CN102370928A - Medicinal combination for harmonizing stomach and alleviating pain and preparation method thereof - Google Patents
Medicinal combination for harmonizing stomach and alleviating pain and preparation method thereof Download PDFInfo
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- CN102370928A CN102370928A CN2011101987553A CN201110198755A CN102370928A CN 102370928 A CN102370928 A CN 102370928A CN 2011101987553 A CN2011101987553 A CN 2011101987553A CN 201110198755 A CN201110198755 A CN 201110198755A CN 102370928 A CN102370928 A CN 102370928A
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Abstract
The invention discloses a medicinal combination for harmonizing a stomach and alleviating pain and a preparation method thereof, which relate to the field of traditional Chinese medicines. The medicinal combination for harmonizing the stomach and alleviating the pain, which is provided by the invention, is prepared from the following traditional Chinese medicinal raw materials: clovershrub, fevervine, aspidium, golden buckwheat rhizone, coptis, fructus amomi, corydalis tuber and 30-50 parts of radix aucklandiae. The medicinal combination has functions of promoting flow of qi and blood circulation, harmonizing the stomach and alleviating the pain. The medicinal combination is used for hepatogastric qi stagnation, the acute and the chronic gastroenteritis caused by damp heat and blood stasis, gastric and duodenal ulcers and chronic colitis.
Description
Technical field
The present invention relates to tcm field, be specifically related to a kind of treatment acute/chronic gastroenteritis, gastric and duodenal ulcers, stomach function regulating analgesic pharmaceutical composition of chronic colitis and preparation method thereof.
Background technology
By traditional theory of Chinese medical science, the main cause that forms gastropathy is that gastropathy is because gastric qi blocks, the stomach network becomes silted up resistance, stomach
Become homeless and support the gastropathy that forms.Gastropathy at first ought be debated anxious delaying, the sudden and violent author of all stomachaches, and how because of the diseases caused by exogenous pathogenic factor cold-evil, polyphagia raw food, so that cold damaging the spleen and stomach resistance stagnate and do not change, stomach-QI being unable to descend normally, stagnation of QI and blood may bring about pain, all stomachaches are gradually often sent out and are caused by stagnation of QI due to depression of the liver.Modern science proves, gastropathy is as ignoring treatment for a long time, or obstinate, also can change gastric cancer or cause other diseases.The basic pathology of gastropathy is a taste sodium fortune abnormal ascending-descending of QI, and the tired resistance of QI and blood is not smooth, so the stomach stagnation of QI and blood may bring about pain is many with logical method in the treatment; It is smooth that QI and blood is transferred, and treatment strain deficiency and excess cold and heat are executed respectively and controlled, like the cold coagulation person; When the cold expelling circulation of qi promoting, food stagnation person works as consumer product dredge stasis, and stagnation of QI person works as liver-smoothing, qi-regulating, blood stasis person's activating blood circulation to dissipate blood stasis; Choke void person works as warming YANG and invigorating QI, and the surplus partially person of cloudy Tianjin yin nourishing stomach reinforcing, damp-heat in the spleen and stomach answers clearing away heat-damp and promoting diuresis.
Summary of the invention
The invention provides a kind of treatment acute/chronic gastroenteritis, gastric and duodenal ulcers, stomach function regulating analgesic pharmaceutical composition of chronic colitis and preparation method thereof.
A kind of stomach function regulating analgesic pharmaceutical composition that the present invention proposes and preparation method thereof is processed by the raw material of Chinese medicine of following weight ratio: Radix Campylotropis Hirtella (Herba Myrsines Africanae) 400-600 part; Fevervine 400-600 part; Herba potentillae fulgentis 200-400 part; Rhizoma Fagopyri Dibotryis 300-500 part; Rhizoma Coptidis 10-30 part; Fructus Amomi 30-50 part; Rhizoma Corydalis 20-50 part; Radix Aucklandiae 30-50 part.
Among the present invention, described a kind of stomach function regulating analgesic pharmaceutical composition and preparation method thereof, a preferred version is for to be processed by the raw material of Chinese medicine of following weight ratio: 500 parts of Radix Campylotropis Hirtella (Herba Myrsines Africanae)s; 500 parts of fevervines; 300 parts of Herba potentillae fulgentis; 400 parts of Rhizoma Fagopyri Dibotryiss; 20 parts of Rhizoma Coptidis; 40 parts of Fructus Amomis; 30 parts of Rhizoma Corydalis; 40 parts of the Radix Aucklandiae.
Among the present invention, described a kind of stomach function regulating analgesic pharmaceutical composition and preparation method thereof is an oral formulations.
Radix Campylotropis Hirtella (Herba Myrsines Africanae) mildly bitter flavor, puckery, warm in nature.Cure mainly regulating menstruation and activating blood, pain relieving, convergence.Be used for amenorrhea, dysmenorrhea, leucorrhea, stomachache; The external chickenpox of harnessing the Yellow River, burn and scald.
Fevervine sweet in the mouth, acid, property is flat.Expelling wind and activating blood circulation, analgesic antidotal, dyspepsia and intestinal stasis relieving, dehumidifying detumescence.Dispelling the wind and dampness pathogens pain, diarrhoea dysentery, dirty abdomen pain, deficiency of vital energy edema, dizzy lack of appetite, hepatosplenomegaly, scrofula, acute appendicitis, innominate toxic swelling, traumatic injury.Herb contains iridoid glycosides, paederoside, fevervine time glycoside, paederosidic acid, rubichloric acid., 10-deacetyl asperulosidic glycoside.Also contain cyanidin glucoside, petunidin glucoside, pelargonidin, embelin and a saturated carbonyl compounds.Contain arbutin, volatile oil in the leaf, C10-table chlorophyll and pheophytin.Fruit contains volatile ingredients such as arbutin, oleanolic acid, melissane, hydroquinone and phenol, terpene aldehyde, butyraldehyde, acetic acid, propanoic acid.
The Herba potentillae fulgentis bitter and puckery flavor, cold in nature, return spleen, large intestine channel.Cure mainly heat-clearing and toxic substances removing, relieving diarrhea with astringents, cooling blood for hemostasis.
Rhizoma Fagopyri Dibotryis heat-clearing and toxic substances removing, the eliminating carbuncle of invigorating blood circulation, expelling wind and removing dampness sore, snake bite and insect sting.Cure mainly lung abscess, lung-heat cough with asthma, laryngopharynx swelling and pain, dysentery, rheumatism arthromyodynia, traumatic injury, carbuncle cancer.Rhizome contains after the former cyanidin of double focusing, hecogenin, cupreol, tannin and a kind of hydrolysis can right-coumaric acid, the glycoside of ferulic acid and glucose.Also contain 3,3 of left-handed epicatechin, 3-galloylepicatechin, former cyanidin B-2, B-4 and former cyanidin B-2 '-digallic acid ester.
The Rhizoma Coptidis bitter in the mouth, cold in nature, nontoxic, GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Cure mainly heat clearing and damp drying, eliminating fire and detoxication.Be used for that damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood are told nosebleed, conjunctival congestion, have a toothache, quenched one's thirst, the carbuncle furuncle; External treatment eczema, eczema, auditory meatus are suppurated.The kind clear part of the body cavity above the diaphragm housing the heart and lungs of Rhizoma Coptidis (processed with wine) is burning hot.Be used for conjunctival congestion, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach stomach function regulating preventing or arresting vomiting.Be used for cold and heat and tie mutually, damp and hot middle resistance, feeling of fullness vomiting.Cornel Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting.Be used for incoordination between the liver and stomach, the vomiting acid regurgitation.Rhizome contains multiple isoquinoline alkaloid, and is the highest with content of berberine, still contains coptisine, 13-methyl-.psi.-coptisine., palmatine, jateorhizine, epiberberine and magnoflorine etc.; Acid ingredient has ferulic acid, chlorogenic acid etc.
The Fructus Amomi acrid in the mouth, warm in nature, return spleen, stomach, kidney.The removing dampness appetizing, warming spleen and stopping diarrha, it is antiabortive to regulate the flow of vital energy.Fructus Amomi contains volatile oil, and its composition is very complicated, mainly contains limonene, linalool, borneol acetate etc.Except that have strong aromatic odor with strong pungent, also intestinal is had inhibitory action.Have that removing dampness is amusing, relieving QI stagnancy in the stomach, the effect that helps digestion.
Rhizoma Corydalis cures mainly all pains of trusted subordinate's waist knee joint, menoxenia, lump in the abdomen, metrorrhagia, puerperal blood faints, lochiorrhea, traumatic injury.Analgesia, calmness, syngignoscism are arranged.The several formulations that experiment showed, Rhizoma Corydalis all has obvious analgesic activity, especially acting as obviously with alcohol system extractum, powder and fluid-acet-extract.The full alkali of Rhizoma Corydalis can significantly increase coronary flow, and is similar with papaverine.Zoopery shows: repeatedly give the Rhizoma Corydalis alcohol extract; Can obviously alleviate the myocardial necrosis degree that the heavy dose of isoproterenol of subcutaneous injection is produced; The prompting Rhizoma Corydalis has the ability of improving the trophism blood supply of downright bad marginal zone, myocardial infarction is had certain control be worth.Some compositions of Rhizoma Corydalis have protective effect to gastric ulcer, and like the plain subcutaneous injection of dehydrogenation Rhizoma Corydalis first, the gastric ulcer to experimental gastric ulcer, particularly pylorus ligation or the aspirin of rat brings out has obvious protective effect.Protopine all has the certain protection effect to the gastric ulcer that pyloric ligation ulcer and tetrahydropalmatine bring out hunger.Rhizoma Corydalis still has myorelaxant effects.Have report to point out, the methyl tetrahydropalmatine is to act on nondepolarizing type neuromuscular blocking drug after the neuromuscular junction, and its flesh pine position is in periphery.The methyl tetrahydropalmatine is compared with tubocurarine, tire low and the effect a little less than; Its blocking effect can be resisted by neostigmine.
The hot acrid in the mouth of the Radix Aucklandiae, hardship, warm in nature.Effect: intestinal stasis relieving in promoting the circulation of QI to relieve pain, the accent.Main dehydrocostuslactone, costunolide, Radix Aucklandiae terpene aldehyde, 4 'beta '-methoxy dehydrocostuslactone, constuslactone, dihydrocostulactone, α-ring costunolide, β-ring costunolide, alantolactone, isoalantolactone, different dehydrocostuslactone, different Sino-U.S. centautin, 2-melonia dehydrocostuslactone, dihydro costunolide, costen, aplotaxene, cymol, myrcene, beta-elemene, cedrene, the Humuleno etc. of containing of root oil.
Among the present invention, described a kind of stomach function regulating analgesic pharmaceutical composition and preparation method thereof, described method for preparing process following steps,
1. take by weighing the raw material of Chinese medicine of said part by weight, Rhizoma Coptidis 20g, Fructus Amomi 40g, Rhizoma Corydalis 30g, Radix Aucklandiae 40g are ground into fine powder, and it is subsequent use to sterilize;
2. with all the other four Chinese medicines, add 8 times of water gagings and decoct 3 times, 2 hours for the first time, 1.5 hours for the second time; 1 hour for the third time, merge decoction liquor, filter, filtrating is concentrated into the thick paste of relative density 1.28-1.35 (50 ℃); Add above-mentioned powder, mixing, drying under reduced pressure; Be ground into fine powder, cross 100 mesh sieves, subsequent use;
3. with above-mentioned fine powder be prepared into suitable oral formulations after other pharmaceutic adjuvants mix.
Among the present invention, described a kind of stomach function regulating analgesic pharmaceutical composition and preparation method thereof, a preferred oral preparation formulation is a tablet.
Among the present invention, the function of described a kind of stomach function regulating analgesic pharmaceutical composition is promoting flow of QI and blood, and stomach and alleviating pain.The doctor of Yi nationality has the judgement of " guessing that the Buddhist nun encloses soon, encloses Si Xi ".Be used for stagnation of liver-QI and stomach-QI, the acute/chronic gastroenteritis due to the dampness and heat stasis, gastric and duodenal ulcers, chronic colitis.
Usage: oral.One time three, three times on the one.Period in a medicine, diet wine, acid, cold, pungent and stodgy food.
The specific embodiment
Below in conjunction with embodiment a kind of stomach function regulating analgesic pharmaceutical composition of the present invention and preparation method thereof is described.
Embodiment 1.
Among the present invention, described a kind of stomach function regulating analgesic pharmaceutical composition and preparation method thereof, described method for preparing process following steps,
1. take by weighing the raw material of Chinese medicine of said part by weight, Rhizoma Coptidis 20g, Fructus Amomi 40g, Rhizoma Corydalis 30g, Radix Aucklandiae 40g are ground into fine powder, and it is subsequent use to sterilize;
2. with all the other four Chinese medicines: Radix Campylotropis Hirtella (Herba Myrsines Africanae) 500g, fevervine 500g, Herba potentillae fulgentis 300g, Rhizoma Fagopyri Dibotryis 400g, add 8 times of water gagings and decoct 3 times, 2 hours for the first time, 1.5 hours for the second time; 1 hour for the third time, merge decoction liquor, filter, filtrating is concentrated into the thick paste of relative density 1.28-1.35 (50 ℃); Add above-mentioned powder, mixing, drying under reduced pressure; Be ground into fine powder, cross 100 mesh sieves, subsequent use;
3. above-mentioned fine powder is added microcrystalline Cellulose 50g, and add appropriate amount of starch, regulate total amount to 360g, mix homogeneously, with 70% ethanol wet granulation, dry granulate adds magnesium stearate 5g, and mixing is pressed into 1000, and the bag film-coat promptly gets.
Case.
Liu, the man, 42 years old, suffered from chronic gastritis 8 years, the Chinese medicine and western medicine curative effect is undesirable, and in June, 2009, after 4 months, patient's subjective symptoms disappeared through the treatment of this medicine, the check gastroscope, the healing of gastric ulcer face does not detect helicobacter pylori, follows up a case by regular visits to not recurrence in a year.
The Wang, the woman, 65 years old, suffered from duodenal ulcer 15 years, in January, 2009, after half a year, it is asymptomatic that the patient feels in vain through the treatment of this medicine, after on inspection, duodenum is normal, follows up a case by regular visits to after 1 year and does not see recurrence.
The above; Be merely the preferable specific embodiment of the present invention; But protection scope of the present invention is not limited thereto; Any technical staff who is familiar with the present technique field is equal to replacement or change according to technical scheme of the present invention and inventive concept thereof in the technical scope that the present invention discloses, all should be encompassed within protection scope of the present invention.
Claims (5)
1. stomach function regulating analgesic pharmaceutical composition, it is characterized in that: the raw material of Chinese medicine by the following weight ratio is processed: Radix Campylotropis Hirtella (Herba Myrsines Africanae) 400-600 part; Fevervine 400-600 part; Herba potentillae fulgentis 200-400 part; Rhizoma Fagopyri Dibotryis 300-500 part; Rhizoma Coptidis 10-30 part; Fructus Amomi 30-50 part; Rhizoma Corydalis 20-50 part; Radix Aucklandiae 30-50 part.
2. a kind of stomach function regulating analgesic pharmaceutical composition according to claim 1 is characterized in that: for being processed by the raw material of Chinese medicine of following weight ratio: 500 parts of Radix Campylotropis Hirtella (Herba Myrsines Africanae)s; 500 parts of fevervines; 300 parts of Herba potentillae fulgentis; 400 parts of Rhizoma Fagopyri Dibotryiss; 20 parts of Rhizoma Coptidis; 40 parts of Fructus Amomis; 30 parts of Rhizoma Corydalis; 40 parts of the Radix Aucklandiae.
3. a kind of stomach function regulating analgesic pharmaceutical composition according to claim 2 is characterized in that: be oral formulations.
4. a kind of stomach function regulating analgesic preparation of drug combination method according to claim 1 is characterized in that: described method for preparing process following steps,
1. take by weighing the raw material of Chinese medicine of said part by weight, Rhizoma Coptidis, Fructus Amomi, Rhizoma Corydalis, Radix Aucklandiae powder are broken into fine powder, it is subsequent use to sterilize;
2. with all the other four Chinese medicines, add 8 times of water gagings and decoct 3 times, 2 hours for the first time, 1.5 hours for the second time; 1 hour for the third time, merge decoction liquor, filter, filtrating is concentrated into the thick paste of relative density 1.28-1.35 (50 ℃); Add above-mentioned Rhizoma Coptidis, Fructus Amomi, Rhizoma Corydalis, Common Aucklandia Root, mixing, drying under reduced pressure; Be ground into fine powder, cross 100 mesh sieves, subsequent use;
3. with above-mentioned fine powder be prepared into suitable oral formulations after other pharmaceutic adjuvants mix.
5. a kind of stomach function regulating analgesic pharmaceutical composition according to claim 4 and preparation method thereof is characterized in that: a preferred oral preparation formulation is a tablet.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104117004A (en) * | 2014-08-17 | 2014-10-29 | 黑龙江江恒医药科技有限公司 | Stomach harmonizing and pain relieving capsule and preparation method thereof |
| CN105381275A (en) * | 2015-11-14 | 2016-03-09 | 王领章 | Traditional Chinese medicine preparation for treating helicobacter pylori infectious peptic ulcer |
| CN108066389A (en) * | 2018-01-10 | 2018-05-25 | 金培林 | A kind of medicinal liquor for treating stomach trouble and preparation method and application |
-
2011
- 2011-07-15 CN CN2011101987553A patent/CN102370928A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104117004A (en) * | 2014-08-17 | 2014-10-29 | 黑龙江江恒医药科技有限公司 | Stomach harmonizing and pain relieving capsule and preparation method thereof |
| CN105381275A (en) * | 2015-11-14 | 2016-03-09 | 王领章 | Traditional Chinese medicine preparation for treating helicobacter pylori infectious peptic ulcer |
| CN108066389A (en) * | 2018-01-10 | 2018-05-25 | 金培林 | A kind of medicinal liquor for treating stomach trouble and preparation method and application |
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Application publication date: 20120314 |