiflori powder, behind the spray-dried or vacuum drying medicated powder, described medicated powder is equipped with suitable pharmaceutic adjuvant, make pharmaceutically acceptable tablet or capsule, the granularity of described medicated powder is 80~100 orders.
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