CN102357179A - Medicine for treating antisperm antibody induced infertility or habitual abortion and preparation method thereof - Google Patents
Medicine for treating antisperm antibody induced infertility or habitual abortion and preparation method thereof Download PDFInfo
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- CN102357179A CN102357179A CN2011103431566A CN201110343156A CN102357179A CN 102357179 A CN102357179 A CN 102357179A CN 2011103431566 A CN2011103431566 A CN 2011103431566A CN 201110343156 A CN201110343156 A CN 201110343156A CN 102357179 A CN102357179 A CN 102357179A
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Abstract
The invention discloses a medicine for treating antisperm antibody induced infertility or habitual abortion and a preparation method thereof. The medicine is prepared from ground beeltle, parched hawthorn, the root of red-rooted salvia, twotooth achyranthes root, dandelion, thlaspi arvense, divaricate saposhnikovia root, cortex moutan, phellodendron, root of rehmannia, verbena officinalis and anemarrhena. The medicine has religious compatibility, and is scientific and reasonable, low in cost, good in treatment, short in treatment course and convenient to use. The medicine has the effects of removing blood stasis, promoting blood circulation and removing obstruction in channels, clearing heat and detoxicating, cooling blood, eliminating dampness, nourishing yin and supplementing blood, and nourishing kidney and liver and strengthening bones and tendons, is used for treating patients with positive antisperm antibody, and has satisfactory treatment effect clinically.
Description
Technical field
The present invention relates to treat the medicine that antisperm antibody causes infertility or habitual abortion, belong to the field of Chinese medicines.
Background technology
Infertility or habitual abortion are the common diseases of child-bearing period women, and its factor maybe be on the wife's side, the bridegroom's or husband's side or men and women.Wherein, immune factor is the generation of antisperm antibody, is a great problem of curing this disease.The seminal fluid that antisperm antibody makes produces spontaneous coagulation and can not pass cervical mucus; Sperm, smart oar or germ cell are antigenic substances, after being absorbed by vagina or endometrium, produce antibody materials through immunoreation, sperm can not be combined or germ cell can not implantation and normal development and cause infertile or embryo's stasi is miscarried with ovum.
Medically to the Therapeutic Method of the male patient Shang Wuhao of antisperm antibody, use condom 6-December that the intravital antisperm antibody level of part patient is descended during to this type of patient's sexual life at present, or the row immunosuppressant therapy.Exist the course of treatment long, uncertain therapeutic efficacy is cut, the defective that endocrine hormone or immunologic mechanism get muddled.
Summary of the invention
The purpose of this invention is to provide a kind of medicine that antisperm antibody causes infertility or habitual abortion of treating.
Another object of the present invention provides a kind of method for preparing that antisperm antibody causes water preparation, unguentum or the pill of the medicine of infertility or habitual abortion of treating.
Treatment antisperm antibody of the present invention causes the pharmaceutical formulation of infertility or habitual abortion and forms following by weight:
5-15 parts of Eupolyphaga Seu Steleophagas, 6-20 parts of Fructus Crataegi (parched to brown)s, 9-25 parts of Radix Salviae Miltiorrhizaes, 5-15 parts of Radix Achyranthis Bidentataes,
12-45 parts, windproof 5-12 parts of 15-45 parts of 、 Herba Thlaspiss of Herba Taraxaci, Cortex Moutan 6--15 part,
Cortex Phellodendri 6--15 part, 10-20 parts in the Radix Rehmanniae, Herba Verbenae 9--20 part, Rhizoma Anemarrhenae 6--20 part.
Medical material in the medicine material of the present invention is formed and the weight portion proportion optimization is:
10 parts of Eupolyphaga Seu Steleophagas, 10 parts of Fructus Crataegi (parched to brown)s, 15 parts of Radix Salviae Miltiorrhizaes, 9 parts of Radix Achyranthis Bidentataes, 30 parts of Herba Taraxacis,
30 parts of Herba Thlaspiss, windproof 9 parts, 9 parts of Cortex Moutans, 9 parts of Cortex Phellodendris, 15 parts in the Radix Rehmanniae, 12 parts of Herba Verbenae, 10 parts of the Rhizoma Anemarrhenaes.
Medicine of the present invention with the method for Chinese medicinal of routine, can be prepared into any common formulations with medicine of the present invention, like water preparation, unguentum, pill, powder, tablet etc. according to the said medicine prescription.When being prepared into medicament, can add conventional adjuvant in the above-mentioned raw materials medicine: like starch etc.
In order better to realize the present invention providing a kind of preferred treatment antisperm antibody to cause the method for preparing of the medicinal agent of infertility or habitual abortion, step is following:
The weighting profit requires the Chinese crude drug of weight proportion in 1, with Eupolyphaga Seu Steleophaga, Fructus Crataegi (parched to brown), Radix Salviae Miltiorrhizae, Radix Achyranthis Bidentatae, Herba Taraxaci 、 Herba Thlaspis, windproof, Cortex Moutan, Cortex Phellodendri, the Radix Rehmanniae, Herba Verbenae, the Rhizoma Anemarrhenae, adds cold water soak 30 minutes; Addition is 4-5 a times of above-mentioned Chinese medicine; Decocted about 40 minutes, and after the cold of drying in the air, filtered and use the plastic bag sealing sterilization packaging; Every bag of 300ml processes water preparation.
In order better to realize the present invention providing a kind of preferred treatment antisperm antibody to cause the method for preparing of the medicine unguentum of infertility or habitual abortion, step is following:
The weighting profit requires the Chinese crude drug Eupolyphaga Seu Steleophaga, Fructus Crataegi (parched to brown), Radix Salviae Miltiorrhizae, Radix Achyranthis Bidentatae, Herba Taraxaci 、 Herba Thlaspis of weight proportion in 1, windproof, Cortex Moutan, Cortex Phellodendri, the Radix Rehmanniae, Herba Verbenae, the Rhizoma Anemarrhenae; The decocte with water secondary; Merge twice decocting liquid, filtration; Be condensed into that relative density is the thick paste of 1:20 under 60 ℃ of temperature, process unguentum.
In order better to realize the present invention, provide the method for preparing step of the bolus of drug that a kind of preferred treatment antisperm antibody causes infertility or habitual abortion following:
The weighting profit requires 20% pulverizing of the Chinese crude drug total amount of weight proportion in 1; Be processed into superfine powder, all the other account for to be blended in the Chinese herbal medicine of Chinese crude drug total amount 80% and account for the duple water of total dose, decoct 2 hours; Sieve and remove slag; The medicine juice that filter is good is brewed into poultice, with the aforesaid herbal powder that accounts for Chinese crude drug total amount 20% pour into fully stir in the poultice after, machine is processed pill.Use plastic bottle packing, per 10 is 5 grams, 100 every bottle.Provide the drug dose that the prescription amount can make any amount by above-mentioned,
In the medicine of the present invention, Eupolyphaga Seu Steleophaga, removing blood stasis, reunion of fractured tendons and bones; Radix Achyranthis Bidentatae, eliminating blood stasis and inducing menstruation, invigorating the liver and kidney, bone and muscle strengthening, inducing diuresis for treating stranguria syndrome, conducting blood to flow downwards are monarch drug; Windproof, Herba Taraxaci 、 Herba Thlaspis, expelling pathogenic wind from the body surface, removing dampness to relieve pain, heat-clearing and toxic substances removing and middle dampness removing, inducing diuresis for treating stranguria syndrome are ministerial drug; Fructus Crataegi (parched to brown), Herba Verbenae, the Radix Rehmanniae, Cortex Phellodendri, Radix Salviae Miltiorrhizae, Cortex Moutan, Rhizoma Anemarrhenae circulation of qi promoting dissipating blood stasis, clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting, heat clearing and damp drying, pathogenic fire purging, skin ulcer is treated in detoxifcation, blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain is adjuvant.
Antisperm antibody is the immune factor that causes infertility or habitual abortion, and the present invention has removing blood stasis, promoting blood circulation to remove obstruction in the collateral, heat-clearing and toxic substances removing; Removing heat from blood, dampness, nourishing YIN and supplementing blood, the effect of nourishing the liver and kidney strengthening bone and muscle, compatibility of the present invention is rigorous; Scientific and reasonable, expense is low, and good effect, short treating period are easy to use.Be used for treating the male patient of antisperm antibody, obtained satisfied curative effect clinically.
The specific embodiment
Following embodiment can further specify the present invention, but does not limit the present invention in any way.
Embodiment 1
Prescription: Eupolyphaga Seu Steleophaga 6 grams, Radix Salviae Miltiorrhizae 10 grams, Herba Taraxaci 20 grams, windproof 6 grams, Cortex Phellodendri 7 grams, Fructus Crataegi (parched to brown) 8 grams, Radix Achyranthis Bidentatae 6 gram 、 Herba Thlaspiss 20 grams, Cortex Moutan 7 grams, the Radix Rehmanniae 12 grams, Herba Verbenae 10 grams, the Rhizoma Anemarrhenae 8 grams.
Get the Chinese crude drug of above weight ratio part, added an amount of cold water soak 30 minutes, amount of water is 4-5 times of above-mentioned Chinese crude drug, decocts about 40 minutes, after the cold of drying in the air, filters and uses the plastic bag sealing sterilization packaging, and every bag of 300ml processes water preparation.
Embodiment 2
Prescription: Eupolyphaga Seu Steleophaga 10 grams, Radix Salviae Miltiorrhizae 15 grams, Herba Taraxaci 30 grams, windproof 9 grams, Cortex Phellodendri 9 grams, Fructus Crataegi (parched to brown) 10 grams, Radix Achyranthis Bidentatae 9 gram 、 Herba Thlaspiss 30 grams, Cortex Moutan 9 grams, the Radix Rehmanniae 15 grams, Herba Verbenae 12 grams, the Rhizoma Anemarrhenae 10 grams.
Get the Chinese crude drug decocte with water secondary of above weight ratio part, each 2 hours, merge decocting liquid twice, filter and be condensed into the thick paste that relative density is 1.20 (60 ℃), process unguentum.
Embodiment 3
Prescription: Eupolyphaga Seu Steleophaga 13 grams, Radix Salviae Miltiorrhizae 20 grams, Herba Taraxaci 40 grams, windproof 10 grams, Cortex Phellodendri 12 grams, Fructus Crataegi (parched to brown) 15 grams, Radix Achyranthis Bidentatae 12 gram 、 Herba Thlaspiss 40 grams, Cortex Moutan 12 grams, the Radix Rehmanniae 18 grams, Herba Verbenae 18 grams, the Rhizoma Anemarrhenae 15 grams;
It is pure to get above weight ratio part Chinese crude drug 20% powder, is processed into superfine powder, and all the other 80% Chinese herbal medicine are blended into the duple water of total dose, decoct 2 hours, sieves and removes slag, and stirs the back machine and processes pill.Using per 10 of plastic bottle packing is 5 grams, 100 every bottle.
Embodiment 4
Prescription: Eupolyphaga Seu Steleophaga 5 grams, Radix Salviae Miltiorrhizae 9 grams, Herba Taraxaci 15 grams, windproof 5 grams, Cortex Phellodendri 6 grams, Fructus Crataegi (parched to brown) 6 grams, Radix Achyranthis Bidentatae 5 gram 、 Herba Thlaspiss 12 grams, Cortex Moutan 6 grams, the Radix Rehmanniae 10 grams, Herba Verbenae 9 grams, the Rhizoma Anemarrhenae 6 grams.
Get the Chinese crude drug of above weight ratio part, added an amount of cold water soak 30 minutes, amount of water is 4-5 times of above-mentioned Chinese crude drug, decocts about 40 minutes, after the cold of drying in the air, filters and uses the plastic bag sealing sterilization packaging, and every bag of 300ml processes water preparation.
Embodiment 5
Prescription: Eupolyphaga Seu Steleophaga 15 grams, Radix Salviae Miltiorrhizae 25 grams, Herba Taraxaci 45 grams, windproof 12 grams, Cortex Phellodendri 15 grams, Fructus Crataegi (parched to brown) 20 grams, Radix Achyranthis Bidentatae 15 gram 、 Herba Thlaspiss 45 grams, Cortex Moutan 15 grams, the Radix Rehmanniae 20 grams, Herba Verbenae 20 grams, the Rhizoma Anemarrhenae 20 grams.
It is pure to get above weight ratio part Chinese crude drug 20% powder, is processed into superfine powder, and all the other 80% Chinese herbal medicine are blended into the duple water of total dose, decoct 2 hours, sieves and removes slag, and stirs the back machine and processes pill.Using per 10 of plastic bottle packing is 5 grams, 100 every bottle.
Clinical experimental data
One, physical data: accept out-patient's 120 examples for medical treatment, wherein, and infertility 60 examples, habitual abortion 60 examples, through antisperm antibody test positive person, 22-35 years old ages.
Two, diagnostic criteria: to the patient of infertility or habitual abortion, the menses antisperm antibody that purifies the blood detects (colloidal gold method) positive person, gets rid of the infertile or habitual abortion that other factors causes.
Three, case inclusion criteria: meet above-mentioned laboratory diagnosis standard, differential diagnosis in tcm is got rid of the Deficiency and coldness of spleen and stomach person, gets rid of this medicine allergy sufferers, gets rid of the serious disease patients of internal organs such as suffering from the heart, brain, liver, kidney, psychotic.
Four, therapeutic scheme:
Oral medicine is water preparation, takes every day 2 times, and each 1 bag, every bag of 300ml, one month is a course of treatment.
Five, efficacy assessment standard: recovery from illness: after the course of treatment, survey feminine gender through the blood examination of laboratory antisperm antibody serum, B ultrasonic is made a definite diagnosis wife's gestation, and gestation month is recovery from illness greater than 14 weeks.Invalid, after the course of treatment, survey still positive through the blood examination of laboratory antisperm antibody serum.
Observation of curative effect:
| ? | Infertility | Habitual abortion | Add up to |
| Before the treatment (example) | Man 35 | Man 0 | Man 35 |
| ? | Woman 25 | Woman 60 | Woman 85 |
| Treatment back (example) | Man 3 | Man 0 | Man 3 |
| ? | Woman 5 | Woman 10 | Woman 15 |
| Cure rate (%) | Man 26.7 | Man 0 | Man 26.7 |
| ? | Woman 16.7 | Woman 41.7 | Woman 58.4 |
Six, statistical disposition: among the 120 routine patients, women's 85 examples, male's 35 examples, age 22---35 year.Recovery from illness 102 examples after one course of treatment, invalid 18 examples.Cure rate is 85%.
Seven, conclusion: in sum, prepare medicine, can reach therapeutic effect after taking, show that with the drug dose treatment of embodiment 1-5 the drug dose curative effect of embodiment 2 is best with the medical material ratio range of claim 1 of the present invention.
Claims (7)
1. treat the medicine that antisperm antibody causes infertility or habitual abortion for one kind, it is characterized in that medical material composition and the weight portion proportioning in the raw material is:
5-15 parts of Eupolyphaga Seu Steleophagas, 6-20 parts of Fructus Crataegi (parched to brown)s, 9-25 parts of Radix Salviae Miltiorrhizaes, 5-15 parts of Radix Achyranthis Bidentataes,
12-45 parts, windproof 5-12 parts of 15-45 parts of 、 Herba Thlaspiss of Herba Taraxaci, Cortex Moutan 6--15 part,
Cortex Phellodendri 6--15 part, 10-20 parts in the Radix Rehmanniae, Herba Verbenae 9--20 part, Rhizoma Anemarrhenae 6--20 part.
2. treatment antisperm antibody according to claim 1 causes the medicine of infertility or habitual abortion, it is characterized in that medical material composition and the weight portion proportioning in the raw material is:
10 parts of Eupolyphaga Seu Steleophagas, 10 parts of Fructus Crataegi (parched to brown)s, 15 parts of Radix Salviae Miltiorrhizaes, 9 parts of Radix Achyranthis Bidentataes, 30 parts of Herba Taraxacis,
30 parts of Herba Thlaspiss, windproof 9 parts, 9 parts of Cortex Moutans, 9 parts of Cortex Phellodendris, 15 parts in the Radix Rehmanniae, 12 parts of Herba Verbenae, 10 parts of the Rhizoma Anemarrhenaes.
3. treatment antisperm antibody according to claim 1 and 2 causes the medicine of infertility or habitual abortion, it is characterized in that this medicine is any dosage form on the pharmaceutics.
4. treatment antisperm antibody according to claim 3 causes the medicine of infertility or habitual abortion, it is characterized in that this medicine is water preparation, unguentum or pill.
5. treat the method for preparing that antisperm antibody causes the medicinal agent of infertility or habitual abortion for one kind, it is characterized in that step is following:
The weighting profit requires the Chinese crude drug of weight proportion in 1, with Eupolyphaga Seu Steleophaga, Fructus Crataegi (parched to brown), Radix Salviae Miltiorrhizae, Radix Achyranthis Bidentatae, Herba Taraxaci 、 Herba Thlaspis, windproof, Cortex Moutan, Cortex Phellodendri, the Radix Rehmanniae, Herba Verbenae, the Rhizoma Anemarrhenae, adds cold water soak 30 minutes; Addition is 4-5 a times of above-mentioned Chinese medicine; Decocted about 40 minutes, and after the cold of drying in the air, filtered and use the plastic bag sealing sterilization packaging; Every bag of 300ml processes water preparation.
6. treat the method for preparing that antisperm antibody causes the medicine unguentum of infertility or habitual abortion for one kind, it is characterized in that step is following:
The weighting profit requires the Chinese crude drug Eupolyphaga Seu Steleophaga, Fructus Crataegi (parched to brown), Radix Salviae Miltiorrhizae, Radix Achyranthis Bidentatae, Herba Taraxaci 、 Herba Thlaspis of weight proportion in 1, windproof, Cortex Moutan, Cortex Phellodendri, the Radix Rehmanniae, Herba Verbenae, the Rhizoma Anemarrhenae; The decocte with water secondary; Merge twice decocting liquid, filtration; Be condensed into that relative density is the thick paste of 1:20 under 60 ℃ of temperature, process unguentum.
7. treat the method for preparing that antisperm antibody causes the bolus of drug of infertility or habitual abortion for one kind; It is characterized in that step is following: the weighting profit requires 20% pulverizing of the Chinese crude drug total amount of weight proportion in 1; Be processed into superfine powder, all the other account for to be blended in the Chinese herbal medicine of Chinese crude drug total amount 80% and account for the duple water of total dose, decoct 2 hours; Sieve and remove slag; The medicine juice that filter is good is brewed into poultice, with the aforesaid herbal powder that accounts for Chinese crude drug total amount 20% pour into fully stir in the poultice after, machine is processed pill.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011103431566A CN102357179B (en) | 2011-11-03 | 2011-11-03 | Medicine for treating antisperm antibody induced infertility or habitual abortion and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011103431566A CN102357179B (en) | 2011-11-03 | 2011-11-03 | Medicine for treating antisperm antibody induced infertility or habitual abortion and preparation method thereof |
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| Publication Number | Publication Date |
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| CN102357179A true CN102357179A (en) | 2012-02-22 |
| CN102357179B CN102357179B (en) | 2012-11-07 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2011103431566A Expired - Fee Related CN102357179B (en) | 2011-11-03 | 2011-11-03 | Medicine for treating antisperm antibody induced infertility or habitual abortion and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015036375A (en) * | 2013-08-14 | 2015-02-23 | リプロバイオ株式会社 | Sperm improving agent and semen improving agent comprising peucedanum japonicum or extract thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1189364A (en) * | 1997-01-28 | 1998-08-05 | 许其辉 | Pregnancy promoting pill |
| CN1356139A (en) * | 2001-09-27 | 2002-07-03 | 孔金立 | Medicine for treating female acyesis and sexual disfunction |
| CN1977959A (en) * | 2005-11-30 | 2007-06-13 | 杨树森 | Chinese medicine compound preparation for comprehensively regulating body function and its preparing method |
| CN102058750A (en) * | 2011-01-10 | 2011-05-18 | 曹思亮 | Plaster for treating female infertility |
-
2011
- 2011-11-03 CN CN2011103431566A patent/CN102357179B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1189364A (en) * | 1997-01-28 | 1998-08-05 | 许其辉 | Pregnancy promoting pill |
| CN1356139A (en) * | 2001-09-27 | 2002-07-03 | 孔金立 | Medicine for treating female acyesis and sexual disfunction |
| CN1977959A (en) * | 2005-11-30 | 2007-06-13 | 杨树森 | Chinese medicine compound preparation for comprehensively regulating body function and its preparing method |
| CN102058750A (en) * | 2011-01-10 | 2011-05-18 | 曹思亮 | Plaster for treating female infertility |
Non-Patent Citations (2)
| Title |
|---|
| 刘欢 等: "中医药在输卵管因素不孕治疗中的应用", 《中日友好医院学报》 * |
| 李祥云: "不孕症中医治疗十法", 《上海中医药杂志》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015036375A (en) * | 2013-08-14 | 2015-02-23 | リプロバイオ株式会社 | Sperm improving agent and semen improving agent comprising peucedanum japonicum or extract thereof |
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| Publication number | Publication date |
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| CN102357179B (en) | 2012-11-07 |
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