CN102379941A - Chinese medicinal compound preparation for treating fracture and preparation method thereof - Google Patents
Chinese medicinal compound preparation for treating fracture and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a Chinese medicinal compound preparation for treating fracture, which comprises the following Chinese medicine raw materials in part by weight: 8 to 12 parts of peach seed, 13 to 17 parts of safflower, 8 to 12 parts of Szechuan lovage rhizome, 8 to 12 parts of red paeony root, 8 to 12 parts of Chinese angelica, 8 to 12 parts of root of red-rooted salvia, 13 to 17 parts of fortune drynaria rhizome, 13 to 17 parts of Himalayan teasel root and 2 to 4 parts of notoginseng root (electuary). A preparation method comprises the following steps of: cleaning the nine medicinal materials, mixing in a ratio, adding water in an amount which is 4 to 7 times the total weight of the medicinal materials or 70 volume percent ethanol, decocting for two times, 80 minutes each time, mixing two-time decoction, filtering, and concentrating to obtain liquid extract of which the specific gravity is 1.18 at the temperature of 60 DEG C. The conventional preparation process is adopted. The preparation can be prepared into any one pharmaceutical formulation such as tablets, capsules, granules, oral liquid, pills and syrup. By the Chinese medicinal compound preparation prepared by the method, fracture healing time is obviously shortened, calluses grow more quickly, firmly and reliably, and the curative effect is far superior to that of the conventional Chinese medicine for treating the fracture.
Description
Technical field
The present invention relates to a kind of compound Chinese medicinal preparation of treating fracture and preparation method thereof, belong to field of traditional Chinese.
Background technology
Fracture is meant a kind of disease that causes sclerotin partially or completely to rupture owing to reasons such as wound or pathology.Its main clinical manifestation is: fractures has limitation pain and tenderness, local swelling and ecchymosis occurs, and limb function position or completely lose, the completeness sclerotin still cacomelia and abnormal movement can occur.
The treatment by Chinese herbs fracture has the history in thousands of years in China, and has obtained good effect.But union of fracture is the process of a complicacy; A lot of cytokines and multiple cell participation effect are arranged in this process; Deep research synthetism class Chinese medicine and compound recipe can better explain that for the mechanism of action of marrow stromal cell Chinese medicine promotes the process of union of fracture; Thereby more help the research of the modernization of Chinese medicine, can also from a large amount of pools of traditional Chinese medicine, pick out the medicine that more helps promoting union of fracture, and the medication of direct clinical.
Compound of Chinese medicine fracture prescription is complicated at present, and curative effect is still waiting to improve.
Summary of the invention
The object of the present invention is to provide a kind of Chinese traditional compound medicine of treating fracture and preparation method thereof.
The present invention provides the compound Chinese medicinal preparation of a kind of Semen Persicae, Flos Carthami, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Rhizoma Drynariae, Radix Dipsaci, Radix Notoginseng (dashing) compatibility to be used for the treatment fracture; Curative effect is better; Healing time obviously shortens, and growth of spur is more solid and reliable sooner.
Technical scheme of the present invention is following:
A kind of Chinese traditional compound medicine of treating fracture comprises the following weight Chinese medicinal raw materials: Semen Persicae 8-12, Flos Carthami 13-17, Rhizoma Chuanxiong 8-12, Radix Paeoniae Rubra 8-12, Radix Angelicae Sinensis 8-12, Radix Salviae Miltiorrhizae 8-12, Rhizoma Drynariae 13-17, Radix Dipsaci 13-17, Radix Notoginseng (dashing) 2-4.
Wherein method for preparing is that above-mentioned 9 flavor medical materials are cleaned, and proportional mixing, the 4-7 that adds medical material gross weight water or volume ratio doubly is that 70% ethanol decocts 2 times; Each 80 minutes, merge 2 times decoction liquor, filter; And concentrate, proportion is 1.18 fluid extract when obtaining 60 ℃, adopts conventional preparation technology; Chinese medicine preparation of the present invention can be made into said dosage form on any pharmaceutics, like tablet, capsule, granule, oral liquid, pill, syrup.
In the present invention's prescription, Semen Persicae increases cerebrovascular and peripheral blood vessel blood flow, anticoagulant is arranged, suppress thrombosis, antiinflammatory action; Flos Carthami promoting blood circulation to restore menstrual flow, reducing swelling and alleviating pain have the thrombosis of inhibition, antiinflammatory, analgesic effect, have the vasoconstrictive effect of eliminating epinephrine, norepinephrine, and " tonneau passages through which vital energy circulates " effect is arranged; The Radix Paeoniae Rubra sending down the abnormal ascending QI, enrich blood, removing blood stasis with potent drugs, Radix Paeoniae Rubra glucoside has pain relieving and anti-thrombosis function, and escherichia coli, Bacillus proteus, Hemolytic streptococcus etc. are had inhibitory action; Chinese angelica blood supplementing is invigorated blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation; Can increase peripheral red blood cells, leukocyte, hemoglobin and bone marrow karyosome cell number; Can reduce platelet aggregation and anti thrombotic action; The Radix Angelicae Sinensis decoct all has antibacterial action to escherichia coli, Hemolytic streptococcus, can reduce and organize inflammatory reaction; Radix Salviae Miltiorrhizae ability expelling wind and removing dampness, promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain improves the union of fracture environment, improves the union of fracture quality; The osteomiosis complementary energy promotes callus formation and ripe, reunion of fractured tendons and bones, and each medication combined effect has improved the treatment curative effect greatly in the prescription, and healing time obviously shortens, and growth of spur is more solid and reliable sooner, has satisfied the requirement of fracture patient to medicine.
Specific embodiment
Embodiment 1:
A kind of Chinese traditional compound medicine of treating fracture comprises the following weight Chinese medicinal raw materials: Semen Persicae 8, Flos Carthami 13, Rhizoma Chuanxiong 8, Radix Paeoniae Rubra 8, Radix Angelicae Sinensis 8, Radix Salviae Miltiorrhizae 8, Rhizoma Drynariae 13, Radix Dipsaci 13, Radix Notoginseng (dashing) 2.
Wherein method for preparing is that above-mentioned 9 flavor medical materials are cleaned, proportional mixing, and 4 times the decocting that adds the medical material gross weight boils 2 times, and each 80 minutes, merge 2 times decoction liquor, to filter, and concentrate, proportion is 1.18 fluid extract when obtaining 60 ℃.
Embodiment 2:
A kind of Chinese traditional compound medicine of treating fracture comprises the following weight Chinese medicinal raw materials: Semen Persicae 10, Flos Carthami 15, Rhizoma Chuanxiong 10, Radix Paeoniae Rubra 10, Radix Angelicae Sinensis 10, Radix Salviae Miltiorrhizae 10, Rhizoma Drynariae 15, Radix Dipsaci 15, Radix Notoginseng (dashing) 3.
All the other are with embodiment 1.
Embodiment 3:
A kind of Chinese traditional compound medicine of treating fracture comprises the following weight Chinese medicinal raw materials: Semen Persicae 12, Flos Carthami 17, Rhizoma Chuanxiong 12, Radix Paeoniae Rubra 12, Radix Angelicae Sinensis 12, Radix Salviae Miltiorrhizae 12, Rhizoma Drynariae 17, Radix Dipsaci 17, Radix Notoginseng (dashing) 4.
Wherein method for preparing is that above-mentioned 9 flavor medical materials are cleaned, proportional mixing, and 4 times of volume ratios that add the medical material gross weight are that 70% ethanol decocts 2 times, each 80 minutes, merges 2 times decoction liquor, filter, and concentrated, proportion is 1.18 fluid extract when obtaining 60 ℃.
Embodiment 4:
A kind of Chinese traditional compound medicine of treating fracture, wherein method for preparing is the medical material in the prescription to be cleaned proportional mixing; 5 times of volume ratios that add the medical material gross weight are that 70% ethanol decocts 2 times; Each 80 minutes, merge 2 times decoction liquor, filter; And concentrate, proportion is 1.18 fluid extract when obtaining 60 ℃.
All the other are with embodiment 1.
Embodiment 5:
A kind of Chinese traditional compound medicine of treating fracture, wherein method for preparing is the medical material in the prescription to be cleaned proportional mixing; 5 times the decocting that adds the medical material gross weight boils 2 times, each 80 minutes, merges 2 times decoction liquor; Filter, and concentrate, proportion is 1.18 fluid extract when obtaining 60 ℃.
All the other are with embodiment 2.
Embodiment 6:
A kind of Chinese traditional compound medicine of treating fracture, wherein method for preparing is the medical material in the prescription to be cleaned proportional mixing; 5 times the decocting that adds the medical material gross weight boils 2 times, each 80 minutes, merges 2 times decoction liquor; Filter, and concentrate, proportion is 1.18 fluid extract when obtaining 60 ℃.
All the other are with embodiment 3.
Embodiment 7:
A kind of Chinese traditional compound medicine of treating fracture, wherein method for preparing is the medical material in the prescription to be cleaned proportional mixing; 7 times of volume ratios that add the medical material gross weight are that 70% ethanol decocts 2 times; Each 80 minutes, merge 2 times decoction liquor, filter; And concentrate, proportion is 1.18 fluid extract when obtaining 60 ℃.
All the other are with embodiment 2.
Embodiment 8:
A kind of Chinese traditional compound medicine of treating fracture comprises the following weight Chinese medicinal raw materials: Semen Persicae 15, Flos Carthami 18, Rhizoma Chuanxiong 15, Radix Paeoniae Rubra 15, Radix Angelicae Sinensis 8, Radix Salviae Miltiorrhizae 8, Rhizoma Drynariae 10, Radix Dipsaci 8, Radix Notoginseng (dashing) 2.
Wherein method for preparing is that the medical material in the prescription is cleaned, proportional mixing, and 7 times the decocting that adds the medical material gross weight boils 2 times, and each 80 minutes, merge 2 times decoction liquor, to filter, and concentrate, proportion is 1.18 fluid extract when obtaining 60 ℃.
All the other are with embodiment 1.
Embodiment 9:
A kind of Chinese traditional compound medicine of treating fracture comprises the following weight Chinese medicinal raw materials: Semen Persicae 5, Flos Carthami 10, Rhizoma Chuanxiong 5, Radix Paeoniae Rubra 5, Radix Angelicae Sinensis 15, Radix Salviae Miltiorrhizae 15, Rhizoma Drynariae 20, Radix Dipsaci 18, Radix Notoginseng (dashing) 6.
Wherein method for preparing is that the medical material in the prescription is cleaned, proportional mixing, and 7 times of volume ratios that add the medical material gross weight are that 70% ethanol decocts 2 times, each 80 minutes, merges 2 times decoction liquor, filter, and concentrated, proportion is 1.18 fluid extract when obtaining 60 ℃.
All the other are with embodiment 3.
Embodiment 10:
A kind of Chinese traditional compound medicine of treating fracture comprises the following weight Chinese medicinal raw materials: Semen Persicae 7, Flos Carthami 18, Rhizoma Chuanxiong 7, Radix Paeoniae Rubra 12, Radix Angelicae Sinensis 7, Radix Salviae Miltiorrhizae 13, Rhizoma Drynariae 12, Radix Dipsaci 18, Radix Notoginseng (dashing) 1.
Wherein method for preparing is that above-mentioned 9 flavor medical materials are cleaned, proportional mixing, and 3 times the decocting that adds the medical material gross weight boils 2 times, and each 80 minutes, merge 2 times decoction liquor, to filter, and concentrate, proportion is 1.18 fluid extract when obtaining 60 ℃.
Embodiment 11:
Be disclosed a kind of Chinese medicine for oral administration prescription of treating fracture in 200510017445.1 the patent according to application number, comprise the following weight Chinese medicinal raw materials: 30 parts of purslane speedwell Herbas, 15 parts on Flos Carthami, 30 parts of Radix Angelicae Sinensis, 3 parts in Moschus, 15 parts of Radix Notoginseng, 15 parts in Semen Persicae, 30 parts of Herba speranskiae tuberculataes, 15 parts of Eupolyphaga Seu Steleophagas, 15 parts in catechu, 15 parts of Radix Dipsacis, 15 parts of Rhizoma Drynariae.
Wherein method for preparing is that the medical material in the prescription is cleaned, proportional mixing, and 5 times the decocting that adds the medical material gross weight boils 2 times, and each 80 minutes, merge 2 times decoction liquor, to filter, and concentrate, proportion is 1.18 fluid extract when obtaining 60 ℃.
Embodiment 12:
Be disclosed a kind of Chinese medicine composition of treating fracture and preparation method thereof in 201110008446.5 the patent according to application number, comprise following raw material of Chinese medicine: Radix Angelicae Sinensis 20g, Radix Paeoniae Rubra 20g, Rhizoma Chuanxiong 20g, Herba Asari 20g, Radix Dipsaci 20g, Cortex Eucommiae 20g, Rhizoma Drynariae 20g, ZHECHONG 20g, Flos Carthami 20g, Semen Persicae 20g, Caulis Spatholobi 20g, Ramulus Sambuci Williamsii 20g, Radix Achyranthis Bidentatae 20g, Herba speranskiae tuberculatae 20g, Herba Lycopodii 20g, Radix Rehmanniae 20g, Radix Notoginseng 20g, Radix Salviae Miltiorrhizae 20g, Rhizoma Corydalis 20g, Pyritum 20g, Sanguis Draxonis 20g, Olibanum 20g, Myrrha 20g, Endoconcha Sepiae 20g, Maifanitum 20g.
Wherein method for preparing is that processing powder is broken into medicated powder with above-mentioned medical material mixing, sterilizes promptly to get in 60 minutes.
Embodiment 13: adopt conventional preparation technology, Chinese medicine preparation of the present invention can be made into said dosage form on any pharmaceutics, like tablet, capsule, granule, oral liquid, pill, syrup.
All the other are with embodiment 1-10.
Embodiment 14: the fluid extract of the mix homogeneously that will be made by embodiment 1-10 concentrates, and according to the operational approach of conventional tablet, adds pharmaceutic adjuvant; With each component mix homogeneously, wet granulation sieves; Adopt conventional tablet preparation method tabletting to process tablet, wherein each components contents is following:
Composition weight (part)
Mixed flow extractum 50
Starch 22
Microcrystalline Cellulose 15
Pulvis Talci 9
Polyethylene Glycol 8
All the other are with embodiment 1-10.
Embodiment 15: the fluid extract of the mix homogeneously that will be made by embodiment 1-10 concentrates, and according to the operational approach of conventional capsule, adds pharmaceutic adjuvant; With each component mix homogeneously; Granulate, adopt conventional capsule preparation method to fill and process capsule, wherein each components contents is following:
Composition weight (part)
Mixed flow extractum 100
Pregelatinized Starch 26
Lactis Anhydrous 18
Microcrystalline Cellulose 16
Calcium hydrogen phosphate 8
All the other are with embodiment 1-10.
Embodiment 16: the fluid extract of the mix homogeneously that will be made by embodiment 1-10 concentrates, according to the operational approach of conventional oral liquid, ethanol precipitation 1-2 time; Filter, concentrate aqueous precipitation; Filter, add pharmaceutic adjuvant, filter; The packing sterilization adopts conventional oral liquid preparation method to prepare oral liquid, and wherein each components contents is following:
Composition weight (part)
Mixed flow extractum 100
Ethanol 158
Sucrose 82
Sodium carboxymethyl cellulose 15
Oleum menthae 5
Sorbic acid 2
All the other are with embodiment 1-10.
The effectiveness study experiment:
Patient's data:
Choose fracture of upper limb 377 examples at various big hospital, fracture of the lower limb 273 examples, spinal fracture 195 examples are totally 845 routine fracture patients, wherein male 452 examples, women 393 examples, age 17-69 years old, average, 41.4 years old.Each case is all made a definite diagnosis through taking the photograph X line sheet, all after wound, is admitted to hospital in 1 week, and no severe complication, and, get rid of the organic disease of other system through inspections such as three big routines, Chest X-rays, electrocardiogram, hepatic and renal functions.
Therapeutic Method:
845 routine fracture patients are divided into 13 groups, and 1 group as matched group, organizes as treatment for 12 groups; Every group of fracture of upper limb 29 examples wherein, fracture of the lower limb 21 examples, spinal fracture 15 examples; All cases all adopt and reset that fixing (repositioning method comprises manual reduction, reduction by traction, open reduction; Fixing means comprises internal fixation such as plintlet, Gypsum Fibrosum and support external fixation and steel plate, steel nail, draw point), early functional exercise, and the Supporting Therapy of generally suiting the medicine to the illness.The Chinese medical concrete that 1-11 embodiment is made is 8 times of dilute with waters by volume, take for respectively 11 groups of treatment groups, and everyone each 100ml, serve on 3 months at every day 2 times; The medicated powder that oral embodiment 12 makes is organized in 1 group of remaining treatment, and one time 3-6g takes after mixing it with water, and one day three times, serve on 3 months; Matched group is given clothes traumatology pill for traumatic injuries, and each 10g, serve on 3 months at every day 2 times.
Observation of curative effect:
The clinical union of bone standard: fractures does not have tenderness, does not have vertical percussion pain; Fracture site does not have bony crepitus and abnormal movement; X line sheet shows that fracture line is fuzzy, has the seriality callus to pass through fracture line; Functional examination: removing under the external fixation situation, upper limb can be put down act 1kg weight and reached 1 minute, the continuous free-hand walking of lower limb ability 3 minutes, and be no less than for 30 steps; Observed for 2 weeks continuously, fracture is indeformable, is the clinical healing date in the 1st day of observation.
Table 1 is respectively organized different parts clinical union of bone situation statistical table
12 groups all after taking medicine 3 months by above-mentioned canonical statistics curative effect, can find out that by last table the curative effect of treatment group as a result obviously is superior to matched group, and be superior to the curative effect of the Chinese medicine medicine that similar prescription makes in the prior art, wherein best with embodiment 5 curative effects; Therefore fracture patient is on the basis of fixing, the functional exercise and the Supporting Therapy of suiting the medicine to the illness that resets; Add the Chinese traditional compound medicine that makes with the present invention; Healing time obviously shortens, and growth of spur is more solid and reliable sooner, and curative effect is superior to existing treatment fracture Chinese medicine greatly.
Claims (5)
1. a compound Chinese medicinal preparation of treating fracture is characterized in that: comprise the following weight Chinese medicinal raw materials: Semen Persicae 8-12, Flos Carthami 13-17, Rhizoma Chuanxiong 8-12.
2. a compound Chinese medicinal preparation of treating fracture is characterized in that: comprise the following weight Chinese medicinal raw materials: Semen Persicae 8-12, Flos Carthami 13-17, Rhizoma Chuanxiong 8-12, Radix Paeoniae Rubra 8-12, Radix Angelicae Sinensis 8-12, Radix Salviae Miltiorrhizae 8-12, Rhizoma Drynariae 13-17, Radix Dipsaci 13-17, Radix Notoginseng (dashing) 2-4.
3. a compound Chinese medicinal preparation of treating fracture is characterized in that: comprise the following weight Chinese medicinal raw materials: Semen Persicae 10, Flos Carthami 15, Rhizoma Chuanxiong 10, Radix Paeoniae Rubra 10, Radix Angelicae Sinensis 10, Radix Salviae Miltiorrhizae 10, Rhizoma Drynariae 15, Radix Dipsaci 15, Radix Notoginseng (dashing) 3.
4. like claim 2 or 3 said a kind of method for preparinies of treating the compound Chinese medicinal preparation of fracture, it is characterized by: 9 flavor medical materials are cleaned proportional mixing; The 4-7 that adds medical material gross weight water or volume ratio doubly is that 70% ethanol decocts 2 times, each 80 minutes, merges 2 times decoction liquor; Filter; And concentrate, proportion is 1.18 fluid extract when obtaining 60 ℃, adopts conventional preparation technology; The present invention can be made into said dosage form on any pharmaceutics, like tablet, capsule, granule, oral liquid, pill, syrup.
5. a kind of method for preparing of treating the compound Chinese medicinal preparation of fracture as claimed in claim 4 is characterized by: 9 flavor medical materials are cleaned proportional mixing; 5 times the decocting that adds the medical material gross weight boils 2 times, each 80 minutes, merges 2 times decoction liquor; Filter, and concentrate, proportion is 1.18 fluid extract when obtaining 60 ℃; Adopt conventional preparation technology, the present invention can be made into said dosage form on any pharmaceutics, like tablet, capsule, granule, oral liquid, pill, syrup.
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| CN107714971A (en) * | 2017-10-26 | 2018-02-23 | 刘恩国 | A kind of Chinese medicine composition for treating fracture and preparation method thereof |
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| CN107714971A (en) * | 2017-10-26 | 2018-02-23 | 刘恩国 | A kind of Chinese medicine composition for treating fracture and preparation method thereof |
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| CN102379941B (en) | 2016-08-10 |
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