CN102379882A - Invert sugar and injection medicinal preparation prepared from same - Google Patents
Invert sugar and injection medicinal preparation prepared from same Download PDFInfo
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- CN102379882A CN102379882A CN2011100610583A CN201110061058A CN102379882A CN 102379882 A CN102379882 A CN 102379882A CN 2011100610583 A CN2011100610583 A CN 2011100610583A CN 201110061058 A CN201110061058 A CN 201110061058A CN 102379882 A CN102379882 A CN 102379882A
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- nulomoline
- fructose
- preparation
- injection
- glucose
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Abstract
The invention provides invert sugar which is used for energy supplement of diabetes mellitus patients and insulin-resistance patients who are burnt, subjected to an operation and infected, as well as energy supplement to drug poisoning and other diseases, as well as an injection medicinal preparation prepared from the invert sugar. In the preparation, cane sugar serving as an initial raw material is hydrolyzed, separated, filtered, concentrated, recrystallized, dried and crushed to prepare fructose and glucose powder; and the fructose and the glucose powder are mixed in an equal proportion to prepare the injection medicinal preparation of the invert sugar.
Description
Technical field:
The present invention relates to a kind of Nulomoline of disease disease energy supplements such as diabetics, the energy supplement of burning insulin resistant patients such as wound, postoperative and infection and drug intoxication and injection medicine preparation of processing thereof of being used for, belong to medicine synthesising preparation field.
Background technology:
Nulomoline is mixed and made into by glucose and fructose.During physical stress, peripheral tissues produces insulin resistant under the stress hormone effect, and glucose can only be given cerebral tissue and can not give the effective energy supply of peripheral tissues; Though fructose can not see through blood brain barrier and give the cerebral tissue energy supply, because of metabolism does not receive the adjusting of insulin, can give effectively be in stress insulin resistant peripheral tissues's energy supply.So Nulomoline has just been accomplished the whole energy supply of brain and periphery, thereby reduce the consumption of body protein, obviously be superior to simple glucose infusion liquid or simple fructose transfusion, help body and repair fast.Its characteristics are fast, efficient, safe, convenient.As non-intestinal intravenous nutrition supplement, its indication is clinically: 1, insulin resistant patient's energy supplement, like postoperative, burn wound, tumor and putting of tumor tumor after, insulin resistant patients such as infection, hepatopathy; 2, all kinds of need keep the skin wet and the patient's of energy fluid-supplement therapy, like patients such as alcoholism, drug intoxication and vomiting, diarrhoea, shock, heatstrokes; 3, pharmaceutical diluents etc.The Nulomoline infusion preparation has obtained vast market prospect with its clear superiority that in Clinical Application, is showed.
Summary of the invention
To said medicine characteristics, the injection medicine preparation that we provide a kind of Nulomoline and have processed is through with sucrose hydrolysis, separation; Filtration, concentrated, recrystallization; Dry, after pulverizing fructose and glucose powder are last, with both mixed in equal amounts, packing is prepared from sugar,invert,injection.Through the Nulomoline and the injection medicine preparation thereof of this law preparation, preparation is convenient, and production cost is low.
Nulomoline provided by the invention and the injection medicine preparation of processing thereof, with sucrose as further preparation and getting of initiation material.
In the Nulomoline injection preparation that the present invention proposes, be main active with fructose and glucose.
In the Nulomoline injection preparation that the present invention proposes, prescription need not to add any adjuvant.
The present invention proposes the method for preparing of Nulomoline injection preparation; The preparation process may further comprise the steps: 1. take by weighing sucrose and be dissolved in the purified water with hydrochloric acid adjusting pH to 2.0; 90 ℃ of hydrolysis 3 hours add purified water and are diluted to 20% in sucrose hydrolysis liquid, take by weighing an amount of calcium hydroxide suspension of processing calcium hydroxide soluble in water and slowly in hydrolyzed solution, add; Stir fast, subsequent use; 2. get said hydrolyzed liquid decompress filter, filter cake is colourless with saturated limewater drip washing to filter liquor, places water to pull an oar; Adopt 42.5% phosphoric acid to regulate pH to 6～7; Sucking filtration, filtrating revolve to steam to be concentrated into and are pulpous state, adopt ethanol to carry out recrystallization after-filtration vacuum drying and get fructose; 3. get above-mentioned filtrating and transfer about pH value to 6～7 with carbon dioxide, filter, filtrating is concentrated into pulpous state, stirs down to add dehydrated alcohol, separates out white solid, and filtration drying obtains glucose; 4. get the glucose and the fructose powder of above-mentioned gained, equal proportion is mixed, and packing gets the injection medicine preparation of Nulomoline.
Technical characterstic of the present invention is to comply with the clinical practice needs through the Nulomoline injection preparation that this method for preparing makes, and preparation is convenient, and cost is low, has improved business efficiency.
The specific embodiment
With by way of example the present invention is described further again below, provides implementation detail of the present invention, but be not to be intended to limit protection scope of the present invention.
Embodiment:
Take by weighing sucrose and be dissolved in the purified water with hydrochloric acid and regulate pH to 2.0,90 ℃ of hydrolysis 3 hours add purified water and are diluted to 20% in sucrose hydrolysis liquid; Take by weighing an amount of calcium hydroxide suspension of processing calcium hydroxide soluble in water and slowly in hydrolyzed solution, add, stir decompress filter fast; Filter cake is colourless with saturated limewater drip washing to filter liquor; Place water to pull an oar, adopt 42.5% phosphoric acid to regulate pH to 6～7, sucking filtration; Filtrating is revolved to steam to be concentrated into and is pulpous state, adopts ethanol to carry out recrystallization after-filtration vacuum drying and gets fructose; Get above-mentioned filtrating and transfer about pH value to 6～7 with carbon dioxide, filter, filtrating is concentrated into pulpous state, stirs down to add dehydrated alcohol, separates out white solid, and filtration drying obtains glucose; Get the glucose and the fructose powder of above-mentioned gained, equal proportion is mixed, and packing gets the injection medicine preparation of Nulomoline.
Claims (8)
1. Nulomoline and the injection medicine preparation processed thereof; It is characterized in that: with sucrose after hydrolysis under the acid condition generates fructose and glucose; Adding calcium hydroxide separates fructose with glucose; Through dissociating, filter, concentrate, recrystallization, dry, after pulverizing fructose and glucose powder: with above-mentioned powder equal proportion mix the injection medicine preparation of Nulomoline.
2. Nulomoline as claimed in claim 1 and the injection medicine preparation of processing thereof is characterized in that, the preparation process of Nulomoline may further comprise the steps:
2.1 taking by weighing sucrose is dissolved in the purified water with hydrochloric acid adjusting pH to 2.0; 90 ℃ of hydrolysis 3 hours add purified water and are diluted to 20% in sucrose hydrolysis liquid, take by weighing an amount of calcium hydroxide suspension of processing calcium hydroxide soluble in water and slowly in hydrolyzed solution, add; Stir fast, subsequent use;
2.2 get said hydrolyzed liquid decompress filter, filter cake is colourless with saturated limewater drip washing to filter liquor, places water to pull an oar; Adopt 42.5% phosphoric acid to regulate pH to 6～7; Sucking filtration, filtrating revolve to steam to be concentrated into and are pulpous state, adopt ethanol to carry out recrystallization after-filtration vacuum drying and get fructose;
Transfer about pH value 6-7 with carbon dioxide 2.3 get above-mentioned filtrating, filter, filtrating is concentrated into pulpous state, stirs down to add dehydrated alcohol, separates out white solid, and filtration drying obtains glucose;
2.4 get the glucose and the fructose powder of above-mentioned gained, equal proportion is mixed, packing gets the injection medicine preparation of Nulomoline.
3. Nulomoline injection preparation as claimed in claim 1 is characterized in that: with fructose and glucose is main active.
4. Nulomoline injection preparation as claimed in claim 1 is characterized in that: prescription need not to add any adjuvant.
5. Nulomoline injection preparation as claimed in claim 1 is characterized in that: with sucrose as further preparation and getting of initiation material.
6. Nulomoline injection preparation as claimed in claim 1 is characterized in that: the method for preparing of fructose is following: take by weighing sucrose and be dissolved in the purified water with hydrochloric acid and regulate pH to 2.0,90 ℃ of hydrolysis 3 hours; In sucrose hydrolysis liquid, add purified water and be diluted to 20%, take by weighing an amount of calcium hydroxide suspension of processing calcium hydroxide soluble in water and slowly in hydrolyzed solution, add, stir fast; Decompress filter, filter cake is colourless with saturated limewater drip washing to filter liquor, places water to pull an oar; Adopt 42.5% phosphoric acid to regulate pH to 6～7; Sucking filtration, filtrating revolve to steam and are concentrated into existing pulpous state, adopt ethanol to carry out recrystallization after-filtration vacuum drying and get fructose.
7. Nulomoline injection preparation as claimed in claim 1; It is characterized in that: the method for preparing of glucose is following: the weighting profit requires 6 described filtratings, transfers about pH value 6-7 with carbon dioxide, filters; Filtrating is concentrated into pulpous state; Stir adding dehydrated alcohol down, separate out white solid, filtration drying obtains glucose.
8. like described Nulomoline of claim 1-2 and the injection medicine preparation processed thereof, obtained through above-mentioned method for preparing is the powder injection formulation of Nulomoline.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011100610583A CN102379882A (en) | 2011-03-10 | 2011-03-10 | Invert sugar and injection medicinal preparation prepared from same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011100610583A CN102379882A (en) | 2011-03-10 | 2011-03-10 | Invert sugar and injection medicinal preparation prepared from same |
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| Publication Number | Publication Date |
|---|---|
| CN102379882A true CN102379882A (en) | 2012-03-21 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN2011100610583A Pending CN102379882A (en) | 2011-03-10 | 2011-03-10 | Invert sugar and injection medicinal preparation prepared from same |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103520192A (en) * | 2013-10-25 | 2014-01-22 | 海南通用康力制药有限公司 | Invert sugar freeze-dried powder preparation for injection and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1981870A (en) * | 2005-12-15 | 2007-06-20 | 张为群 | Invert-sugar powdery injection and its production |
| CN1994111A (en) * | 2006-08-25 | 2007-07-11 | 华南理工大学 | Method for preparing sugar-converted syrup |
| CN101284014A (en) * | 2007-04-10 | 2008-10-15 | 扬子江药业集团上海海尼药业有限公司 | Inverted sugar electrolytes injection and preparation technique thereof |
| CN101716181A (en) * | 2009-11-10 | 2010-06-02 | 陶灵刚 | Invert sugar medicament composition liposome injection and new application thereof |
| CN101884611A (en) * | 2009-12-03 | 2010-11-17 | 四川海思科制药有限公司 | Method for preparing medicinal invert sugar by sugar hydrolysis |
-
2011
- 2011-03-10 CN CN2011100610583A patent/CN102379882A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1981870A (en) * | 2005-12-15 | 2007-06-20 | 张为群 | Invert-sugar powdery injection and its production |
| CN1994111A (en) * | 2006-08-25 | 2007-07-11 | 华南理工大学 | Method for preparing sugar-converted syrup |
| CN101284014A (en) * | 2007-04-10 | 2008-10-15 | 扬子江药业集团上海海尼药业有限公司 | Inverted sugar electrolytes injection and preparation technique thereof |
| CN101716181A (en) * | 2009-11-10 | 2010-06-02 | 陶灵刚 | Invert sugar medicament composition liposome injection and new application thereof |
| CN101884611A (en) * | 2009-12-03 | 2010-11-17 | 四川海思科制药有限公司 | Method for preparing medicinal invert sugar by sugar hydrolysis |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103520192A (en) * | 2013-10-25 | 2014-01-22 | 海南通用康力制药有限公司 | Invert sugar freeze-dried powder preparation for injection and preparation method thereof |
| CN103520192B (en) * | 2013-10-25 | 2015-06-10 | 海南通用康力制药有限公司 | preparation method of invert sugar freeze-dried powder preparation for injection |
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Application publication date: 20120321 |