CN102370918A - Chinese medicinal compound preparation for treating psoriasis and preparation method thereof - Google Patents
Chinese medicinal compound preparation for treating psoriasis and preparation method thereof Download PDFInfo
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- CN102370918A CN102370918A CN2011103642196A CN201110364219A CN102370918A CN 102370918 A CN102370918 A CN 102370918A CN 2011103642196 A CN2011103642196 A CN 2011103642196A CN 201110364219 A CN201110364219 A CN 201110364219A CN 102370918 A CN102370918 A CN 102370918A
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Abstract
The invention relates to a compound Chinese medicinal preparation for treating psoriasis. The compound Chinese medicinal preparation comprises the following Chinese medicinal raw materials by weight: 26-34 grams of glabrous greenbrier rhizome, 8-12 grams of indian buead, 13-17 grams of red-rooted salvia root, 8-12 grams of red paeony root, 8-12 grams of Chinese angelica, 5-7 grams of safflower, 5-7 grams of sinkiang arnebia root, 13-17 grams of spreading hedyotis herb and 5-7 grams of liquoric root. A preparation method of the compound Chinese medicinal preparation comprises the following steps of: cleaning the nine types of medicinal materials; mixing proportionally; adding water or 70 percent by volume of ethanol, with an amount which is 6-8 times the total weight of the medicinal materials for decocting for three times for 50 minutes each time; mixing decoction solutions obtained in the three times; filtering; and concentrating to obtain a liquid extract of which the specific weight is 1.19 at 60 DEG C. The compound Chinese medicinal preparation can be prepared into any pharmaceutical dosage form, such as tablets, capsules, granules, oral liquid, pills and syrup by adopting the conventional preparation process. The compound Chinese medicinal preparation for treating psoriasis prepared with the method has a remarkable curative effect, is free from untoward reactions, and can be used for completely replacing the conventional hormone therapy method for psoriasis.
Description
Technical field
The present invention relates to psoriasic compound Chinese medicinal preparation of a kind of treatment and preparation method thereof, belong to field of traditional Chinese.
Background technology
Psoriasis is also claimed psoriasis, its pathogenesis doctor trained in Western medicine think by the body's immunity under the polygenic inheritance effect not normal due to, also relevant with the metabolism barrier of infection.Be divided into four types of homeliness types, abscess type, arthrosis type, Folium Styracis Suberifoliae type clinically.It mainly shows as pruritus, hypertrophy, desquamation etc.Motherland's medical science thinks that this cause of disease rheumatic fever three heresies accumulate resistance skin, and skin loses supports, or nutrient QI and blood being insufficient, and blood is dry can not to be moistened and support skin and cause this disease.
The immunosuppressant and the hormone medicine that adopt at present; This type medicine is through suppressing the synthetic and epithelial propagation of overrunning of DNA; Symptoms such as alopecia, nausea and vomiting, oral ulcer will soon appear in patient, and hepatic and renal function injure has appearred in patient in a short time that have.
Summary of the invention
The object of the present invention is to provide psoriasic Chinese traditional compound medicine of a kind of treatment and preparation method thereof.
The present invention provides the compound Chinese medicinal preparation of a kind of Rhizoma Smilacis Glabrae, Poria, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Radix Angelicae Sinensis, Flos Carthami, Radix Arnebiae (Radix Lithospermi), Herba Hedyotidis Diffusae, Radix Glycyrrhizae compatibility to be used to treat psoriasis, and is evident in efficacy, has no adverse reaction.
Technical scheme of the present invention is following:
The psoriasic Chinese traditional compound medicine of a kind of treatment comprises the following weight Chinese medicinal raw materials: Rhizoma Smilacis Glabrae 26-34, Poria 8-12, Radix Salviae Miltiorrhizae 13-17, Radix Paeoniae Rubra 8-12, Radix Angelicae Sinensis 8-12, Flos Carthami 5-7, Radix Arnebiae (Radix Lithospermi) 5-7, Herba Hedyotidis Diffusae 13-17, Radix Glycyrrhizae 5-7.
Wherein method for preparing is that above-mentioned 9 flavor medical materials are cleaned, and proportional mixing, the 6-8 that adds medical material gross weight water or volume ratio doubly is that 70% ethanol decocts 3 times; Each 50 minutes, merge 3 times decoction liquor, filter; And concentrate, proportion is 1.19 fluid extract when obtaining 60 ℃, adopts conventional preparation technology; Chinese medicine preparation of the present invention can be made into said dosage form on any pharmaceutics, like tablet, capsule, granule, oral liquid, pill, syrup.
Rhizoma Smilacis Glabrae is with heat-clearing and toxic substances removing in the present invention prescription, and eliminating dampness and dredging channels is main effect, is easy to extort the damp and hot poison that accumulates into network, causes dermopathic medicine commonly used for damp and hot; Radix Angelicae Sinensis and Radix Paeoniae Rubra heat clearing away YIN nourishing are enriched blood and are invigorated blood circulation, blood enriching and dryness moistening; Radix Salviae Miltiorrhizae nourshing blood and promoting blood circulation, blood stasis dispelling, collateral dredging; Herba Hedyotidis Diffusae heat clearing away dissipating blood stasis, the eliminating carbuncle detoxifcation; The Radix Arnebiae (Radix Lithospermi) removing heat from blood, blood circulation promoting and blood stasis dispelling, detoxifcation rash; The plurality of Chinese synergy, heat-clearing and toxic substances removing, eliminating dampness and dredging channels induces sweat; Blood enriching and dryness moistening improves cutaneous circulation, promotes anti-tinea disorganization and absorption; So psoriasis treatment is played good action, so the Chinese traditional compound medicine that the present invention makes is evident in efficacy, has no adverse reaction.
Specific embodiment
Embodiment 1:
The psoriasic Chinese traditional compound medicine of a kind of treatment comprises the following weight Chinese medicinal raw materials: Rhizoma Smilacis Glabrae 26, Poria 8, Radix Salviae Miltiorrhizae 13, Radix Paeoniae Rubra 8, Radix Angelicae Sinensis 8, Flos Carthami 5, Radix Arnebiae (Radix Lithospermi) 5, Herba Hedyotidis Diffusae 13, Radix Glycyrrhizae 5.
Wherein method for preparing is that above-mentioned 9 flavor medical materials are cleaned, proportional mixing, and 6 times the decocting that adds the medical material gross weight boils 3 times, and each 50 minutes, merge 3 times decoction liquor, to filter, and concentrate, proportion is 1.19 fluid extract when obtaining 60 ℃.
Embodiment 2:
The psoriasic Chinese traditional compound medicine of a kind of treatment comprises the following weight Chinese medicinal raw materials: Rhizoma Smilacis Glabrae 30, Poria 10, Radix Salviae Miltiorrhizae 15, Radix Paeoniae Rubra 10, Radix Angelicae Sinensis 10, Flos Carthami 6, Radix Arnebiae (Radix Lithospermi) 6, Herba Hedyotidis Diffusae 15, Radix Glycyrrhizae 6.
All the other are with embodiment 1.
Embodiment 3:
The psoriasic Chinese traditional compound medicine of a kind of treatment comprises the following weight Chinese medicinal raw materials: Rhizoma Smilacis Glabrae 34, Poria 12, Radix Salviae Miltiorrhizae 17, Radix Paeoniae Rubra 12, Radix Angelicae Sinensis 12, Flos Carthami 7, Radix Arnebiae (Radix Lithospermi) 7, Herba Hedyotidis Diffusae 17, Radix Glycyrrhizae 7.
Wherein method for preparing is that above-mentioned 9 flavor medical materials are cleaned, proportional mixing, and 6 times of volume ratios that add the medical material gross weight are that 70% ethanol decocts 3 times, each 50 minutes, merges 3 times decoction liquor, filter, and concentrated, proportion is 1.19 fluid extract when obtaining 60 ℃.
Embodiment 4:
The psoriasic Chinese traditional compound medicine of a kind of treatment, wherein method for preparing is the medical material in the prescription to be cleaned proportional mixing; 7 times of volume ratios that add the medical material gross weight are that 70% ethanol decocts 3 times; Each 50 minutes, merge 3 times decoction liquor, filter; And concentrate, proportion is 1.19 fluid extract when obtaining 60 ℃.
All the other are with embodiment 1.
Embodiment 5:
The psoriasic Chinese traditional compound medicine of a kind of treatment, wherein method for preparing is the medical material in the prescription to be cleaned proportional mixing; 7 times the decocting that adds the medical material gross weight boils 3 times, each 50 minutes, merges 3 times decoction liquor; Filter, and concentrate, proportion is 1.19 fluid extract when obtaining 60 ℃.
All the other are with embodiment 2.
Embodiment 6:
The psoriasic Chinese traditional compound medicine of a kind of treatment, wherein method for preparing is the medical material in the prescription to be cleaned proportional mixing; 7 times the decocting that adds the medical material gross weight boils 3 times, each 50 minutes, merges 3 times decoction liquor; Filter, and concentrate, proportion is 1.19 fluid extract when obtaining 60 ℃.
All the other are with embodiment 3.
Embodiment 7:
The psoriasic Chinese traditional compound medicine of a kind of treatment, wherein method for preparing is the medical material in the prescription to be cleaned proportional mixing; 8 times of volume ratios that add the medical material gross weight are that 70% ethanol decocts 3 times; Each 50 minutes, merge 3 times decoction liquor, filter; And concentrate, proportion is 1.19 fluid extract when obtaining 60 ℃.
All the other are with embodiment 2.
Embodiment 8:
The psoriasic Chinese traditional compound medicine of a kind of treatment comprises the following weight Chinese medicinal raw materials: Rhizoma Smilacis Glabrae 35, Poria 15, Radix Salviae Miltiorrhizae 20, Radix Paeoniae Rubra 15, Radix Angelicae Sinensis 6, Flos Carthami 3, Radix Arnebiae (Radix Lithospermi) 3, Herba Hedyotidis Diffusae 10, Radix Glycyrrhizae 2.
Wherein method for preparing is that the medical material in the prescription is cleaned, proportional mixing, and 8 times the decocting that adds the medical material gross weight boils 3 times, and each 50 minutes, merge 3 times decoction liquor, to filter, and concentrate, proportion is 1.19 fluid extract when obtaining 60 ℃.
Embodiment 9:
The psoriasic Chinese traditional compound medicine of a kind of treatment comprises the following weight Chinese medicinal raw materials: Rhizoma Smilacis Glabrae 25, Poria 6, Radix Salviae Miltiorrhizae 10, Radix Paeoniae Rubra 5, Radix Angelicae Sinensis 13, Flos Carthami 10, Radix Arnebiae (Radix Lithospermi) 10, Herba Hedyotidis Diffusae 18, Radix Glycyrrhizae 10.
Wherein method for preparing is that the medical material in the prescription is cleaned, proportional mixing, and 8 times of volume ratios that add the medical material gross weight are that 70% ethanol decocts 3 times, each 50 minutes, merges 3 times decoction liquor, filter, and concentrated, proportion is 1.19 fluid extract when obtaining 60 ℃.
Embodiment 10:
The psoriasic Chinese traditional compound medicine of a kind of treatment comprises the following weight Chinese medicinal raw materials: Rhizoma Smilacis Glabrae 25, Poria 13, Radix Salviae Miltiorrhizae 12, Radix Paeoniae Rubra 12, Radix Angelicae Sinensis 7, Flos Carthami 8, Radix Arnebiae (Radix Lithospermi) 4, Herba Hedyotidis Diffusae 18, Radix Glycyrrhizae 4.
Wherein method for preparing is that above-mentioned 9 flavor medical materials are cleaned, proportional mixing, and 5 times the decocting that adds the medical material gross weight boils 3 times, and each 50 minutes, merge 3 times decoction liquor, to filter, and concentrate, proportion is 1.19 fluid extract when obtaining 60 ℃.
Embodiment 11:
Be psoriasic Chinese medicine powder of the disclosed a kind of treatment of patent of 200910223509.1 and preparation method thereof according to application number, comprise the following weight Chinese medicinal raw materials: Qin Testudinis (processing) 8, Calculus Bovis 1, the Radix Astragali 25, Radix Angelicae Sinensis 15, Rhizoma Smilacis Glabrae 25, Cortex Phellodendri 8, Cortex Moutan 9, the Fructus Kochiae 9, Radix Paeoniae Rubra 12, Flos Carthami 9, Cortex Dictamni 12, Radix Sophorae Flavescentis 15, Zaocys (processing) 8, Radix Polygoni Multiflori (life) 15, the Radix Rehmanniae 15, windproof 9, Periostracum Cicadae (processing) 6, Fructus Xanthii (processing) 6, Radix Glycyrrhizae 5, Radix Arnebiae (Radix Lithospermi) 12, Scolopendra (processing) 5, Scorpio (processing) 5, Flos Lonicerae 10, Radix Salviae Miltiorrhizae 9.
Wherein method for preparing be with above-mentioned pulverizing medicinal materials cross behind the 80-100 mesh sieve again with the bovine calculus powder mix homogeneously that grinds superfine powder after, weigh pack, every bag of 8g.Each one bag, three times on the one.
Embodiment 12:
According to interim " cooling blood and removing stasis dispelling wind soup treatment psoriasis 62 examples " the disclosed blood stasis dispelling dispelling wind soup side medicine of " the Shaanxi traditional Chinese medical science " calendar year 2001 the 22nd volume the 3rd, comprise the raw material of Chinese medicine of following weight:
The Radix Rehmanniae, each 30g of Caulis Spatholobi, Radix Paeoniae Rubra, Radix Angelicae Sinensis, from each 20g of moss skin, Rhizoma Smilacis Glabrae, Radix Arnebiae (Radix Lithospermi). each 15g of Flos Lonicerae, black groove Serpentis, Rhizoma Paridis, Radix Angelicae Dahuricae, windproof each 10g.Belong to the blood stasis person and add Radix Salviae Miltiorrhizae, Semen Persicae.One day potion, decocting divide clothes sooner or later.
Embodiment 13: adopt conventional preparation technology, Chinese medicine preparation of the present invention can be made into said dosage form on any pharmaceutics, like tablet, capsule, granule, oral liquid, pill, syrup.
All the other are with embodiment 1-10.
Embodiment 14: the fluid extract of the mix homogeneously that will be made by embodiment 1-10 concentrates, and according to the operational approach of conventional tablet, adds pharmaceutic adjuvant; With each component mix homogeneously, wet granulation sieves; Adopt conventional tablet preparation method tabletting to process tablet, wherein each components contents is following:
Composition weight (part)
Mixed flow extractum 50
Starch 18
Microcrystalline Cellulose 12
Pulvis Talci 8
Polyethylene Glycol 5
All the other are with embodiment 1-10.
Embodiment 15: the fluid extract of the mix homogeneously that will be made by embodiment 1-10 concentrates, and according to the operational approach of conventional capsule, adds pharmaceutic adjuvant; With each component mix homogeneously; Granulate, adopt conventional capsule preparation method to fill and process capsule, wherein each components contents is following:
Composition weight (part)
Mixed flow extractum 100
Pregelatinized Starch 28
Lactis Anhydrous 15
Microcrystalline Cellulose 13
Calcium hydrogen phosphate 5
All the other are with embodiment 1-10.
Embodiment 16: the fluid extract of the mix homogeneously that will be made by embodiment 1-10 concentrates, according to the operational approach of conventional oral liquid, ethanol precipitation 1-2 time; Filter, concentrate aqueous precipitation; Filter, add pharmaceutic adjuvant, filter; The packing sterilization adopts conventional oral liquid preparation method to prepare oral liquid, and wherein each components contents is following:
Composition weight (part)
Mixed flow extractum 100
Ethanol 150
Sucrose 72
Sodium carboxymethyl cellulose 13
Oleum menthae 6
Sorbic acid 3
All the other are with embodiment 1-10.
The effectiveness study experiment:
Select patient's 403 examples, age 12-59 year, 37.9 years old mean age, wherein women 194 examples, male 209 examples, course of disease 0.5-20, average course of disease 8.3 years.403 routine patients are divided into 13 groups at random, every group 31 example, 1 group as matched group.Organize as treatment for 12 groups.
Therapeutic Method:
The oral AMT of matched group, every day 0.5mg; With the prepared Chinese medical concrete of embodiment 1-10 9 times of dilute with waters by volume respectively, take for respectively 10 groups of treatment groups, each 100ml, every day 2 times, remaining two groups of treatment groups are taken the Chinese medicine preparation that embodiment 11 and embodiment 12 make; Treatment group and matched group were all taken medicine 1 month continuously.
Criterion of therapeutical effect
Recovery from illness: skin lesion all disappears, and subjective symptoms disappears, and does not see recurrence after the drug withdrawal in 15 months.Produce effects: the skin lesion overwhelming majority disappears, the few and attenuation of squama, and gargalesthesia obviously alleviates, and does not see that skin lesion increased the weight of in 15 months after the drug withdrawal.Effectively: the skin lesion overwhelming majority disappears, the few and attenuation of squama, and gargalesthesia obviously alleviates, and does not see that skin lesion increased the weight of in 5 months after the drug withdrawal.Invalid: skin lesion does not have significant change after the medication.
Table 1 therapeutic outcome
Nausea and vomiting 2 examples appear in matched group in therapeutic process, alopecia 1 example, oral ulcer 1 example; Any untoward reaction does not appear in the treatment group in therapeutic process.
Can find out that from therapeutic effect curative effect of the present invention obviously is superior to the hormone therapy psoriasis, and be superior to the curative effect of the Chinese medicine medicine that similar prescription makes in the prior art; Wherein with the best results of embodiment 5; And do not have any untoward reaction, so the Chinese traditional compound medicine that the present invention makes is used to treat psoriasis, evident in efficacy; Have no adverse reaction, can replace existing psoriasic methods of hormonal treatment fully.
Claims (5)
1. the psoriasic Chinese traditional compound medicine of treatment comprises the following weight Chinese medicinal raw materials: Rhizoma Smilacis Glabrae 26-34, Poria 8-12, Radix Salviae Miltiorrhizae 13-17.
2. the psoriasic Chinese traditional compound medicine of treatment comprises the following weight Chinese medicinal raw materials: Rhizoma Smilacis Glabrae 26-34, Poria 8-12, Radix Salviae Miltiorrhizae 13-17, Radix Paeoniae Rubra 8-12, Radix Angelicae Sinensis 8-12, Flos Carthami 5-7, Radix Arnebiae (Radix Lithospermi) 5-7, Herba Hedyotidis Diffusae 13-17, Radix Glycyrrhizae 5-7.
3. the psoriasic Chinese traditional compound medicine of treatment comprises the following weight Chinese medicinal raw materials: Rhizoma Smilacis Glabrae 30, Poria 10, Radix Salviae Miltiorrhizae 15, Radix Paeoniae Rubra 10, Radix Angelicae Sinensis 10, Flos Carthami 6, Radix Arnebiae (Radix Lithospermi) 6, Herba Hedyotidis Diffusae 15, Radix Glycyrrhizae 6.
4. like claim 2 or 3 said a kind of method for preparinies of treating psoriasic Chinese traditional compound medicine, it is characterized by: 9 flavor medical materials are cleaned proportional mixing; The 6-8 that adds medical material gross weight water or volume ratio doubly is that 70% ethanol decocts 3 times, each 50 minutes, merges 3 times decoction liquor; Filter; And concentrate, proportion is 1.19 fluid extract when obtaining 60 ℃, adopts conventional preparation technology; Can be made into said dosage form on any pharmaceutics, like tablet, capsule, granule, oral liquid, pill, syrup.
5. a kind of method for preparing of treating psoriasic Chinese traditional compound medicine as claimed in claim 4 is characterized by: 9 flavor medical materials are cleaned proportional mixing; 7 times the decocting that adds the medical material gross weight boils 3 times, each 50 minutes, merges 3 times decoction liquor; Filter, and concentrate, proportion is 1.19 fluid extract when obtaining 60 ℃; Adopt conventional preparation technology, can be made into said dosage form on any pharmaceutics, like tablet, capsule, granule, oral liquid, pill, syrup.
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| CN201110364219.6A CN102370918B (en) | 2011-11-17 | 2011-11-17 | One kind treats psoriasic compound Chinese medicinal preparation and preparation method thereof |
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| CN201110364219.6A CN102370918B (en) | 2011-11-17 | 2011-11-17 | One kind treats psoriasic compound Chinese medicinal preparation and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107854659A (en) * | 2017-11-30 | 2018-03-30 | 张�诚 | One kind treats psoriasic Chinese medicine preparation and preparation method thereof |
| CN108686005A (en) * | 2018-07-27 | 2018-10-23 | 章立兰 | A kind of medical composition and its application method for treating psoriasis |
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| CN1095614A (en) * | 1993-09-30 | 1994-11-30 | 卢兰亭 | Oral liquor for treatment of psoriasis |
| CN1706488A (en) * | 2005-05-11 | 2005-12-14 | 韦建奎 | Recipe of Chinese medicine for treating psoriasis |
| CN101698045A (en) * | 2009-11-23 | 2010-04-28 | 赵霞 | Traditional Chinese medicine powder for treating psoriasis and preparation method |
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2011
- 2011-11-17 CN CN201110364219.6A patent/CN102370918B/en not_active Expired - Fee Related
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| CN1095614A (en) * | 1993-09-30 | 1994-11-30 | 卢兰亭 | Oral liquor for treatment of psoriasis |
| CN1706488A (en) * | 2005-05-11 | 2005-12-14 | 韦建奎 | Recipe of Chinese medicine for treating psoriasis |
| CN101698045A (en) * | 2009-11-23 | 2010-04-28 | 赵霞 | Traditional Chinese medicine powder for treating psoriasis and preparation method |
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| 姜春燕等: "利用文本挖掘技术分析银屑病中医用药规律", 《中国中医药信息杂志》 * |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107854659A (en) * | 2017-11-30 | 2018-03-30 | 张�诚 | One kind treats psoriasic Chinese medicine preparation and preparation method thereof |
| CN108686005A (en) * | 2018-07-27 | 2018-10-23 | 章立兰 | A kind of medical composition and its application method for treating psoriasis |
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| CN102370918B (en) | 2017-12-08 |
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